MXPA94001345A - Derivados de poliamina como agentes radioprotectores. - Google Patents

Derivados de poliamina como agentes radioprotectores.

Info

Publication number
MXPA94001345A
MXPA94001345A MXPA94001345A MX9401345A MXPA94001345A MX PA94001345 A MXPA94001345 A MX PA94001345A MX PA94001345 A MXPA94001345 A MX PA94001345A MX 9401345 A MX9401345 A MX 9401345A MX PA94001345 A MXPA94001345 A MX PA94001345A
Authority
MX
Mexico
Prior art keywords
integer
radioprotective agents
polyamine derivatives
nhr
naphthyl
Prior art date
Application number
MXPA94001345A
Other languages
English (en)
Inventor
Michael L Edwards
Ronald D Snyder
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of MXPA94001345A publication Critical patent/MXPA94001345A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C211/57—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings being part of condensed ring systems of the carbon skeleton
    • C07C211/58—Naphthylamines; N-substituted derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C211/14—Amines containing amino groups bound to at least two aminoalkyl groups, e.g. diethylenetriamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C211/44—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring
    • C07C211/45—Monoamines
    • C07C211/48—N-alkylated amines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Polyurethanes Or Polyureas (AREA)
  • Polyamides (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)

Abstract

La presente invención se relaciona con ciertos derivados de poliamina, los cuales son útiles como agentes radioprotectores.
MXPA94001345A 1993-02-23 1994-02-22 Derivados de poliamina como agentes radioprotectores. MXPA94001345A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2136393A 1993-02-23 1993-02-23

Publications (1)

Publication Number Publication Date
MXPA94001345A true MXPA94001345A (es) 2010-10-04

Family

ID=21803772

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA94001345A MXPA94001345A (es) 1993-02-23 1994-02-22 Derivados de poliamina como agentes radioprotectores.

Country Status (19)

Country Link
US (1) US6114394A (es)
EP (1) EP0686142B1 (es)
JP (1) JPH08509699A (es)
KR (1) KR100311851B1 (es)
CN (1) CN1118160A (es)
AT (1) ATE175188T1 (es)
AU (2) AU679972B2 (es)
CA (2) CA2154663C (es)
DE (1) DE69415657T2 (es)
DK (1) DK0686142T3 (es)
ES (1) ES2128557T3 (es)
FI (1) FI953935A (es)
HU (1) HUT74005A (es)
IL (1) IL108695A (es)
MX (1) MXPA94001345A (es)
NO (1) NO305790B1 (es)
NZ (1) NZ262986A (es)
WO (1) WO1994019311A1 (es)
ZA (1) ZA941098B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2154663C (en) * 1993-02-23 2001-05-15 Michael L. Edwards Polyamine derivatives as radioprotective agents
US5994409A (en) * 1997-12-09 1999-11-30 U.S. Bioscience, Inc. Methods for treatment of neuro--and nephro--disorders and therapeutic toxicities using aminothiol compounds
US6489312B1 (en) 1999-06-15 2002-12-03 Medimmune Oncology, Inc. Pharmaceutical formulations comprising aminoalkyl phosphorothioates
ATE327973T1 (de) * 2000-03-24 2006-06-15 Mediquest Therapeutics Inc Polyamin-analoge als cytotoxische wirkstoffe
US7053072B2 (en) * 2001-05-11 2006-05-30 Medimmune Oncology, Inc. Methods for the administration of amifostine and related compounds
WO2003013245A1 (en) 2001-08-07 2003-02-20 Wisconsin Alumni Research Foundation Polyamines and analogs for protecting cells during cancer chemotherapy and radiotherapy
KR20040091014A (ko) * 2002-02-07 2004-10-27 위스콘신 얼럼나이 리서어치 화운데이션 항암 요법과 병행해서 사용하기 위한 폴리아민 화합물 및조성물
WO2005014524A2 (en) * 2003-08-07 2005-02-17 Wisconsin Alumni Research Foundation Amino thiol compounds and compositions for use in conjunction with cancer therapy
US7754463B2 (en) * 2006-06-20 2010-07-13 Dana-Farber Cancer Institute Inhibitors of USP1 Deubiquitinating Enzyme Complex
US20100049284A1 (en) * 2008-05-15 2010-02-25 The Catholic University Of America Use of heat to treat biological systems exposed to damaging radiation
CA2797719C (en) 2010-04-30 2019-11-26 Dana-Farber Cancer Institute, Inc. Small molecule inhibitors of usp1 deubiquitinating enzyme activity
US9439433B2 (en) 2013-05-22 2016-09-13 Curza Global, Llc Compositions and methods comprising a biocidal polyamine
US9034927B2 (en) 2013-05-22 2015-05-19 Curza Global, Llc Methods of use for compositions comprising a biocidal polyamine
WO2014190097A1 (en) * 2013-05-22 2014-11-27 Curza Global, Llc Compositions and methods comprising a polyamine and a silver substance
US9725425B1 (en) 2014-02-25 2017-08-08 Dana-Farber Cancer Institute, Inc. Compounds and methods for treating cancer
CN104926695B (zh) * 2015-06-01 2017-05-31 上海仁力医药科技有限公司 防治辐射损伤的化合物rl‑66301、单晶及其制备方法和应用
AU2018249550B2 (en) 2017-04-05 2023-11-30 Curza, Inc. Compositions and methods comprising a triaryl polyamine
CN107311891B (zh) * 2017-06-08 2019-08-06 山东一航新材料科技有限公司 一种亚胺类除水剂的制备方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2653977A (en) * 1953-09-29 Chxnx
US2951092A (en) * 1956-12-13 1960-08-30 Olin Mathieson Triamine derivatives
US3369905A (en) * 1963-03-19 1968-02-20 Eastman Kodak Co Photographic silver halide emulsions containing polyamine sensitizing agents
US3892824A (en) * 1968-12-16 1975-07-01 Southern Res Inst S-{107 -({107 -aminoalkylamino)alkyl dihydrogen phosphorothioates
US4591605A (en) * 1981-11-10 1986-05-27 Research Foundation Of State University Of New York Method and ingestible formulation for inhibiting the secretion of stomach acid
US5342945A (en) * 1986-12-02 1994-08-30 University Of Florida Research Foundation, Inc. Anti-neoplastic, anti-viral or anti-retroviral spermine derivatives
US5091576A (en) * 1986-12-02 1992-02-25 University Of Florida Anti-neoplastic, anti-viral or anti-retroviral spermine derivatives
ZA88600B (en) * 1987-02-03 1988-07-28 Merrell Dow Pharmaceuticals Inc. Novel polyamine derivatives
US5109024A (en) * 1987-02-03 1992-04-28 Merrell Dow Pharmaceuticals Inc. Polyamine derivatives as antineoplastic agents
US5021567A (en) * 1987-09-24 1991-06-04 Abbott Laboratories 8-hydroxyquinoline chelating agents
ZA887410B (en) * 1987-10-08 1989-06-28 Merrell Dow Pharma Polyamine derivatives as antineoplastic agents
EP0378146B1 (en) * 1989-01-10 1995-03-29 Merrell Pharmaceuticals Inc. Polyamine derivatives as antineoplastic agents
US5108556A (en) * 1990-09-14 1992-04-28 Minnesota Mining And Manufacturing Company Process for preparing tertiary perfluoroamines
AU647569B2 (en) * 1991-01-17 1994-03-24 Merrell Dow Pharmaceuticals Inc. Polyamine phenols as radioprotective agents
US5217964A (en) * 1991-01-23 1993-06-08 Merrell Dow Pharmaceuticals Inc. Polyamine thiols as radioprotective agents
GB9115375D0 (en) * 1991-07-17 1991-09-04 Salutar Inc Compounds
US5488042A (en) * 1992-03-13 1996-01-30 Arch Development Corporation Method for protection against genotoxic mutagenesis
CA2154663C (en) * 1993-02-23 2001-05-15 Michael L. Edwards Polyamine derivatives as radioprotective agents

Also Published As

Publication number Publication date
KR960700996A (ko) 1996-02-24
CN1118160A (zh) 1996-03-06
IL108695A0 (en) 1994-05-30
NO305790B1 (no) 1999-07-26
KR100311851B1 (ko) 2002-04-24
FI953935A (fi) 1995-09-13
AU683872B2 (en) 1997-11-27
EP0686142B1 (en) 1998-12-30
CA2219050A1 (en) 1994-09-01
AU6081596A (en) 1996-10-03
DE69415657D1 (de) 1999-02-11
US6114394A (en) 2000-09-05
CA2154663C (en) 2001-05-15
NO953293L (no) 1995-10-19
EP0686142A1 (en) 1995-12-13
ZA941098B (en) 1994-08-30
WO1994019311A1 (en) 1994-09-01
HUT74005A (en) 1996-10-28
ES2128557T3 (es) 1999-05-16
NZ262986A (en) 1997-06-24
FI953935A0 (fi) 1995-08-22
DE69415657T2 (de) 1999-09-02
AU679972B2 (en) 1997-07-17
CA2154663A1 (en) 1994-09-01
AU6297194A (en) 1994-09-14
JPH08509699A (ja) 1996-10-15
IL108695A (en) 2000-02-17
NO953293D0 (no) 1995-08-22
DK0686142T3 (da) 1999-08-30
ATE175188T1 (de) 1999-01-15
CA2219050C (en) 2001-06-19
HU9502456D0 (en) 1995-10-30

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Legal Events

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