DE69415657T2 - Polyaminderivate als strahlenschutzmittel - Google Patents
Polyaminderivate als strahlenschutzmittelInfo
- Publication number
- DE69415657T2 DE69415657T2 DE69415657T DE69415657T DE69415657T2 DE 69415657 T2 DE69415657 T2 DE 69415657T2 DE 69415657 T DE69415657 T DE 69415657T DE 69415657 T DE69415657 T DE 69415657T DE 69415657 T2 DE69415657 T2 DE 69415657T2
- Authority
- DE
- Germany
- Prior art keywords
- integer
- polyamine derivatives
- radiation protection
- protection agent
- nhr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 229920000768 polyamine Polymers 0.000 title abstract 3
- 239000011814 protection agent Substances 0.000 title 1
- 230000005855 radiation Effects 0.000 title 1
- 125000006528 (C2-C6) alkyl group Chemical group 0.000 abstract 2
- 125000001624 naphthyl group Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 239000000718 radiation-protective agent Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C211/57—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings being part of condensed ring systems of the carbon skeleton
- C07C211/58—Naphthylamines; N-substituted derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/785—Polymers containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C211/14—Amines containing amino groups bound to at least two aminoalkyl groups, e.g. diethylenetriamines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/43—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C211/44—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having amino groups bound to only one six-membered aromatic ring
- C07C211/45—Monoamines
- C07C211/48—N-alkylated amines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Polyurethanes Or Polyureas (AREA)
- Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
- Polyamides (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2136393A | 1993-02-23 | 1993-02-23 | |
| PCT/US1994/001128 WO1994019311A1 (en) | 1993-02-23 | 1994-01-31 | Polyamine derivatives as radioprotective agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69415657D1 DE69415657D1 (de) | 1999-02-11 |
| DE69415657T2 true DE69415657T2 (de) | 1999-09-02 |
Family
ID=21803772
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69415657T Expired - Fee Related DE69415657T2 (de) | 1993-02-23 | 1994-01-31 | Polyaminderivate als strahlenschutzmittel |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US6114394A (de) |
| EP (1) | EP0686142B1 (de) |
| JP (1) | JPH08509699A (de) |
| KR (1) | KR100311851B1 (de) |
| CN (1) | CN1118160A (de) |
| AT (1) | ATE175188T1 (de) |
| AU (2) | AU679972B2 (de) |
| CA (2) | CA2219050C (de) |
| DE (1) | DE69415657T2 (de) |
| DK (1) | DK0686142T3 (de) |
| ES (1) | ES2128557T3 (de) |
| FI (1) | FI953935A (de) |
| HU (1) | HUT74005A (de) |
| IL (1) | IL108695A (de) |
| MX (1) | MXPA94001345A (de) |
| NO (1) | NO305790B1 (de) |
| NZ (1) | NZ262986A (de) |
| WO (1) | WO1994019311A1 (de) |
| ZA (1) | ZA941098B (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ262986A (en) * | 1993-02-23 | 1997-06-24 | Merrell Dow Pharma | Polyamine derivatives; use in protecting mammalian cells from the deleterious effects of ionising radiation and/or mutagenic chemicals |
| US5994409A (en) | 1997-12-09 | 1999-11-30 | U.S. Bioscience, Inc. | Methods for treatment of neuro--and nephro--disorders and therapeutic toxicities using aminothiol compounds |
| US6489312B1 (en) | 1999-06-15 | 2002-12-03 | Medimmune Oncology, Inc. | Pharmaceutical formulations comprising aminoalkyl phosphorothioates |
| US6872852B2 (en) | 2000-03-24 | 2005-03-29 | Mediquest Therapeutics, Inc. | Polyamine analogues as cytotoxic agents |
| US7053072B2 (en) | 2001-05-11 | 2006-05-30 | Medimmune Oncology, Inc. | Methods for the administration of amifostine and related compounds |
| WO2003013245A1 (en) | 2001-08-07 | 2003-02-20 | Wisconsin Alumni Research Foundation | Polyamines and analogs for protecting cells during cancer chemotherapy and radiotherapy |
| KR20040091014A (ko) * | 2002-02-07 | 2004-10-27 | 위스콘신 얼럼나이 리서어치 화운데이션 | 항암 요법과 병행해서 사용하기 위한 폴리아민 화합물 및조성물 |
| WO2005014524A2 (en) * | 2003-08-07 | 2005-02-17 | Wisconsin Alumni Research Foundation | Amino thiol compounds and compositions for use in conjunction with cancer therapy |
| US7754463B2 (en) * | 2006-06-20 | 2010-07-13 | Dana-Farber Cancer Institute | Inhibitors of USP1 Deubiquitinating Enzyme Complex |
| US20100049284A1 (en) * | 2008-05-15 | 2010-02-25 | The Catholic University Of America | Use of heat to treat biological systems exposed to damaging radiation |
| US9518032B2 (en) | 2010-04-30 | 2016-12-13 | Dana-Farber Cancer Institute, Inc. | Small molecule inhibitors of USP1 deubiquitinating enzyme activity |
| WO2014190097A1 (en) * | 2013-05-22 | 2014-11-27 | Curza Global, Llc | Compositions and methods comprising a polyamine and a silver substance |
| US9439433B2 (en) | 2013-05-22 | 2016-09-13 | Curza Global, Llc | Compositions and methods comprising a biocidal polyamine |
| US9034927B2 (en) | 2013-05-22 | 2015-05-19 | Curza Global, Llc | Methods of use for compositions comprising a biocidal polyamine |
| US9725425B1 (en) | 2014-02-25 | 2017-08-08 | Dana-Farber Cancer Institute, Inc. | Compounds and methods for treating cancer |
| CN104926695B (zh) * | 2015-06-01 | 2017-05-31 | 上海仁力医药科技有限公司 | 防治辐射损伤的化合物rl‑66301、单晶及其制备方法和应用 |
| JP7041166B2 (ja) | 2017-04-05 | 2022-03-23 | カーザ グローバル，リミティド ライアビリティ カンパニー | トリアリールポリアミンを含む組成物および方法 |
| CN107311891B (zh) * | 2017-06-08 | 2019-08-06 | 山东一航新材料科技有限公司 | 一种亚胺类除水剂的制备方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2653977A (en) * | 1953-09-29 | Chxnx | ||
| US2951092A (en) * | 1956-12-13 | 1960-08-30 | Olin Mathieson | Triamine derivatives |
| US3369905A (en) * | 1963-03-19 | 1968-02-20 | Eastman Kodak Co | Photographic silver halide emulsions containing polyamine sensitizing agents |
| US3892824A (en) * | 1968-12-16 | 1975-07-01 | Southern Res Inst | S-{107 -({107 -aminoalkylamino)alkyl dihydrogen phosphorothioates |
| US4591605A (en) * | 1981-11-10 | 1986-05-27 | Research Foundation Of State University Of New York | Method and ingestible formulation for inhibiting the secretion of stomach acid |
| US5342945A (en) * | 1986-12-02 | 1994-08-30 | University Of Florida Research Foundation, Inc. | Anti-neoplastic, anti-viral or anti-retroviral spermine derivatives |
| US5091576A (en) * | 1986-12-02 | 1992-02-25 | University Of Florida | Anti-neoplastic, anti-viral or anti-retroviral spermine derivatives |
| US5109024A (en) * | 1987-02-03 | 1992-04-28 | Merrell Dow Pharmaceuticals Inc. | Polyamine derivatives as antineoplastic agents |
| ZA88600B (en) * | 1987-02-03 | 1988-07-28 | Merrell Dow Pharmaceuticals Inc. | Novel polyamine derivatives |
| US5021567A (en) * | 1987-09-24 | 1991-06-04 | Abbott Laboratories | 8-hydroxyquinoline chelating agents |
| ZA887410B (en) * | 1987-10-08 | 1989-06-28 | Merrell Dow Pharma | Polyamine derivatives as antineoplastic agents |
| DE69018099T2 (de) * | 1989-01-10 | 1995-08-03 | Merrell Dow Pharma | Polyamin-Derivate als antineoplastische Mittel. |
| US5108556A (en) * | 1990-09-14 | 1992-04-28 | Minnesota Mining And Manufacturing Company | Process for preparing tertiary perfluoroamines |
| AU647569B2 (en) * | 1991-01-17 | 1994-03-24 | Merrell Dow Pharmaceuticals Inc. | Polyamine phenols as radioprotective agents |
| US5217964A (en) * | 1991-01-23 | 1993-06-08 | Merrell Dow Pharmaceuticals Inc. | Polyamine thiols as radioprotective agents |
| GB9115375D0 (en) * | 1991-07-17 | 1991-09-04 | Salutar Inc | Compounds |
| US5488042A (en) * | 1992-03-13 | 1996-01-30 | Arch Development Corporation | Method for protection against genotoxic mutagenesis |
| NZ262986A (en) * | 1993-02-23 | 1997-06-24 | Merrell Dow Pharma | Polyamine derivatives; use in protecting mammalian cells from the deleterious effects of ionising radiation and/or mutagenic chemicals |
-
1994
- 1994-01-31 NZ NZ262986A patent/NZ262986A/en unknown
- 1994-01-31 CN CN94191275A patent/CN1118160A/zh active Pending
- 1994-01-31 CA CA002219050A patent/CA2219050C/en not_active Expired - Fee Related
- 1994-01-31 KR KR1019950703616A patent/KR100311851B1/ko not_active IP Right Cessation
- 1994-01-31 EP EP94910666A patent/EP0686142B1/de not_active Expired - Lifetime
- 1994-01-31 DK DK94910666T patent/DK0686142T3/da active
- 1994-01-31 WO PCT/US1994/001128 patent/WO1994019311A1/en active IP Right Grant
- 1994-01-31 ES ES94910666T patent/ES2128557T3/es not_active Expired - Lifetime
- 1994-01-31 DE DE69415657T patent/DE69415657T2/de not_active Expired - Fee Related
- 1994-01-31 HU HU9502456A patent/HUT74005A/hu unknown
- 1994-01-31 AU AU62971/94A patent/AU679972B2/en not_active Ceased
- 1994-01-31 CA CA002154663A patent/CA2154663C/en not_active Expired - Fee Related
- 1994-01-31 JP JP6518992A patent/JPH08509699A/ja not_active Ceased
- 1994-01-31 AT AT94910666T patent/ATE175188T1/de not_active IP Right Cessation
- 1994-02-17 IL IL10869594A patent/IL108695A/xx not_active IP Right Cessation
- 1994-02-17 ZA ZA941098A patent/ZA941098B/xx unknown
- 1994-02-22 MX MXPA94001345A patent/MXPA94001345A/es not_active Application Discontinuation
-
1995
- 1995-08-22 NO NO953293A patent/NO305790B1/no unknown
- 1995-08-22 FI FI953935A patent/FI953935A/fi unknown
-
1996
- 1996-07-31 AU AU60815/96A patent/AU683872B2/en not_active Ceased
-
1997
- 1997-10-14 US US08/949,536 patent/US6114394A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0686142B1 (de) | 1998-12-30 |
| DK0686142T3 (da) | 1999-08-30 |
| CN1118160A (zh) | 1996-03-06 |
| ZA941098B (en) | 1994-08-30 |
| NO953293D0 (no) | 1995-08-22 |
| DE69415657D1 (de) | 1999-02-11 |
| IL108695A0 (en) | 1994-05-30 |
| AU6297194A (en) | 1994-09-14 |
| WO1994019311A1 (en) | 1994-09-01 |
| FI953935A0 (fi) | 1995-08-22 |
| NO953293L (no) | 1995-10-19 |
| AU683872B2 (en) | 1997-11-27 |
| NZ262986A (en) | 1997-06-24 |
| HUT74005A (en) | 1996-10-28 |
| IL108695A (en) | 2000-02-17 |
| KR960700996A (ko) | 1996-02-24 |
| NO305790B1 (no) | 1999-07-26 |
| JPH08509699A (ja) | 1996-10-15 |
| AU679972B2 (en) | 1997-07-17 |
| HU9502456D0 (en) | 1995-10-30 |
| KR100311851B1 (ko) | 2002-04-24 |
| CA2154663C (en) | 2001-05-15 |
| FI953935A (fi) | 1995-09-13 |
| AU6081596A (en) | 1996-10-03 |
| CA2219050A1 (en) | 1994-09-01 |
| MXPA94001345A (es) | 2010-10-04 |
| EP0686142A1 (de) | 1995-12-13 |
| ES2128557T3 (es) | 1999-05-16 |
| US6114394A (en) | 2000-09-05 |
| ATE175188T1 (de) | 1999-01-15 |
| CA2219050C (en) | 2001-06-19 |
| CA2154663A1 (en) | 1994-09-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |