DK0956286T3 - Syntese af terfenadin og derivater deraf - Google Patents
Syntese af terfenadin og derivater derafInfo
- Publication number
- DK0956286T3 DK0956286T3 DK98901831T DK98901831T DK0956286T3 DK 0956286 T3 DK0956286 T3 DK 0956286T3 DK 98901831 T DK98901831 T DK 98901831T DK 98901831 T DK98901831 T DK 98901831T DK 0956286 T3 DK0956286 T3 DK 0956286T3
- Authority
- DK
- Denmark
- Prior art keywords
- terfenadine
- synthesis
- derivatives
- processes
- general formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
- C07D317/20—Free hydroxyl or mercaptan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/20—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
- C07D317/22—Radicals substituted by singly bound oxygen or sulfur atoms etherified
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pulmonology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/803,895 US5925761A (en) | 1997-02-04 | 1997-02-04 | Synthesis of terfenadine and derivatives |
| PCT/US1998/000898 WO1998033789A1 (en) | 1997-02-04 | 1998-01-20 | Synthesis of terfenadine and derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0956286T3 true DK0956286T3 (da) | 2003-07-14 |
Family
ID=25187720
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK98901831T DK0956286T3 (da) | 1997-02-04 | 1998-01-20 | Syntese af terfenadin og derivater deraf |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US5925761A (da) |
| EP (1) | EP0956286B1 (da) |
| JP (1) | JP4330179B2 (da) |
| AT (1) | ATE236148T1 (da) |
| AU (1) | AU724665B2 (da) |
| CA (1) | CA2279960C (da) |
| DE (1) | DE69812895T2 (da) |
| DK (1) | DK0956286T3 (da) |
| ES (1) | ES2196531T3 (da) |
| PT (1) | PT956286E (da) |
| WO (1) | WO1998033789A1 (da) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6201124B1 (en) * | 1995-12-21 | 2001-03-13 | Albany Molecular Research, Inc. | Process for production of piperidine derivatives |
| US6153754A (en) * | 1995-12-21 | 2000-11-28 | Albany Molecular Research, Inc. | Process for production of piperidine derivatives |
| IN191492B (da) * | 1999-05-25 | 2003-12-06 | Ranbaxy Lab Ltd | |
| US20030021849A1 (en) * | 2001-04-09 | 2003-01-30 | Ben-Zion Dolitzky | Polymorphs of fexofenadine hydrochloride |
| CA2444456A1 (en) * | 2001-04-09 | 2002-10-17 | Teva Pharmaceutical Industries Ltd. | Polymorphs of fexofenadine hydrochloride |
| WO2003104197A1 (en) * | 2002-06-10 | 2003-12-18 | Teva Pharmaceutical Industries Ltd. | Polymorphic form xvi of fexofenadine hydrochloride |
| SK285548B6 (sk) * | 2002-11-13 | 2007-03-01 | Zentiva, A. S. | Spôsob prípravy terfenadinu a jeho derivátov |
| MXPA06012281A (es) * | 2004-04-26 | 2007-07-18 | Teva Pharma | Formas cristalinas de clorhidrato de fexofenadina y procesos para su preparacion. |
| EP1685106A2 (en) * | 2004-09-28 | 2006-08-02 | Teva Pharmaceutical Industries, Inc. | Fexofendadine crystal form and processes for its preparation thereof |
| WO2007135693A2 (en) * | 2006-05-18 | 2007-11-29 | Ind-Swift Laboratories Limited | Intermediates useful for the preparation of antihistaminic piperidine derivative |
| MEP8009A (en) | 2006-09-15 | 2011-12-20 | Pyrido (2, 3-d) pyrimidin0ne compounds and their use as pi3 inhibitors | |
| US7868200B2 (en) * | 2008-12-30 | 2011-01-11 | Lyondellbasell Flavors & Fragrances, Llc | Process for preparing alicyclic carboxylic acid compounds |
| KR102233327B1 (ko) * | 2013-12-26 | 2021-03-26 | 스미또모 가가꾸 가부시끼가이샤 | 할로겐 치환 프탈리드의 제조 방법 |
| CN104876853B (zh) * | 2015-06-17 | 2017-06-16 | 苏州卫生职业技术学院 | 盐酸非索非那定的合成方法 |
| US10092087B2 (en) | 2016-06-03 | 2018-10-09 | Israel Harry Zimmerman | Self-righting toothbrush |
| US10485330B2 (en) | 2017-02-20 | 2019-11-26 | Israel Harry Zimmerman | Self-righting toothbrush |
| US10517386B2 (en) | 2017-03-30 | 2019-12-31 | Israel Harry Zimmerman | Self-righting toothbrush |
| USD874832S1 (en) | 2018-03-23 | 2020-02-11 | Israel Harry Zimmerman | Toothbrush handle |
| USD876097S1 (en) | 2018-03-23 | 2020-02-25 | Israel Harry Zimmerman | Toothbrush handle |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3141024A (en) * | 1964-07-14 | S-trimethoxy benzoyl amino | ||
| US3806526A (en) * | 1972-01-28 | 1974-04-23 | Richardson Merrell Inc | 1-aroylalkyl-4-diphenylmethyl piperidines |
| US3965257A (en) * | 1972-01-28 | 1976-06-22 | Richardson-Merrell Inc. | Compositions and methods for the treatment of the symptoms of histamine induced allergic reactions |
| US4254129A (en) * | 1979-04-10 | 1981-03-03 | Richardson-Merrell Inc. | Piperidine derivatives |
| EP0479601B1 (en) * | 1990-10-05 | 1999-12-15 | Ajinomoto Co., Inc. | Piperidine derivatives and their use as antiarrhythmic agents |
| RO116043B1 (ro) * | 1992-08-03 | 2000-10-30 | Sepracor Inc | Compozitie farmaceutica |
| WO1995000482A1 (en) * | 1993-06-24 | 1995-01-05 | Albany Molecular Research, Inc. | Piperidine derivatives and process for their production |
| CN1159277C (zh) * | 1993-06-25 | 2004-07-28 | 默里尔药物公司 | 用于制备抗组胺哌啶衍生物的新中间体 |
| CA2189000C (en) * | 1994-05-16 | 2002-08-13 | Mitsuo Nakamura | Process and diastereomeric salts useful for the optical resolution of racemic .alpha.-[4-(1,1-dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-1-piperidinebutanol and derivative compounds |
-
1997
- 1997-02-04 US US08/803,895 patent/US5925761A/en not_active Expired - Lifetime
-
1998
- 1998-01-20 WO PCT/US1998/000898 patent/WO1998033789A1/en active IP Right Grant
- 1998-01-20 ES ES98901831T patent/ES2196531T3/es not_active Expired - Lifetime
- 1998-01-20 AT AT98901831T patent/ATE236148T1/de active
- 1998-01-20 DK DK98901831T patent/DK0956286T3/da active
- 1998-01-20 DE DE69812895T patent/DE69812895T2/de not_active Expired - Lifetime
- 1998-01-20 PT PT98901831T patent/PT956286E/pt unknown
- 1998-01-20 EP EP98901831A patent/EP0956286B1/en not_active Expired - Lifetime
- 1998-01-20 AU AU58262/98A patent/AU724665B2/en not_active Ceased
- 1998-01-20 JP JP53292198A patent/JP4330179B2/ja not_active Expired - Fee Related
- 1998-01-20 CA CA002279960A patent/CA2279960C/en not_active Expired - Fee Related
-
1999
- 1999-05-24 US US09/316,104 patent/US6147217A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE69812895D1 (de) | 2003-05-08 |
| EP0956286A1 (en) | 1999-11-17 |
| PT956286E (pt) | 2003-08-29 |
| ATE236148T1 (de) | 2003-04-15 |
| AU724665B2 (en) | 2000-09-28 |
| EP0956286B1 (en) | 2003-04-02 |
| AU5826298A (en) | 1998-08-25 |
| US5925761A (en) | 1999-07-20 |
| WO1998033789A1 (en) | 1998-08-06 |
| CA2279960C (en) | 2007-07-17 |
| US6147217A (en) | 2000-11-14 |
| JP4330179B2 (ja) | 2009-09-16 |
| CA2279960A1 (en) | 1998-08-06 |
| JP2001511144A (ja) | 2001-08-07 |
| DE69812895T2 (de) | 2004-04-22 |
| ES2196531T3 (es) | 2003-12-16 |
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