KR960705810A - 퀴나졸린 유도체(quinazoline derivatives) - Google Patents

퀴나졸린 유도체(quinazoline derivatives)

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Publication number
KR960705810A
KR960705810A KR1019960702161A KR19960702161A KR960705810A KR 960705810 A KR960705810 A KR 960705810A KR 1019960702161 A KR1019960702161 A KR 1019960702161A KR 19960702161 A KR19960702161 A KR 19960702161A KR 960705810 A KR960705810 A KR 960705810A
Authority
KR
South Korea
Prior art keywords
substituted
hydrogen
lower alkyl
unsubstituted
different
Prior art date
Application number
KR1019960702161A
Other languages
English (en)
Inventor
시게끼 후지와라
유꼬 오까무라
하루끼 다까이
히로미 노나까
다까히로 모리야마
고오죠 야오
아끼라 가라사와
Original Assignee
나까무라 간노스께
교오와학꼬고오교 가부시끼가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 나까무라 간노스께, 교오와학꼬고오교 가부시끼가이샤 filed Critical 나까무라 간노스께
Publication of KR960705810A publication Critical patent/KR960705810A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Lubricants (AREA)
  • Fireproofing Substances (AREA)
  • Luminescent Compositions (AREA)
  • Furan Compounds (AREA)

Abstract

식(I)
[식중, R1은 수소, 저급 알킬, 알케닐 또는 아르알킬을 나타내고, R2, R3, R4및 R5는 수소, 저급 알킬, 저급 알콕시, 저급 알카노일 등을 나타내고, R6, R7, R8및 R9는 수소, 저급 알킬, 저급 알콕시, 아르알킬옥시등을 나타내거나, 인접하는 2개가 함께 되어서 메틸렌디옥시등을 나타내고, R10은 수소, 저급 알킬 등을 나타내고, R11및 R12는 수소, 저급 알킬, 시클로 알킬, 페닐, 아르알킬을 나타내거나 R11과 R12함께되어서 N을 함유하여 형성되는 복소환기를 나타내고, n은 0, 1 또는 2를 나타낸다]으로 표시되는 퀴나졸린 유도체 또는 그의 약리학적으로 허용되는 염.
본 화합물은 아데노신 취입 저해 작용을 가지며, 심근 보호 및 족 부종 등의 염증의 예방 또는 치료에 유용하다.

Description

퀴나졸린 유도체(QUINAZOLINE DERIVATIVES)
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (7)

  1. 식(I)로 표시되는 퀴나졸린 유도체 또는 그의 약리학적으로 허용되는 염:
    [식중, R1은 수소, 치환 또는 비치환의 저급 알킬, 알케닐 또는 치환 또는 비치환의 아르알킬을 나타내고, R2, R3, R4및 R5는 동일 또는 상이되고, 수소, 할로겐, 아미노, 모노 또는 디저급 알킬 아미노, 저급 알카노일 아미노, 니트로, 시아노, 치환 또는 비치환의 저급 알킬, 히드록시, 저급 알콕시, 저급 알킬티오, 카르복시, 저급 알콕시, 카르보닐, 저급 알카노일, 아르알킬옥시 또는 저급 알카노일옥시를 나타내고, R6, R7, R8및 R9는 동일 또는 상이하며 수소, 저급 알킬, 히드록시, 치환 또는 비치환의 저급 알콕시, 아르알킬옥시를 나타내거나, 인접하는 2개가 함께 되어서 메틸렌디옥시 또는 에틸렌디옥시를 나타내고, R10은 수소, 저급 알킬 또는 할로겐을 나타내고, R11및 R12는 동일 또는 상이하며 수소, 치환 또는 비치환의 저급 알킬, 시클로 알킬, 치환 또는 비치환의 페닐,치환 또는 비치환의 아르알킬을 나타내거나 R11과 R12가 함께 되어서 N을 함유하여 형성되는 치환 또는 비치환의 복소환기를 나타내고, n은 0, 1 또는 2를 나타낸다]
  2. 제1항에 있어서, R1이 수소, 또는 저급 알킬인 화합물.
  3. 제1항에 있어서, R2, R3, R4및 R5는 동일 또는 상이하며, 수소, 할로겐, 니트로, 저급 알킬 또는 저급 알카노일인 화합물.
  4. 제1항에 있어서, R6, R7, R8및 R9는 동일 또는 상이하며, 수소, 저급 알콕시 또는 인접하는 2개가 함께 되어서 메틸렌디옥시인 화합물.
  5. 제1항에 있어서, R11및 R12는 동일 또는 상이하며, 수소, 치환 또는 비치환의 저급 알킬, 아르알킬을 나타내거나 R11과 R12가 함께 되어서 N을 함유하여 형성되는 치환 또는 비치환의 복소환기인 화합물.
  6. 제1항에 있어서, n이 0인 화합물.
  7. 제5항에 있어서, R11과 R12가 함께 되어서 N을 함유하여 형성되는 복소환기가 모르폴리노기인 화합물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019960702161A 1994-08-26 1995-08-25 퀴나졸린 유도체(quinazoline derivatives) KR960705810A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP94-202018 1994-08-26
JP6202018A JPH09165385A (ja) 1994-08-26 1994-08-26 キナゾリン誘導体
PCT/JP1995/001694 WO1996006841A1 (fr) 1994-08-26 1995-08-25 Derive de quinazoline

Publications (1)

Publication Number Publication Date
KR960705810A true KR960705810A (ko) 1996-11-08

Family

ID=16450565

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019960702161A KR960705810A (ko) 1994-08-26 1995-08-25 퀴나졸린 유도체(quinazoline derivatives)

Country Status (14)

Country Link
US (1) US5948784A (ko)
EP (1) EP0726267B1 (ko)
JP (1) JPH09165385A (ko)
KR (1) KR960705810A (ko)
CN (1) CN1043991C (ko)
AT (1) ATE197710T1 (ko)
AU (1) AU689304B2 (ko)
CA (1) CA2174854C (ko)
DE (1) DE69519469T2 (ko)
ES (1) ES2153491T3 (ko)
FI (1) FI961758A (ko)
NO (1) NO310658B1 (ko)
NZ (1) NZ291506A (ko)
WO (1) WO1996006841A1 (ko)

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CA2234342A1 (en) * 1997-04-10 1998-10-10 Kyowa Hakko Kogyo Co., Ltd. Pancreatitis remedy
WO1999019326A1 (fr) * 1997-10-15 1999-04-22 Kyowa Hakko Kogyo Co., Ltd. Derives de piperidine
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US6545004B1 (en) * 1999-10-27 2003-04-08 Cytokinetics, Inc. Methods and compositions utilizing quinazolinones
US7230000B1 (en) * 1999-10-27 2007-06-12 Cytokinetics, Incorporated Methods and compositions utilizing quinazolinones
UA74803C2 (uk) 1999-11-11 2006-02-15 Осі Фармасьютікалз, Інк. Стійкий поліморф гідрохлориду n-(3-етинілфеніл)-6,7-біс(2-метоксіетокси)-4-хіназолінаміну, спосіб його одержання (варіанти) та фармацевтичне застосування
US7087613B2 (en) 1999-11-11 2006-08-08 Osi Pharmaceuticals, Inc. Treating abnormal cell growth with a stable polymorph of N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride
CA2475879A1 (en) * 2002-02-15 2003-08-28 Cytokinetics, Inc. Synthesis of quinazolinones
US7214800B2 (en) * 2002-05-09 2007-05-08 Cytokinetics, Inc. Compounds, compositions, and methods
US7166595B2 (en) * 2002-05-09 2007-01-23 Cytokinetics, Inc. Compounds, methods and compositions
US20040053948A1 (en) * 2002-05-10 2004-03-18 Cytokinetics, Inc. Compounds, compositions and methods
WO2003103575A2 (en) * 2002-05-23 2003-12-18 Cytokinetics, Inc. Compounds, compositions, and methods
WO2003106426A1 (en) * 2002-06-14 2003-12-24 Cytokinetics, Inc. Compounds, compositions, and methods
EP1537089A4 (en) * 2002-07-23 2008-04-16 Cytokinetics Inc CONNECTIONS, COMPOSITIONS AND PROCEDURES
US20040048853A1 (en) * 2002-08-21 2004-03-11 Gustave Bergnes Compounds, compositions, and methods
WO2004034972A2 (en) * 2002-09-30 2004-04-29 Cytokinetics, Inc. Compounds, compositions, and methods
WO2004052862A1 (ja) * 2002-12-10 2004-06-24 Ono Pharmaceutical Co., Ltd. 含窒素複素環化合物およびその医薬用途
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EP1680420A4 (en) * 2003-11-07 2008-09-24 Cytokinetics Inc COMPOUNDS, COMPOSITIONS AND METHODS
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US9040533B2 (en) 2012-12-27 2015-05-26 Purdue Pharma L.P. Oxime-substituted-quinoxaline-type piperidine compounds as ORL-1 modulators
JP6522502B2 (ja) 2013-07-29 2019-05-29 協和発酵キリン株式会社 Ｗｎｔシグナル阻害剤

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Also Published As

Publication number Publication date
WO1996006841A1 (fr) 1996-03-07
ATE197710T1 (de) 2000-12-15
NZ291506A (en) 1997-03-24
ES2153491T3 (es) 2001-03-01
CA2174854C (en) 2001-11-20
NO961601L (no) 1996-04-22
FI961758A0 (fi) 1996-04-24
CA2174854A1 (en) 1996-03-07
US5948784A (en) 1999-09-07
EP0726267A1 (en) 1996-08-14
EP0726267B1 (en) 2000-11-22
DE69519469T2 (de) 2001-07-26
AU689304B2 (en) 1998-03-26
NO310658B1 (no) 2001-08-06
CN1043991C (zh) 1999-07-07
NO961601D0 (no) 1996-04-22
JPH09165385A (ja) 1997-06-24
FI961758A (fi) 1996-04-24
EP0726267A4 (en) 1996-12-11
AU3265595A (en) 1996-03-22
DE69519469D1 (de) 2000-12-28
CN1134150A (zh) 1996-10-23

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