DE69811930D1 - Tricyclische triazolobenzazepinderivate, verfahren zu ihrer herstellung und antiallergische mittel - Google Patents

Tricyclische triazolobenzazepinderivate, verfahren zu ihrer herstellung und antiallergische mittel

Info

Publication number
DE69811930D1
DE69811930D1 DE69811930T DE69811930T DE69811930D1 DE 69811930 D1 DE69811930 D1 DE 69811930D1 DE 69811930 T DE69811930 T DE 69811930T DE 69811930 T DE69811930 T DE 69811930T DE 69811930 D1 DE69811930 D1 DE 69811930D1
Authority
DE
Germany
Prior art keywords
production
alkyl
allergic agents
chem
alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69811930T
Other languages
English (en)
Other versions
DE69811930T2 (de
Inventor
Yasuo Ohtsuka
Toshio Nishizuka
Sohjiro Shiokawa
Seiji Tsutsumi
Mami Kawaguchi
Hideo Kitagawa
Hiromi Takata
T Shishikura
T Ishikura
Kenichi Fushihara
Yumiko Okada
Sachiko Miyamoto
Maki Shiobara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Meiji Seika Kaisha Ltd
Original Assignee
Meiji Seika Kaisha Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meiji Seika Kaisha Ltd filed Critical Meiji Seika Kaisha Ltd
Application granted granted Critical
Publication of DE69811930D1 publication Critical patent/DE69811930D1/de
Publication of DE69811930T2 publication Critical patent/DE69811930T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40Unsaturated compounds
    • C07C59/76Unsaturated compounds containing keto groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/041,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE69811930T 1997-09-29 1998-09-29 Tricyclische triazolobenzazepinderivate, verfahren zu ihrer herstellung und antiallergische mittel Expired - Lifetime DE69811930T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP26461197 1997-09-29
JP5206398 1998-03-04
PCT/JP1998/004363 WO1999016770A1 (fr) 1997-09-29 1998-09-29 Derives de triazolobenzazepine tricyclique, leur procede de production et antiallergique

Publications (2)

Publication Number Publication Date
DE69811930D1 true DE69811930D1 (de) 2003-04-10
DE69811930T2 DE69811930T2 (de) 2003-12-18

Family

ID=26392670

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69811930T Expired - Lifetime DE69811930T2 (de) 1997-09-29 1998-09-29 Tricyclische triazolobenzazepinderivate, verfahren zu ihrer herstellung und antiallergische mittel

Country Status (25)

Country Link
US (3) US6372735B1 (de)
EP (1) EP1026167B1 (de)
JP (1) JP3188482B2 (de)
KR (1) KR100389140B1 (de)
CN (2) CN1155599C (de)
AT (1) ATE233764T1 (de)
AU (1) AU744636B2 (de)
BR (1) BR9814055B1 (de)
CA (1) CA2305307C (de)
DE (1) DE69811930T2 (de)
DK (1) DK1026167T3 (de)
ES (1) ES2191963T3 (de)
HK (1) HK1032782A1 (de)
HU (1) HUP0004020A3 (de)
ID (1) ID24101A (de)
IL (1) IL135303A0 (de)
NO (2) NO319542B1 (de)
NZ (1) NZ503601A (de)
PL (1) PL339544A1 (de)
PT (1) PT1026167E (de)
RU (1) RU2198885C2 (de)
SK (1) SK283869B6 (de)
TR (1) TR200000808T2 (de)
TW (1) TW510902B (de)
WO (1) WO1999016770A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE469902T1 (de) * 2001-12-26 2010-06-15 Meiji Seika Kaisha Amorphe substanz eines tricyclischen triazolobenzazepinderivats
ATE359277T1 (de) * 2002-02-01 2007-05-15 Meiji Seika Kaisha Verfahren zur herstellung einer 1,2,3- triazolverbindung
JP4579681B2 (ja) 2002-07-09 2010-11-10 ブリストル−マイヤーズ スクイブ カンパニー 抗糖尿病薬および抗肥満薬として有用な置換ヘテロシクロ誘導体および方法
MXPA05000279A (es) 2002-07-09 2005-03-31 Squibb Bristol Myers Co Derivados heterociclicos sustituidos utiles como agentes antidiabeticos y antiobesidad y metodo.
EP1642900A1 (de) * 2003-06-19 2006-04-05 Meiji Seika Kaisha Ltd. Als neue kristalline substanz hergestelltes tricyclisches triazolobenzazepinderivat
JP4391475B2 (ja) * 2003-06-20 2009-12-24 明治製菓株式会社 難水溶性物質と水溶性高分子との共沈物の製造方法
ES2540987T3 (es) 2004-05-14 2015-07-15 Millennium Pharmaceuticals, Inc. Métodos para preparar inhibidores de la aurora cinasa
CA2644810A1 (en) * 2006-03-02 2007-09-07 Meiji Seika Kaisha, Ltd. Prophylactic or therapeutic agents for allergic ophthalmic diseases or allergic nasal diseases, comprising tricyclic triazolobenzazepine derivative
US8242105B2 (en) * 2006-09-25 2012-08-14 Forschungsverbund Berlin E.V. Structural mimetics of proline-rich peptides and the pharmaceutical use thereof
CL2007003244A1 (es) 2006-11-16 2008-04-04 Millennium Pharm Inc Compuestos derivados de pirimido[5,4-d][2]benzazepina; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento del cancer.
DK2123277T3 (da) * 2007-12-18 2011-03-14 Meiji Seika Kaisha Forebyggende eller terapeutisk middel mod inflammatorisk tarmsygdom
MX2011006725A (es) 2008-12-22 2011-09-15 Millennium Pharm Inc Combinacion de inhibidores de aurora cinasa y anticuerpos anti-cd20.
JO3635B1 (ar) 2009-05-18 2020-08-27 Millennium Pharm Inc مركبات صيدلانية صلبة وطرق لانتاجها
US9107911B2 (en) 2010-01-07 2015-08-18 Alkermes Pharma Ireland Limited Prodrugs of heteraromatic compounds
RU2012140021A (ru) 2010-02-19 2014-03-27 Миллениум Фармасьютикалз, Инк. КРИСТАЛЛИЧЕСКИЕ ФОРМЫ 4-{[9-ХЛОР-7-(2-ФТОР-6-МЕТОКСИФЕНИЛ)-5Н-ПИРИМИДО[5,4-d][2]БЕНЗАЗЕПИН-2-ИЛ]АМИНО}-2-МЕТОКСИБЕНЗОАТА НАТРИЯ
US20130303519A1 (en) 2012-03-20 2013-11-14 Millennium Pharmaceuticals, Inc. Methods of treating cancer using aurora kinase inhibitors
US9724354B2 (en) 2013-03-22 2017-08-08 Millennium Pharmaceuticals, Inc. Combination of catalytic mTORC1/2 inhibitors and selective inhibitors of Aurora A kinase
JP2018524292A (ja) 2015-07-21 2018-08-30 ミレニアム ファーマシューティカルズ, インコーポレイテッドMillennium Pharmaceuticals, Inc. オーロラキナーゼインヒビターと化学療法剤の投与

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3290664B2 (ja) * 1993-12-28 2002-06-10 明治製菓株式会社 3環性ベンゾアゼピンおよびベンゾチアゼピン誘導体
WO1997000258A1 (fr) * 1995-06-15 1997-01-03 Meiji Seika Kabushiki Kaisha Composes de benzazepine tricyclique
US6124281A (en) * 1996-03-08 2000-09-26 Zeneca Limited Azolobenzazepine derivatives as neurologically active agents
US20070059533A1 (en) * 2005-09-12 2007-03-15 Burdette Steven R Thermal reflow of glass and fused silica body

Also Published As

Publication number Publication date
NZ503601A (en) 2002-02-01
ID24101A (id) 2000-07-06
CN1523019A (zh) 2004-08-25
KR100389140B1 (ko) 2003-06-25
CA2305307C (en) 2004-11-30
HUP0004020A2 (hu) 2001-09-28
SK283869B6 (sk) 2004-03-02
US7022860B2 (en) 2006-04-04
CN1155599C (zh) 2004-06-30
DE69811930T2 (de) 2003-12-18
US6372735B1 (en) 2002-04-16
TW510902B (en) 2002-11-21
IL135303A0 (en) 2001-05-20
EP1026167B1 (de) 2003-03-05
RU2198885C2 (ru) 2003-02-20
US20020137739A1 (en) 2002-09-26
EP1026167A4 (de) 2001-07-11
TR200000808T2 (tr) 2000-08-21
AU9186998A (en) 1999-04-23
NO319542B1 (no) 2005-08-29
BR9814055B1 (pt) 2009-05-05
US7238812B2 (en) 2007-07-03
AU744636B2 (en) 2002-02-28
CN1312135C (zh) 2007-04-25
CN1278262A (zh) 2000-12-27
SK4252000A3 (en) 2000-10-09
ATE233764T1 (de) 2003-03-15
PL339544A1 (en) 2000-12-18
EP1026167A1 (de) 2000-08-09
JP3188482B2 (ja) 2001-07-16
NO20043765L (no) 2000-05-18
BR9814055A (pt) 2000-09-26
ES2191963T3 (es) 2003-09-16
KR20010030784A (ko) 2001-04-16
NO20001500D0 (no) 2000-03-23
CA2305307A1 (en) 1999-04-08
WO1999016770A1 (fr) 1999-04-08
PT1026167E (pt) 2003-07-31
NO20001500L (no) 2000-05-18
US20060074074A1 (en) 2006-04-06
HK1032782A1 (en) 2002-08-30
HUP0004020A3 (en) 2002-12-28
DK1026167T3 (da) 2003-05-26

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