PE68299A1 - 1,2,3,4-tetrahidroisoquinolinas terapeuticas - Google Patents

1,2,3,4-tetrahidroisoquinolinas terapeuticas

Info

Publication number
PE68299A1
PE68299A1 PE00028998A PE00028998A PE68299A1 PE 68299 A1 PE68299 A1 PE 68299A1 PE 00028998 A PE00028998 A PE 00028998A PE 00028998 A PE00028998 A PE 00028998A PE 68299 A1 PE68299 A1 PE 68299A1
Authority
PE
Peru
Prior art keywords
hydrogen
halogen
integer
alkyl
methylenedioxy group
Prior art date
Application number
PE00028998A
Other languages
English (en)
Inventor
Alain Claude-Marie Daugan
Pascal Maurice Charles Pianetti
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of PE68299A1 publication Critical patent/PE68299A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA (I), SU SAL O SOLVATO, DONDE Ro ES H, HALOGENO, METILENDIOXI, ENTRE OTROS; R1 ES H, HALOGENO, TRIFLUOROMETOXI, ENTRE OTROS; R2 ES H, HALOGENO, NR4R5, (ALQUILENO C1-C4)-NR6R7, -O-(ALQUILENO C1-C4)-NR8R9, ENTRE OTROS; n, p Y m SON 1-4; R3 ES H o ALQUILO C1-C4; R4-R10 SON H o ALQUILO C1-C4. SON COMPUESTOS PREFERIDOS 2-(4-METILBENZOIL)-N-(7-METIL-1,2,3,4-TETRAHIDRO-NAFTALEN-1-IL)-1,2,3,4-TETRAHIDROISOQUINOLIN-3-CARBOXAMIDA; 2-[3-(2-DIMETILAMINO-ETOXI)-BENZOIL]-N-(7-ISOPROPIL-1,2,3,4-TETRAHIDRO-NAFTALEN-1-IL)-1,2,3,4-TETRAHIDROISOQUINOLIN-3-CARBOXAMIDA, ENTRE OTROS. TAMBIEN SE REFIERE A PROCEDIMIENTOS PARA LA PREPARACION. TAMBIEN SE REFIERE A COMPUESTOS INTERMEDIOS DE FORMULAS II Y VI. EL COMPUESTO DE FORMULA I PUEDE SER UTIL PARA EL TRATAMIENTO DE NIVELES SANGUINEOS ELEVADOS DE LA APO B-100 EL CUAL ES UN COMPONENTE DE LIPOPROTEINA DE BAJA DENSIDAD UNIDO A COLESTEROL; Y PARA EL TRATAMIENTO DE ARTERIOESCLEROSIS, DISMINUCION DE LIPIDOS, COLESTEROL Y TRIGLICERIDOS EN SUERO
PE00028998A 1997-04-22 1998-04-20 1,2,3,4-tetrahidroisoquinolinas terapeuticas PE68299A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9708119.4A GB9708119D0 (en) 1997-04-22 1997-04-22 Chemical compounds

Publications (1)

Publication Number Publication Date
PE68299A1 true PE68299A1 (es) 1999-07-22

Family

ID=10811155

Family Applications (1)

Application Number Title Priority Date Filing Date
PE00028998A PE68299A1 (es) 1997-04-22 1998-04-20 1,2,3,4-tetrahidroisoquinolinas terapeuticas

Country Status (6)

Country Link
AU (1) AU7526598A (es)
GB (1) GB9708119D0 (es)
HR (1) HRP980216A2 (es)
MA (1) MA26483A1 (es)
PE (1) PE68299A1 (es)
WO (1) WO1998047877A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2206703A1 (de) 2008-12-30 2010-07-14 Bayer CropScience AG Pyrimidinderivate und ihre Verwendung zur Bekämpfung unerwünschten Pflanzenwachstums
KR100962972B1 (ko) 2002-07-26 2010-06-09 주식회사유한양행 1-페닐피페리딘-3-온 유도체 및 그의 제조방법
US8124582B2 (en) * 2002-12-06 2012-02-28 Fibrogen, Inc. Treatment of diabetes
MXPA05008295A (es) * 2003-02-05 2005-09-20 Bayer Cropscience Gmbh Amino-1,3,5-triazinas sustituidas en n con radicales biciclicos quirales, procedimiento para su preparacion, composiciones de las mismas, y su uso como herbicidas y reguladores del crecimiento de las plantas.
WO2004096774A1 (en) * 2003-05-01 2004-11-11 Glaxo Group Limited Acyl isoindoline derivatives and acyl isoquinoline derivatives as anti-viral agents
CA3075669A1 (en) 2017-09-13 2019-03-21 Amgen Inc. Bisamide sarcomere activating compounds and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2146026A (en) * 1983-09-07 1985-04-11 Tanabe Seiyaku Co Peptides and process for preparing the same
DK160991C (da) * 1984-05-03 1991-11-11 Glaxo Group Ltd 5,14-dihydrobenzoe5,6aaisoindolooe2,1-baaisoquinolin-8,13-dionderivater, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat indeholdende en saadan forbindelse
AU691201B2 (en) * 1993-11-01 1998-05-14 Japat Ltd. Endothelin receptor antagonists
WO1996040640A1 (en) * 1995-06-07 1996-12-19 Pfizer Inc. BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION
FR2748026B1 (fr) * 1996-04-26 1998-06-05 Adir Nouveaux inhibiteurs de metalloproteases, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
WO1998047877A1 (en) 1998-10-29
HRP980216A2 (en) 1998-12-31
MA26483A1 (fr) 2004-12-20
AU7526598A (en) 1998-11-13
GB9708119D0 (en) 1997-06-11

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal