EA200100090A3 - Новые пиперидин-4-сульфонамидные производные, способ их получения и содержащие их фармацевтические композиции - Google Patents

Новые пиперидин-4-сульфонамидные производные, способ их получения и содержащие их фармацевтические композиции

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Publication number
EA200100090A3
EA200100090A3 EA200100090A EA200100090A EA200100090A3 EA 200100090 A3 EA200100090 A3 EA 200100090A3 EA 200100090 A EA200100090 A EA 200100090A EA 200100090 A EA200100090 A EA 200100090A EA 200100090 A3 EA200100090 A3 EA 200100090A3
Authority
EA
Eurasian Patent Office
Prior art keywords
group
piperide
preparation
new
pharmaceutical compositions
Prior art date
Application number
EA200100090A
Other languages
English (en)
Other versions
EA003096B1 (ru
EA200100090A2 (ru
Inventor
Жан-Луи Пелье
Эме Дессинге
Кристоф Пуатевин
Жан-Поль Вилен
Николь Вийену
Катрин Толлон
Мари-Пьер Буриньён
Original Assignee
Адир Э Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Адир Э Компани filed Critical Адир Э Компани
Publication of EA200100090A2 publication Critical patent/EA200100090A2/ru
Publication of EA200100090A3 publication Critical patent/EA200100090A3/ru
Publication of EA003096B1 publication Critical patent/EA003096B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

В заявке описаны соединения формулыгде Rобозначает атом водорода или алкильную группу,Rи Rобозначают группу, выбранную из ряда, включающего атом водорода, атом галогена, алкильную группу, гидроксигруппу, алкоксигруппу, тригалоалкильную группу, цианогруппу, нитрогруппу, аминогруппу, алкиламиногруппу и диалкиламиногруппу,Rобозначает атом водорода или гидроксигруппу,Х обозначает атом кислорода или метиленовую группу,V обозначает алкиленовую цепь, необязательно ненасыщенную и необязательно замещенную,U обозначает связь или алкиленовую цепь,W обозначает группу, выбранную из ряда, включающего арил и гетероарил, которые необязательно могут быть замещены одной или несколькими одинаковыми или различными группами,их изомеры, их гидраты, их сольваты и их аддитивные соли с фармацевтически приемлемой кислотой. Также описаны лекарственные средства.
EA200100090A 2000-01-31 2001-01-30 Новые пиперидин-4-сульфонамидные производные, способ их получения и содержащие их фармацевтические композиции EA003096B1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0001171A FR2804429B1 (fr) 2000-01-31 2000-01-31 Nouveaux derives de 4-sulfonamides piperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (3)

Publication Number Publication Date
EA200100090A2 EA200100090A2 (ru) 2001-08-27
EA200100090A3 true EA200100090A3 (ru) 2001-10-22
EA003096B1 EA003096B1 (ru) 2002-12-26

Family

ID=8846469

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200100090A EA003096B1 (ru) 2000-01-31 2001-01-30 Новые пиперидин-4-сульфонамидные производные, способ их получения и содержащие их фармацевтические композиции

Country Status (24)

Country Link
US (1) US6323217B2 (ru)
EP (1) EP1122254B1 (ru)
JP (1) JP3513493B2 (ru)
KR (1) KR100463369B1 (ru)
CN (1) CN1298705C (ru)
AR (1) AR027335A1 (ru)
AT (1) ATE294175T1 (ru)
AU (1) AU774808B2 (ru)
BR (1) BR0100234A (ru)
CA (1) CA2332513C (ru)
DE (1) DE60110278T2 (ru)
DK (1) DK1122254T3 (ru)
EA (1) EA003096B1 (ru)
ES (1) ES2241757T3 (ru)
FR (1) FR2804429B1 (ru)
HK (1) HK1039117B (ru)
HU (1) HUP0100489A3 (ru)
MX (1) MXPA01000945A (ru)
NO (1) NO320387B1 (ru)
NZ (1) NZ509636A (ru)
PL (1) PL345528A1 (ru)
PT (1) PT1122254E (ru)
SI (1) SI1122254T1 (ru)
ZA (1) ZA200100864B (ru)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1535912A1 (en) * 2000-04-28 2005-06-01 Arcadia Pharmaceuticals Inc. Muscarinic agonists
RU2269523C2 (ru) * 2000-04-28 2006-02-10 Акадиа Фармасьютикалз, Инк. Мускариновые агонисты
AR040336A1 (es) * 2002-06-26 2005-03-30 Glaxo Group Ltd Compuesto de piperidina, uso del mismo para la fabricacion de un medicamento, composicion farmaceutica que lo comprende y procedimiento para preparar dicho compuesto
WO2004046110A1 (ja) * 2002-11-15 2004-06-03 Yamanouchi Pharmaceutical Co., Ltd. メラニン凝集ホルモン受容体拮抗剤
US20070249690A1 (en) * 2004-07-23 2007-10-25 Darren Mansfield N-[2-(4-Pyridinyl)Ethyl]Benzamide Derivatives as Fungicides
JP4977465B2 (ja) * 2004-07-28 2012-07-18 武田薬品工業株式会社 ピロロ［２，３−ｃ］ピリジン化合物、その製造方法および用途
TW200630337A (en) * 2004-10-14 2006-09-01 Euro Celtique Sa Piperidinyl compounds and the use thereof
DE602006021704D1 (de) 2005-02-25 2011-06-16 Kowa Co Verfahren zur herstellung eines 4-fluorisochinolin-5-sulfonylhalogenids oder eines salzes davon
WO2007110449A1 (en) 2006-03-29 2007-10-04 Euro-Celtique S.A. Benzenesulfonamide compounds and their use
WO2007118853A1 (en) 2006-04-13 2007-10-25 Euro-Celtique S.A. Benzenesulfonamide compounds and their use as blockers of calcium channels
WO2007118854A1 (en) 2006-04-13 2007-10-25 Euro-Celtique S.A. Benzenesulfonamide compounds and the use thereof
PE20080932A1 (es) * 2006-11-10 2008-07-13 Wyeth Corp Piperidinil 4-arilsulfonamidas n-sustituidas como moduladores de la proteina 1 secretada relacionada con frizzled (sfrp-1)
WO2008124118A1 (en) * 2007-04-09 2008-10-16 Purdue Pharma L.P. Benzenesulfonyl compounds and the use therof
US8765736B2 (en) 2007-09-28 2014-07-01 Purdue Pharma L.P. Benzenesulfonamide compounds and the use thereof
AR080375A1 (es) 2010-03-05 2012-04-04 Sanofi Aventis Procedimiento para la preparacion de 2-(cicloheximetil)-n-{2-[(2s)-1-metilpirrolidin-2-il] etil}-1,2,3,4-tetrahidroisoquinolina- 7-sulfonamida
PL395470A1 (pl) * 2011-06-29 2013-01-07 Adamed Spólka Z Ograniczona Odpowiedzialnoscia Sulfonamidowe pochodne amin alicyklicznych do leczenia chorób osrodkowego ukladu nerwowego

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US4956382A (en) * 1987-02-07 1990-09-11 Pfizer Inc. Sulfonamide anti-arrhythmic agents
US4857301A (en) * 1987-09-25 1989-08-15 Schering Corporation Sulfonamide compounds, compositions and method of use
FR2679906B1 (fr) * 1991-07-31 1995-01-20 Adir Nouvelles (isoquinolein-5 yl) sulfonamides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
DK148392D0 (da) * 1992-12-09 1992-12-09 Lundbeck & Co As H Heterocykliske forbindelser
JPH09501404A (ja) * 1993-05-26 1997-02-10 スミスクライン・ビーチャム・ラボラトワール・ファルマソーティク 新規化合物
FR2716679B1 (fr) * 1994-02-25 1996-04-05 Adir Nouvelles sulfonamides substituées, leur procédé de préparation et les compositions pharmaceutiques les renfermant.
HN1997000027A (es) * 1996-12-06 1997-06-05 Pfizer Prod Inc Derivados de 6-fenil piridil - 2 amina

Also Published As

Publication number Publication date
ATE294175T1 (de) 2005-05-15
PT1122254E (pt) 2005-07-29
HUP0100489A3 (en) 2002-10-28
HUP0100489A2 (hu) 2002-05-29
JP3513493B2 (ja) 2004-03-31
HU0100489D0 (en) 2001-04-28
CA2332513C (fr) 2005-11-29
NO20010522L (no) 2001-08-01
AU1674701A (en) 2001-08-02
KR20010078210A (ko) 2001-08-20
HK1039117B (zh) 2007-09-07
EP1122254B1 (fr) 2005-04-27
JP2001233874A (ja) 2001-08-28
CN1314345A (zh) 2001-09-26
PL345528A1 (en) 2001-08-13
MXPA01000945A (es) 2002-06-04
EA003096B1 (ru) 2002-12-26
EP1122254A3 (fr) 2001-11-28
NO20010522D0 (no) 2001-01-30
DK1122254T3 (da) 2005-08-29
EP1122254A2 (fr) 2001-08-08
FR2804429B1 (fr) 2003-05-09
KR100463369B1 (ko) 2004-12-23
CA2332513A1 (fr) 2001-07-31
US20010034352A1 (en) 2001-10-25
DE60110278T2 (de) 2006-02-16
NZ509636A (en) 2001-09-28
BR0100234A (pt) 2001-08-28
EA200100090A2 (ru) 2001-08-27
DE60110278D1 (de) 2005-06-02
CN1298705C (zh) 2007-02-07
US6323217B2 (en) 2001-11-27
AR027335A1 (es) 2003-03-26
NO320387B1 (no) 2005-11-28
AU774808B2 (en) 2004-07-08
SI1122254T1 (ru) 2005-08-31
ZA200100864B (en) 2001-08-08
ES2241757T3 (es) 2005-11-01
FR2804429A1 (fr) 2001-08-03
HK1039117A1 (en) 2002-04-12

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