NO20001500L - Tricykliske triazolbenzazepinderivater, fremgangsmÕte til fremstilling derav, samt antiallergiske midler - Google Patents
Tricykliske triazolbenzazepinderivater, fremgangsmÕte til fremstilling derav, samt antiallergiske midlerInfo
- Publication number
- NO20001500L NO20001500L NO20001500A NO20001500A NO20001500L NO 20001500 L NO20001500 L NO 20001500L NO 20001500 A NO20001500 A NO 20001500A NO 20001500 A NO20001500 A NO 20001500A NO 20001500 L NO20001500 L NO 20001500L
- Authority
- NO
- Norway
- Prior art keywords
- antiallergic agents
- preparation
- alkyl
- benzazepine derivatives
- chem
- Prior art date
Links
- 239000000043 antiallergic agent Substances 0.000 title abstract 2
- -1 triazole benzazepine derivatives Chemical class 0.000 title 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000003884 phenylalkyl group Chemical group 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
- QDEVEJYEXBFIJD-UHFFFAOYSA-N triazolo[4,5-i][1]benzazepine Chemical class C1=CC2=CC=CC=NC2=C2C1=NN=N2 QDEVEJYEXBFIJD-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pulmonology (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP26461197 | 1997-09-29 | ||
| JP5206398 | 1998-03-04 | ||
| PCT/JP1998/004363 WO1999016770A1 (fr) | 1997-09-29 | 1998-09-29 | Derives de triazolobenzazepine tricyclique, leur procede de production et antiallergique |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20001500D0 NO20001500D0 (no) | 2000-03-23 |
| NO20001500L true NO20001500L (no) | 2000-05-18 |
| NO319542B1 NO319542B1 (no) | 2005-08-29 |
Family
ID=26392670
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20001500A NO319542B1 (no) | 1997-09-29 | 2000-03-23 | Tricykliske triazolbenzazepinderivater, fremgangsmate til fremstilling derav, samt antiallergiske midler |
| NO20043765A NO20043765L (no) | 1997-09-29 | 2004-09-08 | Tricykliske triazolbenzazepinderivater, fremgangsmate til fremstilling derav, samt antiallergiske midler |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20043765A NO20043765L (no) | 1997-09-29 | 2004-09-08 | Tricykliske triazolbenzazepinderivater, fremgangsmate til fremstilling derav, samt antiallergiske midler |
Country Status (25)
| Country | Link |
|---|---|
| US (3) | US6372735B1 (no) |
| EP (1) | EP1026167B1 (no) |
| JP (1) | JP3188482B2 (no) |
| KR (1) | KR100389140B1 (no) |
| CN (2) | CN1312135C (no) |
| AT (1) | ATE233764T1 (no) |
| AU (1) | AU744636B2 (no) |
| BR (1) | BR9814055B1 (no) |
| CA (1) | CA2305307C (no) |
| DE (1) | DE69811930T2 (no) |
| DK (1) | DK1026167T3 (no) |
| ES (1) | ES2191963T3 (no) |
| HK (1) | HK1032782A1 (no) |
| HU (1) | HUP0004020A3 (no) |
| ID (1) | ID24101A (no) |
| IL (1) | IL135303A0 (no) |
| NO (2) | NO319542B1 (no) |
| NZ (1) | NZ503601A (no) |
| PL (1) | PL339544A1 (no) |
| PT (1) | PT1026167E (no) |
| RU (1) | RU2198885C2 (no) |
| SK (1) | SK283869B6 (no) |
| TR (1) | TR200000808T2 (no) |
| TW (1) | TW510902B (no) |
| WO (1) | WO1999016770A1 (no) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1275968C (zh) * | 2001-12-26 | 2006-09-20 | 明治制果株式会社 | 三环型三唑并苯并氮杂䓬衍生物的非晶态物质 |
| US7238719B2 (en) * | 2002-02-01 | 2007-07-03 | Meiji Seika Kaisha, Ltd. | Process for producing 1,2,3-Triazole compounds |
| WO2004004665A2 (en) | 2002-07-09 | 2004-01-15 | Bristol-Myers Squibb Company | Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method |
| NZ537251A (en) | 2002-07-09 | 2007-02-23 | Bristol Myers Squibb Co | Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method |
| EP1642900A1 (en) * | 2003-06-19 | 2006-04-05 | Meiji Seika Kaisha Ltd. | Tricyclic triazolobenzazepine derivative produced as novel crystalline substance |
| WO2004113424A1 (ja) * | 2003-06-20 | 2004-12-29 | Meiji Seika Kaisha, Ltd. | 難水溶性物質と水溶性高分子との共沈物の製造方法 |
| DK1771450T5 (da) | 2004-05-14 | 2012-01-09 | Millennium Pharm Inc | Forbindelser og fremgangsmåder til inhibering af mitotisk progression ved inhibering af AURORA-kinase |
| CA2644810A1 (en) * | 2006-03-02 | 2007-09-07 | Meiji Seika Kaisha, Ltd. | Prophylactic or therapeutic agents for allergic ophthalmic diseases or allergic nasal diseases, comprising tricyclic triazolobenzazepine derivative |
| JP5588172B2 (ja) * | 2006-09-25 | 2014-09-10 | フォルシュングフェアブント ベルリン エー．ファウ． | プロリンが豊富なペプチドの構造的模倣薬およびその医薬用途 |
| CL2007003244A1 (es) | 2006-11-16 | 2008-04-04 | Millennium Pharm Inc | Compuestos derivados de pirimido[5,4-d][2]benzazepina; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento del cancer. |
| ATE497386T1 (de) * | 2007-12-18 | 2011-02-15 | Meiji Seika Kaisha | Vorbeuge- oder heilmittel für entzündliche darmerkrankungen |
| RU2535032C2 (ru) | 2008-12-22 | 2014-12-10 | Милленниум Фармасьютикалз, Инк. | Сочетание ингибиторов аврора киназы и анти-cd 20 антител |
| JO3635B1 (ar) | 2009-05-18 | 2020-08-27 | Millennium Pharm Inc | مركبات صيدلانية صلبة وطرق لانتاجها |
| JP6106437B2 (ja) * | 2010-01-07 | 2017-03-29 | アルカーメス ファーマ アイルランド リミテッド | 複素芳香族化合物のプロドラッグ |
| WO2011103089A1 (en) | 2010-02-19 | 2011-08-25 | Millennium Pharmaceuticals, Inc. | Crystalline forms of sodium 4-{[9-chloro-7-(2-fluoro-6--methoxyphenyl)-5h -pyrimido[5,4-d][2]benzazepin-2yl]amino}-2-methoxybenzoate |
| US20130303519A1 (en) | 2012-03-20 | 2013-11-14 | Millennium Pharmaceuticals, Inc. | Methods of treating cancer using aurora kinase inhibitors |
| CA2907726A1 (en) | 2013-03-22 | 2014-09-25 | Millennium Pharmaceuticals, Inc. | Combination of catalytic mtorc1/2 inhibitors and selective inhibitors of aurora a kinase |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2156933T3 (es) | 1993-12-28 | 2001-08-01 | Meiji Seika Co | Derivados triciclicos de benzazepina y benzotiazepina. |
| US6093714A (en) * | 1995-06-15 | 2000-07-25 | Meiji Seika Kaisha, Ltd. | Tricyclic benzazepine compounds |
| EP0888350A1 (en) * | 1996-03-08 | 1999-01-07 | Zeneca Limited | Azolobenzazepine derivatives as neurologically active agents |
| US20070059533A1 (en) * | 2005-09-12 | 2007-03-15 | Burdette Steven R | Thermal reflow of glass and fused silica body |
-
1998
- 1998-09-29 DE DE69811930T patent/DE69811930T2/de not_active Expired - Lifetime
- 1998-09-29 NZ NZ503601A patent/NZ503601A/en unknown
- 1998-09-29 SK SK425-2000A patent/SK283869B6/sk unknown
- 1998-09-29 PT PT98944289T patent/PT1026167E/pt unknown
- 1998-09-29 EP EP98944289A patent/EP1026167B1/en not_active Expired - Lifetime
- 1998-09-29 HU HU0004020A patent/HUP0004020A3/hu unknown
- 1998-09-29 AT AT98944289T patent/ATE233764T1/de active
- 1998-09-29 ID IDW20000808A patent/ID24101A/id unknown
- 1998-09-29 PL PL98339544A patent/PL339544A1/xx unknown
- 1998-09-29 KR KR10-2000-7003362A patent/KR100389140B1/ko not_active IP Right Cessation
- 1998-09-29 CN CNB2003101047539A patent/CN1312135C/zh not_active Expired - Fee Related
- 1998-09-29 WO PCT/JP1998/004363 patent/WO1999016770A1/ja not_active Application Discontinuation
- 1998-09-29 CN CNB98810735XA patent/CN1155599C/zh not_active Expired - Fee Related
- 1998-09-29 JP JP51996999A patent/JP3188482B2/ja not_active Expired - Fee Related
- 1998-09-29 TW TW087116198A patent/TW510902B/zh not_active IP Right Cessation
- 1998-09-29 AU AU91869/98A patent/AU744636B2/en not_active Ceased
- 1998-09-29 CA CA002305307A patent/CA2305307C/en not_active Expired - Fee Related
- 1998-09-29 RU RU2000111517/04A patent/RU2198885C2/ru not_active IP Right Cessation
- 1998-09-29 IL IL13530398A patent/IL135303A0/xx unknown
- 1998-09-29 ES ES98944289T patent/ES2191963T3/es not_active Expired - Lifetime
- 1998-09-29 BR BRPI9814055-8A patent/BR9814055B1/pt not_active IP Right Cessation
- 1998-09-29 US US09/509,494 patent/US6372735B1/en not_active Expired - Lifetime
- 1998-09-29 DK DK98944289T patent/DK1026167T3/da active
- 1998-09-29 TR TR2000/00808T patent/TR200000808T2/xx unknown
-
2000
- 2000-03-23 NO NO20001500A patent/NO319542B1/no unknown
-
2001
- 2001-05-22 HK HK01103502A patent/HK1032782A1/xx not_active IP Right Cessation
-
2002
- 2002-02-13 US US10/073,326 patent/US7022860B2/en not_active Expired - Fee Related
-
2004
- 2004-09-08 NO NO20043765A patent/NO20043765L/no not_active Application Discontinuation
-
2005
- 2005-11-09 US US11/269,828 patent/US7238812B2/en not_active Expired - Fee Related
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