ATE296300T1 - Benzoheterocyclische distamycinderivate, verfahren zu ihrer herstellung und ihre verwendung als antitumormittel - Google Patents
Benzoheterocyclische distamycinderivate, verfahren zu ihrer herstellung und ihre verwendung als antitumormittelInfo
- Publication number
- ATE296300T1 ATE296300T1 AT99915665T AT99915665T ATE296300T1 AT E296300 T1 ATE296300 T1 AT E296300T1 AT 99915665 T AT99915665 T AT 99915665T AT 99915665 T AT99915665 T AT 99915665T AT E296300 T1 ATE296300 T1 AT E296300T1
- Authority
- AT
- Austria
- Prior art keywords
- alkyl
- benzoheterocyclic
- hydrogen
- production
- distamycin derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9806692.1A GB9806692D0 (en) | 1998-03-27 | 1998-03-27 | Benzoheterocyclic distamycin derivatives, process for preparing them and their use as antitumour agents |
| PCT/EP1999/001823 WO1999050266A1 (en) | 1998-03-27 | 1999-03-17 | Benzoheterocyclic distamycin derivatives, process for preparing them, and their use as antitumor agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE296300T1 true ATE296300T1 (de) | 2005-06-15 |
Family
ID=10829461
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99915665T ATE296300T1 (de) | 1998-03-27 | 1999-03-17 | Benzoheterocyclische distamycinderivate, verfahren zu ihrer herstellung und ihre verwendung als antitumormittel |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6458768B1 (de) |
| EP (1) | EP1064281B1 (de) |
| JP (1) | JP2002509930A (de) |
| AT (1) | ATE296300T1 (de) |
| AU (1) | AU3415599A (de) |
| DE (1) | DE69925472T2 (de) |
| ES (1) | ES2244188T3 (de) |
| GB (1) | GB9806692D0 (de) |
| PT (1) | PT1064281E (de) |
| WO (1) | WO1999050266A1 (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6559125B1 (en) | 2000-01-28 | 2003-05-06 | California Institute Of Technology | Polyamide-alkylator conjugates and related products and method |
| DE60103038T2 (de) * | 2000-02-16 | 2004-09-02 | Telefonaktiebolaget Lm Ericsson (Publ) | Stiftdrucker |
| GB0011059D0 (en) * | 2000-05-08 | 2000-06-28 | Pharmacia & Upjohn Spa | Use of substituted acryloyl distamycin derivatives in the treatment of tumours associated with high levels of glutathione |
| GB0015444D0 (en) * | 2000-06-23 | 2000-08-16 | Pharmacia & Upjohn Spa | Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and topoisomerase I and II inhibitors |
| GB0015446D0 (en) * | 2000-06-23 | 2000-08-16 | Pharmacia & Upjohn Spa | Combined therapy against tumors comprising substituted acryloyl distamycin derivates,taxanes and/or antimetabolites |
| GB0015447D0 (en) | 2000-06-23 | 2000-08-16 | Pharmacia & Upjohn Spa | Combined therapy against tumors comprising substituted acryloyl derivates and alkylating agents |
| GB0016447D0 (en) * | 2000-07-04 | 2000-08-23 | Pharmacia & Upjohn Spa | Process for preparing distamycin derivatives |
| GB0029004D0 (en) | 2000-11-28 | 2001-01-10 | Pharmacia & Upjohn Spa | Process for preparing distamycin derivatives |
| AU2002312371A1 (en) | 2001-06-13 | 2002-12-23 | Roland W. Burli | Aryl-benzimidazole compounds having antiinfective activity |
| CA2450628A1 (en) * | 2001-06-13 | 2002-12-19 | Genesoft Pharmaceuticals, Inc. | Benzothiophene compounds having antiinfective activity |
| WO2002101007A2 (en) | 2001-06-13 | 2002-12-19 | Genesoft Pharmaceuticals, Inc | Antipathogenic benzamide compounds |
| US6969592B2 (en) | 2001-09-26 | 2005-11-29 | Pharmacia Italia S.P.A. | Method for predicting the sensitivity to chemotherapy |
| WO2004012736A1 (en) | 2002-08-02 | 2004-02-12 | Genesoft Pharmaceuticals, Inc. | Biaryl compounds having anti-infective activity |
| WO2004026264A2 (en) | 2002-09-20 | 2004-04-01 | Genelabs Technologies, Inc. | Novel aromatic compounds possessing antifungal or antibacterial activity |
| EP1562931A2 (de) * | 2002-10-25 | 2005-08-17 | Genesoft Pharmaceuticals, Inc. | Biarylverbindungen mitantiinfektionswirkung |
| AU2003297822A1 (en) | 2002-12-10 | 2004-06-30 | Oscient Pharmaceuticals Corporation | Antibacterial compounds having a (pyrrole carboxamide)-(benzamide)-(imidazole carboxamide) motif |
| JP5386350B2 (ja) * | 2006-05-31 | 2014-01-15 | タケダ カリフォルニア インコーポレイテッド | グルコキナーゼ活性剤としての、インダゾールおよびイソインドール誘導体 |
| UY31830A (es) | 2008-05-16 | 2010-01-05 | Takeda Pharmaceutical | Activadores de glucoquinasa |
| WO2023209651A1 (en) * | 2022-04-29 | 2023-11-02 | Dong-A St Co., Ltd. | Bicycle compounds as tead inhibitor |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8612218D0 (en) | 1986-05-20 | 1986-06-25 | Erba Farmitalia | Site specific alkylating agents |
| IT1271456B (it) | 1993-03-01 | 1997-05-28 | Menarini Farma Ind | Composti pirrol-amidinici, e loro sali farmaceuticamente accettabili, processi di preparazione e composizioni farmaceutiche che li contengono |
| GB9416005D0 (en) | 1994-08-08 | 1994-09-28 | Erba Carlo Spa | Peptidic compounds analogous to distamycin a and process for their preparation |
| CA2244139C (en) * | 1996-02-02 | 2005-06-07 | Pharmacia & Upjohn S.P.A. | Distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents |
| GB9610079D0 (en) * | 1996-05-14 | 1996-07-17 | Pharmacia Spa | Distamycin deriratives process for preparing them and their use as antitumor and antiviral agents |
| GB9623522D0 (en) | 1996-11-11 | 1997-01-08 | Pharmacia & Upjohn Spa | Benzoheterocycle distamycin derivatives process for preparing them and their use as antitumour and antiviral agents |
-
1998
- 1998-03-27 GB GBGB9806692.1A patent/GB9806692D0/en not_active Ceased
-
1999
- 1999-03-17 WO PCT/EP1999/001823 patent/WO1999050266A1/en active IP Right Grant
- 1999-03-17 AT AT99915665T patent/ATE296300T1/de not_active IP Right Cessation
- 1999-03-17 DE DE69925472T patent/DE69925472T2/de not_active Expired - Fee Related
- 1999-03-17 US US09/623,505 patent/US6458768B1/en not_active Expired - Fee Related
- 1999-03-17 ES ES99915665T patent/ES2244188T3/es not_active Expired - Lifetime
- 1999-03-17 PT PT99915665T patent/PT1064281E/pt unknown
- 1999-03-17 EP EP99915665A patent/EP1064281B1/de not_active Expired - Lifetime
- 1999-03-17 AU AU34155/99A patent/AU3415599A/en not_active Abandoned
- 1999-03-17 JP JP2000541170A patent/JP2002509930A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| PT1064281E (pt) | 2005-10-31 |
| GB9806692D0 (en) | 1998-05-27 |
| JP2002509930A (ja) | 2002-04-02 |
| DE69925472T2 (de) | 2006-02-02 |
| EP1064281A1 (de) | 2001-01-03 |
| DE69925472D1 (de) | 2005-06-30 |
| US6458768B1 (en) | 2002-10-01 |
| EP1064281B1 (de) | 2005-05-25 |
| AU3415599A (en) | 1999-10-18 |
| WO1999050266A1 (en) | 1999-10-07 |
| ES2244188T3 (es) | 2005-12-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1064281 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |