BR0317244A - Derivados de piperazina contendo fósforo como antagonistas ccr1 - Google Patents
Derivados de piperazina contendo fósforo como antagonistas ccr1Info
- Publication number
- BR0317244A BR0317244A BR0317244-9A BR0317244A BR0317244A BR 0317244 A BR0317244 A BR 0317244A BR 0317244 A BR0317244 A BR 0317244A BR 0317244 A BR0317244 A BR 0317244A
- Authority
- BR
- Brazil
- Prior art keywords
- piperazine derivatives
- phosphorus
- ccr1 antagonists
- containing piperazine
- prodrug
- Prior art date
Links
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 title abstract 2
- 239000005557 antagonist Substances 0.000 title abstract 2
- 229910052698 phosphorus Inorganic materials 0.000 title abstract 2
- 239000011574 phosphorus Substances 0.000 title abstract 2
- 229940066771 systemic antihistamines piperazine derivative Drugs 0.000 title abstract 2
- 150000004885 piperazines Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 239000000651 prodrug Substances 0.000 abstract 2
- 229940002612 prodrug Drugs 0.000 abstract 2
- 102100031172 C-C chemokine receptor type 1 Human genes 0.000 abstract 1
- 101710149814 C-C chemokine receptor type 1 Proteins 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical class C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 208000026278 immune system disease Diseases 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/650952—Six-membered rings having the nitrogen atoms in the positions 1 and 4
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Physical Education & Sports Medicine (AREA)
- Virology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Obesity (AREA)
- Neurology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Biochemistry (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Biotechnology (AREA)
- Psychiatry (AREA)
Abstract
"DERIVADOS DE PIPERAZINA CONTENDO FóSFORO COMO ANTAGONISTAS CCR1". Composto de fórmula (I), uma pródroga do mesmo, ou o sal farmaceuticamente aceitável do composto ou pródroga; onde X, Y, a, b, c, d, R¬ 1¬, R¬ 2¬,R¬ 3¬, R¬ 4¬, R¬ 5¬, R¬ 6¬, e R¬ 7¬ são como definidos acima e são úteis para o tratamento de inflamação e de outras desordens imunes. A presente invenção também se refere a composições farmacêuticas que incluem os compostos de fórmula (I) e o veículo farmaceuticamente aceitável. Ademais, a presente invenção se refere aos métodos de uso dos compostos e composições acima descritos, para tratar e evitar as doenças e condições.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43339902P | 2002-12-13 | 2002-12-13 | |
| PCT/IB2003/005571 WO2004055031A1 (en) | 2002-12-13 | 2003-11-28 | Phosphorus-containing piperazine derivatives as ccr1 antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0317244A true BR0317244A (pt) | 2005-11-01 |
Family
ID=32595179
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0317244-9A BR0317244A (pt) | 2002-12-13 | 2003-11-28 | Derivados de piperazina contendo fósforo como antagonistas ccr1 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20040127465A1 (pt) |
| EP (1) | EP1572704A1 (pt) |
| JP (1) | JP2006509815A (pt) |
| AR (1) | AR042624A1 (pt) |
| AU (1) | AU2003303066A1 (pt) |
| BR (1) | BR0317244A (pt) |
| CA (1) | CA2505979A1 (pt) |
| MX (1) | MXPA05006229A (pt) |
| NL (2) | NL1025010C2 (pt) |
| PA (1) | PA8591201A1 (pt) |
| PE (1) | PE20040912A1 (pt) |
| TW (1) | TW200412340A (pt) |
| UY (1) | UY28119A1 (pt) |
| WO (1) | WO2004055031A1 (pt) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009502964A (ja) * | 2005-07-27 | 2009-01-29 | ギリアード サイエンシーズ， インコーポレイテッド | Ｈｉｖを阻害するための抗ウイルス性ホスホン酸結合体 |
| MX2010006215A (es) | 2007-12-05 | 2010-08-17 | Astrazeneca Ab | Derivados de piperazina y su uso como moduladores del receptor de leptina. |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE640616A (pt) * | 1962-12-19 | |||
| US3492397A (en) * | 1967-04-07 | 1970-01-27 | Warner Lambert Pharmaceutical | Sustained release dosage in the pellet form and process thereof |
| US4060598A (en) * | 1967-06-28 | 1977-11-29 | Boehringer Mannheim G.M.B.H. | Tablets coated with aqueous resin dispersions |
| US3538214A (en) * | 1969-04-22 | 1970-11-03 | Merck & Co Inc | Controlled release medicinal tablets |
| US4173626A (en) * | 1978-12-11 | 1979-11-06 | Merck & Co., Inc. | Sustained release indomethacin |
| US4822780A (en) * | 1987-07-08 | 1989-04-18 | Otsuka Pharmaceutical Factory, Inc. | Carboxamide compounds |
| AU729415B2 (en) * | 1996-07-12 | 2001-02-01 | Millennium Pharmaceuticals, Inc. | Chemokine receptor antagonists and methods of use therefor |
| US6207665B1 (en) * | 1997-06-12 | 2001-03-27 | Schering Aktiengesellschaft | Piperazine derivatives and their use as anti-inflammatory agents |
| AU2001238590A1 (en) * | 2000-02-22 | 2001-09-03 | Cv Therapeutics, Inc. | Substituted piperazine compounds |
| UA73553C2 (en) * | 2000-03-31 | 2005-08-15 | Pfizer Prod Inc | Piperazine derivatives |
-
2003
- 2003-11-28 MX MXPA05006229A patent/MXPA05006229A/es unknown
- 2003-11-28 BR BR0317244-9A patent/BR0317244A/pt not_active IP Right Cessation
- 2003-11-28 WO PCT/IB2003/005571 patent/WO2004055031A1/en not_active Application Discontinuation
- 2003-11-28 JP JP2004560018A patent/JP2006509815A/ja active Pending
- 2003-11-28 AU AU2003303066A patent/AU2003303066A1/en not_active Abandoned
- 2003-11-28 CA CA002505979A patent/CA2505979A1/en not_active Abandoned
- 2003-11-28 EP EP03813222A patent/EP1572704A1/en not_active Withdrawn
- 2003-12-09 PA PA20038591201A patent/PA8591201A1/es unknown
- 2003-12-09 TW TW092134724A patent/TW200412340A/zh unknown
- 2003-12-10 PE PE2003001258A patent/PE20040912A1/es not_active Application Discontinuation
- 2003-12-11 UY UY28119A patent/UY28119A1/es not_active Application Discontinuation
- 2003-12-11 AR ARP030104578A patent/AR042624A1/es unknown
- 2003-12-12 US US10/734,411 patent/US20040127465A1/en not_active Abandoned
- 2003-12-12 NL NL1025010A patent/NL1025010C2/nl not_active IP Right Cessation
-
2004
- 2004-10-01 NL NL1027158A patent/NL1027158C2/nl not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004055031A1 (en) | 2004-07-01 |
| PA8591201A1 (es) | 2005-02-04 |
| TW200412340A (en) | 2004-07-16 |
| CA2505979A1 (en) | 2004-07-01 |
| UY28119A1 (es) | 2004-07-30 |
| AU2003303066A1 (en) | 2004-07-09 |
| PE20040912A1 (es) | 2005-01-22 |
| JP2006509815A (ja) | 2006-03-23 |
| US20040127465A1 (en) | 2004-07-01 |
| NL1025010C2 (nl) | 2004-10-14 |
| NL1025010A1 (nl) | 2004-06-24 |
| AR042624A1 (es) | 2005-06-29 |
| EP1572704A1 (en) | 2005-09-14 |
| NL1027158A1 (nl) | 2004-11-24 |
| NL1027158C2 (nl) | 2005-11-15 |
| MXPA05006229A (es) | 2005-08-19 |
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