PE20040912A1 - Derivados de piperazina que contienen fosforo como antagonistas de ccr1 - Google Patents
Derivados de piperazina que contienen fosforo como antagonistas de ccr1Info
- Publication number
- PE20040912A1 PE20040912A1 PE2003001258A PE2003001258A PE20040912A1 PE 20040912 A1 PE20040912 A1 PE 20040912A1 PE 2003001258 A PE2003001258 A PE 2003001258A PE 2003001258 A PE2003001258 A PE 2003001258A PE 20040912 A1 PE20040912 A1 PE 20040912A1
- Authority
- PE
- Peru
- Prior art keywords
- benzyl
- oxo
- piperazin
- fluoro
- chloro
- Prior art date
Links
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical class C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 title abstract 2
- 229940066771 systemic antihistamines piperazine derivative Drugs 0.000 title abstract 2
- 102100031172 C-C chemokine receptor type 1 Human genes 0.000 title 1
- 101710149814 C-C chemokine receptor type 1 Proteins 0.000 title 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- 229910052698 phosphorus Inorganic materials 0.000 title 1
- 239000011574 phosphorus Substances 0.000 title 1
- -1 HYDROXY, AMINO Chemical group 0.000 abstract 4
- 206010061218 Inflammation Diseases 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 102000004500 CCR1 Receptors Human genes 0.000 abstract 1
- 108010017319 CCR1 Receptors Proteins 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical group [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
- TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical class [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6509—Six-membered rings
- C07F9/650952—Six-membered rings having the nitrogen atoms in the positions 1 and 4
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Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Public Health (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
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- Diabetes (AREA)
- Virology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Biochemistry (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
Abstract
SE REFIERE A DERIVADOS DE PIPERAZINA DE FORMULA I DONDE a ES 0 a 5; b Y c SON 0 a 2; d ES 0 a 4; X ES O, S, CH2 o NR6; Y ES ARILO C6-C10 o HETEROARILO C2-C9; R1 ES HIDROXI, HALO, ALQUILO C1-C8 OPCIONALMENTE SUSTITUIDO CON 1-3 ATOMOS DE F, ENTRE OTROS; R2 Y R3, SON OXO, ALQUILO C1-C8 OPCIONALMENTE SUSTITUIDO CON 1-3 F, CICLOALQUILO C3-C8, ENTRE OTROS; R4 ES OH, HALO, CN, HO(C=O), ENTRE OTROS; R5 ES UN ENLACE O UN ALQUIL C1-C8; R6 ES HIDROXI, AMINO o (ALQUIL C1-C6)-NH; R7 ES H, HIDROXILO, ALCOXI C1-C8 o ALQUIL C1-C8. SON COMPUESTOS PREFERIDOS: ACIDO (5-CLORO-2-{2-[4-(4-FLUORO-BENCIL)-(2R,5S)-2,5-DIMETIL-PIPERAZIN-1-IL]-2-OXO-ETOXI}BENCIL)-FOSFONICO; ACIDO (5-CLORO-2-{2-[4-(4-FLUORO-BENCIL)-(2R)-2-METIL-PIPERAZIN-1-IL]-2-OXO-ETOXI}BENCIL)-FOSFONICO; ACIDO (5-CLORO-2-{2-[(2R)-2-ETIL-4-(4-FLUORO-BENCIL)-PIPERAZIN-1-IL]-2-OXO-ETOXI}BENCIL)-FOSFONICO; ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA EN DONDE DICHOS COMPUESTOS SON INHIBIDORES DE LA UNION DE MIP-1a (CCL3) QUE SE UNEN A SU RECEPTOR CCR1 Y SON UTILES PARA TRATAR ENFERMEDADES ASOCIADAS CON LA INFLAMACION Y TRASTORNOS AUTOINMUNES
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43339902P | 2002-12-13 | 2002-12-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20040912A1 true PE20040912A1 (es) | 2005-01-22 |
Family
ID=32595179
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2003001258A PE20040912A1 (es) | 2002-12-13 | 2003-12-10 | Derivados de piperazina que contienen fosforo como antagonistas de ccr1 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20040127465A1 (es) |
| EP (1) | EP1572704A1 (es) |
| JP (1) | JP2006509815A (es) |
| AR (1) | AR042624A1 (es) |
| AU (1) | AU2003303066A1 (es) |
| BR (1) | BR0317244A (es) |
| CA (1) | CA2505979A1 (es) |
| MX (1) | MXPA05006229A (es) |
| NL (2) | NL1025010C2 (es) |
| PA (1) | PA8591201A1 (es) |
| PE (1) | PE20040912A1 (es) |
| TW (1) | TW200412340A (es) |
| UY (1) | UY28119A1 (es) |
| WO (1) | WO2004055031A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009502964A (ja) * | 2005-07-27 | 2009-01-29 | ギリアード サイエンシーズ， インコーポレイテッド | Ｈｉｖを阻害するための抗ウイルス性ホスホン酸結合体 |
| WO2009071668A2 (en) | 2007-12-05 | 2009-06-11 | Biovitrum Ab (Publ) | Piperazine derivatives and their use as leptin receptor modulators |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE640616A (es) * | 1962-12-19 | |||
| US3492397A (en) * | 1967-04-07 | 1970-01-27 | Warner Lambert Pharmaceutical | Sustained release dosage in the pellet form and process thereof |
| US4060598A (en) * | 1967-06-28 | 1977-11-29 | Boehringer Mannheim G.M.B.H. | Tablets coated with aqueous resin dispersions |
| US3538214A (en) * | 1969-04-22 | 1970-11-03 | Merck & Co Inc | Controlled release medicinal tablets |
| US4173626A (en) * | 1978-12-11 | 1979-11-06 | Merck & Co., Inc. | Sustained release indomethacin |
| US4822780A (en) * | 1987-07-08 | 1989-04-18 | Otsuka Pharmaceutical Factory, Inc. | Carboxamide compounds |
| CA2259927A1 (en) * | 1996-07-12 | 1998-01-22 | Leukosite, Inc. | Chemokine receptor antagonists and methods of use therefor |
| US6207665B1 (en) * | 1997-06-12 | 2001-03-27 | Schering Aktiengesellschaft | Piperazine derivatives and their use as anti-inflammatory agents |
| AU2001238590A1 (en) * | 2000-02-22 | 2001-09-03 | Cv Therapeutics, Inc. | Substituted piperazine compounds |
| EA006079B1 (ru) * | 2000-03-31 | 2005-08-25 | Пфайзер Продактс Инк. | Новые пиперазиновые производные |
-
2003
- 2003-11-28 MX MXPA05006229A patent/MXPA05006229A/es unknown
- 2003-11-28 EP EP03813222A patent/EP1572704A1/en not_active Withdrawn
- 2003-11-28 BR BR0317244-9A patent/BR0317244A/pt not_active IP Right Cessation
- 2003-11-28 CA CA002505979A patent/CA2505979A1/en not_active Abandoned
- 2003-11-28 WO PCT/IB2003/005571 patent/WO2004055031A1/en not_active Application Discontinuation
- 2003-11-28 AU AU2003303066A patent/AU2003303066A1/en not_active Abandoned
- 2003-11-28 JP JP2004560018A patent/JP2006509815A/ja active Pending
- 2003-12-09 PA PA20038591201A patent/PA8591201A1/es unknown
- 2003-12-09 TW TW092134724A patent/TW200412340A/zh unknown
- 2003-12-10 PE PE2003001258A patent/PE20040912A1/es not_active Application Discontinuation
- 2003-12-11 AR ARP030104578A patent/AR042624A1/es unknown
- 2003-12-11 UY UY28119A patent/UY28119A1/es not_active Application Discontinuation
- 2003-12-12 US US10/734,411 patent/US20040127465A1/en not_active Abandoned
- 2003-12-12 NL NL1025010A patent/NL1025010C2/nl not_active IP Right Cessation
-
2004
- 2004-10-01 NL NL1027158A patent/NL1027158C2/nl not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2006509815A (ja) | 2006-03-23 |
| AU2003303066A1 (en) | 2004-07-09 |
| MXPA05006229A (es) | 2005-08-19 |
| BR0317244A (pt) | 2005-11-01 |
| NL1027158C2 (nl) | 2005-11-15 |
| PA8591201A1 (es) | 2005-02-04 |
| UY28119A1 (es) | 2004-07-30 |
| NL1025010A1 (nl) | 2004-06-24 |
| US20040127465A1 (en) | 2004-07-01 |
| AR042624A1 (es) | 2005-06-29 |
| NL1025010C2 (nl) | 2004-10-14 |
| TW200412340A (en) | 2004-07-16 |
| EP1572704A1 (en) | 2005-09-14 |
| NL1027158A1 (nl) | 2004-11-24 |
| CA2505979A1 (en) | 2004-07-01 |
| WO2004055031A1 (en) | 2004-07-01 |
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