ATE364044T1 - 5ht2c rezeptor agonisten zur behandlung von diabetes und fettleibigkeit - Google Patents
5ht2c rezeptor agonisten zur behandlung von diabetes und fettleibigkeitInfo
- Publication number
- ATE364044T1 ATE364044T1 AT04740057T AT04740057T ATE364044T1 AT E364044 T1 ATE364044 T1 AT E364044T1 AT 04740057 T AT04740057 T AT 04740057T AT 04740057 T AT04740057 T AT 04740057T AT E364044 T1 ATE364044 T1 AT E364044T1
- Authority
- AT
- Austria
- Prior art keywords
- obesity
- treatment
- diabetes
- receptor agonists
- sup
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0314967.1A GB0314967D0 (en) | 2003-06-26 | 2003-06-26 | Piperazine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE364044T1 true ATE364044T1 (de) | 2007-06-15 |
Family
ID=27637436
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04740057T ATE364044T1 (de) | 2003-06-26 | 2004-06-18 | 5ht2c rezeptor agonisten zur behandlung von diabetes und fettleibigkeit |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7208494B2 (de) |
| EP (1) | EP1641796B1 (de) |
| JP (1) | JP4362511B2 (de) |
| KR (1) | KR100756113B1 (de) |
| CN (1) | CN100400538C (de) |
| AT (1) | ATE364044T1 (de) |
| AU (1) | AU2004251847B2 (de) |
| BR (1) | BRPI0411936A (de) |
| CA (1) | CA2530308C (de) |
| DE (1) | DE602004006869T2 (de) |
| ES (1) | ES2287741T3 (de) |
| GB (1) | GB0314967D0 (de) |
| MX (1) | MXPA05013856A (de) |
| WO (1) | WO2005000849A1 (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5173190B2 (ja) | 2004-08-25 | 2013-03-27 | 武田薬品工業株式会社 | 腹圧性尿失禁の予防・治療剤及びそのスクリーニング方法 |
| KR100895758B1 (ko) | 2005-05-03 | 2009-04-30 | 에프. 호프만-라 로슈 아게 | 5-ｈｔ2 리간드로서 테트라사이클릭 아자피라지노인돌린 |
| WO2006125179A1 (en) * | 2005-05-19 | 2006-11-23 | Xenon Pharmaceuticals Inc. | Tricyclic compounds and their uses as therapeutic agents |
| US20090203750A1 (en) * | 2005-08-24 | 2009-08-13 | Alan Kozikowski | 5-HT2C Receptor Agonists as Anorectic Agents |
| EP1966199B1 (de) * | 2005-11-18 | 2010-10-20 | F. Hoffmann-La Roche AG | Azaindol-2-carboxamid-derivate |
| CN101321761A (zh) | 2005-12-09 | 2008-12-10 | 霍夫曼-拉罗奇有限公司 | 用于治疗肥胖病的三环酰胺衍生物 |
| EP2018863B9 (de) | 2006-05-16 | 2015-02-18 | Takeda Pharmaceutical Company Limited | Kondensierte, heterocyclische Verbindung und ihre Verwendung |
| EP2034916A1 (de) * | 2006-07-04 | 2009-03-18 | Bracco Imaging S.p.A | Vorrichtung zur lokalen wärmeablation von biologischem gewebe, insbesondere tumor- und ähnlichem gewebe |
| US20100266504A1 (en) | 2007-11-15 | 2010-10-21 | Takahiro Matsumoto | Condensed pyridine derivative and use thereof |
| WO2010047982A1 (en) | 2008-10-22 | 2010-04-29 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
| CA2741672A1 (en) | 2008-10-31 | 2010-05-06 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
| EP2510949A4 (de) | 2009-12-11 | 2013-11-13 | Astellas Pharma Inc | Therapeutikum für fibromyalgie |
| AU2011212930B2 (en) | 2010-02-04 | 2016-02-11 | The Board Of Trustees Of The University Of Illinois | Highly selective 5-HT(2C) receptor agonists having antagonist activity at the 5-HT(2B) receptor |
| WO2011106273A1 (en) | 2010-02-25 | 2011-09-01 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
| US20130267500A1 (en) | 2010-09-01 | 2013-10-10 | Arena Pharmaceuticals, Inc. | 5-ht2c receptor agonists in the treatment of disorders ameliorated by reduction of norepinephrine level |
| EA025380B1 (ru) | 2011-02-25 | 2016-12-30 | Мерк Шарп Энд Домэ Корп. | Новые циклические производные азабензимидазола, используемые в качестве антидиабетических агентов |
| KR20150036245A (ko) | 2012-08-02 | 2015-04-07 | 머크 샤프 앤드 돔 코포레이션 | 항당뇨병 트리시클릭 화합물 |
| WO2014139388A1 (en) | 2013-03-14 | 2014-09-18 | Merck Sharp & Dohme Corp. | Novel indole derivatives useful as anti-diabetic agents |
| WO2015066344A1 (en) | 2013-11-01 | 2015-05-07 | Arena Pharmaceuticals, Inc. | 5-ht2c receptor agonists and compositions and methods of use |
| CN107810175B (zh) | 2015-01-29 | 2021-06-15 | 伊利诺伊大学评议会 | 作为选择性5-ht(2c)受体激动剂的环丙基甲胺 |
| US20210052600A1 (en) | 2017-12-27 | 2021-02-25 | Takeda Pharmaceutical Company Limited | Therapeutic agents for stress urinary incontinence and incotinence of feces |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3317524A (en) * | 1965-02-04 | 1967-05-02 | American Home Prod | Substituted 1, 2, 3, 4-tetrahydro-pyrazino[1, 2-a]indoles |
| CA1247547A (en) * | 1983-06-22 | 1988-12-28 | Paul Hadvary | Leucine derivatives |
| US4844839A (en) * | 1984-09-04 | 1989-07-04 | Manchak Frank | In situ treatment and analysis of wastes |
| US4776409A (en) * | 1984-09-04 | 1988-10-11 | Manchak Frank | Insitu waste impoundment treating apparatus and method of using same |
| US5246960A (en) * | 1984-12-21 | 1993-09-21 | Hoffmann-La Roche Inc. | Oxetanones |
| CA1328881C (en) | 1984-12-21 | 1994-04-26 | Pierre Barbier | Process for the manufacture of oxetanones |
| CA1270837A (en) | 1984-12-21 | 1990-06-26 | Hoffmann-La Roche Limited | Oxetanones |
| MC1814A1 (fr) * | 1985-08-26 | 1988-03-18 | Manchak Frank | Appareil de traitement in situ de dechets dangereux et methode d'utilisation de cet appareil |
| CA2035972C (en) * | 1990-02-23 | 2006-07-11 | Martin Karpf | Process for the preparation of oxetanones |
| US5274143A (en) | 1991-07-23 | 1993-12-28 | Hoffmann-La Roche Inc. | Process for the preparation of (R)-3-hexyl-5,6-dihydro-4-hydroxy-6-undecyl-2H-pyran-2-one and (R)-5,6-dihydro-6-undecyl-2H-pyran-2,4(3H)-dione |
| EP0572863A1 (de) | 1992-06-05 | 1993-12-08 | F. Hoffmann-La Roche Ag | ZNS Pyrazinoindole |
| HUT71799A (en) * | 1993-03-01 | 1996-02-28 | Merck Sharp & Dohme | Pyrrolo-pyridine derivatives, pharmaceutical compositions containing the same, process for producing them |
| TW334423B (en) | 1993-10-22 | 1998-06-21 | Hoffmann La Roche | Tricyclic 1-aminoethylpyrrole-derivatives |
| TW270114B (de) | 1993-10-22 | 1996-02-11 | Hoffmann La Roche | |
| AU5343298A (en) | 1997-01-13 | 1998-08-03 | Yamanouchi Pharmaceutical Co., Ltd. | 5-ht2c receptor agonists and aminoalkylindazole derivatives |
| US6004996A (en) * | 1997-02-05 | 1999-12-21 | Hoffman-La Roche Inc. | Tetrahydrolipstatin containing compositions |
| US6267952B1 (en) | 1998-01-09 | 2001-07-31 | Geltex Pharmaceuticals, Inc. | Lipase inhibiting polymers |
| CN1170534C (zh) | 1998-08-14 | 2004-10-13 | 霍夫曼-拉罗奇有限公司 | 含有脂酶抑制剂的药物组合物 |
| TR200100472T2 (tr) | 1998-08-14 | 2001-07-23 | F.Hoffmann-La Roche Ag | Lipaz inhibitörleri ile sitozan içeren farmasötik bileşimler |
| GB9819019D0 (en) | 1998-09-01 | 1998-10-28 | Cerebrus Ltd | Chemical compounds II |
| GB9819032D0 (en) * | 1998-09-01 | 1998-10-28 | Cerebrus Ltd | Chemical compounds IV |
| GB9819033D0 (en) * | 1998-09-01 | 1998-10-28 | Cerebrus Ltd | Chemical compounds VI |
| GB9819020D0 (en) | 1998-09-01 | 1998-10-28 | Cerebrus Ltd | Chemical compounds III |
| GB9819035D0 (en) | 1998-09-01 | 1998-10-28 | Cerebrus Res Ltd | Chemical compounds VII |
| GB9820767D0 (en) | 1998-09-23 | 1998-11-18 | Cerebrus Ltd | Chemical compounds VIII |
| EA200100671A1 (ru) | 1998-12-17 | 2001-12-24 | Американ Хоум Продактс Корпорейшн | ПРОИЗВОДНЫЕ 2,3,4,4a-ТЕТРАГИДРО-1H-ПИРАЗИНО [1,2a]ХИНОКСАЛИН-5(6H)-ОНА, ЯВЛЯЮЩИЕСЯ АГОНИСТАМИ 5HT2C |
| GB9902047D0 (en) * | 1999-01-29 | 1999-03-17 | Cerebrus Ltd | Chemical compounds XI |
| GB9918965D0 (en) | 1999-08-11 | 1999-10-13 | Cerebrus Ltd | Chemical compounds xxi |
| GB9918962D0 (en) * | 1999-08-11 | 1999-10-13 | Cerebrus Ltd | Chemical compounds xxii |
| EP1132389A1 (de) | 2000-03-06 | 2001-09-12 | Vernalis Research Limited | Neue Azaindolyl-Derivate für die Behandlung von Fettleibigheit |
| US6635598B2 (en) * | 2000-04-20 | 2003-10-21 | Indian Petrochemicals Corporation Limited | Stable and selective dehydrogenation catalyst and a process for the preparation thereof |
| AU2001283955B2 (en) * | 2000-07-31 | 2006-05-18 | F. Hoffmann-La Roche Ag | Piperazine derivatives |
| CA2432085C (en) * | 2000-12-27 | 2009-02-24 | F. Hoffmann-La Roche Ag | Indole derivatives and their use as 5-ht2b and 5-ht2c receptor ligands |
| GB0202015D0 (en) * | 2002-01-29 | 2002-03-13 | Hoffmann La Roche | Piperazine Derivatives |
-
2003
- 2003-06-26 GB GBGB0314967.1A patent/GB0314967D0/en not_active Ceased
-
2004
- 2004-06-18 DE DE602004006869T patent/DE602004006869T2/de active Active
- 2004-06-18 WO PCT/EP2004/006612 patent/WO2005000849A1/en active IP Right Grant
- 2004-06-18 MX MXPA05013856A patent/MXPA05013856A/es unknown
- 2004-06-18 CN CNB2004800179181A patent/CN100400538C/zh not_active Expired - Fee Related
- 2004-06-18 KR KR1020057024843A patent/KR100756113B1/ko not_active IP Right Cessation
- 2004-06-18 EP EP04740057A patent/EP1641796B1/de not_active Not-in-force
- 2004-06-18 BR BRPI0411936-3A patent/BRPI0411936A/pt not_active IP Right Cessation
- 2004-06-18 JP JP2006515997A patent/JP4362511B2/ja not_active Expired - Fee Related
- 2004-06-18 AU AU2004251847A patent/AU2004251847B2/en not_active Ceased
- 2004-06-18 ES ES04740057T patent/ES2287741T3/es active Active
- 2004-06-18 CA CA002530308A patent/CA2530308C/en not_active Expired - Fee Related
- 2004-06-18 AT AT04740057T patent/ATE364044T1/de not_active IP Right Cessation
- 2004-06-25 US US10/876,954 patent/US7208494B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU2004251847A1 (en) | 2005-01-06 |
| BRPI0411936A (pt) | 2006-08-29 |
| EP1641796B1 (de) | 2007-06-06 |
| WO2005000849A1 (en) | 2005-01-06 |
| JP2007506667A (ja) | 2007-03-22 |
| DE602004006869D1 (de) | 2007-07-19 |
| CN100400538C (zh) | 2008-07-09 |
| CA2530308C (en) | 2009-06-09 |
| GB0314967D0 (en) | 2003-07-30 |
| US7208494B2 (en) | 2007-04-24 |
| KR100756113B1 (ko) | 2007-09-05 |
| CN1812989A (zh) | 2006-08-02 |
| DE602004006869T2 (de) | 2008-02-07 |
| EP1641796A1 (de) | 2006-04-05 |
| ES2287741T3 (es) | 2007-12-16 |
| US20050026925A1 (en) | 2005-02-03 |
| CA2530308A1 (en) | 2005-01-06 |
| JP4362511B2 (ja) | 2009-11-11 |
| AU2004251847B2 (en) | 2007-08-23 |
| MXPA05013856A (es) | 2006-02-28 |
| KR20060028773A (ko) | 2006-04-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1641796 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |