EA200500191A1 - Кристаллический 2,5-дион-3-(1-метил-1h-индол-3-ил)-4-[1-(пиридин-2-илметил)пиперидин-4-ил]-1h-индол-3-ил]-1h-пирролмоногидрохлорид - Google Patents

Кристаллический 2,5-дион-3-(1-метил-1h-индол-3-ил)-4-[1-(пиридин-2-илметил)пиперидин-4-ил]-1h-индол-3-ил]-1h-пирролмоногидрохлорид

Info

Publication number
EA200500191A1
EA200500191A1 EA200500191A EA200500191A EA200500191A1 EA 200500191 A1 EA200500191 A1 EA 200500191A1 EA 200500191 A EA200500191 A EA 200500191A EA 200500191 A EA200500191 A EA 200500191A EA 200500191 A1 EA200500191 A1 EA 200500191A1
Authority
EA
Eurasian Patent Office
Prior art keywords
indol
piperidin
methyl
pirrolmonhydrochloride
crystallic
Prior art date
Application number
EA200500191A
Other languages
English (en)
Other versions
EA007463B1 (ru
Inventor
Джули Кей Буш
Маргарет Мэри Фол
Сузен Мари Рутзел-Иденс
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42799191&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200500191(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of EA200500191A1 publication Critical patent/EA200500191A1/ru
Publication of EA007463B1 publication Critical patent/EA007463B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Данное изобретение относится к кристаллическому 2,5-дион-3-(1-метил-1H-индол-3-ил)-4-[1-(пиридин-2-илметил)пиперидин-4-ил]-1H-индол-3-ил]-1H-пирролмоногидрохлориду, фармацевтической композиции, содержащей указанную соль, к способам лечения рака, а также ингибирования роста опухолей с использованием указанной соли.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200500191A 2002-07-12 2003-07-08 Кристаллический 2,5-дион-3-(1-метил-1h-индол-3-ил)-4-[1-(пиридин-2-илметил)пиперидин-4-ил]-1h-индол-3-ил-1h-пирролмоногидрохлорид EA007463B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39597602P 2002-07-12 2002-07-12
PCT/US2003/019548 WO2004006928A1 (en) 2002-07-12 2003-07-08 Crystalline 2,5-dione-3-(1-methyl-1h-indol-3-yl)-4-[1-(pyridin-2-ylmethyl)piperidin-4-yl]-1h-indol-3-yl]-1h-pyrrole mono-hydrochloride

Publications (2)

Publication Number Publication Date
EA200500191A1 true EA200500191A1 (ru) 2005-06-30
EA007463B1 EA007463B1 (ru) 2006-10-27

Family

ID=42799191

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200500191A EA007463B1 (ru) 2002-07-12 2003-07-08 Кристаллический 2,5-дион-3-(1-метил-1h-индол-3-ил)-4-[1-(пиридин-2-илметил)пиперидин-4-ил]-1h-индол-3-ил-1h-пирролмоногидрохлорид

Country Status (22)

Country Link
US (2) US8114901B2 (ru)
EP (1) EP1523313B1 (ru)
JP (2) JP4771356B2 (ru)
KR (1) KR100687165B1 (ru)
CN (1) CN100430058C (ru)
AU (1) AU2003280958B9 (ru)
CA (1) CA2393720C (ru)
DE (1) DE60317675T2 (ru)
EA (1) EA007463B1 (ru)
EC (1) ECSP055537A (ru)
ES (1) ES2295605T3 (ru)
HK (1) HK1075839A1 (ru)
HR (1) HRP20050035B1 (ru)
IL (1) IL165747A (ru)
NO (1) NO330254B1 (ru)
NZ (1) NZ537137A (ru)
PE (1) PE20040652A1 (ru)
PL (1) PL373046A1 (ru)
TW (1) TWI315667B (ru)
UA (1) UA78801C2 (ru)
WO (1) WO2004006928A1 (ru)
ZA (1) ZA200500065B (ru)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1845974A1 (en) 2005-01-21 2007-10-24 Astex Therapeutics Limited Pharmaceutical compounds
WO2008044041A1 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Pharmaceutical combinations
EP2073807A1 (en) 2006-10-12 2009-07-01 Astex Therapeutics Limited Pharmaceutical combinations
CN102405018B (zh) 2009-03-02 2014-11-19 第七感生物系统有限公司 与血液取样相关联的技术和装置
US9033898B2 (en) 2010-06-23 2015-05-19 Seventh Sense Biosystems, Inc. Sampling devices and methods involving relatively little pain
WO2011094573A1 (en) 2010-01-28 2011-08-04 Seventh Sense Biosystems, Inc. Monitoring or feedback systems and methods
CN103068308B (zh) 2010-07-16 2016-03-16 第七感生物系统有限公司 用于流体传输装置的低压环境
US8404874B2 (en) * 2010-09-30 2013-03-26 Wisconsin Alumni Research Foundation (20R,25S)-2-Methylene-19,26-Dinor-1α,25-Dihydroxyvitamin D3 in crystalline form
EP2637562B1 (en) 2010-11-09 2016-01-27 Seventh Sense Biosystems, Inc. Systems and interfaces for blood sampling
KR102237667B1 (ko) 2011-04-29 2021-04-12 세븐쓰 센스 바이오시스템즈, 인크. 유체들의 전달 및/또는 수용
EP2701598A1 (en) 2011-04-29 2014-03-05 Seventh Sense Biosystems, Inc. Systems and methods for collecting fluid from a subject
CA3028114A1 (en) 2016-06-17 2017-12-21 Universidad De Los Andes Gelatin polymer derived from natural sources of cold-adapted marine species and uses thereof
WO2018029226A1 (en) 2016-08-10 2018-02-15 F. Hoffmann-La Roche Ag Pharmaceutical compositions comprising akt protein kinase inhibitors
JOP20190025A1 (ar) 2016-09-01 2019-02-19 Denovo Biopharma Llc طرق وتركيبة لتوقع نشاط إنزاستورين

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3625738A1 (de) 1986-07-30 1988-02-11 Goedecke Ag 2-acyloxypropylamin-derivate, verfahren zu deren herstellung und deren verwendung
US4785085A (en) 1986-11-21 1988-11-15 Bristol-Myers Company Rebeccamycin analogs
US4808613A (en) 1986-11-21 1989-02-28 Bristol-Myers Company Rebeccamycin derivative containing pharmaceutical composition
EP0303697B1 (en) 1987-03-09 1997-10-01 Kyowa Hakko Kogyo Co., Ltd. Derivatives of physiologically active substance k-252
DE3803620A1 (de) 1988-02-06 1989-08-17 Goedecke Ag Indolocarbazol-derivate, verfahren zu deren herstellung und diese enthaltende arzneimittel
SK75289A3 (en) 1988-02-10 1998-05-06 Hoffmann La Roche Substituted pyrroles, their use for producing a drug, and the drug on their base
GB8904161D0 (en) 1989-02-23 1989-04-05 Hoffmann La Roche Substituted pyrroles
US5380746A (en) 1989-05-05 1995-01-10 Goedecke Aktiengesellschaft Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
CA2015996C (en) 1989-05-05 2001-08-28 Hartmut Osswald Bis-(1h-indol-3-yl)-maleinimide derivatives and their use as pharmaceuticals
US5489608A (en) 1989-12-21 1996-02-06 Goedecke Aktiengesellschaft Indolocarbazole derivatives and the use thereof
DE4005970A1 (de) 1990-02-26 1991-08-29 Boehringer Mannheim Gmbh Neue trisubstituierte maleinimide, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
DE4005969A1 (de) 1990-02-26 1991-08-29 Boehringer Mannheim Gmbh Neue trisubstituierte pyrrole, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
CA2046801C (en) 1990-08-07 2002-02-26 Peter D. Davis Substituted pyrroles
US5292747A (en) 1990-08-07 1994-03-08 Hoffman-La Roche Inc. Substituted pyrroles
GB9123396D0 (en) 1991-11-04 1991-12-18 Hoffmann La Roche A process for the manufacture of substituted maleimides
US5461146A (en) 1992-07-24 1995-10-24 Cephalon, Inc. Selected protein kinase inhibitors for the treatment of neurological disorders
DE4243321A1 (de) 1992-12-21 1994-06-23 Goedecke Ag Aminosäurederivate von Heterocyclen als PKC-Inhibitoren
US5484926A (en) 1993-10-07 1996-01-16 Agouron Pharmaceuticals, Inc. HIV protease inhibitors
AU678435B2 (en) 1993-05-10 1997-05-29 F. Hoffmann-La Roche Ag Substituted pyrroles
SE501711C2 (sv) * 1993-09-08 1995-05-02 Jimek Int Ab Sprayrör för en duktvättanordning vid en tryckpress
US5624949A (en) 1993-12-07 1997-04-29 Eli Lilly And Company Protein kinase C inhibitors
AU1339895A (en) * 1993-12-23 1995-07-10 Eli Lilly And Company Protein kinase c inhibitors
US5545636A (en) * 1993-12-23 1996-08-13 Eli Lilly And Company Protein kinase C inhibitors
US5481003A (en) 1994-06-22 1996-01-02 Eli Lilly And Company Protein kinase C inhibitors
PE91598A1 (es) 1996-07-29 1998-12-24 Hoffmann La Roche Pirroles sustituidos
GB9620390D0 (en) 1996-09-30 1996-11-13 Eisai London Res Lab Ltd Substances and their uses
WO2001009116A2 (en) * 1999-07-29 2001-02-08 Eli Lilly And Company A NOVEL CRYSTALLINE FORM OF 6-HYDROXY-3- (4-[2-(PIPERIDIN-1-YL) ETHOXY]PHENOXY)- 2-(4-METHOXYPHENYL)BENZO[b]THIOPHENE HYDROCHLORIDE
WO2001030331A2 (en) * 1999-10-22 2001-05-03 Eli Lilly And Company Therapeutic compositions including protein kinase c inhibitors
WO2002002116A2 (en) 2000-06-29 2002-01-10 Eli Lilly And Company Therapeutic treatment of cancer with a protein kinase c inhibitor
WO2002002094A2 (en) 2000-06-29 2002-01-10 Eli Lilly And Company Use of a protein kinase c inhibitor to enhance the clinical efficacy of anti-neoplastic chemotherapeutic agents and radiation therapy
JP2005531609A (ja) * 2002-06-05 2005-10-20 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ キナーゼ阻害剤としてのシスインドリル−マレイミド誘導体

Also Published As

Publication number Publication date
AU2003280958B8 (en) 2009-02-19
ECSP055537A (es) 2005-03-10
CN100430058C (zh) 2008-11-05
TWI315667B (en) 2009-10-11
EP1523313A1 (en) 2005-04-20
ZA200500065B (en) 2006-03-29
JP5242718B2 (ja) 2013-07-24
CA2393720A1 (en) 2004-01-16
NZ537137A (en) 2007-11-30
NO20050676L (no) 2005-02-09
HK1075839A1 (en) 2005-12-30
DE60317675T2 (de) 2008-10-30
JP2006502115A (ja) 2006-01-19
ES2295605T3 (es) 2008-04-16
PE20040652A1 (es) 2004-10-05
PL373046A1 (en) 2005-08-08
HRP20050035B1 (hr) 2013-07-31
CA2393720C (en) 2010-09-14
JP4771356B2 (ja) 2011-09-14
KR20050021453A (ko) 2005-03-07
JP2011144182A (ja) 2011-07-28
IL165747A (en) 2010-05-17
TW200408392A (en) 2004-06-01
US20070270465A1 (en) 2007-11-22
EA007463B1 (ru) 2006-10-27
IL165747A0 (en) 2006-01-15
CN1668304A (zh) 2005-09-14
NO330254B1 (no) 2011-03-14
WO2004006928A1 (en) 2004-01-22
US8114901B2 (en) 2012-02-14
DE60317675D1 (de) 2008-01-03
AU2003280958B9 (en) 2009-07-02
UA78801C2 (en) 2007-04-25
AU2003280958A1 (en) 2004-02-02
KR100687165B1 (ko) 2007-02-27
US20050288332A1 (en) 2005-12-29
HRP20050035A2 (en) 2005-04-30
AU2003280958B2 (en) 2008-12-18
EP1523313B1 (en) 2007-11-21

Similar Documents

Publication Publication Date Title
DK1379520T3 (da) N-substituerede ikke-aryl-heterocykliske NMDA/NR2B-antagonister
ATE381557T1 (de) Rho-kinase inhibitoren
ATE419253T1 (de) Inhibitoren von thienopyridin- und furopyridinkinase
PL406680A1 (pl) Inhibitory kinaz tyrozynowych
EA200300674A1 (ru) Получение гетероциклических сульфонамидных ингибиторов бета-амилоида
NO20053470L (no) Triazolopyridaziner som proteinkinase-inhibitorer
EA200870117A1 (ru) Азаиндоловые ингибиторы аурора-киназ
BRPI0412347A (pt) 2-aminofenil-4-fenilpiridinas como inibidores de quinase
EA200300248A1 (ru) Бициклопиразолы, активные в качестве ингибиторов киназы, способ их получения и включающие их фармацевтические композиции
NO20062256L (no) Hydroksyalkylsubstituerte pyrido-7-pyrimidin-7-oner
ATE482200T1 (de) Als kinaseinhibitoren geeignete arylsubstituierte pyrazolamidverbindungen
EA200500191A1 (ru) Кристаллический 2,5-дион-3-(1-метил-1h-индол-3-ил)-4-[1-(пиридин-2-илметил)пиперидин-4-ил]-1h-индол-3-ил]-1h-пирролмоногидрохлорид
EA200600594A1 (ru) Новые гетероциклические соединения - ингибиторы hsp90 и способы их получения
EA200500312A1 (ru) Новые спироконденсированные хиназолиноны и их применение в качестве ингибиторов фосфодиэстераз
MXPA05009611A (es) Piperidinas sustituidas como nuevos inhibidores de mdm2-p53.
UA84712C2 (en) N-substituted pyrazolyl-amidyl-benzimidazolyl c-kit inhibitors
ATE413388T1 (de) Muskarin antagonisten
EA200800374A1 (ru) 1,4-дигидропиридин-конденсированные гетероциклы, способы их получения, применение и содержащие их композиции
NO20053312L (no) Benzofuranderivat.
MXPA05010440A (es) Amidas del acido isoquinolina-5-sulfonico como inhibidores de la akt (proteina quinasa b).
BRPI0519267A2 (pt) derivado de quinolina, seu uso, produÇço e medicamento contendo o mesmo
NO20050270L (no) Nye forbindelser, deres anvendelse og fremstilling
BRPI0407841A (pt) inibidores heterocìclicos de quinase
PE20010751A1 (es) Quinolin-2-ona como inhibidores de las proteinas resistentes a multiples farmacos
MXPA05013151A (es) 3-fluoro-piperidinas como antagonistas de n-metil-d-aspartato/nr2b.

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU