DE60317675D1 - KRYSTALLINE 2,5-DIONE-3-(1-METHYL-1H-INDOL-3-YL)-4-i1-(PYRIDIN-2-YLMETHYL)PIPERIDIN-4-YL -1H-INDOL-3-YL -1H-PYRROLE MONO-HYDROCHLORIDE - Google Patents

KRYSTALLINE 2,5-DIONE-3-(1-METHYL-1H-INDOL-3-YL)-4-i1-(PYRIDIN-2-YLMETHYL)PIPERIDIN-4-YL -1H-INDOL-3-YL -1H-PYRROLE MONO-HYDROCHLORIDE

Info

Publication number
DE60317675D1
DE60317675D1 DE60317675T DE60317675T DE60317675D1 DE 60317675 D1 DE60317675 D1 DE 60317675D1 DE 60317675 T DE60317675 T DE 60317675T DE 60317675 T DE60317675 T DE 60317675T DE 60317675 D1 DE60317675 D1 DE 60317675D1
Authority
DE
Germany
Prior art keywords
indol
krystalline
ylmethyl
dione
pyridin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60317675T
Other languages
English (en)
Other versions
DE60317675T2 (de
Inventor
Julie Kay Bush
Margaret Mary Faul
Us California
Susan Marie Reutzel-Edens
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42799191&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE60317675(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of DE60317675D1 publication Critical patent/DE60317675D1/de
Application granted granted Critical
Publication of DE60317675T2 publication Critical patent/DE60317675T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE60317675T 2002-07-12 2003-07-08 KRYSTALLINE 2,5-DIONE-3-(1-METHYL-1H-INDOL-3-YL)-4-i1-(PYRIDIN-2-YLMETHYL)PIPERIDIN-4-YL -1H-INDOL-3-YL -1H-PYRROLE MONO-HYDROCHLORIDE Expired - Lifetime DE60317675T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US39597602P 2002-07-12 2002-07-12
US395976P 2002-07-12
PCT/US2003/019548 WO2004006928A1 (en) 2002-07-12 2003-07-08 Crystalline 2,5-dione-3-(1-methyl-1h-indol-3-yl)-4-[1-(pyridin-2-ylmethyl)piperidin-4-yl]-1h-indol-3-yl]-1h-pyrrole mono-hydrochloride

Publications (2)

Publication Number Publication Date
DE60317675D1 true DE60317675D1 (de) 2008-01-03
DE60317675T2 DE60317675T2 (de) 2008-10-30

Family

ID=42799191

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60317675T Expired - Lifetime DE60317675T2 (de) 2002-07-12 2003-07-08 KRYSTALLINE 2,5-DIONE-3-(1-METHYL-1H-INDOL-3-YL)-4-i1-(PYRIDIN-2-YLMETHYL)PIPERIDIN-4-YL -1H-INDOL-3-YL -1H-PYRROLE MONO-HYDROCHLORIDE

Country Status (22)

Country Link
US (2) US8114901B2 (de)
EP (1) EP1523313B1 (de)
JP (2) JP4771356B2 (de)
KR (1) KR100687165B1 (de)
CN (1) CN100430058C (de)
AU (1) AU2003280958B9 (de)
CA (1) CA2393720C (de)
DE (1) DE60317675T2 (de)
EA (1) EA007463B1 (de)
EC (1) ECSP055537A (de)
ES (1) ES2295605T3 (de)
HK (1) HK1075839A1 (de)
HR (1) HRP20050035B1 (de)
IL (1) IL165747A (de)
NO (1) NO330254B1 (de)
NZ (1) NZ537137A (de)
PE (1) PE20040652A1 (de)
PL (1) PL373046A1 (de)
TW (1) TWI315667B (de)
UA (1) UA78801C2 (de)
WO (1) WO2004006928A1 (de)
ZA (1) ZA200500065B (de)

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US20080161251A1 (en) 2005-01-21 2008-07-03 Astex Therapeutics Limited Pharmaceutical Compounds
US8916552B2 (en) 2006-10-12 2014-12-23 Astex Therapeutics Limited Pharmaceutical combinations
EP2073807A1 (de) 2006-10-12 2009-07-01 Astex Therapeutics Limited Pharmazeutische kombinationen
US9033898B2 (en) 2010-06-23 2015-05-19 Seventh Sense Biosystems, Inc. Sampling devices and methods involving relatively little pain
US9041541B2 (en) 2010-01-28 2015-05-26 Seventh Sense Biosystems, Inc. Monitoring or feedback systems and methods
EP2408372B1 (de) 2009-03-02 2019-01-09 Seventh Sense Biosystems, Inc. Vorrichtungen im zusammenhang mit der entnahme von blutproben
US9295417B2 (en) 2011-04-29 2016-03-29 Seventh Sense Biosystems, Inc. Systems and methods for collecting fluid from a subject
US20120016308A1 (en) 2010-07-16 2012-01-19 Seventh Sense Biosystems, Inc. Low-pressure packaging for fluid devices
JP2013540764A (ja) * 2010-09-30 2013-11-07 ウイスコンシン アラムニ リサーチ ファンデーション 結晶形の（２０Ｒ，２５Ｓ）−２−メチレン−１９，２６−ジノル−１α，２５−ジヒドロキシビタミンＤ３
WO2012064802A1 (en) 2010-11-09 2012-05-18 Seventh Sense Biosystems, Inc. Systems and interfaces for blood sampling
ES2597081T3 (es) 2011-04-29 2017-01-13 Seventh Sense Biosystems, Inc. Entrega y/o recepción de fluidos
CA3028114A1 (en) 2016-06-17 2017-12-21 Universidad De Los Andes Gelatin polymer derived from natural sources of cold-adapted marine species and uses thereof
TW202329972A (zh) * 2016-08-10 2023-08-01 瑞士商赫孚孟拉羅股份公司 包含Ａｋｔ蛋白質激酶抑制劑之醫藥組合物
JOP20190025A1 (ar) 2016-09-01 2019-02-19 Denovo Biopharma Llc طرق وتركيبة لتوقع نشاط إنزاستورين

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DE3625738A1 (de) * 1986-07-30 1988-02-11 Goedecke Ag 2-acyloxypropylamin-derivate, verfahren zu deren herstellung und deren verwendung
US4808613A (en) * 1986-11-21 1989-02-28 Bristol-Myers Company Rebeccamycin derivative containing pharmaceutical composition
US4785085A (en) * 1986-11-21 1988-11-15 Bristol-Myers Company Rebeccamycin analogs
EP0303697B1 (de) * 1987-03-09 1997-10-01 Kyowa Hakko Kogyo Co., Ltd. Derivate des physiologisch aktiven mittels k-252
DE3803620A1 (de) 1988-02-06 1989-08-17 Goedecke Ag Indolocarbazol-derivate, verfahren zu deren herstellung und diese enthaltende arzneimittel
CZ280738B6 (cs) * 1988-02-10 1996-04-17 F. Hoffmann - La Roche And Co., Aktiengesellschaft Substituované pyrroly, jejich použití pro výrobu léčiv a léčiva na jejich bázi
GB8904161D0 (en) * 1989-02-23 1989-04-05 Hoffmann La Roche Substituted pyrroles
CA2015996C (en) 1989-05-05 2001-08-28 Hartmut Osswald Bis-(1h-indol-3-yl)-maleinimide derivatives and their use as pharmaceuticals
US5380746A (en) * 1989-05-05 1995-01-10 Goedecke Aktiengesellschaft Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
US5489608A (en) * 1989-12-21 1996-02-06 Goedecke Aktiengesellschaft Indolocarbazole derivatives and the use thereof
DE4005969A1 (de) 1990-02-26 1991-08-29 Boehringer Mannheim Gmbh Neue trisubstituierte pyrrole, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
DE4005970A1 (de) 1990-02-26 1991-08-29 Boehringer Mannheim Gmbh Neue trisubstituierte maleinimide, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
CA2046801C (en) 1990-08-07 2002-02-26 Peter D. Davis Substituted pyrroles
US5292747A (en) * 1990-08-07 1994-03-08 Hoffman-La Roche Inc. Substituted pyrroles
GB9123396D0 (en) 1991-11-04 1991-12-18 Hoffmann La Roche A process for the manufacture of substituted maleimides
US5461146A (en) 1992-07-24 1995-10-24 Cephalon, Inc. Selected protein kinase inhibitors for the treatment of neurological disorders
DE4243321A1 (de) 1992-12-21 1994-06-23 Goedecke Ag Aminosäurederivate von Heterocyclen als PKC-Inhibitoren
US5484926A (en) 1993-10-07 1996-01-16 Agouron Pharmaceuticals, Inc. HIV protease inhibitors
AU678435B2 (en) 1993-05-10 1997-05-29 F. Hoffmann-La Roche Ag Substituted pyrroles
SE501711C2 (sv) * 1993-09-08 1995-05-02 Jimek Int Ab Sprayrör för en duktvättanordning vid en tryckpress
US5624949A (en) * 1993-12-07 1997-04-29 Eli Lilly And Company Protein kinase C inhibitors
US5545636A (en) * 1993-12-23 1996-08-13 Eli Lilly And Company Protein kinase C inhibitors
AU1339895A (en) * 1993-12-23 1995-07-10 Eli Lilly And Company Protein kinase c inhibitors
US5481003A (en) * 1994-06-22 1996-01-02 Eli Lilly And Company Protein kinase C inhibitors
PE91598A1 (es) 1996-07-29 1998-12-24 Hoffmann La Roche Pirroles sustituidos
GB9620390D0 (en) * 1996-09-30 1996-11-13 Eisai London Res Lab Ltd Substances and their uses
WO2001009116A2 (en) * 1999-07-29 2001-02-08 Eli Lilly And Company A NOVEL CRYSTALLINE FORM OF 6-HYDROXY-3- (4-[2-(PIPERIDIN-1-YL) ETHOXY]PHENOXY)- 2-(4-METHOXYPHENYL)BENZO[b]THIOPHENE HYDROCHLORIDE
WO2001030331A2 (en) * 1999-10-22 2001-05-03 Eli Lilly And Company Therapeutic compositions including protein kinase c inhibitors
AU2001271257A1 (en) * 2000-06-29 2002-01-14 Eli Lilly And Company Use of a protein kinase c inhibitor to enhance the clinical efficacy of anti-neoplastic chemotherapeutic agents and radiation therapy
WO2002002116A2 (en) * 2000-06-29 2002-01-10 Eli Lilly And Company Therapeutic treatment of cancer with a protein kinase c inhibitor
KR20050008787A (ko) * 2002-06-05 2005-01-21 얀센 파마슈티카 엔.브이. 키나제 저해제로서의 비스인돌릴-말레이미드 유도체

Also Published As

Publication number Publication date
EP1523313A1 (de) 2005-04-20
IL165747A (en) 2010-05-17
JP2011144182A (ja) 2011-07-28
PL373046A1 (en) 2005-08-08
US20070270465A1 (en) 2007-11-22
NO330254B1 (no) 2011-03-14
EP1523313B1 (de) 2007-11-21
JP4771356B2 (ja) 2011-09-14
JP2006502115A (ja) 2006-01-19
PE20040652A1 (es) 2004-10-05
UA78801C2 (en) 2007-04-25
KR20050021453A (ko) 2005-03-07
AU2003280958B2 (en) 2008-12-18
HRP20050035B1 (hr) 2013-07-31
CN1668304A (zh) 2005-09-14
JP5242718B2 (ja) 2013-07-24
CA2393720A1 (en) 2004-01-16
EA200500191A1 (ru) 2005-06-30
US8114901B2 (en) 2012-02-14
AU2003280958B9 (en) 2009-07-02
CN100430058C (zh) 2008-11-05
EA007463B1 (ru) 2006-10-27
TW200408392A (en) 2004-06-01
US20050288332A1 (en) 2005-12-29
HRP20050035A2 (en) 2005-04-30
AU2003280958A1 (en) 2004-02-02
TWI315667B (en) 2009-10-11
CA2393720C (en) 2010-09-14
DE60317675T2 (de) 2008-10-30
ZA200500065B (en) 2006-03-29
KR100687165B1 (ko) 2007-02-27
ES2295605T3 (es) 2008-04-16
IL165747A0 (en) 2006-01-15
NO20050676L (no) 2005-02-09
WO2004006928A1 (en) 2004-01-22
AU2003280958B8 (en) 2009-02-19
NZ537137A (en) 2007-11-30
ECSP055537A (es) 2005-03-10
HK1075839A1 (en) 2005-12-30

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: KROHER, STROBEL RECHTS- UND PATENTANWAELTE, 80336

8328 Change in the person/name/address of the agent

Representative=s name: DR. SCHOEN & PARTNER, 80336 MUENCHEN