DE60131971D1 - 1,3,8-TRIAZA-SPIROi4,5 DECAN-4-ONDERIVATIVE ALS NEUROKININREZEPTORANTAGONISTEN - Google Patents
1,3,8-TRIAZA-SPIROi4,5 DECAN-4-ONDERIVATIVE ALS NEUROKININREZEPTORANTAGONISTENInfo
- Publication number
- DE60131971D1 DE60131971D1 DE60131971T DE60131971T DE60131971D1 DE 60131971 D1 DE60131971 D1 DE 60131971D1 DE 60131971 T DE60131971 T DE 60131971T DE 60131971 T DE60131971 T DE 60131971T DE 60131971 D1 DE60131971 D1 DE 60131971D1
- Authority
- DE
- Germany
- Prior art keywords
- spiroi4
- onderivative
- neurokininrezeptorantagonisten
- triaza
- decan
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0031—Rectum, anus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP00112285 | 2000-06-08 | ||
EP00112285 | 2000-06-08 | ||
PCT/EP2001/006305 WO2001094346A1 (en) | 2000-06-08 | 2001-06-01 | 1,3,8-TRIAZA-SPIRO'4,5!DECAN-4-ONE DERIVATIVES AS NEUROKININ RECEPTOR ANTAGONISTS |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60131971D1 true DE60131971D1 (de) | 2008-01-31 |
DE60131971T2 DE60131971T2 (de) | 2008-12-04 |
Family
ID=8168940
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60131971T Expired - Lifetime DE60131971T2 (de) | 2000-06-08 | 2001-06-01 | 1,3,8-TRIAZA-SPIROi4,5 DECAN-4-ONDERIVATIVE ALS NEUROKININREZEPTORANTAGONISTEN |
Country Status (17)
Country | Link |
---|---|
US (1) | US6482829B2 (de) |
EP (1) | EP1292596B1 (de) |
JP (1) | JP4245348B2 (de) |
KR (1) | KR100518198B1 (de) |
CN (1) | CN1261433C (de) |
AR (1) | AR028683A1 (de) |
AT (1) | ATE381565T1 (de) |
AU (2) | AU2001267513B2 (de) |
BR (1) | BR0111538A (de) |
CA (1) | CA2411716C (de) |
DE (1) | DE60131971T2 (de) |
ES (1) | ES2296761T3 (de) |
MX (1) | MXPA02012001A (de) |
PE (1) | PE20020298A1 (de) |
UY (1) | UY26754A1 (de) |
WO (1) | WO2001094346A1 (de) |
ZA (1) | ZA200209488B (de) |
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ538307A (en) * | 2002-09-09 | 2008-04-30 | Janssen Pharmaceutica Nv | Hydroxy alkyl substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders |
EP1619193A4 (de) * | 2003-04-18 | 2010-08-11 | Ono Pharmaceutical Co | Spiropiperidinverbindung und deren medizinische verwendung |
ES2359707T3 (es) * | 2004-01-08 | 2011-05-26 | F. Hoffmann-La Roche Ag | Derivados de diaza-espiropiperidina. |
JO2527B1 (en) * | 2004-04-06 | 2010-03-17 | شركة جانسين فارماسوتيكا ان. في | Derivatives of second-aza-Spiro- (5,5) -andecan and their use as antihistamines |
JO2676B1 (en) * | 2004-04-06 | 2012-06-17 | جانسين فارماسوتيكا ان. في | Derivatives of second-aza-spiro- (5,4) -dikan and their use as antihistamines |
US7951816B2 (en) | 2004-08-27 | 2011-05-31 | Ono Pharmaceutical Co., Ltd. | Compound containing basic group and use thereof |
US8138342B2 (en) * | 2004-10-12 | 2012-03-20 | High Point Pharmacueticals, LLC | 11β-hydroxysteroid dehydrogenase type 1 active spiro compounds |
EP1855655A2 (de) | 2005-02-25 | 2007-11-21 | F. Hoffmann-Roche AG | Tabletten mit verbesserter dispergierbarkeit der arzneisubstanz |
CA2598530C (en) | 2005-03-03 | 2014-12-16 | Janssen Pharmaceutica N.V. | Substituted oxa-diaza-spiro-[5.5]-undecanone derivatives and their use as neurokinin antagonists |
WO2006094948A1 (en) * | 2005-03-08 | 2006-09-14 | Janssen Pharmaceutica N.V. | Diaza-spiro-[4.4]-nonane derivatives as neurokinin (nk1) antagonists |
US7709517B2 (en) | 2005-05-13 | 2010-05-04 | The Regents Of The University Of California | Diarylhydantoin compounds |
US20090099186A1 (en) * | 2005-10-11 | 2009-04-16 | Leonid Beigelman | Inhibitors of viral replication |
JP2009513611A (ja) * | 2005-11-01 | 2009-04-02 | ハイ ポイント ファーマシューティカルズ,リミティド ライアビリティ カンパニー | 置換アミドの医薬用途 |
EA200801243A1 (ru) * | 2005-11-01 | 2008-10-30 | Транстек Фарма | Фармацевтическое применение замещенных амидов |
WO2007065256A1 (en) * | 2005-12-06 | 2007-06-14 | Virochem Pharma Inc. | Novel spiropiperidine compounds and methods for the modulation of chemokine receptor activity |
GB0601402D0 (en) * | 2006-01-24 | 2006-03-08 | Syngenta Participations Ag | Chemical Compounds |
EP2007722A1 (de) * | 2006-03-21 | 2008-12-31 | High Point Pharmaceuticals, LLC | Adamantanderivate zur behandlung des metabolischen syndroms |
JP5133975B2 (ja) * | 2006-03-27 | 2013-01-30 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 前立腺癌およびアンドロゲン受容体関連病態の治療のためのアンドロゲン受容体の調節剤 |
KR101600230B1 (ko) * | 2006-03-29 | 2016-03-04 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | 디아릴티오히단토인 화합물 |
CN101448782A (zh) | 2006-04-07 | 2009-06-03 | 高点制药有限责任公司 | 对1型11β-羟基甾体脱氢酶具有活性的化合物 |
US20090306048A1 (en) * | 2006-06-16 | 2009-12-10 | John Paul Kilburn | Pharmaceutical use of substituted piperidine carboxamides |
AR061522A1 (es) * | 2006-06-20 | 2008-09-03 | Wyeth Corp | Derivados de 4-oxo-1, 3, 8-triaza[4.5]decanos como inhibidores del canal de potasio kv1.5, una composicion que los comprende y su empleo en el tratamiento de afecciones cardiacas. |
EP1878721A1 (de) * | 2006-07-13 | 2008-01-16 | Novo Nordisk A/S | 4-Piperidylbenzamide als Inhibitoren der 11-beta-hydroxysteroiddehydrogenase Typ 1 |
US8048908B2 (en) * | 2006-07-13 | 2011-11-01 | High Point Pharmaceuticals, Llc | 11β-hydroxysteroid dehydrogenase type 1 active compounds |
US20080016751A1 (en) * | 2006-07-20 | 2008-01-24 | Steven Frisch | Rodent trap with calming agent |
EA200970517A1 (ru) | 2006-11-28 | 2009-12-30 | Янссен Фармацевтика Н.В. | Соли 3-(3-амино-2-(r)-гидроксипропил)-1-(4-фторфенил)-8-(8-метилнафталин-1-илметил)-1,3,8-триазаспиро[4,5]декан-4-она |
KR20090112722A (ko) | 2007-01-24 | 2009-10-28 | 글락소 그룹 리미티드 | 3,5-디아미노-6-(2,3-디클로로페닐)-1,2,4-트리아진 또는 r(-)-2,4-디아미노-5-(2,3-디클로로페닐)-6-플루오로메틸 피리미딘 및 nk1을 포함하는 제약 조성물 |
US20110003856A1 (en) * | 2007-02-23 | 2011-01-06 | Soren Ebdrup | N-adamantyl benzamides as inhibitors of 11-beta-hydroxysteroid dehydrogenase |
JP2010519239A (ja) * | 2007-02-23 | 2010-06-03 | ハイ ポイント ファーマシューティカルズ,リミティド ライアビリティ カンパニー | 11−ベータ−ヒドロキシステロイドデヒドロゲナーゼの阻害因子としてのn−アドマンチルベンザミド |
US8383820B2 (en) * | 2007-02-23 | 2013-02-26 | High Point Pharmaceuticals, Llc | N-adamantyl benzamides as inhibitors of 11-β-hydroxysteroid dehydrogenase |
US8334305B2 (en) * | 2007-02-23 | 2012-12-18 | High Point Pharmaceuticals, Llc | N-adamantyl benzamides as inhibitors of 11-β-hydroxysteroid dehydrogenase |
CA2679866A1 (en) * | 2007-03-09 | 2008-09-18 | High Point Pharmaceuticals, Llc | Indole- and benzimidazole amides as hydroxysteroid dehydrogenase inhibitors |
JP2010522766A (ja) * | 2007-03-28 | 2010-07-08 | ハイ ポイント ファーマシューティカルズ,リミティド ライアビリティ カンパニー | 11ベータ−hsd1活性化合物 |
WO2008124209A1 (en) * | 2007-04-09 | 2008-10-16 | Janssen Pharmaceutica, N.V. | 1,3,8-trisubstituted-1,3,8-triaza-spiro[4.5]decan-4-one derivatives as ligands of the orl-i receptor for the treatment of anxiety and depression |
ES2399912T3 (es) * | 2007-04-11 | 2013-04-04 | High Point Pharmaceuticals, Llc | Nuevos compuestos |
CA2685036A1 (en) * | 2007-04-24 | 2008-11-06 | High Point Pharmaceuticals, Llc | Pharmaceutical use of substituted amides |
PE20091262A1 (es) | 2007-10-26 | 2009-09-09 | Univ California | Compuestos de diarilhidantoina como antagonistas del receptor de androgeno |
US7981904B2 (en) * | 2008-03-20 | 2011-07-19 | Takeda Pharmaceutical Company Limited | Acetyl CoA carboxylase inhibitors |
US20100076003A1 (en) * | 2008-09-19 | 2010-03-25 | Kathleen Battista | 5-oxazolidin-2-one substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives useful as orl-1 receptor modulators |
EP2443124B1 (de) | 2009-06-16 | 2014-01-22 | Merck Sharp & Dohme Corp. | Substituierte 1,3,8-triazaspiro-[4.5-]decan-2,4-dione |
EP2456307B1 (de) * | 2009-07-24 | 2016-11-02 | Vanderbilt University | Isoform-selektive phospholipase-d-hemmer |
EP2536708A4 (de) | 2010-02-16 | 2013-05-29 | Aragon Pharmaceuticals Inc | Androgenrezeptormodulatoren und ihre verwendung |
US9453017B2 (en) | 2011-09-30 | 2016-09-27 | Vanderbilt University | Antiviral therapies with phospholipase D inhibitors |
CA2885415C (en) | 2012-09-26 | 2021-06-29 | Aragon Pharmaceuticals, Inc. | Anti-androgens for the treatment of non-metastatic castrate-resistant prostate cancer |
JOP20200097A1 (ar) | 2013-01-15 | 2017-06-16 | Aragon Pharmaceuticals Inc | معدل مستقبل أندروجين واستخداماته |
TW201712012A (zh) | 2015-06-16 | 2017-04-01 | 美國禮來大藥廠 | 2-側氧基-1,3,8-三氮雜螺[4.5]癸-3-基羧酸衍生物 |
JP7002335B2 (ja) | 2015-07-03 | 2022-01-20 | エフ.ホフマン-ラ ロシュ アーゲー | Ddr1阻害剤としてのトリアザ-スピロデカノン |
TWI726969B (zh) | 2016-01-11 | 2021-05-11 | 比利時商健生藥品公司 | 用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物 |
JP6990657B2 (ja) | 2016-02-08 | 2022-01-13 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | Ddr1阻害剤としてのスピロインドリノン |
CN111479560A (zh) | 2017-10-16 | 2020-07-31 | 阿拉贡药品公司 | 用于治疗非转移性去势难治性前列腺癌的抗雄激素 |
CA3191436A1 (en) * | 2020-08-11 | 2022-02-17 | Board Of Trustees Of Michigan State University | Proteasome enhancers and uses thereof |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5416193A (en) | 1993-04-30 | 1995-05-16 | Pfizer Inc. | Coupling reagent and method |
IL111960A (en) | 1993-12-17 | 1999-12-22 | Merck & Co Inc | Morpholines and thiomorpholines their preparation and pharmaceutical compositions containing them |
US5612337A (en) | 1993-12-29 | 1997-03-18 | Merck Sharp & Dohme Limited | Substituted morpholine derivatives and their use as therapeutic agents |
IL112778A0 (en) | 1994-03-04 | 1995-05-26 | Merck & Co Inc | Substituted heterocycles, their preparation and pharmaceutical compositions containing them |
JPH11512723A (ja) | 1995-09-29 | 1999-11-02 | イーライ リリー アンド カンパニー | フィブリノゲン依存血小板凝集抑制物質としてのスピロ化合物 |
PL326353A1 (en) | 1995-10-17 | 1998-09-14 | Astra Pharma Prod | Pharmaceutically active quinozolinic compounds |
US5776954A (en) | 1996-10-30 | 1998-07-07 | Merck & Co., Inc. | Substituted pyridyl pyrroles, compositions containing such compounds and methods of use |
US5972938A (en) | 1997-12-01 | 1999-10-26 | Merck & Co., Inc. | Method for treating or preventing psychoimmunological disorders |
EP1126833A4 (de) | 1998-10-29 | 2004-09-08 | Trega Biosciences Inc | Derivate von oxadiazolen, thiadiazolen und triazolen sowie kombinatorische bibliotheken davon |
-
2001
- 2001-05-21 US US09/861,795 patent/US6482829B2/en not_active Expired - Fee Related
- 2001-06-01 JP JP2002501895A patent/JP4245348B2/ja not_active Expired - Fee Related
- 2001-06-01 AU AU2001267513A patent/AU2001267513B2/en not_active Ceased
- 2001-06-01 WO PCT/EP2001/006305 patent/WO2001094346A1/en active IP Right Grant
- 2001-06-01 CA CA2411716A patent/CA2411716C/en not_active Expired - Fee Related
- 2001-06-01 CN CNB018109403A patent/CN1261433C/zh not_active Expired - Fee Related
- 2001-06-01 BR BR0111538-3A patent/BR0111538A/pt not_active IP Right Cessation
- 2001-06-01 DE DE60131971T patent/DE60131971T2/de not_active Expired - Lifetime
- 2001-06-01 EP EP01945242A patent/EP1292596B1/de not_active Expired - Lifetime
- 2001-06-01 ES ES01945242T patent/ES2296761T3/es not_active Expired - Lifetime
- 2001-06-01 AU AU6751301A patent/AU6751301A/xx active Pending
- 2001-06-01 AT AT01945242T patent/ATE381565T1/de not_active IP Right Cessation
- 2001-06-01 KR KR10-2002-7016671A patent/KR100518198B1/ko not_active IP Right Cessation
- 2001-06-01 MX MXPA02012001A patent/MXPA02012001A/es active IP Right Grant
- 2001-06-06 AR ARP010102690A patent/AR028683A1/es unknown
- 2001-06-07 UY UY26754A patent/UY26754A1/es not_active Application Discontinuation
- 2001-06-07 PE PE2001000533A patent/PE20020298A1/es not_active Application Discontinuation
-
2002
- 2002-11-21 ZA ZA200209488A patent/ZA200209488B/en unknown
Also Published As
Publication number | Publication date |
---|---|
US6482829B2 (en) | 2002-11-19 |
ES2296761T3 (es) | 2008-05-01 |
MXPA02012001A (es) | 2003-04-22 |
AU6751301A (en) | 2001-12-17 |
UY26754A1 (es) | 2001-12-28 |
WO2001094346A1 (en) | 2001-12-13 |
KR20030016283A (ko) | 2003-02-26 |
ATE381565T1 (de) | 2008-01-15 |
CA2411716C (en) | 2010-06-22 |
EP1292596A1 (de) | 2003-03-19 |
BR0111538A (pt) | 2003-07-01 |
EP1292596B1 (de) | 2007-12-19 |
CA2411716A1 (en) | 2001-12-13 |
CN1261433C (zh) | 2006-06-28 |
JP2003535863A (ja) | 2003-12-02 |
ZA200209488B (en) | 2004-02-23 |
DE60131971T2 (de) | 2008-12-04 |
KR100518198B1 (ko) | 2005-10-04 |
CN1436188A (zh) | 2003-08-13 |
AU2001267513B2 (en) | 2006-03-16 |
PE20020298A1 (es) | 2002-04-17 |
JP4245348B2 (ja) | 2009-03-25 |
AR028683A1 (es) | 2003-05-21 |
US20020006932A1 (en) | 2002-01-17 |
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