PE20040652A1 - Monoclorhidrato de 2,5-diona-3-(1-metil-1h-indol-3-il)-4-[1-(piridin-2-ilmetil)piperidin-4-il]-1h-indol-3-il]-1h-pirrol cristalino - Google Patents

Monoclorhidrato de 2,5-diona-3-(1-metil-1h-indol-3-il)-4-[1-(piridin-2-ilmetil)piperidin-4-il]-1h-indol-3-il]-1h-pirrol cristalino

Info

Publication number
PE20040652A1
PE20040652A1 PE2003000687A PE2003000687A PE20040652A1 PE 20040652 A1 PE20040652 A1 PE 20040652A1 PE 2003000687 A PE2003000687 A PE 2003000687A PE 2003000687 A PE2003000687 A PE 2003000687A PE 20040652 A1 PE20040652 A1 PE 20040652A1
Authority
PE
Peru
Prior art keywords
indol
diona
piperidin
pyridin
methyl
Prior art date
Application number
PE2003000687A
Other languages
English (en)
Inventor
Margaret Mary Faul
Susan Marie Reutzel-Edens
Julie Kay Bush
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42799191&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20040652(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of PE20040652A1 publication Critical patent/PE20040652A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

SE REFIERE AL MONOCLORHIDRATO DE 2,5-DIONA-3-(1-METIL-1H-INDOL-3-IL)-4-[1-(PIRIDIN-2-ILMETIL)PIPERIDIN-4-IL]-1H-INDOL-3-IL]-1H-PIRROL CRISTALINO (ENZASTAURINA), UN HIDRATO O MEZCLAS DE LOS MISMOS, CUYO MODELO DE DIFRACCION DE RAYOS X QUE COMPRENDE, ENTRE OTROS, LOS PICOS: 6,8± 0,1; 10,9± 0,1; 14,2 ± 0,1 Y 16,6± 0,1º, EN 2q, CUANDO EL MODELO SE OBTIENE A PARTIR DE UNA FUENTE DE RADIACION DE COBRE (CuKa; l=1,54056 Å). SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHO COMPUESTO ES UTIL EN EL TRATAMIENTO DE GLIOBLASTOMAS, DE CANCER DE PULMON DE CELULAS NO PEQUENAS Y DE LINFOMAS QUE NO SON TIPO HODGKINGS
PE2003000687A 2002-07-12 2003-07-09 Monoclorhidrato de 2,5-diona-3-(1-metil-1h-indol-3-il)-4-[1-(piridin-2-ilmetil)piperidin-4-il]-1h-indol-3-il]-1h-pirrol cristalino PE20040652A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US39597602P 2002-07-12 2002-07-12

Publications (1)

Publication Number Publication Date
PE20040652A1 true PE20040652A1 (es) 2004-10-05

Family

ID=42799191

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2003000687A PE20040652A1 (es) 2002-07-12 2003-07-09 Monoclorhidrato de 2,5-diona-3-(1-metil-1h-indol-3-il)-4-[1-(piridin-2-ilmetil)piperidin-4-il]-1h-indol-3-il]-1h-pirrol cristalino

Country Status (22)

Country Link
US (2) US8114901B2 (es)
EP (1) EP1523313B1 (es)
JP (2) JP4771356B2 (es)
KR (1) KR100687165B1 (es)
CN (1) CN100430058C (es)
AU (1) AU2003280958B9 (es)
CA (1) CA2393720C (es)
DE (1) DE60317675T2 (es)
EA (1) EA007463B1 (es)
EC (1) ECSP055537A (es)
ES (1) ES2295605T3 (es)
HK (1) HK1075839A1 (es)
HR (1) HRP20050035B1 (es)
IL (1) IL165747A (es)
NO (1) NO330254B1 (es)
NZ (1) NZ537137A (es)
PE (1) PE20040652A1 (es)
PL (1) PL373046A1 (es)
TW (1) TWI315667B (es)
UA (1) UA78801C2 (es)
WO (1) WO2004006928A1 (es)
ZA (1) ZA200500065B (es)

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US8883790B2 (en) 2006-10-12 2014-11-11 Astex Therapeutics Limited Pharmaceutical combinations
EP2073803B1 (en) 2006-10-12 2018-09-19 Astex Therapeutics Limited Pharmaceutical combinations
WO2010101620A2 (en) 2009-03-02 2010-09-10 Seventh Sense Biosystems, Inc. Systems and methods for creating and using suction blisters or other pooled regions of fluid within the skin
US9041541B2 (en) 2010-01-28 2015-05-26 Seventh Sense Biosystems, Inc. Monitoring or feedback systems and methods
US9033898B2 (en) 2010-06-23 2015-05-19 Seventh Sense Biosystems, Inc. Sampling devices and methods involving relatively little pain
CN103068308B (zh) 2010-07-16 2016-03-16 第七感生物系统有限公司 用于流体传输装置的低压环境
AU2011308911B2 (en) * 2010-09-30 2014-10-02 Wisconsin Alumni Research Foundation (20R,25S)-2-methylene-19,26-dinor-1alpha, 25-dihydroxyvitamin D3 in crystalline form
CN103370007B (zh) 2010-11-09 2018-12-18 第七感生物系统有限公司 用于采血的系统和界面
EP2701598A1 (en) 2011-04-29 2014-03-05 Seventh Sense Biosystems, Inc. Systems and methods for collecting fluid from a subject
ES2597081T3 (es) 2011-04-29 2017-01-13 Seventh Sense Biosystems, Inc. Entrega y/o recepción de fluidos
KR20190086655A (ko) 2016-06-17 2019-07-23 유니버시다드 데 로스 안데스 저온-적응된 해양생물종의 천연 공급원으로부터 유래된 젤라틴 중합체 및 그것의 용도
BR112019002007B1 (pt) 2016-08-10 2024-01-16 F. Hoffmann-La Roche Ag Composição farmacêutica e uso de uma composição farmacêutica
JOP20190025A1 (ar) 2016-09-01 2019-02-19 Denovo Biopharma Llc طرق وتركيبة لتوقع نشاط إنزاستورين

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Also Published As

Publication number Publication date
ECSP055537A (es) 2005-03-10
HK1075839A1 (en) 2005-12-30
CN100430058C (zh) 2008-11-05
IL165747A0 (en) 2006-01-15
CA2393720A1 (en) 2004-01-16
KR20050021453A (ko) 2005-03-07
JP5242718B2 (ja) 2013-07-24
TW200408392A (en) 2004-06-01
DE60317675D1 (de) 2008-01-03
AU2003280958B9 (en) 2009-07-02
AU2003280958A1 (en) 2004-02-02
NO20050676L (no) 2005-02-09
AU2003280958B8 (en) 2009-02-19
US8114901B2 (en) 2012-02-14
EP1523313A1 (en) 2005-04-20
EP1523313B1 (en) 2007-11-21
DE60317675T2 (de) 2008-10-30
PL373046A1 (en) 2005-08-08
NO330254B1 (no) 2011-03-14
UA78801C2 (en) 2007-04-25
CA2393720C (en) 2010-09-14
HRP20050035B1 (hr) 2013-07-31
US20050288332A1 (en) 2005-12-29
JP2006502115A (ja) 2006-01-19
TWI315667B (en) 2009-10-11
JP4771356B2 (ja) 2011-09-14
CN1668304A (zh) 2005-09-14
ZA200500065B (en) 2006-03-29
NZ537137A (en) 2007-11-30
WO2004006928A1 (en) 2004-01-22
JP2011144182A (ja) 2011-07-28
HRP20050035A2 (en) 2005-04-30
EA007463B1 (ru) 2006-10-27
US20070270465A1 (en) 2007-11-22
ES2295605T3 (es) 2008-04-16
IL165747A (en) 2010-05-17
KR100687165B1 (ko) 2007-02-27
EA200500191A1 (ru) 2005-06-30
AU2003280958B2 (en) 2008-12-18

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