ES2188946T3 - Polimorfos de clorhidrato de donepecil y proceso de fabricacion de los mismos. - Google Patents

Polimorfos de clorhidrato de donepecil y proceso de fabricacion de los mismos.

Info

Publication number
ES2188946T3
ES2188946T3 ES97924337T ES97924337T ES2188946T3 ES 2188946 T3 ES2188946 T3 ES 2188946T3 ES 97924337 T ES97924337 T ES 97924337T ES 97924337 T ES97924337 T ES 97924337T ES 2188946 T3 ES2188946 T3 ES 2188946T3
Authority
ES
Spain
Prior art keywords
donepecil
polymorphes
chlorhydrate
manufacturing process
same manufacturing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97924337T
Other languages
English (en)
Inventor
Akio Imai
Hideaki Watanabe
Takashi Kajima
Yasushi Ishihama
Akiyo Ohtsuka
Tomohide Tanaka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai Co Ltd
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/JP1996/003881 external-priority patent/WO1997046526A1/en
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Application granted granted Critical
Publication of ES2188946T3 publication Critical patent/ES2188946T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Clorhidrato de donepecil, clorhidrato de 1-bencil-4-[(5, 6-dimetoxi-1-indanon)-2-il]metilpiperidina, en forma de polimorfo (III) especificado por los picos que se indican a continuación para grados de difracción con la intensidad que se muestra más adelante en términos de I/I0 en el modelo de difracción por rayos-X de material en polvo y los picos de absorción mostrados más adelante en espectros de absorción de infrarrojos en bromuro de potasio en términos de centímetros recíprocos: Polimorfo (III)**(Fórmula)** Números de ondas (cm-1)del espectro de absorción de infrarrojos en bromuro potásico: 559, 641, 648, 702, 749, 765, 786, 807, 851, 872, 927, 949, 966, 975, 982, 1007, 1034, 1071, 1080, 1111, 1119, 1131, 1177, 1190, 1205, 1217, 1230, 1250, 1265, 1292, 1313, 1367, 1389, 1420, 1438, 1453, 1461, 1470, 1500, 1589, 1605, 1697, 2407, 2419, 2461, 2624, 2641, 2651, 2667, 2837, 2848, 2873, 2924, 2954, 2961, 2993, 3007, 3377, 3433 cm-1.
ES97924337T 1996-06-07 1997-06-06 Polimorfos de clorhidrato de donepecil y proceso de fabricacion de los mismos. Expired - Lifetime ES2188946T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP14629396 1996-06-07
PCT/JP1996/003881 WO1997046526A1 (en) 1996-06-07 1996-12-27 Stable polymorphs of donepezil (1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine) hydrochloride and process for production
US08/774,802 US6140321A (en) 1996-06-07 1996-12-30 Polymorphs of donepezil hydrochloride and process for production

Publications (1)

Publication Number Publication Date
ES2188946T3 true ES2188946T3 (es) 2003-07-01

Family

ID=27307991

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97924337T Expired - Lifetime ES2188946T3 (es) 1996-06-07 1997-06-06 Polimorfos de clorhidrato de donepecil y proceso de fabricacion de los mismos.

Country Status (12)

Country Link
EP (2) EP1211243B1 (es)
AU (1) AU731282B2 (es)
CA (1) CA2252806C (es)
DK (1) DK1019374T3 (es)
ES (1) ES2188946T3 (es)
HK (1) HK1020952A1 (es)
NO (1) NO321267B1 (es)
NZ (1) NZ333197A (es)
RU (1) RU2190603C2 (es)
SI (1) SI9720038B (es)
SK (1) SK285312B6 (es)
WO (1) WO1997046527A1 (es)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4095676B2 (ja) * 1997-03-03 2008-06-04 エーザイ株式会社 注意障害を治療するためのコリンエステラーゼ阻害剤の使用
GB9716879D0 (en) * 1997-08-08 1997-10-15 Shire Int Licensing Bv Treatment of attention deficit disorders
DK1048653T3 (da) * 1997-12-05 2004-05-24 Eisai Co Ltd Donepezilpolykrystaller og fremgangsmåde til fremstilling deraf
US6193993B1 (en) 1998-03-03 2001-02-27 Eisai Co., Ltd. Suppository containing an antidementia medicament
HUP0103834A2 (hu) * 1998-06-16 2002-05-29 Eli Lilly And Co. Eljárás az acetil-kolin-szint növelésére
CN1305377A (zh) 1998-06-16 2001-07-25 伊莱利利公司 提高乙酰胆碱水平的方法
US6288108B1 (en) 1998-06-16 2001-09-11 Eli Lilly And Company Methods for increasing levels of acetylcholine
ATE345803T1 (de) 2000-03-03 2006-12-15 Eisai Co Ltd Neue methoden unter verwendung von cholinesteraseinhibitoren
SI21223A (sl) * 2002-06-19 2003-12-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Farmacevtska formulacija s stabiliziranim amorfnim donepezilijevim kloridom
IL150509A (en) 2002-07-01 2007-07-04 Joseph Kaspi Pharmaceutical preparations containing donafazil hydrochloride
US20040142970A1 (en) * 2002-11-01 2004-07-22 Kathryn Chung Treatment of hyperkinetic movement disorder with donepezil
US7186842B2 (en) 2003-02-12 2007-03-06 Usv, Ltd. Polymorph of (1-benzyl-4-[(5,6-dimethoxy-1-indanone)-2-y1] methyl piperidine hydrochloride (Donepezil hydrochloride) and a process for producing thereof
US20050288330A1 (en) * 2004-06-29 2005-12-29 Avinash Naidu Process for producing a polymorphic form of (1-Benzyl-4-[(5,6-dimethoxy-1-indanone)-2-yl] methyl piperidine hydrochloride (donepezil hydrochloride)
US7560560B2 (en) * 2003-04-16 2009-07-14 Hetero Drugs Limited Crystalline forms of donepezil hydrochloride
EP1771416A1 (en) * 2004-07-28 2007-04-11 USV Limited A novel polymorph of (1-benzyl-4-[(5,6-dimethoxy-1-indanone)-2-yl] methyl piperidine hydrochloride (donepezil hydrochloride) and a process for producing thereof
US20080114173A1 (en) * 2004-07-30 2008-05-15 Mathad Vijayavitthal Thippanna Crystalline Form of Donepezil Hydrochloride
EP2039349A1 (en) * 2004-10-19 2009-03-25 KRKA, tovarna zdravil, d.d., Novo mesto Solid pharmaceutical composition comprising donepezil hydrochloride
WO2006090263A1 (en) * 2005-02-28 2006-08-31 Ranbaxy Laboratories Limited Stable form i donepezil hydrochloride and process for its preparation and use in pharmaceutical compositions
EP1858848A1 (en) * 2005-03-17 2007-11-28 Synthon B.V. Process for making crystalline donepezil hydrochloride monohydrate
WO2006111983A2 (en) * 2005-04-21 2006-10-26 Jubilant Organosys Limited NOVEL POLYMORPHIC FORM OF (l-BENZYL-4-[(5,6-DIMETHOXY-l- INDANONE)-2-YL]METHYL PIPERIDINE HYDROCHLORIDE AND PROCESS FOR PREPARING THE SAME
GB0515803D0 (en) * 2005-07-30 2005-09-07 Pliva Hrvatska D O O Intermediate compounds
HU227474B1 (en) * 2005-12-20 2011-07-28 Richter Gedeon Nyrt Process for industrial scale production of high purity donepezil hydrochloride polymorph i.
DE602007003024D1 (de) 2006-06-27 2009-12-10 Sandoz Ag Neues verfahren zur salzherstellung
BRPI0720211A2 (pt) 2006-12-11 2013-12-24 Reviva Pharmaceuticals Inc Derivado de indanona, composição, e, uso de uma composição
DE102007037932A1 (de) 2007-08-11 2009-02-12 Alfred E. Tiefenbacher Gmbh & Co.Kg Donepezilhydrochlorid in amorpher Form enthaltende Tablette
ES2415166T3 (es) * 2007-09-28 2013-07-24 Tianjin Hemay Bio-Tech Co., Ltd. Polímorfos de sales de Donepezilo, métodos de preparación y usos de los mismos
JP5562337B2 (ja) * 2008-12-17 2014-07-30 エーザイ・アール・アンド・ディー・マネジメント株式会社 ドネペジルの多形結晶及びその製造方法
DE102010010998A1 (de) 2010-03-10 2011-09-15 Stada Arzneimittel Ag Feste pharmazeutische Zusammensetzung, umfassend Donepezil-Hydrochlorid der kristallinen polymorphen Form I
WO2011151359A1 (en) 2010-06-02 2011-12-08 Noscira, S.A. Combined treatment with a cholinesterase inhibitor and a thiadiazolidinedione derivative
EP2502620A1 (en) 2011-03-24 2012-09-26 Krka Tovarna Zdravil, D.D., Novo Mesto Solid pharmaceutical composition comprising donepezil
CN110393440B (zh) * 2019-06-28 2021-08-13 顾美红 一种即热式烧水机
WO2024145319A1 (en) 2022-12-28 2024-07-04 Corium, Llc Method of preparing transdermal delivery system
WO2024145323A1 (en) 2022-12-28 2024-07-04 Corium, Llc Pre-mixing method of preparing transdermal delivery system

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI95572C (fi) * 1987-06-22 1996-02-26 Eisai Co Ltd Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi

Also Published As

Publication number Publication date
EP1211243A1 (en) 2002-06-05
HK1020952A1 (en) 2000-05-26
NO321267B1 (no) 2006-04-10
WO1997046527A1 (en) 1997-12-11
NO985721L (no) 1999-01-28
RU2190603C2 (ru) 2002-10-10
AU731282B2 (en) 2001-03-29
DK1019374T3 (da) 2003-04-07
EP1019374B1 (en) 2003-01-02
SI9720038A (sl) 1999-06-30
SK285312B6 (sk) 2006-10-05
EP1211243B1 (en) 2009-10-14
SI9720038B (sl) 2010-06-30
EP1019374A1 (en) 2000-07-19
CA2252806C (en) 2005-11-22
NZ333197A (en) 2001-03-30
CA2252806A1 (en) 1997-12-11
AU2979297A (en) 1998-01-05
SK167698A3 (en) 1999-06-11
NO985721D0 (no) 1998-12-07

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