DE69330114D1 - Methandiphosphonat-derivat, dessen produktion und dessen verwendung als arzneimittel - Google Patents

Methandiphosphonat-derivat, dessen produktion und dessen verwendung als arzneimittel

Info

Publication number
DE69330114D1
DE69330114D1 DE69330114T DE69330114T DE69330114D1 DE 69330114 D1 DE69330114 D1 DE 69330114D1 DE 69330114 T DE69330114 T DE 69330114T DE 69330114 T DE69330114 T DE 69330114T DE 69330114 D1 DE69330114 D1 DE 69330114D1
Authority
DE
Germany
Prior art keywords
methandiphosphonate
derivative
production
medicinal product
medicinal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69330114T
Other languages
English (en)
Other versions
DE69330114T2 (de
Inventor
Norio Kawabe
Hiromi Uchiro
Teruo Nakadate
Masahiko Tanahashi
Yuriko Funaba
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Toray Industries Inc
Original Assignee
Toray Industries Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP18386692A external-priority patent/JP3341303B2/ja
Application filed by Toray Industries Inc filed Critical Toray Industries Inc
Application granted granted Critical
Publication of DE69330114D1 publication Critical patent/DE69330114D1/de
Publication of DE69330114T2 publication Critical patent/DE69330114T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3865—Polyphosphonic acids containing sulfur substituents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/386—Polyphosphonic acids containing hydroxy substituents in the hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4025—Esters of poly(thio)phosphonic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69330114T 1992-07-10 1993-01-08 Methandiphosphonat-derivat, dessen produktion und dessen verwendung als arzneimittel Expired - Fee Related DE69330114T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP18386692A JP3341303B2 (ja) 1991-07-11 1992-07-10 メチレンジホスホン酸誘導体、その製造方法およびその医薬用途
PCT/JP1993/000014 WO1994001442A1 (en) 1992-07-10 1993-01-08 Methanediphosphonate derivative, production thereof, and pharmaceutical use thereof

Publications (2)

Publication Number Publication Date
DE69330114D1 true DE69330114D1 (de) 2001-05-17
DE69330114T2 DE69330114T2 (de) 2001-08-02

Family

ID=16143201

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69330114T Expired - Fee Related DE69330114T2 (de) 1992-07-10 1993-01-08 Methandiphosphonat-derivat, dessen produktion und dessen verwendung als arzneimittel

Country Status (7)

Country Link
US (1) US5618804A (de)
EP (1) EP0603401B1 (de)
KR (1) KR100272907B1 (de)
CA (1) CA2111670A1 (de)
DE (1) DE69330114T2 (de)
ES (1) ES2155446T3 (de)
WO (1) WO1994001442A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6458772B1 (en) 1909-10-07 2002-10-01 Medivir Ab Prodrugs
US5886206A (en) * 1994-08-24 1999-03-23 Toray Industries, Inc. Process for production of methanediphosphonic acid compound
US20020128301A1 (en) * 1998-02-13 2002-09-12 Medivir AB Non-nucleoside reverse transcriptase inhibitors
CA2321864A1 (en) * 1998-12-25 2000-07-06 Toray Industries, Inc. Interleukin-6 production inhibitor
ES2498046T3 (es) 1999-12-03 2014-09-24 The Regents Of The University Of California Compuestos antivirales de éster de fosfonato
GB0019272D0 (en) * 2000-08-04 2000-09-27 Symphar Sa Pharmaceutical compounds
US6548042B2 (en) 2000-08-07 2003-04-15 Arstad Erik Bis-phosphonate compounds
US20090304821A1 (en) * 2006-03-08 2009-12-10 Takeda Pharmaceutical Company Limited Pharmaceutical Combination

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4020091A (en) * 1965-10-28 1977-04-26 Plains Chemical Development Co. Chelation
US3683080A (en) * 1970-08-28 1972-08-08 Procter & Gamble Compositions for inhibiting anomalous deposition and mobilization of calcium phosphate in animal tissue
DE3270547D1 (en) * 1981-02-21 1986-05-22 Gfo Ges Fuer Oberflaechentech Antistatic and scratch-resistant sound/picture recording supports and method for their production
DE3203308A1 (de) * 1982-01-27 1983-07-28 Schering Ag, 1000 Berlin Und 4619 Bergkamen Diphosphonsaeure-derivate und diese enthaltende pharmazeutische praeparate
EP0084822B1 (de) * 1982-01-27 1986-01-08 Schering Aktiengesellschaft Diphosphonsäure-Derivate und diese enthaltende pharmazeutische Präparate
DE3365492D1 (en) * 1982-01-27 1986-10-02 Schering Ag Diphosphonic acid derivatives and pharmaceutical preparations containing them
DE3203309A1 (de) * 1982-01-27 1983-07-28 Schering Ag, 1000 Berlin Und 4619 Bergkamen Diphosphonsaeure-derivate und diese enthaltende pharmazeutische praeparate
FR2531088B1 (fr) * 1982-07-29 1987-08-28 Sanofi Sa Produits anti-inflammatoires derives de l'acide methylenediphosphonique et leur procede de preparation
FR2558837B1 (fr) * 1984-01-26 1986-06-27 Sanofi Sa Derives de l'acide methylenediphosphonique, procede d'obtention et medicaments antirhumatismaux les contenant
GB8419489D0 (en) * 1984-07-31 1984-09-05 Leo Pharm Prod Ltd Chemical compounds
US4902679A (en) * 1985-12-13 1990-02-20 Norwich Eaton Pharmaceuticals, Inc. Methods of treating diseases with certain geminal diphosphonates
JPS63185993A (ja) * 1987-01-27 1988-08-01 Yamanouchi Pharmaceut Co Ltd ２−置換−２−オキソ−エチレン−１，１−ジホスホン酸
CH675422A5 (de) * 1988-03-31 1990-09-28 Symphar Sa
JPH0377894A (ja) * 1989-08-18 1991-04-03 Toray Ind Inc メチレンジホスホン酸化合物
AU624733B2 (en) * 1989-09-14 1992-06-18 Symphar S.A. Naphthalene and tetrahydronaphthalene substituted gem- diphosphonate compounds and their use in therapy

Also Published As

Publication number Publication date
CA2111670A1 (en) 1994-01-20
EP0603401A1 (de) 1994-06-29
DE69330114T2 (de) 2001-08-02
EP0603401B1 (de) 2001-04-11
KR100272907B1 (ko) 2001-03-02
US5618804A (en) 1997-04-08
WO1994001442A1 (en) 1994-01-20
EP0603401A4 (de) 1995-02-01
ES2155446T3 (es) 2001-05-16
KR940702503A (ko) 1994-08-20

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee