HUP0103834A2 - Eljárás az acetil-kolin-szint növelésére - Google Patents
Eljárás az acetil-kolin-szint növeléséreInfo
- Publication number
- HUP0103834A2 HUP0103834A2 HU0103834A HUP0103834A HUP0103834A2 HU P0103834 A2 HUP0103834 A2 HU P0103834A2 HU 0103834 A HU0103834 A HU 0103834A HU P0103834 A HUP0103834 A HU P0103834A HU P0103834 A2 HUP0103834 A2 HU P0103834A2
- Authority
- HU
- Hungary
- Prior art keywords
- acetylcholine
- methods
- increasing levels
- optionally
- benzoyl
- Prior art date
Links
- OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical compound CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 title abstract 2
- 229960004373 acetylcholine Drugs 0.000 title abstract 2
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 2
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 229940124596 AChE inhibitor Drugs 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- -1 methyl - Chemical class 0.000 abstract 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
A jelen találmány tárgyát az acetil-kolin-szint növelésére szolgálóeljárás képezi, melynek során az arra rászoruló emlősbe az (I)általános képletű vegyület és opcionálisan egy AChE-inhibitor hatékonymennyiségét adják be, ahol a képletben az R1 és az R3 jelentéseegymástól függetlenül hidrogénatom, metil-, benzoil-, szubsztituáltbenzoil- vagy C(O)-(1-6 szénatomos alkil)csoport; az R2 jelentésepedig pirrolidin-l-il-, piperidin-l-il- vagy hexametilén-imin-1-il-csoport, és az R2-csoport opcionálisan az N-oxid; Ó
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8948898P | 1998-06-16 | 1998-06-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUP0103834A2 true HUP0103834A2 (hu) | 2002-05-29 |
Family
ID=22217922
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0103834A HUP0103834A2 (hu) | 1998-06-16 | 1999-06-04 | Eljárás az acetil-kolin-szint növelésére |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0966964A1 (hu) |
| JP (1) | JP2002518299A (hu) |
| KR (1) | KR20010052892A (hu) |
| CN (1) | CN1305343A (hu) |
| AU (1) | AU748659B2 (hu) |
| BR (1) | BR9911217A (hu) |
| CA (1) | CA2333453A1 (hu) |
| HR (1) | HRP20000861A2 (hu) |
| HU (1) | HUP0103834A2 (hu) |
| IL (1) | IL138914A0 (hu) |
| NO (1) | NO20006088L (hu) |
| PL (1) | PL346242A1 (hu) |
| SK (1) | SK18812000A3 (hu) |
| TR (1) | TR200003714T2 (hu) |
| TW (1) | TW486367B (hu) |
| WO (1) | WO1999065309A1 (hu) |
| ZA (1) | ZA200005885B (hu) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6288108B1 (en) | 1998-06-16 | 2001-09-11 | Eli Lilly And Company | Methods for increasing levels of acetylcholine |
| CN1305377A (zh) | 1998-06-16 | 2001-07-25 | 伊莱利利公司 | 提高乙酰胆碱水平的方法 |
| KR101226702B1 (ko) * | 2010-10-08 | 2013-01-25 | 충북대학교 산학협력단 | 인간 콜린 아세틸트랜스퍼라아제를 발현하는 인간 신경줄기세포 및 이의 용도 |
| KR102117741B1 (ko) * | 2017-12-31 | 2020-06-01 | 롯데첨단소재(주) | 도금용 열가소성 수지 조성물 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU1440395A (en) * | 1993-12-21 | 1995-07-10 | Eli Lilly And Company | Methods for the treatment or prevention of conditions associated with amyloidogenic reptides |
| US5552415A (en) * | 1993-12-21 | 1996-09-03 | Eli Lilly And Company | Method of inhibiting Alzheimer's Disease |
| PL182493B1 (pl) * | 1995-02-28 | 2002-01-31 | Lilly Co Eli | Nowe pochodne benzotiofenu, nowe związki pośrednie i sposób wytwarzania nowych pochodnych benzotiofenu oraz środek farmaceutyczny |
| US5510357A (en) * | 1995-02-28 | 1996-04-23 | Eli Lilly And Company | Benzothiophene compounds as anti-estrogenic agents |
| SI9720038B (sl) * | 1996-06-07 | 2010-06-30 | Eisai Co Ltd | Polimorfi donepezil hidroklorida in postopek izdelave |
| ZA982877B (en) * | 1997-04-09 | 1999-10-04 | Lilly Co Eli | Treatment of central nervous system disorders with selective estrogen receptor modulators. |
-
1999
- 1999-06-04 HU HU0103834A patent/HUP0103834A2/hu unknown
- 1999-06-04 WO PCT/US1999/012603 patent/WO1999065309A1/en not_active Application Discontinuation
- 1999-06-04 IL IL13891499A patent/IL138914A0/xx unknown
- 1999-06-04 BR BR9911217-5A patent/BR9911217A/pt not_active IP Right Cessation
- 1999-06-04 AU AU48191/99A patent/AU748659B2/en not_active Ceased
- 1999-06-04 KR KR1020007014237A patent/KR20010052892A/ko not_active Application Discontinuation
- 1999-06-04 TR TR2000/03714T patent/TR200003714T2/xx unknown
- 1999-06-04 SK SK1881-2000A patent/SK18812000A3/sk unknown
- 1999-06-04 CA CA002333453A patent/CA2333453A1/en not_active Abandoned
- 1999-06-04 PL PL99346242A patent/PL346242A1/xx unknown
- 1999-06-04 CN CN99807286A patent/CN1305343A/zh active Pending
- 1999-06-04 JP JP2000554200A patent/JP2002518299A/ja not_active Withdrawn
- 1999-06-10 TW TW088109701A patent/TW486367B/zh not_active IP Right Cessation
- 1999-06-11 EP EP99304581A patent/EP0966964A1/en not_active Withdrawn
-
2000
- 2000-10-20 ZA ZA200005885A patent/ZA200005885B/en unknown
- 2000-11-30 NO NO20006088A patent/NO20006088L/no not_active Application Discontinuation
- 2000-12-14 HR HR20000861A patent/HRP20000861A2/hr not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200005885B (en) | 2001-10-22 |
| EP0966964A1 (en) | 1999-12-29 |
| WO1999065309A1 (en) | 1999-12-23 |
| HRP20000861A2 (en) | 2001-10-31 |
| AU748659B2 (en) | 2002-06-06 |
| AU4819199A (en) | 2000-01-05 |
| JP2002518299A (ja) | 2002-06-25 |
| TW486367B (en) | 2002-05-11 |
| NO20006088D0 (no) | 2000-11-30 |
| SK18812000A3 (sk) | 2002-01-07 |
| BR9911217A (pt) | 2001-03-06 |
| PL346242A1 (en) | 2002-01-28 |
| NO20006088L (no) | 2000-11-30 |
| TR200003714T2 (tr) | 2001-07-23 |
| KR20010052892A (ko) | 2001-06-25 |
| CA2333453A1 (en) | 1999-12-23 |
| IL138914A0 (en) | 2001-11-25 |
| CN1305343A (zh) | 2001-07-25 |
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