HUP0300741A2 - Biciklopirazolok mint kináz inhibitorok, előállítási eljárásuk és a vegyületeket tartalmazó gyógyszerkészítmények - Google Patents

Biciklopirazolok mint kináz inhibitorok, előállítási eljárásuk és a vegyületeket tartalmazó gyógyszerkészítmények

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Publication number
HUP0300741A2
HUP0300741A2 HU0300741A HUP0300741A HUP0300741A2 HU P0300741 A2 HUP0300741 A2 HU P0300741A2 HU 0300741 A HU0300741 A HU 0300741A HU P0300741 A HUP0300741 A HU P0300741A HU P0300741 A2 HUP0300741 A2 HU P0300741A2
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Hungary
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group
independently
aryl
alkyl
hydrogen atom
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HU0300741A
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English (en)
Inventor
Daniele Fancelli
Valeria Pittala'
Mario Varasi
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Pharmacia Italia S.P.A.
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Application filed by Pharmacia Italia S.P.A. filed Critical Pharmacia Italia S.P.A.
Publication of HUP0300741A2 publication Critical patent/HUP0300741A2/hu
Publication of HUP0300741A3 publication Critical patent/HUP0300741A3/hu
Publication of HU229824B1 publication Critical patent/HU229824B1/hu

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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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  • Nitrogen Condensed Heterocyclic Rings (AREA)
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Abstract

A találmány diszregulált protein-kinázokkal kapcsolatos betegségekkezelésére felhasználható (I) általános képletű biciklopirazol-vegyületekre - amelynek képletében R és R1 jelentése azonosan vagyeltérően, egymástól függetlenül hidrogénatom vagy egy adott esetbenszubsztituált csoport a következők közül közül kiválasztva: -R', -COR', -COOR', -CONHR', -CONR'R<, -NH-C(=NH)NHR', -C(=NH)NHR', -SO2R',-SO2NHR' vagy -SO2NR'R< általános képletű csoport; ahol R' és R<jelentése azonosan vagy eltérően, egymástól függetlenül hidrogénatomvagy egy adott esetben tovább szubsztituált egyenes vagy elágazó láncú1-6 szénatomos alkilcsoport, arilcsoport, 3-6 szénatomoscikloalkilcsoport vagy aril-(1-6 szénatomos alkil)-csoport, vagy R' ésR< együtt egy 4-6 szénatomos alkilénláncot képez; Ra, Rb, Rc és Rdjelentése azonosan vagy eltérően, egymástól függetlenül hidrogénatom,adott esetben tovább szubsztituált egyenes vagy elágazó láncú 1-6szénatomos alkilcsoport, arilcsoport, aril-(1-6 szénatomos alkil)-csoport vagy -CH2OR' általános képletű csoport, amelyben R' jelentésea fentiekben meghatározott, vagy Ra és Rb és/vagy Rc és Rd azzal aszénatommal együtt, amelyhez kapcsolódik, egy adott esetbenszubsztituált 3-6 szénatomos cikloalkilcsoportot képez; m és n értékeegymástól függetlenül 0, 1 vagy 2, azzal a megkötéssel, hogy m és nösszege legfeljebb 2 (m + n < 2) - és gyógyászatilag elfogadhatósóikra vonatkozik. Ó
HU0300741A 2000-08-10 2001-07-25 Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them HU229824B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63591400A 2000-08-10 2000-08-10
PCT/EP2001/008639 WO2002012242A2 (en) 2000-08-10 2001-07-25 Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them

Publications (3)

Publication Number Publication Date
HUP0300741A2 true HUP0300741A2 (hu) 2003-11-28
HUP0300741A3 HUP0300741A3 (en) 2005-12-28
HU229824B1 HU229824B1 (en) 2014-08-28

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ID=24549630

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0300741A HU229824B1 (en) 2000-08-10 2001-07-25 Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them

Country Status (29)

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US (3) US7541354B2 (hu)
EP (1) EP1320531B1 (hu)
JP (2) JP4555547B2 (hu)
KR (1) KR100904157B1 (hu)
CN (2) CN1447810A (hu)
AR (1) AR034137A1 (hu)
AT (1) ATE480539T1 (hu)
AU (2) AU8765401A (hu)
BR (1) BR0113176A (hu)
CA (1) CA2416527C (hu)
CY (1) CY1110914T1 (hu)
CZ (1) CZ2003591A3 (hu)
DE (1) DE60143041D1 (hu)
DK (1) DK1320531T3 (hu)
EA (1) EA006381B1 (hu)
EE (1) EE05405B1 (hu)
ES (1) ES2349762T3 (hu)
HU (1) HU229824B1 (hu)
IL (2) IL153997A0 (hu)
MX (1) MXPA03001169A (hu)
MY (1) MY148632A (hu)
NO (1) NO325530B1 (hu)
NZ (1) NZ524475A (hu)
PE (1) PE20020274A1 (hu)
PL (1) PL213199B1 (hu)
PT (1) PT1320531E (hu)
SK (1) SK1882003A3 (hu)
WO (1) WO2002012242A2 (hu)
ZA (1) ZA200301813B (hu)

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