HUP9902628A2 - Angiogenezis gátló borrelidinszármazékok, alkalmazásuk és a vegyületeket tartalmazó gyógyszerkészítmények - Google Patents
Angiogenezis gátló borrelidinszármazékok, alkalmazásuk és a vegyületeket tartalmazó gyógyszerkészítményekInfo
- Publication number
- HUP9902628A2 HUP9902628A2 HU9902628A HUP9902628A HUP9902628A2 HU P9902628 A2 HUP9902628 A2 HU P9902628A2 HU 9902628 A HU9902628 A HU 9902628A HU P9902628 A HUP9902628 A HU P9902628A HU P9902628 A2 HUP9902628 A2 HU P9902628A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- alkyl
- atom
- amino
- carbon atoms
- Prior art date
Links
- 230000033115 angiogenesis Effects 0.000 title abstract 2
- OJCKRNPLOZHAOU-RSXXJMTFSA-N (1r,2r)-2-[(2s,4e,6e,8r,9s,11r,13s,15s,16s)-7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxo-1-oxacyclooctadeca-4,6-dien-2-yl]cyclopentane-1-carboxylic acid Chemical class O1C(=O)C[C@H](O)[C@@H](C)C[C@@H](C)C[C@@H](C)C[C@H](C)[C@@H](O)\C(C#N)=C\C=C\C[C@H]1[C@H]1[C@H](C(O)=O)CCC1 OJCKRNPLOZHAOU-RSXXJMTFSA-N 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 5
- -1 hydroxyl- Chemical group 0.000 abstract 4
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000003277 amino group Chemical group 0.000 abstract 2
- 125000006615 aromatic heterocyclic group Chemical group 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 2
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 229920006395 saturated elastomer Polymers 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 206010027476 Metastases Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 229940121369 angiogenesis inhibitor Drugs 0.000 abstract 1
- 239000004037 angiogenesis inhibitor Substances 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 210000004204 blood vessel Anatomy 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 230000004614 tumor growth Effects 0.000 abstract 1
- 230000029663 wound healing Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrane Compounds (AREA)
Abstract
A találmány (I) általános képletű újborrelidinszármazékokra, amely képletben R jelentése -COOR1, -CONR2R3;CONR4CONR4R5 vagy -CH2OR6 általános képletű csoport, ahol R1 jelentése1-6 szénatomos alkilcsoport, amely adott esetben egy hidroxil-,amino-, di(1-4 szénatomos alkil)-amino-csoporttal vagy egy 5-8 tagútelített, nitrogéntartalmú heterociklusos csoporttal - amely anitrogénatomon kívül egy oxigénatomot vagy egy vagy kettő továbbinitrogénatomot is tartalmazhat - vagy egy 5-6 tagú, nitrogéntartalmúaromás heterociklusos csoporttal - amely a nitrogénatomon kívül egyoxigénatomot vagy egy vagy kettő további nitrogénatomot istartalmazhat - lehet helyettesítve vagy 3-6 szénatomos cikloalkil-csoport, R2 és R3 azonos vagy különböző és jelentésük egymástólfüggetlenül hidrogénatom vagy 1-6 szénatomos alkilcsoport, amely adottesetben egy halogénatommal, egy hidroxil-, amino-, di(1-4 szénatomosalkil)-amino-csoporttal vagy a fentiek szerinti telített vagy aromásheterociklusos csoporttal lehet helyettesítve. R4 és R5 azonos vagykülönböző és jelentésük egymástól függetlenül hidrogénatom, 1-6szénatomos alkilcsoport vagy adott esetben helyettesítettfenilcsoport, R6 jelentése hidrogénatom; 1-6 szénatomos alkil-, 3-6szénatomos cikloalkil- vagy 2-6 szénatomos alifás acilcsoport, amelyadott esetben halogénatommal, amino, di(1-4 szénatomos alkil)-amino-csoporttal vagy adott esetben helyettesített fenilcsoporttal lehethelyettesítve, adott esetben helyettesített karbamoilcsoport, továbbáadott esetben helyettesített benzoilcsoport vagy valamely 1-4szénatomos alkil-szulfonil-csoport azzal a megkötéssel, hogy R1 csakmetilcsoporttól eltérő jelentésű lehet, ezek tautomerjeire,szolvátjaira, valamint ezek keverékére és mindezek savaddíciós sóiravonatkozik. A találmány szerinti angiogenezis inhibitorok gátolják újerek kialakulását az élő szövetekben, s mint ilyenek asebgyógyulással, gyulladással, tumor növekedéssel összefüggésbenfellépő angiogenezis megelőzésére, gátlására, valamint tumormetasztázisok megelőzésére használhatók. Ó
Priority Applications (34)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU9902628A HUP9902628A3 (en) | 1999-08-02 | 1999-08-02 | Angiogenesis inhibiting borrelidin derivatives, their use and pharmaceutical compositions containing them |
| CNB008123578A CN1243746C (zh) | 1999-08-02 | 2000-08-02 | 抑制血管生成的杂环化合物 |
| NZ517422A NZ517422A (en) | 1999-08-02 | 2000-08-02 | Heterocyclic compounds inhibiting angiogenesis |
| APAP/P/2002/002413A AP1383A (en) | 1999-08-02 | 2000-08-02 | Heterocyclic compounds inhibiting angiogenesis. |
| OA1200200042A OA12004A (en) | 1999-08-02 | 2000-08-02 | Heterocyclic compounds inhibiting angiogenesis. |
| CZ2002405A CZ2002405A3 (cs) | 1999-08-02 | 2000-08-02 | Heterocyklické sloučeniny inhibující angiogenezi, farmaceutický prostředek obsahující tyto sloučeniny a pouľití těchto sloučenin |
| CA002378176A CA2378176A1 (en) | 1999-08-02 | 2000-08-02 | Heterocyclic compounds inhibiting angiogenesis |
| KR1020027001484A KR20020068495A (ko) | 1999-08-02 | 2000-08-02 | 혈관형성을 억제하는 헤테로고리 화합물 |
| SI200030164T SI1206462T1 (en) | 1999-08-02 | 2000-08-02 | Heterocyclic compounds inhibiting angiogenesis |
| DK00949831T DK1206462T3 (da) | 1999-08-02 | 2000-08-02 | Hererocykliske forbindelser til inhibering af angiogenese |
| AT00949831T ATE241611T1 (de) | 1999-08-02 | 2000-08-02 | Heterozyclische verbindungen als angiogenese inhibitoren |
| SK182-2002A SK1822002A3 (en) | 1999-08-02 | 2000-08-02 | Heterocyclic compounds inhibiting angiogenesis |
| DE60003045T DE60003045T2 (de) | 1999-08-02 | 2000-08-02 | Heterozyclische verbindungen als angiogenese inhibitoren |
| US10/048,659 US6815465B1 (en) | 1999-08-02 | 2000-08-02 | Heterocyclic compounds inhibiting angiogenesis |
| EP00949831A EP1206462B1 (en) | 1999-08-02 | 2000-08-02 | Heterocyclic compounds inhibiting angiogenesis |
| MXPA02001117A MXPA02001117A (es) | 1999-08-02 | 2000-08-02 | Compuestos heterociclicos inhibidores de angiogenesis. |
| HU0202197A HUP0202197A3 (en) | 1999-08-02 | 2000-08-02 | Borrelidine derivatives inhibiting angiogenesis, and medicaments containing the same |
| AU63090/00A AU772206B2 (en) | 1999-08-02 | 2000-08-02 | Heterocyclic compounds inhibiting angiogenesis |
| PL00354281A PL354281A1 (en) | 1999-08-02 | 2000-08-02 | Heterocyclic compounds inhibiting angiogenesis |
| BR0012968-2A BR0012968A (pt) | 1999-08-02 | 2000-08-02 | Compostos heterocìclicos de inibição de angiogênese |
| UA2002010814A UA74341C2 (uk) | 1999-08-02 | 2000-08-02 | Похідні борелідину, які інгібують ангіогенез |
| RU2002105518/04A RU2247723C2 (ru) | 1999-08-02 | 2000-08-02 | Производные боррелидина и фармацевтическая композиция на их основе |
| PCT/HU2000/000088 WO2001009113A2 (en) | 1999-08-02 | 2000-08-02 | Heterocyclic compounds inhibiting angiogenesis |
| JP2001514316A JP2003506366A (ja) | 1999-08-02 | 2000-08-02 | 血管形成を抑制する複素環式化合物 |
| ES00949831T ES2200900T3 (es) | 1999-08-02 | 2000-08-02 | Compuestos heterociclicos que inhiben la angiogenesis. |
| IL14790400A IL147904A (en) | 1999-08-02 | 2000-08-02 | Heterocyclic compounds inhibiting angiogenesis |
| YU7302A YU7302A (sh) | 1999-08-02 | 2000-08-02 | Heterociklična jedinjenja za inhibiranje angiogeneze |
| PT00949831T PT1206462E (pt) | 1999-08-02 | 2000-08-02 | Compostos heterociclicos para inibicao da angiogenese |
| ZA200200838A ZA200200838B (en) | 1999-08-02 | 2002-01-30 | Heterocyclic compounds inhibiting angiogenesis. |
| NO20020485A NO20020485L (no) | 1999-08-02 | 2002-01-30 | Heterocykliske forbindelser som inhiberer angiogenese |
| BG06373A BG106373A (en) | 1999-08-02 | 2002-01-31 | Heterocyclic compounds inhibiting angiogenesis |
| IS6258A IS2137B (is) | 1999-08-02 | 2002-02-01 | Heteróhringlaga efnasambönd sem tálma æðamyndun |
| HR20020103A HRP20020103B1 (en) | 1999-08-02 | 2002-02-01 | Heterocyclic compounds inhibiting angiogenesis |
| HK03101165.4A HK1048995B (zh) | 1999-08-02 | 2003-02-18 | 抑制血管生成的雜環化合物 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU9902628A HUP9902628A3 (en) | 1999-08-02 | 1999-08-02 | Angiogenesis inhibiting borrelidin derivatives, their use and pharmaceutical compositions containing them |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| HU9902628D0 HU9902628D0 (en) | 1999-10-28 |
| HUP9902628A2 true HUP9902628A2 (hu) | 2001-05-28 |
| HUP9902628A3 HUP9902628A3 (en) | 2001-07-30 |
Family
ID=89998954
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9902628A HUP9902628A3 (en) | 1999-08-02 | 1999-08-02 | Angiogenesis inhibiting borrelidin derivatives, their use and pharmaceutical compositions containing them |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US6815465B1 (hu) |
| EP (1) | EP1206462B1 (hu) |
| JP (1) | JP2003506366A (hu) |
| KR (1) | KR20020068495A (hu) |
| CN (1) | CN1243746C (hu) |
| AP (1) | AP1383A (hu) |
| AT (1) | ATE241611T1 (hu) |
| AU (1) | AU772206B2 (hu) |
| BG (1) | BG106373A (hu) |
| BR (1) | BR0012968A (hu) |
| CA (1) | CA2378176A1 (hu) |
| CZ (1) | CZ2002405A3 (hu) |
| DE (1) | DE60003045T2 (hu) |
| DK (1) | DK1206462T3 (hu) |
| ES (1) | ES2200900T3 (hu) |
| HK (1) | HK1048995B (hu) |
| HR (1) | HRP20020103B1 (hu) |
| HU (1) | HUP9902628A3 (hu) |
| IL (1) | IL147904A (hu) |
| IS (1) | IS2137B (hu) |
| MX (1) | MXPA02001117A (hu) |
| NO (1) | NO20020485L (hu) |
| NZ (1) | NZ517422A (hu) |
| OA (1) | OA12004A (hu) |
| PL (1) | PL354281A1 (hu) |
| PT (1) | PT1206462E (hu) |
| RU (1) | RU2247723C2 (hu) |
| SK (1) | SK1822002A3 (hu) |
| UA (1) | UA74341C2 (hu) |
| WO (1) | WO2001009113A2 (hu) |
| YU (1) | YU7302A (hu) |
| ZA (1) | ZA200200838B (hu) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6693099B2 (en) * | 2000-10-17 | 2004-02-17 | The Procter & Gamble Company | Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance |
| ATE452896T1 (de) | 2002-03-12 | 2010-01-15 | Bristol Myers Squibb Co | C3-cyanoepothilonderivate |
| GB0230217D0 (en) | 2002-12-27 | 2003-02-05 | Biotica Tech Ltd | Borrelidin-producing polyketide synthase and its uses |
| US8440217B1 (en) | 2005-06-15 | 2013-05-14 | Mawaheb M. EL-Naggar | Method and system with contact lens product for treating and preventing adverse eye conditions |
| GB0609981D0 (en) * | 2006-05-19 | 2006-06-28 | Biotica Tech Ltd | Novel compounds |
| GB0713563D0 (en) * | 2007-07-13 | 2007-08-22 | Biotica Tech Ltd | Methods of screening for anti-angiogenic compounds |
| PL2197280T3 (pl) * | 2007-08-27 | 2013-11-29 | Basf Se | Związki pirazolowe do zwalczania szkodników będących bezkręgowcami |
| DE102008014077A1 (de) | 2008-03-13 | 2009-09-17 | Discovery Partner International Gmbh | Borrelidin-Derivate |
| WO2009141786A2 (en) * | 2008-05-21 | 2009-11-26 | Piramal Life Sciences Limited | Anti-inflammatory compounds |
| ES2720781T3 (es) | 2014-12-15 | 2019-07-24 | Borealis Ag | Uso de una composición de polipropileno |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH08173176A (ja) * | 1994-12-22 | 1996-07-09 | Mercian Corp | 血管新生阻害剤 |
| JP3786461B2 (ja) * | 1996-02-22 | 2006-06-14 | メルシャン株式会社 | 新生理活性物質 |
-
1999
- 1999-08-02 HU HU9902628A patent/HUP9902628A3/hu unknown
-
2000
- 2000-08-02 AP APAP/P/2002/002413A patent/AP1383A/en active
- 2000-08-02 YU YU7302A patent/YU7302A/sh unknown
- 2000-08-02 CZ CZ2002405A patent/CZ2002405A3/cs unknown
- 2000-08-02 CN CNB008123578A patent/CN1243746C/zh not_active Expired - Fee Related
- 2000-08-02 AT AT00949831T patent/ATE241611T1/de not_active IP Right Cessation
- 2000-08-02 MX MXPA02001117A patent/MXPA02001117A/es active IP Right Grant
- 2000-08-02 CA CA002378176A patent/CA2378176A1/en not_active Abandoned
- 2000-08-02 DK DK00949831T patent/DK1206462T3/da active
- 2000-08-02 PL PL00354281A patent/PL354281A1/xx not_active Application Discontinuation
- 2000-08-02 DE DE60003045T patent/DE60003045T2/de not_active Expired - Fee Related
- 2000-08-02 ES ES00949831T patent/ES2200900T3/es not_active Expired - Lifetime
- 2000-08-02 UA UA2002010814A patent/UA74341C2/uk unknown
- 2000-08-02 IL IL14790400A patent/IL147904A/xx not_active IP Right Cessation
- 2000-08-02 EP EP00949831A patent/EP1206462B1/en not_active Expired - Lifetime
- 2000-08-02 OA OA1200200042A patent/OA12004A/en unknown
- 2000-08-02 AU AU63090/00A patent/AU772206B2/en not_active Ceased
- 2000-08-02 NZ NZ517422A patent/NZ517422A/en unknown
- 2000-08-02 RU RU2002105518/04A patent/RU2247723C2/ru not_active IP Right Cessation
- 2000-08-02 JP JP2001514316A patent/JP2003506366A/ja not_active Withdrawn
- 2000-08-02 KR KR1020027001484A patent/KR20020068495A/ko not_active Application Discontinuation
- 2000-08-02 BR BR0012968-2A patent/BR0012968A/pt not_active IP Right Cessation
- 2000-08-02 WO PCT/HU2000/000088 patent/WO2001009113A2/en not_active Application Discontinuation
- 2000-08-02 PT PT00949831T patent/PT1206462E/pt unknown
- 2000-08-02 SK SK182-2002A patent/SK1822002A3/sk unknown
- 2000-08-02 US US10/048,659 patent/US6815465B1/en not_active Expired - Fee Related
-
2002
- 2002-01-30 ZA ZA200200838A patent/ZA200200838B/en unknown
- 2002-01-30 NO NO20020485A patent/NO20020485L/no not_active Application Discontinuation
- 2002-01-31 BG BG06373A patent/BG106373A/xx unknown
- 2002-02-01 HR HR20020103A patent/HRP20020103B1/xx not_active IP Right Cessation
- 2002-02-01 IS IS6258A patent/IS2137B/xx unknown
-
2003
- 2003-02-18 HK HK03101165.4A patent/HK1048995B/zh not_active IP Right Cessation
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