UA74341C2 - Похідні борелідину, які інгібують ангіогенез - Google Patents

Похідні борелідину, які інгібують ангіогенез

Info

Publication number
UA74341C2
UA74341C2 UA2002010814A UA200210814A UA74341C2 UA 74341 C2 UA74341 C2 UA 74341C2 UA 2002010814 A UA2002010814 A UA 2002010814A UA 200210814 A UA200210814 A UA 200210814A UA 74341 C2 UA74341 C2 UA 74341C2
Authority
UA
Ukraine
Prior art keywords
group
compounds
general formula
inhibiting angiogenesis
stands
Prior art date
Application number
UA2002010814A
Other languages
English (en)
Russian (ru)
Inventor
Нандор МАКК
Габор АМБРУС
Аніко Тегдес
Андраш Еней
Ференц Тімар
Original Assignee
Івакс Драг Рісерч Інститьют Лімітед Лайебіліті Компані
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Івакс Драг Рісерч Інститьют Лімітед Лайебіліті Компані filed Critical Івакс Драг Рісерч Інститьют Лімітед Лайебіліті Компані
Publication of UA74341C2 publication Critical patent/UA74341C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

( І ) Винахід стосується сполук загальної формули (I), де R - група загальної формули -COOR1, -CONR2R3, -CONR4CONR4R5 aбo -CH2OR6, де R1 - С2-6 алкільна група; С1-6 заміщена алкільна група; або С3-6 циклоалкільна група; R2 i R3 - однакові або різні й незалежно одно від одної є атомом водню або С1-6 алкільною групою, яка необов'язково може бути заміщена; 5- або 6-членна циклоалкільна або гетероарильна група; та їх таутомери, сольвати й суміші, а також адитивно-кислотні солі цих сполук. Винахід також стосується фармацевтичних композицій, що містять сполуки загальної формули (І) як активний агент. Ангіогенез-інгібітори згідно з винаходом інгібують неоваскуляризацію в живих тканинах і, як такі, можуть бути використані для запобігання й інгібування ангіогенезу, що з'явився у зв'язку з ростом пухлин і для запобігання утворенню метастазів пухлин.
UA2002010814A 1999-08-02 2000-08-02 Похідні борелідину, які інгібують ангіогенез UA74341C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU9902628A HUP9902628A3 (en) 1999-08-02 1999-08-02 Angiogenesis inhibiting borrelidin derivatives, their use and pharmaceutical compositions containing them
PCT/HU2000/000088 WO2001009113A2 (en) 1999-08-02 2000-08-02 Heterocyclic compounds inhibiting angiogenesis

Publications (1)

Publication Number Publication Date
UA74341C2 true UA74341C2 (uk) 2005-12-15

Family

ID=89998954

Family Applications (1)

Application Number Title Priority Date Filing Date
UA2002010814A UA74341C2 (uk) 1999-08-02 2000-08-02 Похідні борелідину, які інгібують ангіогенез

Country Status (32)

Country Link
US (1) US6815465B1 (uk)
EP (1) EP1206462B1 (uk)
JP (1) JP2003506366A (uk)
KR (1) KR20020068495A (uk)
CN (1) CN1243746C (uk)
AP (1) AP1383A (uk)
AT (1) ATE241611T1 (uk)
AU (1) AU772206B2 (uk)
BG (1) BG106373A (uk)
BR (1) BR0012968A (uk)
CA (1) CA2378176A1 (uk)
CZ (1) CZ2002405A3 (uk)
DE (1) DE60003045T2 (uk)
DK (1) DK1206462T3 (uk)
ES (1) ES2200900T3 (uk)
HK (1) HK1048995B (uk)
HR (1) HRP20020103B1 (uk)
HU (1) HUP9902628A3 (uk)
IL (1) IL147904A (uk)
IS (1) IS2137B (uk)
MX (1) MXPA02001117A (uk)
NO (1) NO20020485L (uk)
NZ (1) NZ517422A (uk)
OA (1) OA12004A (uk)
PL (1) PL354281A1 (uk)
PT (1) PT1206462E (uk)
RU (1) RU2247723C2 (uk)
SK (1) SK1822002A3 (uk)
UA (1) UA74341C2 (uk)
WO (1) WO2001009113A2 (uk)
YU (1) YU7302A (uk)
ZA (1) ZA200200838B (uk)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6693099B2 (en) * 2000-10-17 2004-02-17 The Procter & Gamble Company Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance
ATE452896T1 (de) 2002-03-12 2010-01-15 Bristol Myers Squibb Co C3-cyanoepothilonderivate
GB0230217D0 (en) * 2002-12-27 2003-02-05 Biotica Tech Ltd Borrelidin-producing polyketide synthase and its uses
US8440217B1 (en) 2005-06-15 2013-05-14 Mawaheb M. EL-Naggar Method and system with contact lens product for treating and preventing adverse eye conditions
GB0609981D0 (en) * 2006-05-19 2006-06-28 Biotica Tech Ltd Novel compounds
GB0713563D0 (en) * 2007-07-13 2007-08-22 Biotica Tech Ltd Methods of screening for anti-angiogenic compounds
MX2010001462A (es) * 2007-08-27 2010-03-01 Basf Se Compuestos de pirazol para controlar plagas de invertebrados.
DE102008014077A1 (de) 2008-03-13 2009-09-17 Discovery Partner International Gmbh Borrelidin-Derivate
WO2009141786A2 (en) * 2008-05-21 2009-11-26 Piramal Life Sciences Limited Anti-inflammatory compounds
EP3492499A1 (en) 2014-12-15 2019-06-05 Borealis AG Melt-blown webs without shots and with improved barrier properties

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08173176A (ja) * 1994-12-22 1996-07-09 Mercian Corp 血管新生阻害剤
JP3786461B2 (ja) * 1996-02-22 2006-06-14 メルシャン株式会社 新生理活性物質

Also Published As

Publication number Publication date
NO20020485L (no) 2002-03-21
PL354281A1 (en) 2003-12-29
RU2247723C2 (ru) 2005-03-10
HUP9902628A3 (en) 2001-07-30
HRP20020103B1 (en) 2005-06-30
PT1206462E (pt) 2003-10-31
YU7302A (sh) 2004-09-03
CN1243746C (zh) 2006-03-01
AU6309000A (en) 2001-02-19
ES2200900T3 (es) 2004-03-16
MXPA02001117A (es) 2003-08-20
HUP9902628A2 (hu) 2001-05-28
BG106373A (en) 2002-09-30
DK1206462T3 (da) 2003-09-29
WO2001009113A3 (en) 2001-06-14
IS6258A (is) 2002-02-01
AP2002002413A0 (en) 2002-03-31
NZ517422A (en) 2005-02-25
US6815465B1 (en) 2004-11-09
KR20020068495A (ko) 2002-08-27
DE60003045T2 (de) 2004-04-01
ZA200200838B (en) 2003-08-27
IL147904A0 (en) 2002-08-14
AP1383A (en) 2005-04-05
EP1206462B1 (en) 2003-05-28
CZ2002405A3 (cs) 2002-07-17
CN1372556A (zh) 2002-10-02
JP2003506366A (ja) 2003-02-18
ATE241611T1 (de) 2003-06-15
EP1206462A2 (en) 2002-05-22
HK1048995B (zh) 2006-07-21
HU9902628D0 (en) 1999-10-28
AU772206B2 (en) 2004-04-22
IL147904A (en) 2005-09-25
HRP20020103A2 (en) 2004-02-29
CA2378176A1 (en) 2001-02-08
WO2001009113A2 (en) 2001-02-08
OA12004A (en) 2006-04-18
NO20020485D0 (no) 2002-01-30
DE60003045D1 (de) 2003-07-03
BR0012968A (pt) 2002-05-14
IS2137B (is) 2006-08-14
HK1048995A1 (en) 2003-04-25
SK1822002A3 (en) 2002-08-06

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