SI1483251T1 - C cian epotilonski derivati - Google Patents
C cian epotilonski derivatiInfo
- Publication number
- SI1483251T1 SI1483251T1 SI200331741T SI200331741T SI1483251T1 SI 1483251 T1 SI1483251 T1 SI 1483251T1 SI 200331741 T SI200331741 T SI 200331741T SI 200331741 T SI200331741 T SI 200331741T SI 1483251 T1 SI1483251 T1 SI 1483251T1
- Authority
- SI
- Slovenia
- Prior art keywords
- cyano
- epothilone derivatives
- cancer
- treatment
- proliferative diseases
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36344102P | 2002-03-12 | 2002-03-12 | |
| EP03714096A EP1483251B1 (en) | 2002-03-12 | 2003-03-11 | C3-cyano epothilone derivatives |
| PCT/US2003/007584 WO2003078411A1 (en) | 2002-03-12 | 2003-03-11 | C3-cyano epothilone derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI1483251T1 true SI1483251T1 (sl) | 2010-03-31 |
Family
ID=28041767
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200331741T SI1483251T1 (sl) | 2002-03-12 | 2003-03-11 | C cian epotilonski derivati |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6719540B2 (sl) |
| EP (1) | EP1483251B1 (sl) |
| AT (1) | ATE452896T1 (sl) |
| AU (1) | AU2003218110A1 (sl) |
| CY (1) | CY1109906T1 (sl) |
| DE (1) | DE60330651D1 (sl) |
| DK (1) | DK1483251T3 (sl) |
| ES (1) | ES2337134T3 (sl) |
| PT (1) | PT1483251E (sl) |
| SI (1) | SI1483251T1 (sl) |
| WO (1) | WO2003078411A1 (sl) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050043376A1 (en) * | 1996-12-03 | 2005-02-24 | Danishefsky Samuel J. | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
| US6242469B1 (en) | 1996-12-03 | 2001-06-05 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
| US20020058286A1 (en) * | 1999-02-24 | 2002-05-16 | Danishefsky Samuel J. | Synthesis of epothilones, intermediates thereto and analogues thereof |
| WO2003077903A1 (en) | 2002-03-12 | 2003-09-25 | Bristol-Myers Squibb Company | C12-cyano epothilone derivatives |
| CA2496477C (en) | 2002-08-23 | 2012-10-16 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
| US6921769B2 (en) | 2002-08-23 | 2005-07-26 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| US7649006B2 (en) | 2002-08-23 | 2010-01-19 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| DE10355223A1 (de) * | 2003-11-26 | 2005-06-30 | Institut für Pflanzenbiochemie (IPB) | Neue Makrocyclen zur Behandlung von Krebserkrankungen |
| GB0405898D0 (en) | 2004-03-16 | 2004-04-21 | Novartis Ag | Organic compounds |
| US20050215604A1 (en) * | 2004-03-26 | 2005-09-29 | Kosan Biosciences, Inc. | Combination therapies with epothilones and carboplatin |
| EP1824458A1 (en) * | 2004-11-18 | 2007-08-29 | Bristol-Myers Squibb Company | Enteric coated bead comprising epothilone or an epothilone analog, and preparation and administration thereof |
| SI1817013T1 (sl) * | 2004-11-18 | 2008-12-31 | Bristol Myers Squibb Co | Peleta z gastrorezistentno oblogo, ki vsebuje iksabepilon |
| US20060121511A1 (en) | 2004-11-30 | 2006-06-08 | Hyerim Lee | Biomarkers and methods for determining sensitivity to microtubule-stabilizing agents |
| EP1856255A4 (en) | 2005-02-11 | 2010-01-27 | Univ Southern California | METHODS OF EXPRESSING PROTEINS WITH DISULFIDE BRIDGES |
| US20110104664A1 (en) | 2006-03-31 | 2011-05-05 | Bristol-Myers Squibb Company | Biomarkers and methods for determining sensitivity to micortubule-stabilizing agents |
| EP2029156A4 (en) | 2006-05-01 | 2010-07-21 | Univ Southern California | POLY THERAPY FOR TREATING CANCER |
| CA2722371C (en) * | 2008-04-24 | 2016-06-21 | Bristol-Myers Squibb Company | Use of epothelone d in treating tau-associated diseases including alzheimer's disease |
| WO2010056901A2 (en) | 2008-11-13 | 2010-05-20 | University Of Southern California | Method of expressing proteins with disulfide bridges with enhanced yields and activity |
| EP2571525A4 (en) | 2010-05-18 | 2016-04-27 | Cerulean Pharma Inc | Compositions and methods for treating autoimmune and other diseases |
| US8921533B2 (en) | 2011-07-25 | 2014-12-30 | Chromatin Technologies | Glycosylated valproic acid analogs and uses thereof |
| IN2013MU03491A (sl) * | 2013-11-04 | 2015-07-31 | Emcure Pharmaceuticals Ltd |
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| US4820695A (en) | 1982-09-13 | 1989-04-11 | Eli Lilly And Company | C-20-dihydro-deoxy-(cyclic amino)-derivatives of macrolide antibiotics |
| US5217960A (en) | 1991-05-03 | 1993-06-08 | Abbott Laboratories | Erythromycin derivatives |
| DE4138042C2 (de) | 1991-11-19 | 1993-10-14 | Biotechnolog Forschung Gmbh | Epothilone, deren Herstellungsverfahren sowie diese Verbindungen enthaltende Mittel |
| TW226373B (sl) | 1992-07-15 | 1994-07-11 | Pfizer | |
| AU6019794A (en) | 1993-03-18 | 1994-10-11 | Pfizer Inc. | Antibacterial 16-membered ring macrolides containing olefins at c-20 |
| WO1995002594A1 (en) | 1993-07-15 | 1995-01-26 | Pfizer Inc. | Amide derivatives of 16-membered ring antibiotic macrolides |
| SG49853A1 (en) | 1993-08-16 | 2001-07-24 | Novartis Ag | Novel macrolides and the use thereof |
| WO1996009312A1 (en) | 1994-09-22 | 1996-03-28 | Pfizer Inc. | Antibiotic macrolides |
| IL117200A0 (en) | 1995-02-21 | 1996-06-18 | Schering Ag | Diethylenetriamine-pentaacetic acid monoamide derivatives pharmaceutical compostions containing the same and processes for the preparation thereof |
| US6124453A (en) | 1995-07-04 | 2000-09-26 | Novartis Ag | Macrolides |
| EP1440973A3 (de) | 1995-11-17 | 2004-10-20 | Gesellschaft für biotechnologische Forschung mbH (GBF) | Epothilonderivate, Herstellung und Mittel |
| EP0778283A3 (en) | 1995-12-05 | 1998-01-28 | Pfizer Inc. | Antibiotic macrolides |
| DE19613933A1 (de) | 1996-04-06 | 1997-10-09 | Merck Patent Gmbh | Cyclische Adhäsionsinhibitoren |
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| GB9615498D0 (en) | 1996-07-24 | 1996-09-04 | Ciba Geigy Ag | Kinase |
| DE69736067T9 (de) | 1996-08-30 | 2007-10-31 | University Of Hawaii, Honolulu | Neue cryptophycin-derivate als antineoplastika |
| WO1998008849A1 (de) | 1996-08-30 | 1998-03-05 | Novartis Aktiengesellschaft | Verfahren zur herstellung von epothilonen und zwischenprodukte innerhalb des verfahrens |
| EP0941227B2 (de) | 1996-11-18 | 2009-10-14 | Gesellschaft für biotechnologische Forschung mbH (GBF) | Epothilon d, dessen herstellung und dessen verwendung als cytostatisches mittel bzw. als pflanzenschutzmittel |
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| EP0975622B1 (de) | 1997-04-18 | 2002-10-09 | Studiengesellschaft Kohle mbH | Selektive olefinmetathese von bi- oder polyfunktionellen substraten in komprimiertem kohlendioxid als reaktionsmedium |
| GB9801231D0 (en) | 1997-06-05 | 1998-03-18 | Merck & Co Inc | A method of treating cancer |
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| DK1005465T3 (da) | 1997-08-09 | 2007-11-05 | Bayer Schering Pharma Ag | Nye epothilon-derivater, fremgangsmåde til fremstilling heraf og deres farmaceutiske anvendelse |
| JP2001515888A (ja) | 1997-09-08 | 2001-09-25 | ノバルティス アクチエンゲゼルシャフト | 農薬としてのヘテロ環式化合物 |
| DE19744135C1 (de) | 1997-09-29 | 1999-03-25 | Schering Ag | Beschichtete medizinische Implantate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Restenoseprophylaxe |
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| SI0948967T1 (sl) | 1998-03-02 | 2005-06-30 | Eli Lilly And Company | Zdravljenje virusne infekcije pri svinjah |
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| JP2002519427A (ja) | 1998-07-02 | 2002-07-02 | メルク エンド カムパニー インコーポレーテッド | プレニル蛋白トランスフェラーゼ阻害薬 |
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| KR100851418B1 (ko) | 1998-11-20 | 2008-08-08 | 코산 바이오사이언시즈, 인코포레이티드 | 에포틸론 및 에포틸론 유도체의 생산을 위한 재조합 방법 및 물질 |
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| EA009206B1 (ru) | 1999-02-18 | 2007-12-28 | Шеринг Акциенгезельшафт | Производные 16-галогенэпотилона и их фармацевтическое использование |
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| CA2368658A1 (en) | 1999-03-29 | 2000-10-05 | Soong-Hoon Kim | A process for the preparation of aziridinyl epothilones from oxiranyl epothilones |
| US6291684B1 (en) | 1999-03-29 | 2001-09-18 | Bristol-Myers Squibb Company | Process for the preparation of aziridinyl epothilones from oxiranyl epothilones |
| US6211412B1 (en) | 1999-03-29 | 2001-04-03 | The University Of Kansas | Synthesis of epothilones |
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| AR023792A1 (es) | 1999-04-30 | 2002-09-04 | Bayer Schering Pharma Ag | Derivados 6-alquenilo- y 6-alquinilo-epotilona, los procedimientos para prepararlos y su empleo en productos farmaceuticos |
| US6268488B1 (en) | 1999-05-25 | 2001-07-31 | Barbas, Iii Carlos F. | Prodrug activation using catalytic antibodies |
| AU6233600A (en) | 1999-07-22 | 2001-02-13 | Schering Aktiengesellschaft | Process for the production of epothiolone b and derivatives as well as intermediate products for this process |
| HUP9902628A3 (en) | 1999-08-02 | 2001-07-30 | Ivax Gyogyszerki Kft | Angiogenesis inhibiting borrelidin derivatives, their use and pharmaceutical compositions containing them |
| WO2001027308A2 (en) | 1999-10-08 | 2001-04-19 | Novartis Ag | 13-alkyl epothilone derivatives |
| US6489314B1 (en) * | 2001-04-03 | 2002-12-03 | Kosan Biosciences, Inc. | Epothilone derivatives and methods for making and using the same |
-
2003
- 2003-03-11 US US10/386,072 patent/US6719540B2/en not_active Expired - Lifetime
- 2003-03-11 AU AU2003218110A patent/AU2003218110A1/en not_active Abandoned
- 2003-03-11 WO PCT/US2003/007584 patent/WO2003078411A1/en not_active Application Discontinuation
- 2003-03-11 ES ES03714096T patent/ES2337134T3/es not_active Expired - Lifetime
- 2003-03-11 DE DE60330651T patent/DE60330651D1/de not_active Expired - Lifetime
- 2003-03-11 SI SI200331741T patent/SI1483251T1/sl unknown
- 2003-03-11 DK DK03714096.9T patent/DK1483251T3/da active
- 2003-03-11 AT AT03714096T patent/ATE452896T1/de not_active IP Right Cessation
- 2003-03-11 EP EP03714096A patent/EP1483251B1/en not_active Expired - Lifetime
- 2003-03-11 PT PT03714096T patent/PT1483251E/pt unknown
-
2010
- 2010-03-19 CY CY20101100251T patent/CY1109906T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1483251A1 (en) | 2004-12-08 |
| US20030191089A1 (en) | 2003-10-09 |
| CY1109906T1 (el) | 2014-09-10 |
| ES2337134T3 (es) | 2010-04-21 |
| EP1483251A4 (en) | 2006-02-08 |
| PT1483251E (pt) | 2010-02-26 |
| US6719540B2 (en) | 2004-04-13 |
| DK1483251T3 (da) | 2010-04-12 |
| ATE452896T1 (de) | 2010-01-15 |
| EP1483251B1 (en) | 2009-12-23 |
| WO2003078411A1 (en) | 2003-09-25 |
| AU2003218110A1 (en) | 2003-09-29 |
| DE60330651D1 (en) | 2010-02-04 |
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