MXPA05007462A - Derivados de pirrolopiridazina. - Google Patents
Derivados de pirrolopiridazina.Info
- Publication number
- MXPA05007462A MXPA05007462A MXPA05007462A MXPA05007462A MXPA05007462A MX PA05007462 A MXPA05007462 A MX PA05007462A MX PA05007462 A MXPA05007462 A MX PA05007462A MX PA05007462 A MXPA05007462 A MX PA05007462A MX PA05007462 A MXPA05007462 A MX PA05007462A
- Authority
- MX
- Mexico
- Prior art keywords
- pyrrolopyridazine derivatives
- pyrrolopyridazine
- derivatives
- pde
- tnf
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
La invencion se relaciona con un compuesto de formula (I) o su sal, en el cual R1, R2, R3 y R4 son como se definen en la descripcion, su uso como un medicamento, el procedimiento para su preparacion y el uso para el tratamiento de enfermedades mediadas por PDE-IV o TNF-( (ver formula (I)).
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2003900189A AU2003900189A0 (en) | 2003-01-09 | 2003-01-09 | Heterocyclic derivatives |
AU2003903628A AU2003903628A0 (en) | 2003-07-14 | 2003-07-14 | Pyrrolopyridazine derivatives |
PCT/JP2003/017091 WO2004063197A1 (en) | 2003-01-09 | 2003-12-26 | Pyrrolopyridazine derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA05007462A true MXPA05007462A (es) | 2006-01-27 |
Family
ID=32714072
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA05007462A MXPA05007462A (es) | 2003-01-09 | 2003-12-26 | Derivados de pirrolopiridazina. |
Country Status (22)
Country | Link |
---|---|
US (2) | US7153854B2 (es) |
EP (1) | EP1581535B3 (es) |
JP (1) | JP4671104B2 (es) |
KR (1) | KR101026819B1 (es) |
AR (1) | AR042833A1 (es) |
AT (1) | ATE376549T1 (es) |
BR (1) | BR0317358A (es) |
CA (1) | CA2513081C (es) |
CY (1) | CY1107084T1 (es) |
DE (1) | DE60317102T3 (es) |
DK (1) | DK1581535T5 (es) |
ES (1) | ES2291729T7 (es) |
HK (1) | HK1088900A1 (es) |
IL (1) | IL169500A0 (es) |
MX (1) | MXPA05007462A (es) |
NO (1) | NO20053748L (es) |
NZ (1) | NZ541232A (es) |
PL (1) | PL378245A1 (es) |
PT (1) | PT1581535E (es) |
RU (1) | RU2328499C2 (es) |
TW (1) | TWI332004B (es) |
WO (1) | WO2004063197A1 (es) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL378245A1 (pl) | 2003-01-09 | 2006-03-20 | Astellas Pharma Inc. | Pochodne pirolopirydazyny |
US7030112B2 (en) * | 2003-03-25 | 2006-04-18 | Bristol-Myers Squibb Company | Pyrrolopyridazine compounds and methods of use thereof for the treatment of proliferative disorders |
GB0411056D0 (en) | 2004-05-18 | 2004-06-23 | Novartis Ag | Organic compounds |
EP1763528B1 (en) * | 2004-07-05 | 2008-11-26 | Astellas Pharma Inc. | Pyrazolopyridine derivatives |
WO2006004191A1 (en) * | 2004-07-05 | 2006-01-12 | Astellas Pharma Inc. | Pyrrolopyridazine derivatives which inhibit pde iv and tnf alfa |
GB0422057D0 (en) * | 2004-10-05 | 2004-11-03 | Astrazeneca Ab | Novel compounds |
GB0601951D0 (en) | 2006-01-31 | 2006-03-15 | Novartis Ag | Organic compounds |
JP2010508315A (ja) | 2006-10-30 | 2010-03-18 | ノバルティス アーゲー | 抗炎症剤としてのヘテロ環式化合物 |
JP2009114123A (ja) * | 2007-11-06 | 2009-05-28 | Astellas Pharma Inc | 2−アシル−1−アミノピロール化合物の新規製造法 |
EP2674417A3 (en) * | 2007-11-21 | 2014-04-09 | Decode Genetics EHF | Biaryl PDE4 inhibitors for treating inflammation |
ES2442930T3 (es) | 2008-01-11 | 2014-02-14 | Novartis Ag | Pirimidinas como inhibidores de cinasas |
US20110105510A1 (en) * | 2008-06-17 | 2011-05-05 | Hiroshi Ishikawa | Prophylactic/ameliorating or therapeutic agent for non-alcoholic steatohepatitis |
CA2738429C (en) * | 2008-09-26 | 2016-10-25 | Intellikine, Inc. | Heterocyclic kinase inhibitors |
WO2010059836A1 (en) * | 2008-11-20 | 2010-05-27 | Decode Genetics Ehf | Substituted aza-bridged bicyclics for cardiovascular and cns disease |
RU2624506C2 (ru) | 2009-04-29 | 2017-07-04 | АМАРИН КОРПОРЕЙШН ПиЭлСи | Фармацевтические композиции, содержащие ера и сердечно-сосудистое средство, и способы их применения |
WO2011133229A2 (en) * | 2010-04-23 | 2011-10-27 | Steam Tech, Llc | Surface wiper system |
CA2799926A1 (en) * | 2010-05-28 | 2011-12-01 | Biocryst Pharmaceuticals, Inc. | Heterocyclic compounds as janus kinase inhibitors |
RS54834B1 (sr) | 2010-09-07 | 2016-10-31 | Astellas Pharma Inc | Jedinjenja pirazolokvinolina |
US8637516B2 (en) | 2010-09-09 | 2014-01-28 | Irm Llc | Compounds and compositions as TRK inhibitors |
WO2012034095A1 (en) | 2010-09-09 | 2012-03-15 | Irm Llc | Compounds and compositions as trk inhibitors |
US9034883B2 (en) | 2010-11-15 | 2015-05-19 | Boehringer Ingelheim International Gmbh | Vasoprotective and cardioprotective antidiabetic therapy |
BR112013021638A2 (pt) | 2011-02-25 | 2016-08-02 | Irm Llc | "compostos inibidores de trk, seu uso e composições que os compreendem" |
JP5988941B2 (ja) * | 2012-09-20 | 2016-09-07 | 富士フイルム株式会社 | 有機銅錯体、有機銅錯体溶液、銅酸化物薄膜、銅酸化物薄膜の製造方法、および、化合物 |
US10434132B2 (en) * | 2013-06-04 | 2019-10-08 | Academia Sinica | Galactolipids-enriched plant extracts and the uses thereof |
EP3710005B8 (en) * | 2017-11-17 | 2023-06-14 | Academia Sinica | SUBSTITUTED PYRROLO[2,1,-ALPHA]PHTHALAZINES AND BENZO[g]PYRROL[2,1,-ALPHA]PHTHALAZINES AND THEIR USES IN THE TREATMENT OF CANCER |
CA3116506C (en) * | 2018-10-17 | 2023-08-01 | Suven Life Sciences Limited | Pyrrolo-pyridazine derivatives as muscarinic m1 receptor positive allosteric modulators |
CN113825543A (zh) | 2019-03-19 | 2021-12-21 | 勃林格殷格翰动物保健美国公司 | 驱虫的氮杂-苯并噻吩和氮杂-苯并呋喃化合物 |
MX2022015038A (es) | 2020-05-29 | 2023-01-04 | Boehringer Ingelheim Animal Health Usa Inc | Compuestos heterociclicos como anthelminticos. |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH06501918A (ja) * | 1990-05-25 | 1994-03-03 | 藤沢薬品工業株式会社 | ピロロピリダジン化合物 |
EP1085021A4 (en) | 1998-05-21 | 2003-01-08 | Shionogi & Co | DERIVATIVES OF PYRROLO 1,2-B] PYRIDAZINE, WITH INHIBITOR EFFECT ON SPLA 2? |
IT1303272B1 (it) * | 1998-10-29 | 2000-11-06 | Zambon Spa | Derivati triciclici inibitori della fosfodiesterasi 4 |
FR2792938B1 (fr) * | 1999-04-28 | 2001-07-06 | Warner Lambert Co | NOUVELLES 1-AMINO TRIAZOLO [4,3-a] QUINAZOLINE-5-ONES INHIBITRICES DE PHOSPHODIESTERASES IV |
DE60136530D1 (de) * | 2000-03-01 | 2008-12-24 | Janssen Pharmaceutica Nv | 2,4-disubstituierte thiazolyl derivate |
AU2001267823A1 (en) * | 2000-06-29 | 2002-01-08 | Shionogi And Co., Ltd. | Compounds exhibiting x-type spla2 inhibiting effect |
CA2429628A1 (en) * | 2000-11-17 | 2002-05-23 | Bristol-Myers Squibb Company | Methods of treating p38 kinase-associated conditions and pyrrolotriazine compounds useful as kinase inhibitors |
TWI312347B (en) * | 2001-02-08 | 2009-07-21 | Eisai R&D Man Co Ltd | Bicyclic nitrogen-containing condensed ring compounds |
EP1426050A4 (en) * | 2001-08-23 | 2005-05-25 | Takeda Pharmaceutical | INHIBITORS OF JNK |
US6900208B2 (en) * | 2002-03-28 | 2005-05-31 | Bristol Myers Squibb Company | Pyrrolopyridazine compounds and methods of use thereof for the treatment of proliferative disorders |
PL378245A1 (pl) | 2003-01-09 | 2006-03-20 | Astellas Pharma Inc. | Pochodne pirolopirydazyny |
-
2003
- 2003-12-26 PL PL378245A patent/PL378245A1/pl unknown
- 2003-12-26 NZ NZ541232A patent/NZ541232A/en not_active IP Right Cessation
- 2003-12-26 PT PT03789642T patent/PT1581535E/pt unknown
- 2003-12-26 BR BR0317358-5A patent/BR0317358A/pt not_active IP Right Cessation
- 2003-12-26 JP JP2004566309A patent/JP4671104B2/ja not_active Expired - Fee Related
- 2003-12-26 CA CA2513081A patent/CA2513081C/en not_active Expired - Fee Related
- 2003-12-26 MX MXPA05007462A patent/MXPA05007462A/es active IP Right Grant
- 2003-12-26 EP EP03789642A patent/EP1581535B3/en not_active Expired - Lifetime
- 2003-12-26 DK DK03789642T patent/DK1581535T5/da active
- 2003-12-26 KR KR1020057012805A patent/KR101026819B1/ko not_active IP Right Cessation
- 2003-12-26 ES ES03789642T patent/ES2291729T7/es active Active
- 2003-12-26 RU RU2005125209/04A patent/RU2328499C2/ru not_active IP Right Cessation
- 2003-12-26 AT AT03789642T patent/ATE376549T1/de active
- 2003-12-26 DE DE60317102T patent/DE60317102T3/de not_active Expired - Lifetime
- 2003-12-26 WO PCT/JP2003/017091 patent/WO2004063197A1/en active IP Right Grant
- 2003-12-30 US US10/747,079 patent/US7153854B2/en not_active Expired - Fee Related
-
2004
- 2004-01-08 TW TW093100400A patent/TWI332004B/zh active
- 2004-01-09 AR ARP040100063A patent/AR042833A1/es unknown
-
2005
- 2005-07-03 IL IL169500A patent/IL169500A0/en unknown
- 2005-08-04 NO NO20053748A patent/NO20053748L/no unknown
-
2006
- 2006-08-08 US US11/500,293 patent/US7317009B2/en not_active Expired - Fee Related
- 2006-08-18 HK HK06109178A patent/HK1088900A1/xx not_active IP Right Cessation
-
2007
- 2007-12-12 CY CY20071101578T patent/CY1107084T1/el unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |