ATE376549T1 - Pyrrolopyridazin derivate - Google Patents

Pyrrolopyridazin derivate

Info

Publication number
ATE376549T1
ATE376549T1 AT03789642T AT03789642T ATE376549T1 AT E376549 T1 ATE376549 T1 AT E376549T1 AT 03789642 T AT03789642 T AT 03789642T AT 03789642 T AT03789642 T AT 03789642T AT E376549 T1 ATE376549 T1 AT E376549T1
Authority
AT
Austria
Prior art keywords
pyrrolopyridazine derivatives
pyrrolopyridazine
derivatives
Prior art date
Application number
AT03789642T
Other languages
English (en)
Inventor
Yoshito Abe
Makoto Inoue
T Mizutani
Kozo Sawada
Kazuhiko Ohne
M Okumura
Yuki Sawada
K Imamura
Original Assignee
Astellas Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2003900189A external-priority patent/AU2003900189A0/en
Priority claimed from AU2003903628A external-priority patent/AU2003903628A0/en
Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc
Application granted granted Critical
Publication of ATE376549T1 publication Critical patent/ATE376549T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AT03789642T 2003-01-09 2003-12-26 Pyrrolopyridazin derivate ATE376549T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AU2003900189A AU2003900189A0 (en) 2003-01-09 2003-01-09 Heterocyclic derivatives
AU2003903628A AU2003903628A0 (en) 2003-07-14 2003-07-14 Pyrrolopyridazine derivatives

Publications (1)

Publication Number Publication Date
ATE376549T1 true ATE376549T1 (de) 2007-11-15

Family

ID=32714072

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03789642T ATE376549T1 (de) 2003-01-09 2003-12-26 Pyrrolopyridazin derivate

Country Status (22)

Country Link
US (2) US7153854B2 (de)
EP (1) EP1581535B3 (de)
JP (1) JP4671104B2 (de)
KR (1) KR101026819B1 (de)
AR (1) AR042833A1 (de)
AT (1) ATE376549T1 (de)
BR (1) BR0317358A (de)
CA (1) CA2513081C (de)
CY (1) CY1107084T1 (de)
DE (1) DE60317102T3 (de)
DK (1) DK1581535T5 (de)
ES (1) ES2291729T7 (de)
HK (1) HK1088900A1 (de)
IL (1) IL169500A0 (de)
MX (1) MXPA05007462A (de)
NO (1) NO20053748L (de)
NZ (1) NZ541232A (de)
PL (1) PL378245A1 (de)
PT (1) PT1581535E (de)
RU (1) RU2328499C2 (de)
TW (1) TWI332004B (de)
WO (1) WO2004063197A1 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2328499C2 (ru) 2003-01-09 2008-07-10 Астеллас Фарма Инк. Производные пирролопиридазина, фармацевтическая композиция, способ профилактики или лечения заболеваний, применение в качестве ингибитора фосфодиэстеразы iv, и/или продуцирования tnf
US7030112B2 (en) * 2003-03-25 2006-04-18 Bristol-Myers Squibb Company Pyrrolopyridazine compounds and methods of use thereof for the treatment of proliferative disorders
GB0411056D0 (en) 2004-05-18 2004-06-23 Novartis Ag Organic compounds
WO2006004191A1 (en) * 2004-07-05 2006-01-12 Astellas Pharma Inc. Pyrrolopyridazine derivatives which inhibit pde iv and tnf alfa
US7459451B2 (en) * 2004-07-05 2008-12-02 Astellas Pharma Inc. Pyrazolopyridine derivatives
GB0422057D0 (en) * 2004-10-05 2004-11-03 Astrazeneca Ab Novel compounds
GB0601951D0 (en) 2006-01-31 2006-03-15 Novartis Ag Organic compounds
WO2008052734A1 (en) 2006-10-30 2008-05-08 Novartis Ag Heterocyclic compounds as antiinflammatory agents
JP2009114123A (ja) * 2007-11-06 2009-05-28 Astellas Pharma Inc ２−アシル−１−アミノピロール化合物の新規製造法
WO2009067621A1 (en) * 2007-11-21 2009-05-28 Decode Genetics Ehf Biaryl pde4 inhibitors for treating pulmonary and cardiovascular disorders
PT2231642E (pt) 2008-01-11 2014-03-12 Novartis Ag Pirimidinas como inibidores de quinase
WO2009154230A1 (ja) * 2008-06-17 2009-12-23 持田製薬株式会社 非アルコール性脂肪肝炎の予防／改善・治療薬
WO2010036380A1 (en) 2008-09-26 2010-04-01 Intellikine, Inc. Heterocyclic kinase inhibitors
WO2010059836A1 (en) * 2008-11-20 2010-05-27 Decode Genetics Ehf Substituted aza-bridged bicyclics for cardiovascular and cns disease
NZ789295A (en) 2009-04-29 2024-02-23 Amarin Pharmaceuticals Ie Ltd Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same
WO2011133229A2 (en) * 2010-04-23 2011-10-27 Steam Tech, Llc Surface wiper system
AU2011258005A1 (en) * 2010-05-28 2013-01-17 Biocryst Pharmaceuticals, Inc. Heterocyclic compounds as Janus kinase inhibitors
EA023493B1 (ru) 2010-09-07 2016-06-30 Астеллас Фарма Инк. Производное пиразолохинолина
WO2012034095A1 (en) 2010-09-09 2012-03-15 Irm Llc Compounds and compositions as trk inhibitors
UY33597A (es) 2010-09-09 2012-04-30 Irm Llc Compuestos y composiciones como inhibidores de la trk
US9034883B2 (en) 2010-11-15 2015-05-19 Boehringer Ingelheim International Gmbh Vasoprotective and cardioprotective antidiabetic therapy
CA2828219A1 (en) 2011-02-25 2012-08-30 Irm Llc Pyrazolo [1,5-a] pyridines as trk inhibitors
JP5988941B2 (ja) * 2012-09-20 2016-09-07 富士フイルム株式会社 有機銅錯体、有機銅錯体溶液、銅酸化物薄膜、銅酸化物薄膜の製造方法、および、化合物
US10434132B2 (en) * 2013-06-04 2019-10-08 Academia Sinica Galactolipids-enriched plant extracts and the uses thereof
EP3710005B8 (de) * 2017-11-17 2023-06-14 Academia Sinica SUBSTITUIERTE PYRROLO[2,1,-ALPHA]PHTHALAZINE- UND BENZO[g]PYRROL[2,1,-ALPHA]PHTHALAZINEDERIVATE UND IHRE VERWENDUNG ZUR BEHANDLUNG VON KREBS
BR112021007168A2 (pt) * 2018-10-17 2021-08-10 Suven Life Sciences Limited derivados de pirrolo-piridazina como moduladores alostericos positivos do receptor muscarínico m1
KR20220002890A (ko) 2019-03-19 2022-01-07 뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드 구충성 아자-벤조티오펜 및 아자-벤조푸란 화합물
KR20230028268A (ko) 2020-05-29 2023-02-28 뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드 구충성 헤테로시클릭 화합물

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06501918A (ja) * 1990-05-25 1994-03-03 藤沢薬品工業株式会社 ピロロピリダジン化合物
BR9911048A (pt) 1998-05-21 2001-02-06 Shionogi & Co Inibidor de spla2 de pirrolo[1,2-b]piridazina
IT1303272B1 (it) * 1998-10-29 2000-11-06 Zambon Spa Derivati triciclici inibitori della fosfodiesterasi 4
FR2792938B1 (fr) * 1999-04-28 2001-07-06 Warner Lambert Co NOUVELLES 1-AMINO TRIAZOLO [4,3-a] QUINAZOLINE-5-ONES INHIBITRICES DE PHOSPHODIESTERASES IV
WO2001064674A1 (en) * 2000-03-01 2001-09-07 Janssen Pharmaceutica N.V. 2,4-disubstituted thiazolyl derivatives
JPWO2002000621A1 (ja) * 2000-06-29 2004-04-22 塩野義製薬株式会社 Ｘ型ｓＰＬＡ２阻害作用を有する化合物
CZ20031370A3 (cs) * 2000-11-17 2003-10-15 Bristol-Myers Squibb Company Způsob léčení stavů souvisejících s p38 kinázou a pyrrolotriazinové sloučeniny použitelné jako inhibitory kináz
TWI312347B (en) * 2001-02-08 2009-07-21 Eisai R&D Man Co Ltd Bicyclic nitrogen-containing condensed ring compounds
US20040254189A1 (en) * 2001-08-23 2004-12-16 Hideaki Nagaya Jnk inhibitors
US6900208B2 (en) * 2002-03-28 2005-05-31 Bristol Myers Squibb Company Pyrrolopyridazine compounds and methods of use thereof for the treatment of proliferative disorders
RU2328499C2 (ru) 2003-01-09 2008-07-10 Астеллас Фарма Инк. Производные пирролопиридазина, фармацевтическая композиция, способ профилактики или лечения заболеваний, применение в качестве ингибитора фосфодиэстеразы iv, и/или продуцирования tnf

Also Published As

Publication number Publication date
ES2291729T3 (es) 2008-03-01
CA2513081C (en) 2011-04-19
WO2004063197A1 (en) 2004-07-29
KR20050092738A (ko) 2005-09-22
KR101026819B1 (ko) 2011-04-04
PL378245A1 (pl) 2006-03-20
CA2513081A1 (en) 2004-07-29
IL169500A0 (en) 2007-07-04
JP2006515597A (ja) 2006-06-01
US20050075342A1 (en) 2005-04-07
NO20053748D0 (no) 2005-08-04
JP4671104B2 (ja) 2011-04-13
TW200418861A (en) 2004-10-01
EP1581535A1 (de) 2005-10-05
US7317009B2 (en) 2008-01-08
RU2328499C2 (ru) 2008-07-10
EP1581535B3 (de) 2009-09-02
NZ541232A (en) 2008-02-29
DE60317102T3 (de) 2010-02-18
NO20053748L (no) 2005-10-07
CY1107084T1 (el) 2012-10-24
HK1088900A1 (en) 2006-11-17
PT1581535E (pt) 2007-12-12
MXPA05007462A (es) 2006-01-27
US7153854B2 (en) 2006-12-26
BR0317358A (pt) 2005-12-13
TWI332004B (en) 2010-10-21
AR042833A1 (es) 2005-07-06
DK1581535T3 (da) 2008-02-11
EP1581535B1 (de) 2007-10-24
DE60317102T2 (de) 2009-01-29
RU2005125209A (ru) 2006-01-27
DK1581535T5 (da) 2009-12-21
EP1581535B9 (de) 2008-03-19
ES2291729T7 (es) 2010-03-31
US20060270678A1 (en) 2006-11-30
DE60317102D1 (de) 2007-12-06

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