MXPA05006530A - Derivados de 1-n-fenilamino-1h-imidazola como inhibidores aromatasa. - Google Patents

Derivados de 1-n-fenilamino-1h-imidazola como inhibidores aromatasa.

Info

Publication number
MXPA05006530A
MXPA05006530A MXPA05006530A MXPA05006530A MXPA05006530A MX PA05006530 A MXPA05006530 A MX PA05006530A MX PA05006530 A MXPA05006530 A MX PA05006530A MX PA05006530 A MXPA05006530 A MX PA05006530A MX PA05006530 A MXPA05006530 A MX PA05006530A
Authority
MX
Mexico
Prior art keywords
phenylamino
imidazole derivatives
aromatase inhibitors
derivatives
relates
Prior art date
Application number
MXPA05006530A
Other languages
English (en)
Inventor
Jean-Claude Pascal
Original Assignee
Theramex
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP02293107A external-priority patent/EP1431292A1/en
Application filed by Theramex filed Critical Theramex
Publication of MXPA05006530A publication Critical patent/MXPA05006530A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/61—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms not forming part of a nitro radical, attached to ring nitrogen atoms
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/16—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • C07D231/40—Acylated on said nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Dentistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Plant Pathology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicinal Preparation (AREA)

Abstract

La presente invencion refiere a derivados de imidazola de la formula (I) en donde R1, R2, R3, R4, R5, R6 y n son como de definen en la especificacion. La invencion tambien refiere a compuestos farmaceuticos conteniendo estos derivados, y a usos de los mismos.
MXPA05006530A 2002-12-16 2003-12-15 Derivados de 1-n-fenilamino-1h-imidazola como inhibidores aromatasa. MXPA05006530A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US43384102P 2002-12-16 2002-12-16
EP02293107A EP1431292A1 (en) 2002-12-16 2002-12-16 1-N-phenylamino-1H-imidazole derivatives as aromatase inhibitors
PCT/EP2003/015027 WO2004054983A2 (en) 2002-12-16 2003-12-15 1-n-phenylamino-1h-imidazole derivatives as aromatase inhibitors

Publications (1)

Publication Number Publication Date
MXPA05006530A true MXPA05006530A (es) 2006-02-17

Family

ID=42041569

Family Applications (2)

Application Number Title Priority Date Filing Date
MXPA03011500A MXPA03011500A (es) 2002-12-16 2003-12-11 N-fenil-3-ciclopropilpirazol-4-carbonitrilos como agentes ectoparasiticidas.
MXPA05006530A MXPA05006530A (es) 2002-12-16 2003-12-15 Derivados de 1-n-fenilamino-1h-imidazola como inhibidores aromatasa.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MXPA03011500A MXPA03011500A (es) 2002-12-16 2003-12-11 N-fenil-3-ciclopropilpirazol-4-carbonitrilos como agentes ectoparasiticidas.

Country Status (23)

Country Link
EP (2) EP1431291A1 (es)
JP (2) JP2004196795A (es)
KR (1) KR20050084299A (es)
CN (1) CN100390151C (es)
AT (1) ATE325102T1 (es)
AU (2) AU2003268835A1 (es)
BR (1) BR0317339A (es)
CA (1) CA2510175C (es)
CY (1) CY1106317T1 (es)
DE (1) DE60305069T2 (es)
DK (1) DK1572665T3 (es)
ES (1) ES2264032T3 (es)
HK (1) HK1083218A1 (es)
MA (1) MA27502A1 (es)
MX (2) MXPA03011500A (es)
NO (1) NO330337B1 (es)
NZ (1) NZ540643A (es)
PL (1) PL377095A1 (es)
PT (1) PT1572665E (es)
RU (1) RU2327691C2 (es)
SI (1) SI1572665T1 (es)
UA (1) UA80307C2 (es)
ZA (1) ZA200504570B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1890221B (zh) * 2003-12-15 2014-07-16 沙拉麦斯实验公司 1-n-苯基-氨基-1h-咪唑衍生物和含有它们的医药组合物
US20060288955A1 (en) * 2005-05-24 2006-12-28 Wyeth Device and method for controlling insects
TWI368505B (en) * 2005-05-24 2012-07-21 Wyeth Corp Versatile high load concentrate compositions for control of ecto-parasites
WO2011057984A1 (de) * 2009-11-11 2011-05-19 Bayer Cropscience Ag Neue diazinyl-pyrazolylverbindungen
CN103275013A (zh) * 2013-05-27 2013-09-04 云南大学 一种新型含氮杂环磺酰胺衍生物型芳香化酶抑制剂及其制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5232940A (en) * 1985-12-20 1993-08-03 Hatton Leslie R Derivatives of N-phenylpyrazoles
US6372774B1 (en) * 1985-12-20 2002-04-16 Rhone-Poulenc Agriculture Ltd. Derivatives of N-phenylpyrazoles
GB8531485D0 (en) * 1985-12-20 1986-02-05 May & Baker Ltd Compositions of matter
US4749713A (en) * 1986-03-07 1988-06-07 Ciba-Geigy Corporation Alpha-heterocycle substituted tolunitriles
US5071861A (en) * 1986-03-07 1991-12-10 Ciba-Geigy Corporation Alpha-heterocycle substituted tolunitriles
WO1993005027A1 (en) * 1991-09-02 1993-03-18 Yamanouchi Pharmaceutical Co., Ltd. Triazolylated tertiary amine compound or salt thereof
JP2500849B2 (ja) * 1991-09-02 1996-05-29 山之内製薬株式会社 トリアゾリル置換３級アミノ化合物又はその塩
GB2273704B (en) * 1992-12-16 1997-01-22 Orion Yhtymae Oy Triazolyl diaryl selective aromatase inhibiting compounds
KR20040035846A (ko) * 2001-09-25 2004-04-29 바스프 악티엔게젤샤프트 살충성 및 살진드기성 3-치환된 피라졸

Also Published As

Publication number Publication date
CA2510175C (en) 2011-07-05
NO330337B1 (no) 2011-03-28
UA80307C2 (en) 2007-09-10
CN1720235A (zh) 2006-01-11
KR20050084299A (ko) 2005-08-26
ATE325102T1 (de) 2006-06-15
MXPA03011500A (es) 2004-09-10
PT1572665E (pt) 2006-09-29
DE60305069T2 (de) 2006-12-07
AU2003298259A1 (en) 2004-07-09
CY1106317T1 (el) 2011-10-12
NO20052780L (no) 2005-06-08
PL377095A1 (pl) 2006-01-23
CA2510175A1 (en) 2004-07-01
RU2327691C2 (ru) 2008-06-27
ES2264032T3 (es) 2006-12-16
EP1431291A1 (en) 2004-06-23
BR0317339A (pt) 2005-11-08
DK1572665T3 (da) 2006-08-28
JP2004196795A (ja) 2004-07-15
RU2005122469A (ru) 2006-02-27
ZA200504570B (en) 2006-08-30
DE60305069D1 (de) 2006-06-08
MA27502A1 (fr) 2005-08-01
JP2006511546A (ja) 2006-04-06
AU2003298259B2 (en) 2009-04-02
EP1572665A2 (en) 2005-09-14
NZ540643A (en) 2007-11-30
SI1572665T1 (sl) 2006-10-31
AU2003268835A1 (en) 2004-07-01
HK1083218A1 (en) 2006-06-30
CN100390151C (zh) 2008-05-28
EP1572665B1 (en) 2006-05-03

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