ATE452896T1 - C3-cyanoepothilonderivate - Google Patents
C3-cyanoepothilonderivateInfo
- Publication number
- ATE452896T1 ATE452896T1 AT03714096T AT03714096T ATE452896T1 AT E452896 T1 ATE452896 T1 AT E452896T1 AT 03714096 T AT03714096 T AT 03714096T AT 03714096 T AT03714096 T AT 03714096T AT E452896 T1 ATE452896 T1 AT E452896T1
- Authority
- AT
- Austria
- Prior art keywords
- cyanoepothilone
- derivatives
- cancer
- treatment
- proliferative diseases
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Mechanical Pencils And Projecting And Retracting Systems Therefor, And Multi-System Writing Instruments (AREA)
- Lubricants (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36344102P | 2002-03-12 | 2002-03-12 | |
| PCT/US2003/007584 WO2003078411A1 (en) | 2002-03-12 | 2003-03-11 | C3-cyano epothilone derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE452896T1 true ATE452896T1 (de) | 2010-01-15 |
Family
ID=28041767
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03714096T ATE452896T1 (de) | 2002-03-12 | 2003-03-11 | C3-cyanoepothilonderivate |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6719540B2 (de) |
| EP (1) | EP1483251B1 (de) |
| AT (1) | ATE452896T1 (de) |
| AU (1) | AU2003218110A1 (de) |
| CY (1) | CY1109906T1 (de) |
| DE (1) | DE60330651D1 (de) |
| DK (1) | DK1483251T3 (de) |
| ES (1) | ES2337134T3 (de) |
| PT (1) | PT1483251E (de) |
| SI (1) | SI1483251T1 (de) |
| WO (1) | WO2003078411A1 (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0977563B1 (de) | 1996-12-03 | 2005-10-12 | Sloan-Kettering Institute For Cancer Research | Synthese von epothilonen, zwischenprodukte dazu, analoga und verwendungen davon |
| US20050043376A1 (en) * | 1996-12-03 | 2005-02-24 | Danishefsky Samuel J. | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
| US20020058286A1 (en) * | 1999-02-24 | 2002-05-16 | Danishefsky Samuel J. | Synthesis of epothilones, intermediates thereto and analogues thereof |
| US7211593B2 (en) | 2002-03-12 | 2007-05-01 | Bristol-Myers Squibb Co. | C12-cyano epothilone derivatives |
| US7649006B2 (en) | 2002-08-23 | 2010-01-19 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| US6921769B2 (en) | 2002-08-23 | 2005-07-26 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| WO2004018478A2 (en) * | 2002-08-23 | 2004-03-04 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
| DE10355223A1 (de) * | 2003-11-26 | 2005-06-30 | Institut für Pflanzenbiochemie (IPB) | Neue Makrocyclen zur Behandlung von Krebserkrankungen |
| GB0405898D0 (en) | 2004-03-16 | 2004-04-21 | Novartis Ag | Organic compounds |
| US20050215604A1 (en) * | 2004-03-26 | 2005-09-29 | Kosan Biosciences, Inc. | Combination therapies with epothilones and carboplatin |
| EP1824458A1 (de) * | 2004-11-18 | 2007-08-29 | Bristol-Myers Squibb Company | Kügelchen mit magensaftresistentem überzug mit epothilon oder einem epothilon-analogon und seine herstellung und verabreichung |
| BRPI0518286A2 (pt) * | 2004-11-18 | 2008-11-11 | Bristol Myers Squibb Co | microesfera com revestimento entÉrico contendo ixabepilona e sua preparaÇço |
| US20060121511A1 (en) | 2004-11-30 | 2006-06-08 | Hyerim Lee | Biomarkers and methods for determining sensitivity to microtubule-stabilizing agents |
| EP1856255A4 (de) | 2005-02-11 | 2010-01-27 | Univ Southern California | Verfahren zur expression von proteinen über disulfidbrücken |
| US20110104664A1 (en) | 2006-03-31 | 2011-05-05 | Bristol-Myers Squibb Company | Biomarkers and methods for determining sensitivity to micortubule-stabilizing agents |
| EP2029156A4 (de) * | 2006-05-01 | 2010-07-21 | Univ Southern California | Kombinationstherapie zur krebsbehandlung |
| MX2010011209A (es) * | 2008-04-24 | 2010-11-12 | Squibb Bristol Myers Co | Uso de epotilona d en el tratamiento de enfermedades asociadas a tau incluyendo enfermedad de alzheimer. |
| US8802394B2 (en) | 2008-11-13 | 2014-08-12 | Radu O. Minea | Method of expressing proteins with disulfide bridges with enhanced yields and activity |
| CA2799202C (en) | 2010-05-18 | 2016-07-05 | Cerulean Pharma Inc. | Compositions and methods for treatment of autoimmune and other diseases |
| US8921533B2 (en) | 2011-07-25 | 2014-12-30 | Chromatin Technologies | Glycosylated valproic acid analogs and uses thereof |
| IN2013MU03491A (de) * | 2013-11-04 | 2015-07-31 | Emcure Pharmaceuticals Ltd |
Family Cites Families (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4272525A (en) | 1978-10-23 | 1981-06-09 | Schering Corporation | Derivatives of polyene macrolide antibiotics containing an amino sugar moiety, process for the preparation thereof, and pharmaceutical compositions containing them |
| US4820695A (en) | 1982-09-13 | 1989-04-11 | Eli Lilly And Company | C-20-dihydro-deoxy-(cyclic amino)-derivatives of macrolide antibiotics |
| US5217960A (en) | 1991-05-03 | 1993-06-08 | Abbott Laboratories | Erythromycin derivatives |
| DE4138042C2 (de) | 1991-11-19 | 1993-10-14 | Biotechnolog Forschung Gmbh | Epothilone, deren Herstellungsverfahren sowie diese Verbindungen enthaltende Mittel |
| TW226373B (de) | 1992-07-15 | 1994-07-11 | Pfizer | |
| AU6019794A (en) | 1993-03-18 | 1994-10-11 | Pfizer Inc. | Antibacterial 16-membered ring macrolides containing olefins at c-20 |
| US5716939A (en) | 1993-07-15 | 1998-02-10 | Pfizer Inc. | Amide derivatives of 16-membered ring antibiotic macrolides |
| SG49853A1 (en) | 1993-08-16 | 2001-07-24 | Novartis Ag | Novel macrolides and the use thereof |
| AU3121095A (en) | 1994-09-22 | 1996-04-09 | Pfizer Inc. | Antibiotic macrolides |
| IL117200A0 (en) | 1995-02-21 | 1996-06-18 | Schering Ag | Diethylenetriamine-pentaacetic acid monoamide derivatives pharmaceutical compostions containing the same and processes for the preparation thereof |
| US6124453A (en) | 1995-07-04 | 2000-09-26 | Novartis Ag | Macrolides |
| EP1440973A3 (de) | 1995-11-17 | 2004-10-20 | Gesellschaft für biotechnologische Forschung mbH (GBF) | Epothilonderivate, Herstellung und Mittel |
| EP0778283A3 (de) | 1995-12-05 | 1998-01-28 | Pfizer Inc. | Antibiotische Makrolide |
| DE19613933A1 (de) | 1996-04-06 | 1997-10-09 | Merck Patent Gmbh | Cyclische Adhäsionsinhibitoren |
| US6174434B1 (en) | 1996-04-26 | 2001-01-16 | The Lenox Institute Of Water Technology, Inc. | Three zone dissolved air floatation clarifier with fixed lamellae and improved paddle-and-ramp sludge removal system |
| ATE278711T1 (de) | 1996-07-11 | 2004-10-15 | Novo Nordisk As | Verfahren zur selektiven acetylierung |
| GB9615498D0 (en) | 1996-07-24 | 1996-09-04 | Ciba Geigy Ag | Kinase |
| DK0934065T3 (da) | 1996-08-30 | 2006-10-09 | Univ Hawaii | Hidtil ukendte cruptophycinderivater som antieoplastiske midler |
| WO1998008849A1 (de) | 1996-08-30 | 1998-03-05 | Novartis Aktiengesellschaft | Verfahren zur herstellung von epothilonen und zwischenprodukte innerhalb des verfahrens |
| PL193229B1 (pl) | 1996-11-18 | 2007-01-31 | F Biotechnologische Forschung | Epotylon C, epotylon D, epotylon E i epotylon F, sposób biotransformacji epotylonu A, sposób biotransformacji epotylonu B oraz środek leczniczy |
| US6515016B2 (en) | 1996-12-02 | 2003-02-04 | Angiotech Pharmaceuticals, Inc. | Composition and methods of paclitaxel for treating psoriasis |
| EP0977563B1 (de) | 1996-12-03 | 2005-10-12 | Sloan-Kettering Institute For Cancer Research | Synthese von epothilonen, zwischenprodukte dazu, analoga und verwendungen davon |
| US6204388B1 (en) | 1996-12-03 | 2001-03-20 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| US6441186B1 (en) | 1996-12-13 | 2002-08-27 | The Scripps Research Institute | Epothilone analogs |
| US6380394B1 (en) * | 1996-12-13 | 2002-04-30 | The Scripps Research Institute | Epothilone analogs |
| WO1998038192A1 (de) | 1997-02-25 | 1998-09-03 | GESELLSCHAFT FüR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) | Seitenkettenmodifizierte epothilone |
| EP0975622B1 (de) | 1997-04-18 | 2002-10-09 | Studiengesellschaft Kohle mbH | Selektive olefinmetathese von bi- oder polyfunktionellen substraten in komprimiertem kohlendioxid als reaktionsmedium |
| GB9801231D0 (en) | 1997-06-05 | 1998-03-18 | Merck & Co Inc | A method of treating cancer |
| US6605599B1 (en) | 1997-07-08 | 2003-08-12 | Bristol-Myers Squibb Company | Epothilone derivatives |
| ES2184307T3 (es) | 1997-07-16 | 2003-04-01 | Schering Ag | Derivados de tiazol, procedimiento para su preparacion y su utilizacion. |
| US6140051A (en) | 1997-07-21 | 2000-10-31 | Promega Biosciences, Inc. | Fluorescent dibenzazole derivatives and methods related thereto |
| JP2001512723A (ja) | 1997-08-09 | 2001-08-28 | シエーリング アクチエンゲゼルシヤフト | 新規エポチロン誘導体、その製法およびその薬学的使用 |
| AU9537298A (en) | 1997-09-08 | 1999-03-29 | Novartis Ag | Heterocyclic compounds as pesticides |
| DE19744135C1 (de) | 1997-09-29 | 1999-03-25 | Schering Ag | Beschichtete medizinische Implantate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Restenoseprophylaxe |
| US6365749B1 (en) | 1997-12-04 | 2002-04-02 | Bristol-Myers Squibb Company | Process for the preparation of ring-opened epothilone intermediates which are useful for the preparation of epothilone analogs |
| US6320045B1 (en) | 1997-12-04 | 2001-11-20 | Bristol-Myers Squibb Company | Process for the reduction of oxiranyl epothilones to olefinic epothilones |
| US6090601A (en) | 1998-01-23 | 2000-07-18 | Kosan Bioscience | Sorangium polyketide synthase |
| MXPA00008365A (es) | 1998-02-25 | 2002-11-07 | Sloan Kettering Inst Cancer | Sintesis de epotilonas, intermediarios y analogos de las mismas. |
| DK0948967T3 (da) | 1998-03-02 | 2005-02-14 | Lilly Co Eli | Behandling af virussygdom hos svin |
| US6498257B1 (en) | 1998-04-21 | 2002-12-24 | Bristol-Myers Squibb Company | 2,3-olefinic epothilone derivatives |
| US6380395B1 (en) | 1998-04-21 | 2002-04-30 | Bristol-Myers Squibb Company | 12, 13-cyclopropane epothilone derivatives |
| DE19820599A1 (de) | 1998-05-08 | 1999-11-11 | Biotechnolog Forschung Gmbh | Epothilonderivate, Verfahren zu deren Herstellung und deren Verwendung |
| JP2002516090A (ja) | 1998-05-28 | 2002-06-04 | コーサン バイオサイエンシーズ， インコーポレイテッド | 組換えナルボノライドポリケチドシンターゼ |
| EP1087951B9 (de) | 1998-06-18 | 2006-09-13 | Bristol-Myers Squibb Company | Durch kohlenstoff substituierte aminothiazole als inhibitoren von zyclin-abhägigen kinasen |
| DE19826988A1 (de) | 1998-06-18 | 1999-12-23 | Biotechnolog Forschung Gmbh | Epothilon-Nebenkomponenten |
| NZ508326A (en) | 1998-06-18 | 2003-10-31 | Novartis Ag | A polyketide synthase and non ribosomal peptide synthase genes, isolated from a myxobacterium, necessary for synthesis of epothiones A and B |
| US6121029A (en) | 1998-06-18 | 2000-09-19 | Novartis Ag | Genes for the biosynthesis of epothilones |
| WO1999067253A2 (en) | 1998-06-22 | 1999-12-29 | Novartis Ag | Desmethyl epothilones |
| JP2002519428A (ja) | 1998-07-02 | 2002-07-02 | メルク エンド カムパニー インコーポレーテッド | プレニル−タンパク質トランスフェラーゼの阻害剤 |
| US6410534B1 (en) | 1998-07-02 | 2002-06-25 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
| DE19848306A1 (de) | 1998-10-14 | 2000-04-20 | Schering Ag | Verfahren zur Herstellung von Epothilon B und Derivaten sowie Zwischenprodukte für dieses Verfahren |
| CA2347412A1 (en) | 1998-10-29 | 2000-05-11 | Kosan Biosciences, Inc. | Recombinant oleandolide polyketide synthase |
| EP1135470A2 (de) | 1998-11-20 | 2001-09-26 | Kosan Biosciences, Inc. | Rekombinante methoden und produkte zur herstellung von epothilone und epothilone derivaten |
| AU2795000A (en) | 1998-12-22 | 2000-07-12 | Novartis Ag | Epothilone derivatives and their use as antitumor agents |
| HUP0200296A2 (en) | 1998-12-23 | 2002-05-29 | Bristol Myers Squibb Co | Microbial transformation method for the preparation of an epothilone |
| PL350190A1 (en) | 1999-02-11 | 2002-11-18 | Schering Ag | Epothilon derivatives, method for the production and the use thereof as pharmaceuticals |
| DE19908760A1 (de) | 1999-02-18 | 2000-08-24 | Schering Ag | Neue Epothilon-Derivate, Verfahren zu deren Herstellung und ihre pharmazeutische Verwendung |
| DE19908763A1 (de) | 1999-02-18 | 2000-08-24 | Schering Ag | Neue Epothilon-Derivate, Verfahren zu deren Herstellung und ihre pharmazeutische Verwendung |
| AU3156700A (en) | 1999-02-18 | 2000-09-04 | Schering Aktiengesellschaft | 16-halogen-epothilone derivatives, method for producing them and their pharmaceutical use |
| SK287200B6 (sk) | 1999-02-22 | 2010-03-08 | Gesellschaft Fuer Biotechnologische Forschung Mbh (Gbf) | C-21 modifikované epotilóny, spôsob ich prípravy, farmaceutický prostriedok s ich obsahom a použitie |
| WO2000057874A1 (en) | 1999-03-29 | 2000-10-05 | Bristol-Myers Squibb Co. | A process for the preparation of aziridinyl epothilones from oxiranyl epothilones |
| US6291684B1 (en) | 1999-03-29 | 2001-09-18 | Bristol-Myers Squibb Company | Process for the preparation of aziridinyl epothilones from oxiranyl epothilones |
| US6211412B1 (en) | 1999-03-29 | 2001-04-03 | The University Of Kansas | Synthesis of epothilones |
| ATE340183T1 (de) | 1999-04-16 | 2006-10-15 | Kosan Biosciences Inc | Antiinfektiöse makrolidderivate |
| AR023792A1 (es) | 1999-04-30 | 2002-09-04 | Bayer Schering Pharma Ag | Derivados 6-alquenilo- y 6-alquinilo-epotilona, los procedimientos para prepararlos y su empleo en productos farmaceuticos |
| US6268488B1 (en) | 1999-05-25 | 2001-07-31 | Barbas, Iii Carlos F. | Prodrug activation using catalytic antibodies |
| EP1226142A2 (de) | 1999-07-22 | 2002-07-31 | Schering Aktiengesellschaft | Verfahren zur herstellung von epothiolon-b und derivaten davon, sowie von zwischenprodukten für dieses verfahren |
| HUP9902628A3 (en) | 1999-08-02 | 2001-07-30 | Ivax Gyogyszerki Kft | Angiogenesis inhibiting borrelidin derivatives, their use and pharmaceutical compositions containing them |
| CA2425620A1 (en) | 1999-10-08 | 2001-04-19 | The Scripps Research Institute | 13-alkyl epothilone derivatives |
| US6489314B1 (en) * | 2001-04-03 | 2002-12-03 | Kosan Biosciences, Inc. | Epothilone derivatives and methods for making and using the same |
-
2003
- 2003-03-11 DK DK03714096.9T patent/DK1483251T3/da active
- 2003-03-11 ES ES03714096T patent/ES2337134T3/es not_active Expired - Lifetime
- 2003-03-11 WO PCT/US2003/007584 patent/WO2003078411A1/en not_active Ceased
- 2003-03-11 DE DE60330651T patent/DE60330651D1/de not_active Expired - Lifetime
- 2003-03-11 AU AU2003218110A patent/AU2003218110A1/en not_active Abandoned
- 2003-03-11 SI SI200331741T patent/SI1483251T1/sl unknown
- 2003-03-11 US US10/386,072 patent/US6719540B2/en not_active Expired - Lifetime
- 2003-03-11 AT AT03714096T patent/ATE452896T1/de not_active IP Right Cessation
- 2003-03-11 EP EP03714096A patent/EP1483251B1/de not_active Expired - Lifetime
- 2003-03-11 PT PT03714096T patent/PT1483251E/pt unknown
-
2010
- 2010-03-19 CY CY20101100251T patent/CY1109906T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CY1109906T1 (el) | 2014-09-10 |
| PT1483251E (pt) | 2010-02-26 |
| WO2003078411A1 (en) | 2003-09-25 |
| DK1483251T3 (da) | 2010-04-12 |
| EP1483251A4 (de) | 2006-02-08 |
| EP1483251A1 (de) | 2004-12-08 |
| DE60330651D1 (en) | 2010-02-04 |
| EP1483251B1 (de) | 2009-12-23 |
| US20030191089A1 (en) | 2003-10-09 |
| ES2337134T3 (es) | 2010-04-21 |
| SI1483251T1 (sl) | 2010-03-31 |
| AU2003218110A1 (en) | 2003-09-29 |
| US6719540B2 (en) | 2004-04-13 |
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