BRPI0406646A - Compostos de(2-carboxamido)(3-amina)tiofenos, bem como composições e usos compreendendo os mesmos - Google Patents
Compostos de(2-carboxamido)(3-amina)tiofenos, bem como composições e usos compreendendo os mesmosInfo
- Publication number
- BRPI0406646A BRPI0406646A BR0406646-4A BRPI0406646A BRPI0406646A BR PI0406646 A BRPI0406646 A BR PI0406646A BR PI0406646 A BRPI0406646 A BR PI0406646A BR PI0406646 A BRPI0406646 A BR PI0406646A
- Authority
- BR
- Brazil
- Prior art keywords
- compositions
- carboxamido
- well
- amine
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Abstract
"COMPOSTOS DE (2-CARBOXAMIDO)(3AMINA)TIOFENOS, BEM COMO COMPOSIçõES E USOS COMPREENDENDO OS MESMOS". A presente invenção refere-se a compostos representados por Fórmula (1): ou um sal farmaceuticamente aceitável ou N-óxido dos compostos, onde R~ 1~ é e R~ 3~ é C~ 0~-~ 4~alquila, são úteis no tratamento de câncer.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US43815203P | 2003-01-06 | 2003-01-06 | |
US52497203P | 2003-11-25 | 2003-11-25 | |
US52635803P | 2003-12-02 | 2003-12-02 | |
PCT/US2004/001188 WO2004063330A2 (en) | 2003-01-06 | 2004-01-06 | (2-carboxamido) (3-amino) thiophene compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0406646A true BRPI0406646A (pt) | 2005-12-06 |
Family
ID=32719185
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0406646-4A BRPI0406646A (pt) | 2003-01-06 | 2004-01-06 | Compostos de(2-carboxamido)(3-amina)tiofenos, bem como composições e usos compreendendo os mesmos |
Country Status (14)
Country | Link |
---|---|
US (3) | US6949563B2 (pt) |
EP (1) | EP1590328B1 (pt) |
JP (1) | JP4685755B2 (pt) |
KR (1) | KR101017140B1 (pt) |
AR (1) | AR042706A1 (pt) |
AT (1) | ATE546435T1 (pt) |
BR (1) | BRPI0406646A (pt) |
CA (1) | CA2512608C (pt) |
ES (1) | ES2379874T3 (pt) |
LV (1) | LV13360B (pt) |
MX (1) | MXPA05007296A (pt) |
PE (1) | PE20040938A1 (pt) |
TW (1) | TWI299664B (pt) |
WO (1) | WO2004063330A2 (pt) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL372246A1 (en) * | 2002-05-28 | 2005-07-11 | 3-Dimensional Pharmaceuticals, Inc. | Novel thiophene amidines, compositions thereof, and methods of treating complement-mediated diseases and conditions |
TWI299664B (en) * | 2003-01-06 | 2008-08-11 | Osi Pharm Inc | (2-carboxamido)(3-amino)thiophene compounds |
US7696225B2 (en) * | 2003-01-06 | 2010-04-13 | Osi Pharmaceuticals, Inc. | (2-carboxamido)(3-Amino) thiophene compounds |
AU2005230676B2 (en) * | 2004-04-01 | 2010-10-07 | Rexahn Corporation | Nucleoside derivatives and therapeutic use thereof |
WO2006023707A2 (en) * | 2004-08-20 | 2006-03-02 | Bayer Pharmaceuticals Corporation | 2-aminothiophenecarboxamides useful as cancer chemotherapeutic agents |
WO2006034016A1 (en) * | 2004-09-17 | 2006-03-30 | Osi Pharmaceuticals, Inc. | (arylamidoanilino) nitroethylene compounds |
US7388012B2 (en) * | 2004-09-17 | 2008-06-17 | Osi Pharmaceuticals, Inc. | (Hydrazido)(amino)thiophene compounds |
CN101061112A (zh) * | 2004-09-17 | 2007-10-24 | Osi制药公司 | 作为c-Kit原癌基因抑制剂的(螺环基酰氨基)氨基噻吩化合物 |
AU2006221037A1 (en) * | 2005-03-04 | 2006-09-14 | Bayer Pharmaceuticals Corporation | 1,3-thiazole-5-carboxamides useful as cancer chemotherapeutic agents |
WO2007028145A2 (en) * | 2005-09-02 | 2007-03-08 | Dara Biosciences, Inc. | Agents and methods for reducing protein tyrosine phosphatase 1b activity in the central nervous system |
TW200730529A (en) * | 2005-12-07 | 2007-08-16 | Osi Pharm Inc | Process to prepare substituted imidazopyrazine compounds |
KR100863094B1 (ko) * | 2007-08-21 | 2008-10-13 | 현대자동차주식회사 | 셀프 클리닝 효과를 이용한 에어백 저항 과대방지 시스템 |
WO2009073139A2 (en) * | 2007-11-28 | 2009-06-11 | Osi Pharmaceuticals, Inc. | Combined treatment with an egfr kinase inhibitor and an inhibitor of c-kit |
WO2010088000A2 (en) * | 2009-02-02 | 2010-08-05 | Angion Biomedica Corp. | Antifibrotic compounds and uses thereof |
JP2012518657A (ja) | 2009-02-25 | 2012-08-16 | オーエスアイ・ファーマシューティカルズ,エルエルシー | 併用抗癌治療 |
WO2010099138A2 (en) | 2009-02-27 | 2010-09-02 | Osi Pharmaceuticals, Inc. | Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation |
WO2010099363A1 (en) | 2009-02-27 | 2010-09-02 | Osi Pharmaceuticals, Inc. | Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation |
US8465912B2 (en) | 2009-02-27 | 2013-06-18 | OSI Pharmaceuticals, LLC | Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation |
WO2012149014A1 (en) | 2011-04-25 | 2012-11-01 | OSI Pharmaceuticals, LLC | Use of emt gene signatures in cancer drug discovery, diagnostics, and treatment |
UY34305A (es) | 2011-09-01 | 2013-04-30 | Novartis Ag | Derivados de heterociclos bicíclicos para el tratamiento de la hipertensión arterial pulmonar |
WO2013152252A1 (en) | 2012-04-06 | 2013-10-10 | OSI Pharmaceuticals, LLC | Combination anti-cancer therapy |
US9073921B2 (en) | 2013-03-01 | 2015-07-07 | Novartis Ag | Salt forms of bicyclic heterocyclic derivatives |
US9845507B2 (en) | 2014-09-30 | 2017-12-19 | Sysmex Corporation | Methods for detecting oncogenic mutations |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4133814A (en) * | 1975-10-28 | 1979-01-09 | Eli Lilly And Company | 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents |
US4418068A (en) * | 1981-04-03 | 1983-11-29 | Eli Lilly And Company | Antiestrogenic and antiandrugenic benzothiophenes |
US4380635A (en) * | 1981-04-03 | 1983-04-19 | Eli Lilly And Company | Synthesis of acylated benzothiophenes |
US5242921A (en) * | 1988-04-27 | 1993-09-07 | Yale University | Compositions and methods for treating cutaneous hyperproliferative disorders |
US5430049A (en) * | 1993-12-08 | 1995-07-04 | Gaut; Zane N. | Treating hyperproliferative disorders |
GB9511694D0 (en) | 1995-06-09 | 1995-08-02 | Fujisawa Pharmaceutical Co | Benzamide derivatives |
US5968965A (en) | 1996-01-30 | 1999-10-19 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
AUPO395396A0 (en) | 1996-12-02 | 1997-01-02 | Fujisawa Pharmaceutical Co., Ltd. | Benzamide derivatives |
US6187799B1 (en) * | 1997-05-23 | 2001-02-13 | Onyx Pharmaceuticals | Inhibition of raf kinase activity using aryl ureas |
US6140351A (en) | 1997-12-19 | 2000-10-31 | Berlex Laboratories, Inc. | Ortho-anthranilamide derivatives as anti-coagulants |
IL135536A0 (en) | 1997-12-19 | 2001-05-20 | Schering Ag | Ortho-anthranilamide derivatives and pharmaceutical compositions containing the same |
US6410561B1 (en) | 1998-03-26 | 2002-06-25 | Japan Tobacco Inc. | Amide derivatives and nociceptin antagonists |
US6528529B1 (en) | 1998-03-31 | 2003-03-04 | Acadia Pharmaceuticals Inc. | Compounds with activity on muscarinic receptors |
US6262066B1 (en) | 1998-07-27 | 2001-07-17 | Schering Corporation | High affinity ligands for nociceptin receptor ORL-1 |
GB9824579D0 (en) * | 1998-11-10 | 1999-01-06 | Novartis Ag | Organic compounds |
UA71587C2 (uk) | 1998-11-10 | 2004-12-15 | Шерінг Акцієнгезелльшафт | Аміди антранілової кислоти та їхнє застосування як лікарських засобів |
RU2002110295A (ru) | 1999-09-17 | 2003-12-10 | Милленниум Фармасьютикалс, Инк. (Us) | Ингибиторы фактора Ха |
DOP2000000070A (es) | 1999-09-28 | 2002-02-28 | Bayer Healthcare Llc | Piridinas y piridacinas sustituidas con actividad de inhibición de angiogénesis |
WO2001064642A2 (en) | 2000-02-29 | 2001-09-07 | Cor Therapeutics, Inc. | Benzamides and related inhibitors of factor xa |
WO2002000651A2 (en) | 2000-06-27 | 2002-01-03 | Bristol-Myers Squibb Pharma Company | Factor xa inhibitors |
US7105682B2 (en) | 2001-01-12 | 2006-09-12 | Amgen Inc. | Substituted amine derivatives and methods of use |
US20020147198A1 (en) | 2001-01-12 | 2002-10-10 | Guoqing Chen | Substituted arylamine derivatives and methods of use |
US6995162B2 (en) | 2001-01-12 | 2006-02-07 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
TWI299664B (en) * | 2003-01-06 | 2008-08-11 | Osi Pharm Inc | (2-carboxamido)(3-amino)thiophene compounds |
-
2003
- 2003-12-19 TW TW092136301A patent/TWI299664B/zh not_active IP Right Cessation
-
2004
- 2004-01-05 AR ARP040100012A patent/AR042706A1/es unknown
- 2004-01-06 KR KR1020057012689A patent/KR101017140B1/ko not_active IP Right Cessation
- 2004-01-06 AT AT04700407T patent/ATE546435T1/de active
- 2004-01-06 JP JP2006500994A patent/JP4685755B2/ja not_active Expired - Fee Related
- 2004-01-06 MX MXPA05007296A patent/MXPA05007296A/es active IP Right Grant
- 2004-01-06 WO PCT/US2004/001188 patent/WO2004063330A2/en active Search and Examination
- 2004-01-06 PE PE2004000046A patent/PE20040938A1/es not_active Application Discontinuation
- 2004-01-06 US US10/752,342 patent/US6949563B2/en not_active Expired - Lifetime
- 2004-01-06 CA CA2512608A patent/CA2512608C/en not_active Expired - Fee Related
- 2004-01-06 ES ES04700407T patent/ES2379874T3/es not_active Expired - Lifetime
- 2004-01-06 EP EP04700407A patent/EP1590328B1/en not_active Expired - Lifetime
- 2004-01-06 BR BR0406646-4A patent/BRPI0406646A/pt not_active IP Right Cessation
-
2005
- 2005-04-27 US US11/116,007 patent/US7101893B2/en not_active Expired - Fee Related
- 2005-07-05 LV LVP-05-85A patent/LV13360B/en unknown
-
2006
- 2006-06-28 US US11/476,952 patent/US7524859B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP1590328A2 (en) | 2005-11-02 |
US6949563B2 (en) | 2005-09-27 |
EP1590328B1 (en) | 2012-02-22 |
US20040186124A1 (en) | 2004-09-23 |
ES2379874T3 (es) | 2012-05-04 |
CA2512608C (en) | 2011-06-28 |
US20060247275A1 (en) | 2006-11-02 |
TW200503712A (en) | 2005-02-01 |
US7101893B2 (en) | 2006-09-05 |
KR20050114210A (ko) | 2005-12-05 |
AR042706A1 (es) | 2005-06-29 |
CA2512608A1 (en) | 2004-07-29 |
TWI299664B (en) | 2008-08-11 |
US20050192320A1 (en) | 2005-09-01 |
PE20040938A1 (es) | 2004-12-27 |
MXPA05007296A (es) | 2005-09-30 |
EP1590328A4 (en) | 2007-09-19 |
US7524859B2 (en) | 2009-04-28 |
JP2007524571A (ja) | 2007-08-30 |
AU2004204135A1 (en) | 2004-07-29 |
JP4685755B2 (ja) | 2011-05-18 |
ATE546435T1 (de) | 2012-03-15 |
WO2004063330A3 (en) | 2005-02-17 |
KR101017140B1 (ko) | 2011-02-25 |
WO2004063330A2 (en) | 2004-07-29 |
LV13360B (en) | 2006-01-20 |
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Legal Events
Date | Code | Title | Description |
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B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B15K | Others concerning applications: alteration of classification |
Free format text: PARA INT.CL: C07D 215/38, C07D 409/00, A61K 31/47, A61K 31/44, A61P 31/00, A61P 35/00 Ipc: C07D 215/38 (2011.01), C07D 409/00 (2011.01), A61K |
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B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |