BR0313727A - Derivados de isoquinolina como inibidores de metaloproteinase da matriz - Google Patents

Derivados de isoquinolina como inibidores de metaloproteinase da matriz

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Publication number
BR0313727A
BR0313727A BR0313727-9A BR0313727A BR0313727A BR 0313727 A BR0313727 A BR 0313727A BR 0313727 A BR0313727 A BR 0313727A BR 0313727 A BR0313727 A BR 0313727A
Authority
BR
Brazil
Prior art keywords
matrix metalloproteinase
metalloproteinase inhibitors
isoquinoline derivatives
formula
compound
Prior art date
Application number
BR0313727-9A
Other languages
English (en)
Inventor
Amy Mae Bunker
Daniel Fred Ortwine
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of BR0313727A publication Critical patent/BR0313727A/pt

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    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Abstract

"DERIVADOS DE ISOQUINOLINA COMO INIBIDORES DE METALOPROTEINASE DA MATRIZ". A presente invenção refere-se a compostos definidos pela Fórmula I ou um seu sal farmaceuticamente aceitável, em que R^ 1^, Q, Y, R^ 2^, R^ 3^, R^ 4^, R^ 5^, e n são conforme definidos no relatório descritivo como inibidores de enzima MMP-13. A invenção também proporciona composições farmacêuticas compreendendo um composto de Fórmula I, e o uso de um composto de fórmula 1 para a fabricação de um: medicamento útil para o tratamento de osteoartrite e artrite reumatóide.
BR0313727-9A 2002-08-13 2003-08-04 Derivados de isoquinolina como inibidores de metaloproteinase da matriz BR0313727A (pt)

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US40303102P 2002-08-13 2002-08-13
PCT/IB2003/003521 WO2004014379A1 (en) 2002-08-13 2003-08-04 Isoquinoline derivatives as matrix metalloproteinase inhibitors

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AU (1) AU2003250469A1 (pt)
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US20040044000A1 (en) 2004-03-04
JP2006500350A (ja) 2006-01-05
EP1530472A1 (en) 2005-05-18
MXPA05001784A (es) 2005-04-25
AU2003250469A1 (en) 2004-02-25
WO2004014379A1 (en) 2004-02-19

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