BR0211289A - Derivados de dolastatina 10 - Google Patents

Derivados de dolastatina 10

Info

Publication number
BR0211289A
BR0211289A BR0211289-2A BR0211289A BR0211289A BR 0211289 A BR0211289 A BR 0211289A BR 0211289 A BR0211289 A BR 0211289A BR 0211289 A BR0211289 A BR 0211289A
Authority
BR
Brazil
Prior art keywords
compounds
formula
dolastatin derivatives
preparation
relates
Prior art date
Application number
BR0211289-2A
Other languages
English (en)
Inventor
Toshihiko Fujii
Takehiro Okada
Mikio Taniguchi
Fumio Watanabe
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR0211289A publication Critical patent/BR0211289A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof

Abstract

"DERIVADOS DE DOLASTATINA 10". A presente invenção refere-se a compostos da fórmula I, tendo atividade antitumor, onde R^ 1^, R^ 2^, R^ 3^, R^ 4^, R^ 5^ e n são conforme definido no relatório e nas reivindicações e seus sais farmaceuticamente aceitáveis. A presente invenção refere-se também à composição farmacêutica compreendendo compostos da fórmula (I), o uso de compostos da fórmula (I) para a preparação de medicamentos e processo para a preparação de compostos (I).
BR0211289-2A 2001-07-19 2002-07-17 Derivados de dolastatina 10 BR0211289A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01117410 2001-07-19
PCT/EP2002/007931 WO2003008378A1 (en) 2001-07-19 2002-07-17 Dolastatin 10 derivatives

Publications (1)

Publication Number Publication Date
BR0211289A true BR0211289A (pt) 2004-08-03

Family

ID=8178073

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0211289-2A BR0211289A (pt) 2001-07-19 2002-07-17 Derivados de dolastatina 10

Country Status (30)

Country Link
US (1) US6737409B2 (pt)
EP (1) EP1412328B1 (pt)
JP (1) JP2004534859A (pt)
KR (2) KR20060057652A (pt)
CN (1) CN1553897A (pt)
AR (1) AR036175A1 (pt)
AT (1) ATE341537T1 (pt)
BR (1) BR0211289A (pt)
CA (1) CA2453987A1 (pt)
CO (1) CO5550462A2 (pt)
DE (1) DE60215179T2 (pt)
DK (1) DK1412328T3 (pt)
ES (1) ES2272763T3 (pt)
GT (1) GT200200154A (pt)
HR (1) HRP20040043A2 (pt)
HU (1) HUP0401253A2 (pt)
IL (1) IL159890A0 (pt)
MX (1) MXPA04000577A (pt)
MY (1) MY127718A (pt)
NO (1) NO20040198L (pt)
NZ (1) NZ530655A (pt)
PA (1) PA8551001A1 (pt)
PE (1) PE20030258A1 (pt)
PL (1) PL367682A1 (pt)
PT (1) PT1412328E (pt)
RU (1) RU2296750C2 (pt)
SI (1) SI1412328T1 (pt)
UY (1) UY27388A1 (pt)
WO (1) WO2003008378A1 (pt)
ZA (1) ZA200400334B (pt)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7256257B2 (en) 2001-04-30 2007-08-14 Seattle Genetics, Inc. Pentapeptide compounds and uses related thereto
US7064211B2 (en) 2002-03-22 2006-06-20 Eisai Co., Ltd. Hemiasterlin derivatives and uses thereof
RU2342399C2 (ru) 2002-03-22 2008-12-27 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Производные гемиастерлина и их применение при лечении рака
HUE027549T2 (hu) 2002-07-31 2016-10-28 Seattle Genetics Inc Hatóanyagot tartalmazó konjugátumok és alkalmazásuk rák, autoimmun betegség vagy fertõzéses betegség kezelésére
KR101192496B1 (ko) 2003-11-06 2012-10-18 시애틀 지네틱스, 인크. 리간드에 접합될 수 있는 모노메틸발린 화합물
CN1960965A (zh) * 2004-06-02 2007-05-09 霍夫曼-拉罗奇有限公司 氨基－烷氧基－庚酸烷基酯的合成
CA2586909A1 (en) 2004-11-12 2006-12-14 Seattle Genetics, Inc. Auristatins having an aminobenzoic acid unit at the n terminus
KR20070086123A (ko) * 2004-12-13 2007-08-27 에프. 호프만-라 로슈 아게 하나 이상의 돌라스타틴 10 유도체를 포함하는 신규 약학조성물
JP2008523001A (ja) * 2004-12-13 2008-07-03 エフ．ホフマン−ラ ロシュ アーゲー ３−ピロリジン−２−イル−プロピオン酸誘導体を製造するための新規な方法
US20060189893A1 (en) * 2005-01-06 2006-08-24 Diamics, Inc. Systems and methods for detecting abnormal cells
US20060161076A1 (en) * 2005-01-06 2006-07-20 Diamics, Inc. Systems and methods for collection of cell clusters
CN101102993A (zh) * 2005-01-13 2008-01-09 霍夫曼-拉罗奇有限公司 有用的双取代胺类的新型一步合成
WO2006122408A1 (en) 2005-05-18 2006-11-23 Aegera Therapeutics Inc. Bir domain binding compounds
CA2614436C (en) 2005-07-07 2016-05-17 Seattle Genetics, Inc. Monomethylvaline compounds having phenylalanine side-chain modifications at the c-terminus
WO2007008848A2 (en) 2005-07-07 2007-01-18 Seattle Genetics, Inc. Monomethylvaline compounds having phenylalanine carboxy modifications at the c-terminus
US7750116B1 (en) 2006-02-18 2010-07-06 Seattle Genetics, Inc. Antibody drug conjugate metabolites
MY159563A (en) 2006-05-16 2017-01-13 Pharmascience Inc Iap bir domain binding compounds
US20080003652A1 (en) * 2006-06-28 2008-01-03 Hans Iding Novel enzymatic process for the manufacture of Boc-Dap-Oh priority to related application(s)
PE20090943A1 (es) 2007-07-16 2009-08-05 Genentech Inc Anticuerpos anti-cd79b e inmunoconjugados
CN101802013B (zh) 2007-07-16 2014-07-02 健泰科生物技术公司 人源化抗cd79b抗体和免疫偶联物及使用方法
EP2657253B1 (en) 2008-01-31 2017-07-19 Genentech, Inc. Anti-CD79b antibodies and immunoconjugates and methods of use
ES2647927T3 (es) 2008-03-18 2017-12-27 Seattle Genetics, Inc. Conjugados enlazadores del fármaco auriestatina
BR112012020102A2 (pt) 2010-02-10 2016-11-29 Immunogen Inc anticorpos cd20 e usos dos mesmos.
RU2567544C2 (ru) 2010-02-12 2015-11-10 Фармасайенс Инк. Bir домен iap связывающие соединения
WO2011154359A1 (de) 2010-06-10 2011-12-15 Bayer Pharma Aktiengesellschaft Neue auristatin-derivate und ihre verwendung
EP2621508B1 (de) 2010-09-29 2015-08-26 Seattle Genetics, Inc. N-carboxyalkyl-auristatine und ihre verwendung
ES2543888T3 (es) * 2011-03-16 2015-08-25 Seattle Genetics, Inc. N-carboxialquil-auristatinas y su utilización
JP6581774B2 (ja) 2011-05-27 2019-09-25 アンブルックス, インコーポレイテッドAmbrx, Inc. 非天然アミノ酸結合ドラスタチン誘導体を含有する化合物またはその化合物の溶媒和物、およびドラスタチンアナログを誘導体化するための方法
EP3170821B1 (en) * 2011-05-27 2021-09-15 Ambrx, Inc. Compositions containing, methods involving, and uses of non-natural amino acid linked dolastatin derivatives
JP6089108B2 (ja) * 2012-09-20 2017-03-01 セルトリオン， インク． ドラスタチン１０誘導体、その製造方法およびそれを含む抗癌剤組成物
MX2016008444A (es) 2013-12-27 2017-01-11 Zymeworks Inc Sistemas de enlace que contienen sulfonamida para conjugados de farmacos.
HUE049175T2 (hu) 2014-09-23 2020-09-28 Hoffmann La Roche Eljárás anti-CD79b immunkonjugátumok alkalmazására
CN105949277B (zh) * 2015-05-05 2019-03-01 成都永泰诺科技有限公司 一种抗肿瘤化合物及其用途
PL3438118T3 (pl) * 2016-03-29 2023-07-10 Toray Industries, Inc. Pochodna peptydu i jej zastosowanie
CN109021065B (zh) * 2017-06-08 2021-10-01 复旦大学 一种制备海兔毒素Dolastatin10的方法
WO2023033129A1 (ja) 2021-09-03 2023-03-09 東レ株式会社 癌の治療及び／又は予防用医薬組成物

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6323315B1 (en) 1999-09-10 2001-11-27 Basf Aktiengesellschaft Dolastatin peptides

Also Published As

Publication number Publication date
IL159890A0 (en) 2004-06-20
EP1412328B1 (en) 2006-10-04
KR20060057652A (ko) 2006-05-26
DE60215179T2 (de) 2007-10-18
ATE341537T1 (de) 2006-10-15
GT200200154A (es) 2003-05-16
ES2272763T3 (es) 2007-05-01
UY27388A1 (es) 2003-01-31
PA8551001A1 (es) 2003-09-17
MY127718A (en) 2006-12-29
PE20030258A1 (es) 2003-03-19
KR20040023661A (ko) 2004-03-18
MXPA04000577A (es) 2004-04-20
US6737409B2 (en) 2004-05-18
NO20040198L (no) 2004-02-19
CO5550462A2 (es) 2005-08-31
CA2453987A1 (en) 2003-01-30
EP1412328A1 (en) 2004-04-28
HRP20040043A2 (en) 2004-08-31
JP2004534859A (ja) 2004-11-18
RU2004105145A (ru) 2005-07-10
US20030055002A1 (en) 2003-03-20
CN1553897A (zh) 2004-12-08
SI1412328T1 (sl) 2007-02-28
DE60215179D1 (de) 2006-11-16
KR100611540B1 (ko) 2006-08-10
AR036175A1 (es) 2004-08-18
RU2296750C2 (ru) 2007-04-10
PT1412328E (pt) 2007-01-31
NZ530655A (en) 2006-08-31
PL367682A1 (en) 2005-03-07
DK1412328T3 (da) 2007-02-12
ZA200400334B (en) 2005-06-29
WO2003008378A1 (en) 2003-01-30
HUP0401253A2 (hu) 2004-12-28

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2060 DE 29/06/2010.