IL159890A0 - Dolastatin 10 derivatives - Google Patents
Dolastatin 10 derivativesInfo
- Publication number
- IL159890A0 IL159890A0 IL15989002A IL15989002A IL159890A0 IL 159890 A0 IL159890 A0 IL 159890A0 IL 15989002 A IL15989002 A IL 15989002A IL 15989002 A IL15989002 A IL 15989002A IL 159890 A0 IL159890 A0 IL 159890A0
- Authority
- IL
- Israel
- Prior art keywords
- dolastatin
- derivatives
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01117410 | 2001-07-19 | ||
| PCT/EP2002/007931 WO2003008378A1 (en) | 2001-07-19 | 2002-07-17 | Dolastatin 10 derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL159890A0 true IL159890A0 (en) | 2004-06-20 |
Family
ID=8178073
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL15989002A IL159890A0 (en) | 2001-07-19 | 2002-07-17 | Dolastatin 10 derivatives |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US6737409B2 (xx) |
| EP (1) | EP1412328B1 (xx) |
| JP (1) | JP2004534859A (xx) |
| KR (2) | KR20060057652A (xx) |
| CN (1) | CN1553897A (xx) |
| AR (1) | AR036175A1 (xx) |
| AT (1) | ATE341537T1 (xx) |
| BR (1) | BR0211289A (xx) |
| CA (1) | CA2453987A1 (xx) |
| CO (1) | CO5550462A2 (xx) |
| DE (1) | DE60215179T2 (xx) |
| DK (1) | DK1412328T3 (xx) |
| ES (1) | ES2272763T3 (xx) |
| GT (1) | GT200200154A (xx) |
| HR (1) | HRP20040043A2 (xx) |
| HU (1) | HUP0401253A2 (xx) |
| IL (1) | IL159890A0 (xx) |
| MX (1) | MXPA04000577A (xx) |
| MY (1) | MY127718A (xx) |
| NO (1) | NO20040198L (xx) |
| NZ (1) | NZ530655A (xx) |
| PA (1) | PA8551001A1 (xx) |
| PE (1) | PE20030258A1 (xx) |
| PL (1) | PL367682A1 (xx) |
| PT (1) | PT1412328E (xx) |
| RU (1) | RU2296750C2 (xx) |
| SI (1) | SI1412328T1 (xx) |
| UY (1) | UY27388A1 (xx) |
| WO (1) | WO2003008378A1 (xx) |
| ZA (1) | ZA200400334B (xx) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7256257B2 (en) | 2001-04-30 | 2007-08-14 | Seattle Genetics, Inc. | Pentapeptide compounds and uses related thereto |
| US7064211B2 (en) | 2002-03-22 | 2006-06-20 | Eisai Co., Ltd. | Hemiasterlin derivatives and uses thereof |
| NZ535139A (en) * | 2002-03-22 | 2007-07-27 | Eisai Co Ltd | Hemiasterlin derivatives and uses thereof in the treatment of cancer |
| EP2357006B1 (en) | 2002-07-31 | 2015-09-16 | Seattle Genetics, Inc. | Drug conjugates and their use for treating cancer, an autoimmune disease or an infectious disease |
| BR122018071968B8 (pt) | 2003-11-06 | 2021-07-27 | Seattle Genetics Inc | conjugado de anticorpo-droga, composição farmacêutica, artigo de manufatura e uso de um conjugado de anticorpo-droga |
| JP2008501653A (ja) * | 2004-06-02 | 2008-01-24 | エフ．ホフマン−ラ ロシュ アーゲー | アミノ−アルコキシ−ヘプタン酸アルキルエステルの合成 |
| EP3505191A1 (en) | 2004-11-12 | 2019-07-03 | Seattle Genetics, Inc. | Auristatins having an aminobenzoic acid unit at the n terminus |
| BRPI0519023A2 (pt) * | 2004-12-13 | 2008-12-23 | Hoffmann La Roche | composiÇço farmacÊutica contendo pelo menos um derivado de dolastatina 10 |
| EP1828117A1 (en) * | 2004-12-13 | 2007-09-05 | F. Hoffmann-Roche AG | Novel process for the manufacture of 3-pyrrolidin-2-yl-propionic acid derivatives |
| US20060161076A1 (en) * | 2005-01-06 | 2006-07-20 | Diamics, Inc. | Systems and methods for collection of cell clusters |
| US20060189893A1 (en) * | 2005-01-06 | 2006-08-24 | Diamics, Inc. | Systems and methods for detecting abnormal cells |
| CA2592969A1 (en) * | 2005-01-13 | 2006-07-20 | F. Hoffmann-La Roche Ag | New one-step synthesis of useful disubstituted amines |
| JP4954983B2 (ja) | 2005-05-18 | 2012-06-20 | ファーマサイエンス・インコーポレイテッド | Ｂｉｒドメイン結合化合物 |
| WO2007008848A2 (en) | 2005-07-07 | 2007-01-18 | Seattle Genetics, Inc. | Monomethylvaline compounds having phenylalanine carboxy modifications at the c-terminus |
| EP2722051B1 (en) | 2005-07-07 | 2018-11-07 | Seattle Genetics, Inc. | Monomethylvaline compounds having phenylalanine side-chain modifications at the C-terminus |
| US7750116B1 (en) | 2006-02-18 | 2010-07-06 | Seattle Genetics, Inc. | Antibody drug conjugate metabolites |
| CN101535300B (zh) | 2006-05-16 | 2014-05-28 | 埃格拉医疗公司 | Iap bir域结合化合物 |
| US20080003652A1 (en) * | 2006-06-28 | 2008-01-03 | Hans Iding | Novel enzymatic process for the manufacture of Boc-Dap-Oh priority to related application(s) |
| CA2692819A1 (en) | 2007-07-16 | 2009-01-22 | Genentech, Inc. | Humanized anti-cd79b antibodies and immunoconjugates and methods of use |
| PE20140614A1 (es) | 2007-07-16 | 2014-05-28 | Genentech Inc | Anticuerpos anti-cd79b e inmunoconjugados |
| SI2247620T1 (sl) | 2008-01-31 | 2016-09-30 | Genentech, Inc. | Protitelesa proti CD79b in imunokonjugati in postopki za uporabo |
| EP2842575B1 (en) | 2008-03-18 | 2017-09-27 | Seattle Genetics, Inc. | Auristatin drug linker conjugates |
| AU2011215900A1 (en) | 2010-02-10 | 2012-07-26 | Immunogen, Inc. | CD20 antibodies and uses thereof |
| WO2011098904A1 (en) | 2010-02-12 | 2011-08-18 | Aegera Therapeutics, Inc. | Iap bir domain binding compounds |
| EP2579887B1 (de) | 2010-06-10 | 2014-11-12 | Seattle Genetics, Inc. | Neue auristatin-derivate und ihre verwendung |
| ES2553874T3 (es) | 2010-09-29 | 2015-12-14 | Seattle Genetics, Inc. | N-Carboxialquil-auristatinas y su uso |
| CN103764667B (zh) * | 2011-03-16 | 2017-06-20 | 西雅图基因公司 | N‑羧烷基耳他汀类及其应用 |
| EP3170821B1 (en) * | 2011-05-27 | 2021-09-15 | Ambrx, Inc. | Compositions containing, methods involving, and uses of non-natural amino acid linked dolastatin derivatives |
| JP6581774B2 (ja) | 2011-05-27 | 2019-09-25 | アンブルックス, インコーポレイテッドAmbrx, Inc. | 非天然アミノ酸結合ドラスタチン誘導体を含有する化合物またはその化合物の溶媒和物、およびドラスタチンアナログを誘導体化するための方法 |
| KR101520302B1 (ko) | 2012-09-20 | 2015-05-15 | (주)셀트리온 | 돌라스타틴 10 유도체, 그의 제조방법 및 그를 포함하는 항암제 조성물 |
| ES2916722T3 (es) | 2013-12-27 | 2022-07-05 | Zymeworks Inc | Sistemas de enlace que contienen sulfonamida para conjugados de fármacos |
| EP3689910A3 (en) | 2014-09-23 | 2020-12-02 | F. Hoffmann-La Roche AG | Method of using anti-cd79b immunoconjugates |
| CN105949277B (zh) * | 2015-05-05 | 2019-03-01 | 成都永泰诺科技有限公司 | 一种抗肿瘤化合物及其用途 |
| ES2948846T3 (es) * | 2016-03-29 | 2023-09-20 | Toray Industries | Derivado peptídico y uso del mismo |
| CN109021065B (zh) * | 2017-06-08 | 2021-10-01 | 复旦大学 | 一种制备海兔毒素Dolastatin10的方法 |
| WO2023033129A1 (ja) | 2021-09-03 | 2023-03-09 | 東レ株式会社 | 癌の治療及び／又は予防用医薬組成物 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6323315B1 (en) | 1999-09-10 | 2001-11-27 | Basf Aktiengesellschaft | Dolastatin peptides |
-
2002
- 2002-07-15 US US10/195,698 patent/US6737409B2/en not_active Expired - Fee Related
- 2002-07-17 NZ NZ530655A patent/NZ530655A/en unknown
- 2002-07-17 SI SI200230447T patent/SI1412328T1/sl unknown
- 2002-07-17 MY MYPI20022704A patent/MY127718A/en unknown
- 2002-07-17 HU HU0401253A patent/HUP0401253A2/hu unknown
- 2002-07-17 PL PL02367682A patent/PL367682A1/xx not_active Application Discontinuation
- 2002-07-17 AT AT02764710T patent/ATE341537T1/de not_active IP Right Cessation
- 2002-07-17 CN CNA028177622A patent/CN1553897A/zh active Pending
- 2002-07-17 AR ARP020102678A patent/AR036175A1/es not_active Application Discontinuation
- 2002-07-17 MX MXPA04000577A patent/MXPA04000577A/es active IP Right Grant
- 2002-07-17 ES ES02764710T patent/ES2272763T3/es not_active Expired - Lifetime
- 2002-07-17 EP EP02764710A patent/EP1412328B1/en not_active Expired - Lifetime
- 2002-07-17 PT PT02764710T patent/PT1412328E/pt unknown
- 2002-07-17 UY UY27388A patent/UY27388A1/es not_active Application Discontinuation
- 2002-07-17 WO PCT/EP2002/007931 patent/WO2003008378A1/en active IP Right Grant
- 2002-07-17 BR BR0211289-2A patent/BR0211289A/pt not_active IP Right Cessation
- 2002-07-17 CA CA002453987A patent/CA2453987A1/en not_active Abandoned
- 2002-07-17 DE DE60215179T patent/DE60215179T2/de not_active Expired - Fee Related
- 2002-07-17 KR KR1020067008692A patent/KR20060057652A/ko not_active Application Discontinuation
- 2002-07-17 DK DK02764710T patent/DK1412328T3/da active
- 2002-07-17 JP JP2003513938A patent/JP2004534859A/ja active Pending
- 2002-07-17 RU RU2004105145/04A patent/RU2296750C2/ru not_active IP Right Cessation
- 2002-07-17 IL IL15989002A patent/IL159890A0/xx unknown
- 2002-07-17 KR KR1020047000854A patent/KR100611540B1/ko not_active IP Right Cessation
- 2002-07-18 GT GT200200154A patent/GT200200154A/es unknown
- 2002-07-18 PA PA20028551001A patent/PA8551001A1/es unknown
- 2002-07-19 PE PE2002000643A patent/PE20030258A1/es not_active Application Discontinuation
-
2004
- 2004-01-15 ZA ZA2004/00334A patent/ZA200400334B/en unknown
- 2004-01-16 NO NO20040198A patent/NO20040198L/no not_active Application Discontinuation
- 2004-01-19 HR HR20040043A patent/HRP20040043A2/hr not_active Application Discontinuation
- 2004-01-20 CO CO04003736A patent/CO5550462A2/es not_active Application Discontinuation
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