PE20030258A1 - Derivados de dolastatina con actividad antitumoral - Google Patents
Derivados de dolastatina con actividad antitumoralInfo
- Publication number
- PE20030258A1 PE20030258A1 PE2002000643A PE2002000643A PE20030258A1 PE 20030258 A1 PE20030258 A1 PE 20030258A1 PE 2002000643 A PE2002000643 A PE 2002000643A PE 2002000643 A PE2002000643 A PE 2002000643A PE 20030258 A1 PE20030258 A1 PE 20030258A1
- Authority
- PE
- Peru
- Prior art keywords
- methyl
- butyl
- carbamoyl
- metoxy
- butyramide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Crystallography & Structural Chemistry (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
SE REFIERE A DERIVADOS DE DOLASTATINA 10 QUE TIENEN VARIOS GRUPOS TIO EN LA PARTE DE DOLAPROINA DE FORMULA I DONDE R1, R2, R3 SON H, ALQUILO C1-C4; R4 ES H, ALQUILO OPCIONALMENTE SUSTITUIDO CON HIDROXILO, ALCOXILO, AMINO, DIALQUILAMINO, CARBOXILO, ALCOXICARBONILO, CARBAMOILO, ALQUILCARBONILOXILO, HALOGENO, ALQUENILO, ALQUINILO, CICLOALQUILO C3-C7, ARILO, ENTRE OTROS; R5 ES ALQUILAMINO C1-C6, HIDROXILO, CICLOALQUILAMINO C3-C7, ARILAMINO, ARALQUILAMINO, BENZHIDRAZINO, ENTRE OTROS; n ES 0-2. SON COMPUESTOS PREFERIDOS N-[1-({1-SEC-BUTIL-4-[2-(1-METANOSULFINIL-2-FENETILCARBAMOIL-ETIL)-PIRROLIDIN-1-IL]-2-METOXI-4-OXO-BUTIL}-METIL-CARBAMOIL)-2-METIL-PROPIL]-2-DIMETILAMINO-3-METIL-BUTIRAMIDA; N-[1-({1-SEC-BUTIL-2-METOXI-4-OXO-4-[2-(2-FENETIL-CARBAMOIL-1-FENILSULFANIL-ETIL)-PIRROLIDIN-1-IL]-BUTIL}-METIL-CARBAMOIL)-2-METIL-PROPIL]-2-DIMETILAMINO-3-METIL-BUTIRAMIDA; N-[1-({1-SEC-BUTIL-2-METOXI-4-[2-(1-METILSULFANIL-2-FENETILCARBAMOIL-ETIL)-PIRROLIDIN-1-IL]-4-OXO-BUTIL}-METIL-CARBAMOIL)-2-METIL-PROPIL]-2-DIMETILAMINO-3-METIL-BUTIRAMIDA, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. LOS COMPUESTOS SON DERIVADOS DE DOLASTINA 10, PEPTIDO ANTIMITOTICO POTENTE MUESTRAN ACTIVIDAD ANTITUMORAL MEJORADA Y PUEDEN SER UTILES PARA EL TRATAMIENTO DE CANCER
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01117410 | 2001-07-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20030258A1 true PE20030258A1 (es) | 2003-03-19 |
Family
ID=8178073
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2002000643A PE20030258A1 (es) | 2001-07-19 | 2002-07-19 | Derivados de dolastatina con actividad antitumoral |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US6737409B2 (es) |
| EP (1) | EP1412328B1 (es) |
| JP (1) | JP2004534859A (es) |
| KR (2) | KR20060057652A (es) |
| CN (1) | CN1553897A (es) |
| AR (1) | AR036175A1 (es) |
| AT (1) | ATE341537T1 (es) |
| BR (1) | BR0211289A (es) |
| CA (1) | CA2453987A1 (es) |
| CO (1) | CO5550462A2 (es) |
| DE (1) | DE60215179T2 (es) |
| DK (1) | DK1412328T3 (es) |
| ES (1) | ES2272763T3 (es) |
| GT (1) | GT200200154A (es) |
| HR (1) | HRP20040043A2 (es) |
| HU (1) | HUP0401253A2 (es) |
| IL (1) | IL159890A0 (es) |
| MX (1) | MXPA04000577A (es) |
| MY (1) | MY127718A (es) |
| NO (1) | NO20040198L (es) |
| NZ (1) | NZ530655A (es) |
| PA (1) | PA8551001A1 (es) |
| PE (1) | PE20030258A1 (es) |
| PL (1) | PL367682A1 (es) |
| PT (1) | PT1412328E (es) |
| RU (1) | RU2296750C2 (es) |
| SI (1) | SI1412328T1 (es) |
| UY (1) | UY27388A1 (es) |
| WO (1) | WO2003008378A1 (es) |
| ZA (1) | ZA200400334B (es) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7256257B2 (en) | 2001-04-30 | 2007-08-14 | Seattle Genetics, Inc. | Pentapeptide compounds and uses related thereto |
| US7064211B2 (en) | 2002-03-22 | 2006-06-20 | Eisai Co., Ltd. | Hemiasterlin derivatives and uses thereof |
| IL163868A0 (en) * | 2002-03-22 | 2005-12-18 | Eisai Co Ltd | Hermiasterlin derivatives and uses thereof |
| ES2556641T3 (es) | 2002-07-31 | 2016-01-19 | Seattle Genetics, Inc. | Conjugados de fármacos y su uso para tratar cáncer, una enfermedad autoinmune o una enfermedad infecciosa |
| KR101438983B1 (ko) | 2003-11-06 | 2014-09-05 | 시애틀 지네틱스, 인크. | 리간드에 접합될 수 있는 모노메틸발린 화합물 |
| US7312343B2 (en) * | 2004-06-02 | 2007-12-25 | Hoffmann-La Roche Inc. | Synthesis of α-amino-β-alkoxy-carboxylic acid esters |
| WO2006132670A2 (en) | 2004-11-12 | 2006-12-14 | Seattle Genetics, Inc. | Auristatins having an aminobenzoic acid unit at the n terminus |
| EP1828117A1 (en) * | 2004-12-13 | 2007-09-05 | F. Hoffmann-Roche AG | Novel process for the manufacture of 3-pyrrolidin-2-yl-propionic acid derivatives |
| EP1827603A2 (en) * | 2004-12-13 | 2007-09-05 | F. Hoffmann-Roche AG | Novel pharmaceutical composition containing at least one dolastatin 10 derivative |
| US20060161076A1 (en) * | 2005-01-06 | 2006-07-20 | Diamics, Inc. | Systems and methods for collection of cell clusters |
| US20060189893A1 (en) * | 2005-01-06 | 2006-08-24 | Diamics, Inc. | Systems and methods for detecting abnormal cells |
| MX2007008349A (es) * | 2005-01-13 | 2007-07-25 | Hoffmann La Roche | Nueva sintesis de una etapa de aminas disustituidas utiles. |
| EP1883627B1 (en) | 2005-05-18 | 2018-04-18 | Pharmascience Inc. | Bir domain binding compounds |
| EP3498289A1 (en) | 2005-07-07 | 2019-06-19 | Seattle Genetics, Inc. | Monomethylvaline compounds having phenylalanine side-chain modifications at the c-terminus |
| WO2007008848A2 (en) * | 2005-07-07 | 2007-01-18 | Seattle Genetics, Inc. | Monomethylvaline compounds having phenylalanine carboxy modifications at the c-terminus |
| US7750116B1 (en) | 2006-02-18 | 2010-07-06 | Seattle Genetics, Inc. | Antibody drug conjugate metabolites |
| AU2007250443B2 (en) | 2006-05-16 | 2013-06-13 | Pharmascience Inc. | IAP BIR domain binding compounds |
| US20080003652A1 (en) * | 2006-06-28 | 2008-01-03 | Hans Iding | Novel enzymatic process for the manufacture of Boc-Dap-Oh priority to related application(s) |
| JP2010533495A (ja) | 2007-07-16 | 2010-10-28 | ジェネンテック， インコーポレイテッド | ヒト化ＣＤ７９ｂ抗体およびイムノコンジュゲートならびにそれらの使用 |
| PT2176296E (pt) | 2007-07-16 | 2012-05-14 | Genentech Inc | Anticorpos e imunoconjugados anti-cd79b e métodos de utilização |
| MY157403A (en) | 2008-01-31 | 2016-06-15 | Genentech Inc | Anti-cd79b antibodies and immunoconjugates and methods of use |
| PL2842575T3 (pl) | 2008-03-18 | 2018-02-28 | Seattle Genetics, Inc. | Koniugaty aurystatyny lek łącznik |
| MX341687B (es) | 2010-02-10 | 2016-08-30 | Immunogen Inc | "anticuerpos cd20 y su utilización". |
| ES2625637T3 (es) | 2010-02-12 | 2017-07-20 | Pharmascience Inc. | Compuestos de unión al dominio BIR IAP |
| JP5791707B2 (ja) | 2010-06-10 | 2015-10-07 | シアトル ジェネティックス， インコーポレイテッド | 新規アウリスタチン誘導体およびその使用 |
| JP5933562B2 (ja) | 2010-09-29 | 2016-06-15 | シアトル ジェネティックス， インコーポレイテッド | Ｎ−カルボキシアルキル−アウリスタチンおよびその使用 |
| ES2543888T3 (es) * | 2011-03-16 | 2015-08-25 | Seattle Genetics, Inc. | N-carboxialquil-auristatinas y su utilización |
| EP3170821B1 (en) * | 2011-05-27 | 2021-09-15 | Ambrx, Inc. | Compositions containing, methods involving, and uses of non-natural amino acid linked dolastatin derivatives |
| JP6581774B2 (ja) * | 2011-05-27 | 2019-09-25 | アンブルックス, インコーポレイテッドAmbrx, Inc. | 非天然アミノ酸結合ドラスタチン誘導体を含有する化合物またはその化合物の溶媒和物、およびドラスタチンアナログを誘導体化するための方法 |
| ES2604766T3 (es) | 2012-09-20 | 2017-03-09 | Celltrion, Inc. | Derivado de dolastatina-10, procedimiento de producción del mismo y composición de fármaco anticanceroso que contiene el mismo |
| ES2916722T3 (es) | 2013-12-27 | 2022-07-05 | Zymeworks Inc | Sistemas de enlace que contienen sulfonamida para conjugados de fármacos |
| CA3069221C (en) | 2014-09-23 | 2023-04-04 | Genentech, Inc. | Methods of using anti-cd79b immunoconjugates |
| CN105949277B (zh) * | 2015-05-05 | 2019-03-01 | 成都永泰诺科技有限公司 | 一种抗肿瘤化合物及其用途 |
| DK3438118T3 (da) * | 2016-03-29 | 2023-05-30 | Toray Industries | Peptidderivat og anvendelse deraf |
| CN109021065B (zh) * | 2017-06-08 | 2021-10-01 | 复旦大学 | 一种制备海兔毒素Dolastatin10的方法 |
| AU2022338463A1 (en) | 2021-09-03 | 2024-03-21 | Toray Industries, Inc. | Pharmaceutical composition for cancer treatment and/or prevention |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6323315B1 (en) | 1999-09-10 | 2001-11-27 | Basf Aktiengesellschaft | Dolastatin peptides |
-
2002
- 2002-07-15 US US10/195,698 patent/US6737409B2/en not_active Expired - Fee Related
- 2002-07-17 DE DE60215179T patent/DE60215179T2/de not_active Expired - Fee Related
- 2002-07-17 BR BR0211289-2A patent/BR0211289A/pt not_active IP Right Cessation
- 2002-07-17 MX MXPA04000577A patent/MXPA04000577A/es active IP Right Grant
- 2002-07-17 DK DK02764710T patent/DK1412328T3/da active
- 2002-07-17 PT PT02764710T patent/PT1412328E/pt unknown
- 2002-07-17 IL IL15989002A patent/IL159890A0/xx unknown
- 2002-07-17 CN CNA028177622A patent/CN1553897A/zh active Pending
- 2002-07-17 AR ARP020102678A patent/AR036175A1/es not_active Application Discontinuation
- 2002-07-17 KR KR1020067008692A patent/KR20060057652A/ko not_active Application Discontinuation
- 2002-07-17 WO PCT/EP2002/007931 patent/WO2003008378A1/en active IP Right Grant
- 2002-07-17 RU RU2004105145/04A patent/RU2296750C2/ru not_active IP Right Cessation
- 2002-07-17 PL PL02367682A patent/PL367682A1/xx not_active Application Discontinuation
- 2002-07-17 KR KR1020047000854A patent/KR100611540B1/ko not_active IP Right Cessation
- 2002-07-17 ES ES02764710T patent/ES2272763T3/es not_active Expired - Lifetime
- 2002-07-17 AT AT02764710T patent/ATE341537T1/de not_active IP Right Cessation
- 2002-07-17 CA CA002453987A patent/CA2453987A1/en not_active Abandoned
- 2002-07-17 HU HU0401253A patent/HUP0401253A2/hu unknown
- 2002-07-17 SI SI200230447T patent/SI1412328T1/sl unknown
- 2002-07-17 NZ NZ530655A patent/NZ530655A/en unknown
- 2002-07-17 EP EP02764710A patent/EP1412328B1/en not_active Expired - Lifetime
- 2002-07-17 JP JP2003513938A patent/JP2004534859A/ja active Pending
- 2002-07-17 UY UY27388A patent/UY27388A1/es not_active Application Discontinuation
- 2002-07-17 MY MYPI20022704A patent/MY127718A/en unknown
- 2002-07-18 GT GT200200154A patent/GT200200154A/es unknown
- 2002-07-18 PA PA20028551001A patent/PA8551001A1/es unknown
- 2002-07-19 PE PE2002000643A patent/PE20030258A1/es not_active Application Discontinuation
-
2004
- 2004-01-15 ZA ZA2004/00334A patent/ZA200400334B/en unknown
- 2004-01-16 NO NO20040198A patent/NO20040198L/no not_active Application Discontinuation
- 2004-01-19 HR HR20040043A patent/HRP20040043A2/hr not_active Application Discontinuation
- 2004-01-20 CO CO04003736A patent/CO5550462A2/es not_active Application Discontinuation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |