AR041566A1 - Derivados de indol utiles para el tratamiento de enfermedades - Google Patents

Derivados de indol utiles para el tratamiento de enfermedades

Info

Publication number
AR041566A1
AR041566A1 ARP030103677A ARP030103677A AR041566A1 AR 041566 A1 AR041566 A1 AR 041566A1 AR P030103677 A ARP030103677 A AR P030103677A AR P030103677 A ARP030103677 A AR P030103677A AR 041566 A1 AR041566 A1 AR 041566A1
Authority
AR
Argentina
Prior art keywords
diseases
hydrogen
alkyl
treatment
disorders
Prior art date
Application number
ARP030103677A
Other languages
English (en)
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP20020292513 external-priority patent/EP1407769A1/en
Priority claimed from EP03290069A external-priority patent/EP1440966A1/en
Application filed by Pfizer filed Critical Pfizer
Publication of AR041566A1 publication Critical patent/AR041566A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Se refiere a derivados de indol y a procedimientos para la preparación de intermediarios usados en la preparación de composiciones que los contienen y el uso de dichos derivados. Los derivados de indol según la presente invención son útiles en numerosas enfermedades, trastornos y afecciones, en particular enfermedades,trastornos y afecciones inflamatorias, alérgicas y respiratorias. Reivindicación 1: Un compuesto de fórmula 1 caracterizado porque n es un número entero igual a 0, 1, 2, 3 o 4; R1 y R2 son cada uno de ellos independientemente seleccionados de hidrógeno y alquilo (C1-4); R3 se selecciona del grupo constituído por hidrógeno o alquilo ( C1-6) sustituido opcionalemtne con un hidroxi; y R4, R5, R6, R7 y R8 cada uno de ellos se selecci0ona independientemente del grupo constituido por hidrógeno, hidroxi, alquilo (C1-6), alcoxi (C1-6), benciloxi, hidroxialquilo (C1-6), tioalquilo (C1-6), halo y trifluorometilo, o una sal y/o isómero, tautómero, solvato o variación isotópica faramcéuticamente aceptables del mismo.
ARP030103677A 2002-10-11 2003-10-09 Derivados de indol utiles para el tratamiento de enfermedades AR041566A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP20020292513 EP1407769A1 (en) 2002-10-11 2002-10-11 Indole derivatives as beta-2 agonists
EP03290069A EP1440966A1 (en) 2003-01-10 2003-01-10 Indole derivatives useful for the treatment of diseases

Publications (1)

Publication Number Publication Date
AR041566A1 true AR041566A1 (es) 2005-05-18

Family

ID=32095049

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP030103677A AR041566A1 (es) 2002-10-11 2003-10-09 Derivados de indol utiles para el tratamiento de enfermedades

Country Status (25)

Country Link
EP (1) EP1556034B1 (es)
JP (1) JP4490911B2 (es)
KR (1) KR20050047552A (es)
AP (1) AP2005003283A0 (es)
AR (1) AR041566A1 (es)
AT (1) ATE392206T1 (es)
AU (1) AU2003269316A1 (es)
BR (1) BR0315234A (es)
CA (1) CA2499314C (es)
CO (1) CO5550421A2 (es)
DE (1) DE60320439T2 (es)
EA (1) EA200500618A1 (es)
EC (1) ECSP055780A (es)
ES (1) ES2302938T3 (es)
IS (1) IS7751A (es)
MA (1) MA27452A1 (es)
MX (1) MXPA05003866A (es)
NO (1) NO20051406L (es)
OA (1) OA12938A (es)
PA (1) PA8586001A1 (es)
PE (1) PE20040775A1 (es)
PL (1) PL376396A1 (es)
TW (1) TW200424171A (es)
UY (1) UY28013A1 (es)
WO (1) WO2004032921A1 (es)

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Also Published As

Publication number Publication date
ES2302938T3 (es) 2008-08-01
CA2499314A1 (en) 2004-04-22
EP1556034B1 (en) 2008-04-16
AP2005003283A0 (en) 2005-06-30
PA8586001A1 (es) 2005-02-04
ATE392206T1 (de) 2008-05-15
BR0315234A (pt) 2005-08-23
PL376396A1 (en) 2005-12-27
EA200500618A1 (ru) 2005-12-29
KR20050047552A (ko) 2005-05-20
MA27452A1 (fr) 2005-07-01
NO20051406L (no) 2005-04-22
JP4490911B2 (ja) 2010-06-30
IS7751A (is) 2005-03-17
TW200424171A (en) 2004-11-16
MXPA05003866A (es) 2005-06-22
PE20040775A1 (es) 2004-12-10
DE60320439D1 (de) 2008-05-29
ECSP055780A (es) 2005-08-11
JP2006511596A (ja) 2006-04-06
CA2499314C (en) 2010-08-24
WO2004032921A1 (en) 2004-04-22
OA12938A (en) 2006-10-13
UY28013A1 (es) 2004-04-30
AU2003269316A1 (en) 2004-05-04
DE60320439T2 (de) 2009-05-20
EP1556034A1 (en) 2005-07-27
CO5550421A2 (es) 2005-08-31

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