YU45095A - Derivati benzimidazola, postupci za njihovo prirpremanje i primena tih derivata u medicinskoj terapiji, naročito za lečenje ili sprečavanje virusnih infekcija - Google Patents

Derivati benzimidazola, postupci za njihovo prirpremanje i primena tih derivata u medicinskoj terapiji, naročito za lečenje ili sprečavanje virusnih infekcija

Info

Publication number
YU45095A
YU45095A YU45095A YU45095A YU45095A YU 45095 A YU45095 A YU 45095A YU 45095 A YU45095 A YU 45095A YU 45095 A YU45095 A YU 45095A YU 45095 A YU45095 A YU 45095A
Authority
YU
Yugoslavia
Prior art keywords
alkyl
derivatives
prevention
preparation
viral infections
Prior art date
Application number
YU45095A
Other languages
English (en)
Other versions
YU49443B (sh
Inventor
Stanley Dawes Chamberlain
Georg Walter Koszalka
Original Assignee
The Wellcome Foundation Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Wellcome Foundation Limited filed Critical The Wellcome Foundation Limited
Publication of YU45095A publication Critical patent/YU45095A/sh
Publication of YU49443B publication Critical patent/YU49443B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/052—Imidazole radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Pronalazak se odnosi na derivate benzimidazola formule (I): gde R predstavlja vodonik, atom halogena, ili -NR1R2, gde se R1 i R2, koji mogu biti isti ili različiti, biraju nezavisno od vodonika, C1-6 alkila, cijano C1-6 alkila, hidroksi C1-6 alkila, halo C1-6 alkila, C3-7 cikloalkila, C1-6 alkil C3-7 cikloalkila, C2-6 alkenila, C3-7 cikloalkil C1-6 alkila, C2-6 alkinila, arila, aril C1-6 alkila, heterocikličnog C1-6 alkila, ili R1 i R2 zajedno sa N atomom na koji su vezani obrazuju 3, 4, 5 ili 6-člani heterociklični prsten, kao i njihovi farmaceutski prihvatljivi derivati, i njihovu primenu u medicinskoj terapiji, posebno za lečenje ili sprečavanje virusnih infekcija kao što su one koje izazivaju herpes virusi. Pronalazak se takođe odnosi na pripremanje derivata benzimidazola i na farmaceutske preparate koji ih sadrže.
YU45095A 1994-07-07 1995-07-06 Derivati benzimidazola, postupci za njihovo pripremanje i primena tih derivata u medicinskoj terapiji, naročito za lečenje ili sprečavanje virusnih infekcija YU49443B (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9413724A GB9413724D0 (en) 1994-07-07 1994-07-07 Therapeutic nucleosides

Publications (2)

Publication Number Publication Date
YU45095A true YU45095A (sh) 1999-03-04
YU49443B YU49443B (sh) 2006-03-03

Family

ID=10757983

Family Applications (1)

Application Number Title Priority Date Filing Date
YU45095A YU49443B (sh) 1994-07-07 1995-07-06 Derivati benzimidazola, postupci za njihovo pripremanje i primena tih derivata u medicinskoj terapiji, naročito za lečenje ili sprečavanje virusnih infekcija

Country Status (44)

Country Link
US (4) US6077832A (sh)
EP (1) EP0769017B1 (sh)
JP (1) JP3225045B2 (sh)
KR (1) KR100376075B1 (sh)
CN (2) CN1052010C (sh)
AP (1) AP736A (sh)
AT (1) ATE193298T1 (sh)
AU (1) AU702248B2 (sh)
BG (1) BG63435B1 (sh)
BR (1) BR9508237A (sh)
CY (1) CY2249B1 (sh)
CZ (1) CZ290800B6 (sh)
DE (1) DE69517172T2 (sh)
DK (1) DK0769017T3 (sh)
EE (1) EE03568B1 (sh)
ES (1) ES2147294T3 (sh)
FI (1) FI117629B (sh)
GB (1) GB9413724D0 (sh)
GE (1) GEP20002298B (sh)
GR (1) GR3033744T3 (sh)
HK (1) HK1003711A1 (sh)
HR (1) HRP950382B1 (sh)
HU (1) HU227679B1 (sh)
IL (1) IL114492A (sh)
IS (1) IS1812B (sh)
MD (1) MD1838G2 (sh)
MX (1) MX9606732A (sh)
MY (1) MY117892A (sh)
NO (1) NO308854B1 (sh)
NZ (1) NZ288722A (sh)
OA (1) OA10339A (sh)
PL (1) PL181136B1 (sh)
PT (1) PT769017E (sh)
RO (1) RO117699B1 (sh)
RU (1) RU2145963C1 (sh)
SA (1) SA95160202B1 (sh)
SK (1) SK282046B6 (sh)
TJ (1) TJ270B (sh)
TR (1) TR199500832A2 (sh)
TW (1) TW418196B (sh)
UA (1) UA66744C2 (sh)
WO (1) WO1996001833A1 (sh)
YU (1) YU49443B (sh)
ZA (1) ZA955644B (sh)

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WO1997007125A1 (en) * 1995-08-18 1997-02-27 The Regents Of The University Of Michigan 5'-substituted-ribofuranosyl benzimidazoles as antiviral agents
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BR9810745A (pt) * 1997-06-10 2001-03-13 Glaxo Group Ltd Derivados de benzimidazol
PL338454A1 (en) 1997-07-30 2000-11-06 Univ Michigan Lixofuranosilbenzimidazoles as antiviral agents
US6258264B1 (en) 1998-04-10 2001-07-10 Transgenomic, Inc. Non-polar media for polynucleotide separations
GB9807354D0 (en) * 1998-04-07 1998-06-03 Glaxo Group Ltd Antiviral compound
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WO2014145852A2 (en) 2013-03-15 2014-09-18 Knopp Biosciences Llc Imidazo(4,5-b) pyridin-2-yl amides as kv7 channel activators
ES2960991T3 (es) 2014-09-12 2024-03-07 Biohaven Therapeutics Ltd Benzoimidazol-1,2-ilamidas como activadores del canal Kv7
EP3223816B1 (en) 2014-11-26 2020-04-22 The J. David Gladstone Institutes Methods for treating a cytomegalovirus infection
RU2629670C2 (ru) * 2016-08-04 2017-08-31 Федеральное государственное бюджетное учреждение науки институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Российской академии наук (ИБХ РАН) 2-Амино-5,6-дифтор-1-(бета-D-рибофуранозил)-бензимидазол, способ получения и противовирусная активность его в отношении вируса герпеса простого 1-го типа
SG11202008030WA (en) 2018-03-19 2020-10-29 Knopp Biosciences Llc Kv7 channel activators compositions and methods of use
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Also Published As

Publication number Publication date
FI970032A0 (fi) 1997-01-03
IS4394A (is) 1996-12-09
EE03568B1 (et) 2001-12-17
AU702248B2 (en) 1999-02-18
DE69517172T2 (de) 2000-10-19
GEP20002298B (en) 2000-11-25
GB9413724D0 (en) 1994-08-24
AU2805195A (en) 1996-02-09
IL114492A0 (en) 1995-11-27
ZA955644B (en) 1997-01-06
AP736A (en) 1999-03-09
IL114492A (en) 2002-05-23
JP3225045B2 (ja) 2001-11-05
US6077832A (en) 2000-06-20
MX9606732A (es) 1997-04-30
CN1236616A (zh) 1999-12-01
ATE193298T1 (de) 2000-06-15
PT769017E (pt) 2000-09-29
US5998605A (en) 1999-12-07
PL318062A1 (en) 1997-05-12
HU9700034D0 (en) 1997-02-28
MD1838F2 (en) 2002-01-31
GR3033744T3 (en) 2000-10-31
SK168896A3 (en) 1997-09-10
MY117892A (en) 2004-08-30
EP0769017B1 (en) 2000-05-24
RU2145963C1 (ru) 2000-02-27
CN1052010C (zh) 2000-05-03
JPH10502356A (ja) 1998-03-03
NZ288722A (en) 1998-07-28
OA10339A (en) 1997-10-07
SA95160202B1 (ar) 2005-04-16
PL181136B1 (pl) 2001-06-29
NO970040L (no) 1997-01-29
BG101118A (en) 1998-04-30
DK0769017T3 (da) 2000-09-11
CZ4097A3 (en) 1997-08-13
AP9600895A0 (en) 1997-01-31
FI970032A (fi) 1997-01-03
HRP950382A2 (en) 1997-08-31
BR9508237A (pt) 1999-06-01
NO308854B1 (no) 2000-11-06
HUT77285A (hu) 1998-03-30
DE69517172D1 (de) 2000-06-29
UA66744C2 (en) 2004-06-15
CY2249B1 (en) 2003-07-04
US20010003744A1 (en) 2001-06-14
IS1812B (is) 2002-05-15
TW418196B (en) 2001-01-11
WO1996001833A1 (en) 1996-01-25
US6307043B1 (en) 2001-10-23
SK282046B6 (sk) 2001-10-08
BG63435B1 (bg) 2002-01-31
EP0769017A1 (en) 1997-04-23
FI117629B (fi) 2006-12-29
EE9700013A (et) 1997-06-16
HK1003711A1 (en) 1998-11-06
CN1159194A (zh) 1997-09-10
TR199500832A2 (tr) 1996-06-21
MD1838G2 (ro) 2002-08-31
RO117699B1 (ro) 2002-06-28
KR100376075B1 (ko) 2004-02-18
CZ290800B6 (cs) 2002-10-16
HU227679B1 (en) 2011-11-28
TJ270B (en) 2000-08-07
ES2147294T3 (es) 2000-09-01
NO970040D0 (no) 1997-01-06
YU49443B (sh) 2006-03-03
HRP950382B1 (en) 2000-12-31

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