GR3033744T3 - Therapeutic compounds - Google Patents

Therapeutic compounds

Info

Publication number
GR3033744T3
GR3033744T3 GR20000401439T GR20000401439T GR3033744T3 GR 3033744 T3 GR3033744 T3 GR 3033744T3 GR 20000401439 T GR20000401439 T GR 20000401439T GR 20000401439 T GR20000401439 T GR 20000401439T GR 3033744 T3 GR3033744 T3 GR 3033744T3
Authority
GR
Greece
Prior art keywords
therapeutic compounds
therapeutic
compounds
Prior art date
Application number
GR20000401439T
Other languages
English (en)
Inventor
Stanley Dawes Chamberlain
George Walter Koszalka
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of GR3033744T3 publication Critical patent/GR3033744T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/052—Imidazole radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GR20000401439T 1994-07-07 2000-06-22 Therapeutic compounds GR3033744T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9413724A GB9413724D0 (en) 1994-07-07 1994-07-07 Therapeutic nucleosides
PCT/GB1995/001597 WO1996001833A1 (en) 1994-07-07 1995-07-06 Therapeutic compounds

Publications (1)

Publication Number Publication Date
GR3033744T3 true GR3033744T3 (en) 2000-10-31

Family

ID=10757983

Family Applications (1)

Application Number Title Priority Date Filing Date
GR20000401439T GR3033744T3 (en) 1994-07-07 2000-06-22 Therapeutic compounds

Country Status (44)

Country Link
US (4) US6077832A (el)
EP (1) EP0769017B1 (el)
JP (1) JP3225045B2 (el)
KR (1) KR100376075B1 (el)
CN (2) CN1052010C (el)
AP (1) AP736A (el)
AT (1) ATE193298T1 (el)
AU (1) AU702248B2 (el)
BG (1) BG63435B1 (el)
BR (1) BR9508237A (el)
CY (1) CY2249B1 (el)
CZ (1) CZ290800B6 (el)
DE (1) DE69517172T2 (el)
DK (1) DK0769017T3 (el)
EE (1) EE03568B1 (el)
ES (1) ES2147294T3 (el)
FI (1) FI117629B (el)
GB (1) GB9413724D0 (el)
GE (1) GEP20002298B (el)
GR (1) GR3033744T3 (el)
HK (1) HK1003711A1 (el)
HR (1) HRP950382B1 (el)
HU (1) HU227679B1 (el)
IL (1) IL114492A (el)
IS (1) IS1812B (el)
MD (1) MD1838G2 (el)
MX (1) MX9606732A (el)
MY (1) MY117892A (el)
NO (1) NO308854B1 (el)
NZ (1) NZ288722A (el)
OA (1) OA10339A (el)
PL (1) PL181136B1 (el)
PT (1) PT769017E (el)
RO (1) RO117699B1 (el)
RU (1) RU2145963C1 (el)
SA (1) SA95160202B1 (el)
SK (1) SK282046B6 (el)
TJ (1) TJ270B (el)
TR (1) TR199500832A2 (el)
TW (1) TW418196B (el)
UA (1) UA66744C2 (el)
WO (1) WO1996001833A1 (el)
YU (1) YU49443B (el)
ZA (1) ZA955644B (el)

Families Citing this family (34)

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GB9413724D0 (en) * 1994-07-07 1994-08-24 Wellcome Found Therapeutic nucleosides
EP0845001B1 (en) * 1995-08-18 2002-11-13 The Regents of The University of Michigan 5'-substituted-ribofuranosyl benzimidazoles as antiviral agents
GB9518465D0 (en) * 1995-09-09 1995-11-08 Smithkline Beecham Seiyaku Kk Pharmaceuticals
GB9600142D0 (en) * 1996-01-05 1996-03-06 Wellcome Found Chemical compounds
GB9600143D0 (en) * 1996-01-05 1996-03-06 Wellcome Found Therapeutic compounds
WO1997027205A1 (en) * 1996-01-23 1997-07-31 The Regents Of The University Of Michigan Imidazo[1,2-a]pyridine c-nucleosides as antiviral agents
US6475388B1 (en) 1996-11-13 2002-11-05 Transgenomic, Inc. Method and system for RNA analysis by matched ion polynucleotide chromatography
US6576133B2 (en) 1996-11-13 2003-06-10 Transgenomic, Inc Method and system for RNA analysis by matched ion polynucleotide chromatography
GB2319961A (en) * 1996-12-07 1998-06-10 Glaxo Group Ltd Pharmaceutical composition for treatment of restenosis
JP2001512453A (ja) 1997-02-13 2001-08-21 グラックス グループ リミテッド ベンゾイミダゾール誘導体
WO1998056761A2 (en) * 1997-06-10 1998-12-17 Glaxo Group Limited Benzimidazole derivatives
EP1000080A1 (en) 1997-07-30 2000-05-17 The Regents of The University of Michigan Lyxofuranosyl benzimidazoles as antiviral agents
US6258264B1 (en) 1998-04-10 2001-07-10 Transgenomic, Inc. Non-polar media for polynucleotide separations
GB9807354D0 (en) 1998-04-07 1998-06-03 Glaxo Group Ltd Antiviral compound
GB9807355D0 (en) 1998-04-07 1998-06-03 Glaxo Group Ltd Antiviral compound
US6277830B1 (en) * 1998-10-16 2001-08-21 Schering Corporation 5′-amino acid esters of ribavirin and the use of same to treat hepatitis C with interferon
US6576265B1 (en) 1999-12-22 2003-06-10 Acell, Inc. Tissue regenerative composition, method of making, and method of use thereof
GB0008939D0 (en) * 2000-04-11 2000-05-31 Glaxo Group Ltd Process for preparing substituted benzimidazole compounds
WO2005002601A1 (en) 2003-06-25 2005-01-13 Badylak Stephen F Conditioned matrix compositions for tissue restoration
ATE537181T1 (de) * 2003-12-26 2011-12-15 Kissei Pharmaceutical Benzimidazolderivate und deren medizinische verwendungen
JPWO2006115137A1 (ja) * 2005-04-22 2008-12-18 キッセイ薬品工業株式会社 ２−アミノベンズイミダゾール誘導体及びその医薬用途
EA008737B1 (ru) * 2005-12-07 2007-08-31 Леонид Андреевич Кожемякин Средство для профилактики и лечения конъюнктивитов и кератитов различной этиологии (варианты), способ его применения
US8940707B2 (en) 2010-10-28 2015-01-27 Viropharma Incorporated Maribavir isomers, compositions, methods of making and methods of using
US8541391B2 (en) 2010-10-28 2013-09-24 Viropharma Incorporated Crystalline phases of 5,6-dichloro-2-(isopropylamino)-1-β-L-ribofuranosyl-1H-benzimidazole
US8546344B2 (en) 2010-10-28 2013-10-01 Viropharma Incorporated Crystalline phases of 5,6-dichloro-2-(isopropylamino)-1-β-L-ribofuranosyl)-1H-benzimidazole
US9447050B2 (en) 2011-04-05 2016-09-20 The Translational Genomics Research Institute Solid forms of curcumin
EP2867010A1 (en) 2012-06-29 2015-05-06 The Procter & Gamble Company Textured fibrous webs, apparatus and methods for forming textured fibrous webs
ES2885424T3 (es) 2013-03-15 2021-12-13 Knopp Biosciences Llc Imidazo(4,5-B)piridin-2-il amidas como activadores del canal Kv7
US9481653B2 (en) 2014-09-12 2016-11-01 Knopp Biosciences Llc Benzoimidazol-1,2-yl amides as Kv7 channel activators
WO2016086060A1 (en) * 2014-11-26 2016-06-02 The J. David Gladstone Institutes Methods for treating a cytomegalovirus infection
RU2629670C2 (ru) * 2016-08-04 2017-08-31 Федеральное государственное бюджетное учреждение науки институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Российской академии наук (ИБХ РАН) 2-Амино-5,6-дифтор-1-(бета-D-рибофуранозил)-бензимидазол, способ получения и противовирусная активность его в отношении вируса герпеса простого 1-го типа
US10851067B2 (en) 2018-03-19 2020-12-01 Knopp Biosciences Llc Kv7 channel activators compositions and methods of use
US20210395289A1 (en) 2020-06-23 2021-12-23 Biometrix Technology Inc Novel benzimidazole derivatives, preparation method thereof and use thereof as anti-cancer agent or anti-virus agent comprising the same
WO2024081308A1 (en) 2022-10-12 2024-04-18 Takeda Pharmaceutical Company Limited Method of preparing maribavir

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US3399987A (en) * 1965-08-02 1968-09-03 United States Borax Chem 2-alkylaminobenzimidazoles as herbicides
CH443777A (de) * 1965-08-06 1968-02-15 Agripat Sa Verfahren zum Schützen textiler Keratinfasern vor Insektenfrass und Mittel zur Durchführung dieses Verfahrens
US3655901A (en) * 1970-07-30 1972-04-11 Merck & Co Inc Method of inhibiting the formation of phenylethanalamine-n-methyl transferase with 2-aminobenzimidazoles
DE2130030A1 (de) * 1971-06-18 1972-12-21 Bayer Ag Fungizide und bakterizide Mittel
US4002623A (en) * 1974-08-07 1977-01-11 Pfizer Inc. Anti-inflammatory 1-[3-(dialkylamino)propyl]-2-acylaminobenzimidazoles and 2-acylamino-3-[3-(dialkylamino)-propyl]imidazo[4,5-b]pyridines
FR2549938B1 (fr) * 1983-07-25 1987-08-07 Fonderie Soc Gen De Bruleur a premelange gazeux et chaudiere equipee d'un tel bruleur
FR2551442B1 (fr) * 1983-09-05 1987-04-30 Centre Nat Rech Scient Nouveaux derives furaniques, leur preparation et leur application
DK405988A (da) * 1987-07-29 1989-01-30 Hoffmann La Roche Benzimidazolderivater
IT1226100B (it) * 1988-07-07 1990-12-10 Dompe Farmaceutici Spa Derivati benzimidazolici farmacologicamente attivi.
SE9003151D0 (sv) * 1990-10-02 1990-10-02 Medivir Ab Nucleoside derivatives
US5248672A (en) * 1990-11-01 1993-09-28 The Regents Of The University Of Michigan Polysubstituted benzimidazole nucleosides as antiviral agents
WO1992018517A1 (en) * 1991-04-17 1992-10-29 Yale University Method of treating or preventing hepatitis b virus
ZA923641B (en) * 1991-05-21 1993-02-24 Iaf Biochem Int Processes for the diastereoselective synthesis of nucleosides
GB9205071D0 (en) * 1992-03-09 1992-04-22 Wellcome Found Therapeutic nucleosides
WO1994008456A1 (en) * 1992-10-21 1994-04-28 The Regents Of The University Of Michigan Polysubstituted benzimidazoles as antiviral agents
US5399580A (en) * 1993-03-08 1995-03-21 Burroughs Wellcome Co. Therapeutic nucleosides-uses
GB9413724D0 (en) * 1994-07-07 1994-08-24 Wellcome Found Therapeutic nucleosides
JP6217655B2 (ja) * 2015-01-15 2017-10-25 トヨタ自動車株式会社 電力変換装置

Also Published As

Publication number Publication date
UA66744C2 (en) 2004-06-15
HUT77285A (hu) 1998-03-30
WO1996001833A1 (en) 1996-01-25
IS4394A (is) 1996-12-09
EE03568B1 (et) 2001-12-17
FI970032A0 (fi) 1997-01-03
SA95160202B1 (ar) 2005-04-16
GEP20002298B (en) 2000-11-25
CZ290800B6 (cs) 2002-10-16
DE69517172T2 (de) 2000-10-19
ZA955644B (en) 1997-01-06
NZ288722A (en) 1998-07-28
PL318062A1 (en) 1997-05-12
CY2249B1 (en) 2003-07-04
CN1236616A (zh) 1999-12-01
ATE193298T1 (de) 2000-06-15
OA10339A (en) 1997-10-07
NO970040L (no) 1997-01-29
MD1838G2 (ro) 2002-08-31
NO308854B1 (no) 2000-11-06
SK282046B6 (sk) 2001-10-08
CZ4097A3 (en) 1997-08-13
TJ270B (en) 2000-08-07
PT769017E (pt) 2000-09-29
YU45095A (sh) 1999-03-04
MY117892A (en) 2004-08-30
US6077832A (en) 2000-06-20
HU227679B1 (en) 2011-11-28
IS1812B (is) 2002-05-15
EE9700013A (et) 1997-06-16
RU2145963C1 (ru) 2000-02-27
EP0769017B1 (en) 2000-05-24
JPH10502356A (ja) 1998-03-03
TR199500832A2 (tr) 1996-06-21
SK168896A3 (en) 1997-09-10
US5998605A (en) 1999-12-07
MX9606732A (es) 1997-04-30
NO970040D0 (no) 1997-01-06
IL114492A (en) 2002-05-23
DE69517172D1 (de) 2000-06-29
AP9600895A0 (en) 1997-01-31
YU49443B (sh) 2006-03-03
PL181136B1 (pl) 2001-06-29
FI117629B (fi) 2006-12-29
AP736A (en) 1999-03-09
HU9700034D0 (en) 1997-02-28
EP0769017A1 (en) 1997-04-23
RO117699B1 (ro) 2002-06-28
AU2805195A (en) 1996-02-09
ES2147294T3 (es) 2000-09-01
JP3225045B2 (ja) 2001-11-05
DK0769017T3 (da) 2000-09-11
HK1003711A1 (en) 1998-11-06
HRP950382A2 (en) 1997-08-31
IL114492A0 (en) 1995-11-27
BR9508237A (pt) 1999-06-01
KR100376075B1 (ko) 2004-02-18
TW418196B (en) 2001-01-11
MD1838F2 (en) 2002-01-31
FI970032A (fi) 1997-01-03
BG63435B1 (bg) 2002-01-31
CN1052010C (zh) 2000-05-03
AU702248B2 (en) 1999-02-18
CN1159194A (zh) 1997-09-10
US6307043B1 (en) 2001-10-23
GB9413724D0 (en) 1994-08-24
HRP950382B1 (en) 2000-12-31
US20010003744A1 (en) 2001-06-14
BG101118A (en) 1998-04-30

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