DE69517172T2 - Therapeutische verbindungen - Google Patents

Therapeutische verbindungen

Info

Publication number
DE69517172T2
DE69517172T2 DE69517172T DE69517172T DE69517172T2 DE 69517172 T2 DE69517172 T2 DE 69517172T2 DE 69517172 T DE69517172 T DE 69517172T DE 69517172 T DE69517172 T DE 69517172T DE 69517172 T2 DE69517172 T2 DE 69517172T2
Authority
DE
Germany
Prior art keywords
therapeutic
connections
therapeutic connections
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69517172T
Other languages
English (en)
Other versions
DE69517172D1 (de
Inventor
Dawes Chamberlain
Walter Koszalka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Publication of DE69517172D1 publication Critical patent/DE69517172D1/de
Application granted granted Critical
Publication of DE69517172T2 publication Critical patent/DE69517172T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/052—Imidazole radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69517172T 1994-07-07 1995-07-06 Therapeutische verbindungen Expired - Lifetime DE69517172T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9413724A GB9413724D0 (en) 1994-07-07 1994-07-07 Therapeutic nucleosides
PCT/GB1995/001597 WO1996001833A1 (en) 1994-07-07 1995-07-06 Therapeutic compounds

Publications (2)

Publication Number Publication Date
DE69517172D1 DE69517172D1 (de) 2000-06-29
DE69517172T2 true DE69517172T2 (de) 2000-10-19

Family

ID=10757983

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69517172T Expired - Lifetime DE69517172T2 (de) 1994-07-07 1995-07-06 Therapeutische verbindungen

Country Status (44)

Country Link
US (4) US6077832A (de)
EP (1) EP0769017B1 (de)
JP (1) JP3225045B2 (de)
KR (1) KR100376075B1 (de)
CN (2) CN1052010C (de)
AP (1) AP736A (de)
AT (1) ATE193298T1 (de)
AU (1) AU702248B2 (de)
BG (1) BG63435B1 (de)
BR (1) BR9508237A (de)
CY (1) CY2249B1 (de)
CZ (1) CZ290800B6 (de)
DE (1) DE69517172T2 (de)
DK (1) DK0769017T3 (de)
EE (1) EE03568B1 (de)
ES (1) ES2147294T3 (de)
FI (1) FI117629B (de)
GB (1) GB9413724D0 (de)
GE (1) GEP20002298B (de)
GR (1) GR3033744T3 (de)
HK (1) HK1003711A1 (de)
HR (1) HRP950382B1 (de)
HU (1) HU227679B1 (de)
IL (1) IL114492A (de)
IS (1) IS1812B (de)
MD (1) MD1838G2 (de)
MX (1) MX9606732A (de)
MY (1) MY117892A (de)
NO (1) NO308854B1 (de)
NZ (1) NZ288722A (de)
OA (1) OA10339A (de)
PL (1) PL181136B1 (de)
PT (1) PT769017E (de)
RO (1) RO117699B1 (de)
RU (1) RU2145963C1 (de)
SA (1) SA95160202B1 (de)
SK (1) SK282046B6 (de)
TJ (1) TJ270B (de)
TR (1) TR199500832A2 (de)
TW (1) TW418196B (de)
UA (1) UA66744C2 (de)
WO (1) WO1996001833A1 (de)
YU (1) YU49443B (de)
ZA (1) ZA955644B (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9413724D0 (en) * 1994-07-07 1994-08-24 Wellcome Found Therapeutic nucleosides
US5874413A (en) * 1995-08-18 1999-02-23 University Of Michigan 5'-substituted-ribofuranosyl benzimidazoles as antiviral agents
GB9518465D0 (en) * 1995-09-09 1995-11-08 Smithkline Beecham Seiyaku Kk Pharmaceuticals
GB9600142D0 (en) * 1996-01-05 1996-03-06 Wellcome Found Chemical compounds
GB9600143D0 (en) * 1996-01-05 1996-03-06 Wellcome Found Therapeutic compounds
IL125447A0 (en) 1996-01-23 1999-03-12 Univ Michigan Modified benzimidazole nucleosides as antiviral agents
US6576133B2 (en) 1996-11-13 2003-06-10 Transgenomic, Inc Method and system for RNA analysis by matched ion polynucleotide chromatography
US6475388B1 (en) 1996-11-13 2002-11-05 Transgenomic, Inc. Method and system for RNA analysis by matched ion polynucleotide chromatography
GB2319961A (en) * 1996-12-07 1998-06-10 Glaxo Group Ltd Pharmaceutical composition for treatment of restenosis
DE69819695D1 (en) 1997-02-13 2003-12-18 Glaxo Group Ltd Benzimidazolderivate
DK0994890T3 (da) * 1997-06-10 2003-12-01 Univ Michigan Benzimidazolderivater
WO1999006424A1 (en) 1997-07-30 1999-02-11 The Regents Of The University Of Michigan Lyxofuranosyl benzimidazoles as antiviral agents
US6258264B1 (en) 1998-04-10 2001-07-10 Transgenomic, Inc. Non-polar media for polynucleotide separations
GB9807355D0 (en) * 1998-04-07 1998-06-03 Glaxo Group Ltd Antiviral compound
GB9807354D0 (en) * 1998-04-07 1998-06-03 Glaxo Group Ltd Antiviral compound
US6277830B1 (en) * 1998-10-16 2001-08-21 Schering Corporation 5′-amino acid esters of ribavirin and the use of same to treat hepatitis C with interferon
US6576265B1 (en) 1999-12-22 2003-06-10 Acell, Inc. Tissue regenerative composition, method of making, and method of use thereof
GB0008939D0 (en) * 2000-04-11 2000-05-31 Glaxo Group Ltd Process for preparing substituted benzimidazole compounds
EP1644011A1 (de) 2003-06-25 2006-04-12 Stephen F. Badylak Konditionierte matrix-zusammensetzungen zur gewebe-wiederherstellung
ES2377937T3 (es) * 2003-12-26 2012-04-03 Kissei Pharmaceutical Co., Ltd. Derivados de benzimidazol y usos médicos de los mismos
WO2006115137A1 (ja) * 2005-04-22 2006-11-02 Kissei Pharmaceutical Co., Ltd. ２－アミノベンズイミダゾール誘導体及びその医薬用途
EA008737B1 (ru) * 2005-12-07 2007-08-31 Леонид Андреевич Кожемякин Средство для профилактики и лечения конъюнктивитов и кератитов различной этиологии (варианты), способ его применения
US8546344B2 (en) 2010-10-28 2013-10-01 Viropharma Incorporated Crystalline phases of 5,6-dichloro-2-(isopropylamino)-1-β-L-ribofuranosyl)-1H-benzimidazole
US8940707B2 (en) * 2010-10-28 2015-01-27 Viropharma Incorporated Maribavir isomers, compositions, methods of making and methods of using
US8541391B2 (en) 2010-10-28 2013-09-24 Viropharma Incorporated Crystalline phases of 5,6-dichloro-2-(isopropylamino)-1-β-L-ribofuranosyl-1H-benzimidazole
WO2012138907A2 (en) * 2011-04-05 2012-10-11 Translational Genomics Research Institute Solid forms of curcumin
US20140004307A1 (en) 2012-06-29 2014-01-02 The Procter & Gamble Company Textured Fibrous Webs, Apparatus And Methods For Forming Textured Fibrous Webs
EP2970277B1 (de) 2013-03-15 2021-07-28 Knopp Biosciences LLC Imidazo(4,5-b)pyridin-2-yl-amide als kv7-kanalaktivatoren
FI3572405T3 (fi) 2014-09-12 2023-09-22 Knopp Biosciences Llc Benzoimidatsol-1,2-yyli amidit kv7 kanavan aktivaattoreina
EP3223816B1 (de) 2014-11-26 2020-04-22 The J. David Gladstone Institutes Verfahren zur behandlung einer cytomegalovirusfektion
RU2629670C2 (ru) * 2016-08-04 2017-08-31 Федеральное государственное бюджетное учреждение науки институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Российской академии наук (ИБХ РАН) 2-Амино-5,6-дифтор-1-(бета-D-рибофуранозил)-бензимидазол, способ получения и противовирусная активность его в отношении вируса герпеса простого 1-го типа
KR20200133259A (ko) 2018-03-19 2020-11-26 놉 바이오사이언시스 엘엘씨 Kv7 채널 활성화제 조성물 및 이의 사용 방법
CN114096549A (zh) 2020-06-23 2022-02-25 博美利克斯技术公司 新型苯并咪唑衍生物、其制备方法及其作为抗癌剂或者抗病毒剂的用途
WO2024081308A1 (en) 2022-10-12 2024-04-18 Takeda Pharmaceutical Company Limited Method of preparing maribavir

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Publication number Priority date Publication date Assignee Title
US3399987A (en) * 1965-08-02 1968-09-03 United States Borax Chem 2-alkylaminobenzimidazoles as herbicides
CH443777A (de) * 1965-08-06 1968-02-15 Agripat Sa Verfahren zum Schützen textiler Keratinfasern vor Insektenfrass und Mittel zur Durchführung dieses Verfahrens
US3655901A (en) * 1970-07-30 1972-04-11 Merck & Co Inc Method of inhibiting the formation of phenylethanalamine-n-methyl transferase with 2-aminobenzimidazoles
DE2130030A1 (de) * 1971-06-18 1972-12-21 Bayer Ag Fungizide und bakterizide Mittel
US4002623A (en) * 1974-08-07 1977-01-11 Pfizer Inc. Anti-inflammatory 1-[3-(dialkylamino)propyl]-2-acylaminobenzimidazoles and 2-acylamino-3-[3-(dialkylamino)-propyl]imidazo[4,5-b]pyridines
FR2549938B1 (fr) * 1983-07-25 1987-08-07 Fonderie Soc Gen De Bruleur a premelange gazeux et chaudiere equipee d'un tel bruleur
FR2551442B1 (fr) * 1983-09-05 1987-04-30 Centre Nat Rech Scient Nouveaux derives furaniques, leur preparation et leur application
EP0304624A3 (de) * 1987-07-29 1989-03-22 F. Hoffmann-La Roche Ag Benzimidazol-2-yl-pyridiniumverbindungen
IT1226100B (it) * 1988-07-07 1990-12-10 Dompe Farmaceutici Spa Derivati benzimidazolici farmacologicamente attivi.
SE9003151D0 (sv) * 1990-10-02 1990-10-02 Medivir Ab Nucleoside derivatives
US5248672A (en) * 1990-11-01 1993-09-28 The Regents Of The University Of Michigan Polysubstituted benzimidazole nucleosides as antiviral agents
WO1992018517A1 (en) * 1991-04-17 1992-10-29 Yale University Method of treating or preventing hepatitis b virus
ZA923640B (en) * 1991-05-21 1993-02-24 Iaf Biochem Int Processes for the diastereoselective synthesis of nucleosides
GB9205071D0 (en) * 1992-03-09 1992-04-22 Wellcome Found Therapeutic nucleosides
AU5447094A (en) * 1992-10-21 1994-05-09 Regents Of The University Of Michigan, The Polysubstituted benzimidazoles as antiviral agents
US5399580A (en) * 1993-03-08 1995-03-21 Burroughs Wellcome Co. Therapeutic nucleosides-uses
GB9413724D0 (en) * 1994-07-07 1994-08-24 Wellcome Found Therapeutic nucleosides
JP6217655B2 (ja) * 2015-01-15 2017-10-25 トヨタ自動車株式会社 電力変換装置

Also Published As

Publication number Publication date
TJ270B (en) 2000-08-07
DE69517172D1 (de) 2000-06-29
HK1003711A1 (en) 1998-11-06
TW418196B (en) 2001-01-11
IS4394A (is) 1996-12-09
RO117699B1 (ro) 2002-06-28
JP3225045B2 (ja) 2001-11-05
CN1236616A (zh) 1999-12-01
GB9413724D0 (en) 1994-08-24
BG63435B1 (bg) 2002-01-31
WO1996001833A1 (en) 1996-01-25
NO970040D0 (no) 1997-01-06
AP736A (en) 1999-03-09
EE03568B1 (et) 2001-12-17
HUT77285A (hu) 1998-03-30
EE9700013A (et) 1997-06-16
YU49443B (sh) 2006-03-03
OA10339A (en) 1997-10-07
ZA955644B (en) 1997-01-06
EP0769017A1 (de) 1997-04-23
AU702248B2 (en) 1999-02-18
HU227679B1 (en) 2011-11-28
AP9600895A0 (en) 1997-01-31
SK282046B6 (sk) 2001-10-08
IL114492A (en) 2002-05-23
MX9606732A (es) 1997-04-30
PL181136B1 (pl) 2001-06-29
FI970032A0 (fi) 1997-01-03
FI117629B (fi) 2006-12-29
BG101118A (en) 1998-04-30
JPH10502356A (ja) 1998-03-03
AU2805195A (en) 1996-02-09
US5998605A (en) 1999-12-07
CZ4097A3 (en) 1997-08-13
EP0769017B1 (de) 2000-05-24
FI970032A (fi) 1997-01-03
SK168896A3 (en) 1997-09-10
CZ290800B6 (cs) 2002-10-16
NO308854B1 (no) 2000-11-06
RU2145963C1 (ru) 2000-02-27
HU9700034D0 (en) 1997-02-28
PL318062A1 (en) 1997-05-12
IL114492A0 (en) 1995-11-27
DK0769017T3 (da) 2000-09-11
SA95160202B1 (ar) 2005-04-16
GR3033744T3 (en) 2000-10-31
IS1812B (is) 2002-05-15
US6077832A (en) 2000-06-20
YU45095A (sh) 1999-03-04
MD1838G2 (ro) 2002-08-31
BR9508237A (pt) 1999-06-01
TR199500832A2 (tr) 1996-06-21
ATE193298T1 (de) 2000-06-15
CN1052010C (zh) 2000-05-03
HRP950382A2 (en) 1997-08-31
MY117892A (en) 2004-08-30
US20010003744A1 (en) 2001-06-14
MD1838F2 (en) 2002-01-31
UA66744C2 (en) 2004-06-15
NZ288722A (en) 1998-07-28
NO970040L (no) 1997-01-29
HRP950382B1 (en) 2000-12-31
KR100376075B1 (ko) 2004-02-18
PT769017E (pt) 2000-09-29
ES2147294T3 (es) 2000-09-01
CN1159194A (zh) 1997-09-10
CY2249B1 (en) 2003-07-04
US6307043B1 (en) 2001-10-23
GEP20002298B (en) 2000-11-25

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition