MD1838G2 - Derivaţi de 5,6-diclorbenzimidazol, procedeu de obţinere a lor, compoziţie farmaceutică şi metodă de tratament sau de prevenire a infecţiei virotice herpetice - Google Patents

Derivaţi de 5,6-diclorbenzimidazol, procedeu de obţinere a lor, compoziţie farmaceutică şi metodă de tratament sau de prevenire a infecţiei virotice herpetice Download PDF

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Publication number
MD1838G2
MD1838G2 MD97-0052A MD970052A MD1838G2 MD 1838 G2 MD1838 G2 MD 1838G2 MD 970052 A MD970052 A MD 970052A MD 1838 G2 MD1838 G2 MD 1838G2
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MD
Moldova
Prior art keywords
dichlorbenzimidazole
prevention
derivatives
obtaining
treatment
Prior art date
Application number
MD97-0052A
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English (en)
Russian (ru)
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MD1838F2 (ro
Inventor
Стэнли Дейвс ЧАМБЕРЛАЙН
Георге Уолтер КОСЗАЛКА
Original Assignee
Зэ Уелкэм Фаундейшэн Лимитид
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Зэ Уелкэм Фаундейшэн Лимитид filed Critical Зэ Уелкэм Фаундейшэн Лимитид
Publication of MD1838F2 publication Critical patent/MD1838F2/ro
Publication of MD1838G2 publication Critical patent/MD1838G2/ro

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/052—Imidazole radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Invenţia se referă la derivaţii de 5,6-diclorbenzimidazol cu formula (I)(I)în care substituenţii au semnificaţia indicată în descriere.De asemenea se revendică procedeul de obţinere a lor, compoziţia farmaceutică şi metoda de tratament sau de prevenire a simptomelor infecţiei virotice herpetice.
MD97-0052A 1994-07-07 1995-07-06 Derivaţi de 5,6-diclorbenzimidazol, procedeu de obţinere a lor, compoziţie farmaceutică şi metodă de tratament sau de prevenire a infecţiei virotice herpetice MD1838G2 (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9413724A GB9413724D0 (en) 1994-07-07 1994-07-07 Therapeutic nucleosides
PCT/GB1995/001597 WO1996001833A1 (en) 1994-07-07 1995-07-06 Therapeutic compounds

Publications (2)

Publication Number Publication Date
MD1838F2 MD1838F2 (ro) 2002-01-31
MD1838G2 true MD1838G2 (ro) 2002-08-31

Family

ID=10757983

Family Applications (1)

Application Number Title Priority Date Filing Date
MD97-0052A MD1838G2 (ro) 1994-07-07 1995-07-06 Derivaţi de 5,6-diclorbenzimidazol, procedeu de obţinere a lor, compoziţie farmaceutică şi metodă de tratament sau de prevenire a infecţiei virotice herpetice

Country Status (43)

Country Link
US (4) US6077832A (ro)
EP (1) EP0769017B1 (ro)
JP (1) JP3225045B2 (ro)
KR (1) KR100376075B1 (ro)
CN (2) CN1052010C (ro)
AP (1) AP736A (ro)
AT (1) ATE193298T1 (ro)
AU (1) AU702248B2 (ro)
BG (1) BG63435B1 (ro)
BR (1) BR9508237A (ro)
CY (1) CY2249B1 (ro)
CZ (1) CZ290800B6 (ro)
DE (1) DE69517172T2 (ro)
DK (1) DK0769017T3 (ro)
EE (1) EE03568B1 (ro)
ES (1) ES2147294T3 (ro)
FI (1) FI117629B (ro)
GB (1) GB9413724D0 (ro)
GE (1) GEP20002298B (ro)
GR (1) GR3033744T3 (ro)
HR (1) HRP950382B1 (ro)
HU (1) HU227679B1 (ro)
IL (1) IL114492A (ro)
IS (1) IS1812B (ro)
MD (1) MD1838G2 (ro)
MX (1) MX9606732A (ro)
MY (1) MY117892A (ro)
NO (1) NO308854B1 (ro)
NZ (1) NZ288722A (ro)
OA (1) OA10339A (ro)
PL (1) PL181136B1 (ro)
PT (1) PT769017E (ro)
RO (1) RO117699B1 (ro)
RU (1) RU2145963C1 (ro)
SA (1) SA95160202B1 (ro)
SK (1) SK282046B6 (ro)
TJ (1) TJ270B (ro)
TR (1) TR199500832A2 (ro)
TW (1) TW418196B (ro)
UA (1) UA66744C2 (ro)
WO (1) WO1996001833A1 (ro)
YU (1) YU49443B (ro)
ZA (1) ZA955644B (ro)

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SK171499A3 (en) 1997-06-10 2000-08-14 Glaxo Group Ltd Benzimidazole derivatives, process for their production pharmaceutical composition containing said derivatives and use of said derivatives
WO1999006424A1 (en) 1997-07-30 1999-02-11 The Regents Of The University Of Michigan Lyxofuranosyl benzimidazoles as antiviral agents
US6258264B1 (en) 1998-04-10 2001-07-10 Transgenomic, Inc. Non-polar media for polynucleotide separations
GB9807354D0 (en) 1998-04-07 1998-06-03 Glaxo Group Ltd Antiviral compound
GB9807355D0 (en) * 1998-04-07 1998-06-03 Glaxo Group Ltd Antiviral compound
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GB0008939D0 (en) 2000-04-11 2000-05-31 Glaxo Group Ltd Process for preparing substituted benzimidazole compounds
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ES2377937T3 (es) * 2003-12-26 2012-04-03 Kissei Pharmaceutical Co., Ltd. Derivados de benzimidazol y usos médicos de los mismos
RU2268741C1 (ru) * 2004-08-04 2006-01-27 Государственное образовательное учреждение высшего профессионального образования "Южно-Уральский государственный университет" Способ лечения герпетического поражения вестибулярного, спирального, тригеминального и коленчатого ганглиев
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EA008737B1 (ru) * 2005-12-07 2007-08-31 Леонид Андреевич Кожемякин Средство для профилактики и лечения конъюнктивитов и кератитов различной этиологии (варианты), способ его применения
US8541391B2 (en) 2010-10-28 2013-09-24 Viropharma Incorporated Crystalline phases of 5,6-dichloro-2-(isopropylamino)-1-β-L-ribofuranosyl-1H-benzimidazole
US8546344B2 (en) 2010-10-28 2013-10-01 Viropharma Incorporated Crystalline phases of 5,6-dichloro-2-(isopropylamino)-1-β-L-ribofuranosyl)-1H-benzimidazole
US8940707B2 (en) * 2010-10-28 2015-01-27 Viropharma Incorporated Maribavir isomers, compositions, methods of making and methods of using
US9447050B2 (en) 2011-04-05 2016-09-20 The Translational Genomics Research Institute Solid forms of curcumin
US20140004307A1 (en) 2012-06-29 2014-01-02 The Procter & Gamble Company Textured Fibrous Webs, Apparatus And Methods For Forming Textured Fibrous Webs
ES2885424T3 (es) 2013-03-15 2021-12-13 Knopp Biosciences Llc Imidazo(4,5-B)piridin-2-il amidas como activadores del canal Kv7
HRP20231071T1 (hr) 2014-09-12 2024-03-01 Biohaven Therapeutics Ltd. Benzoimidazol-1,2-il amidi kao aktivatori kv7 kanala
US10478431B2 (en) 2014-11-26 2019-11-19 The J. David Gladstone Institutes Methods for treating a cytomegalovirus infection
RU2629670C2 (ru) * 2016-08-04 2017-08-31 Федеральное государственное бюджетное учреждение науки институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Российской академии наук (ИБХ РАН) 2-Амино-5,6-дифтор-1-(бета-D-рибофуранозил)-бензимидазол, способ получения и противовирусная активность его в отношении вируса герпеса простого 1-го типа
JP7757036B2 (ja) 2018-03-19 2025-10-21 バイオヘイブン・セラピューティクス・リミテッド Ｋｖ７チャネル活性化剤の構成および使用方法
JP7376108B2 (ja) * 2020-06-23 2023-11-08 バイオメトリックス テクノロジーズ インコーポレイテッド 新規なベンズイミダゾール誘導体、その製造方法及びその抗癌剤または抗ウイルス剤としての用途
CN119136799A (zh) 2022-10-12 2024-12-13 武田药品工业株式会社 制备马立巴韦的方法
WO2024103979A1 (zh) * 2022-11-17 2024-05-23 北京凯因科技股份有限公司 一种抑制疱疹病毒的化合物

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WO1993018009A1 (en) * 1992-03-09 1993-09-16 The Wellcome Foundation Limited Antiviral nucleoside analogues
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Also Published As

Publication number Publication date
KR100376075B1 (ko) 2004-02-18
CN1052010C (zh) 2000-05-03
AP9600895A0 (en) 1997-01-31
AU702248B2 (en) 1999-02-18
CZ290800B6 (cs) 2002-10-16
IL114492A (en) 2002-05-23
PT769017E (pt) 2000-09-29
MD1838F2 (ro) 2002-01-31
AP736A (en) 1999-03-09
CN1236616A (zh) 1999-12-01
ES2147294T3 (es) 2000-09-01
US20010003744A1 (en) 2001-06-14
MX9606732A (es) 1997-04-30
MY117892A (en) 2004-08-30
PL318062A1 (en) 1997-05-12
HRP950382B1 (en) 2000-12-31
RO117699B1 (ro) 2002-06-28
TR199500832A2 (tr) 1996-06-21
YU49443B (sh) 2006-03-03
BG101118A (en) 1998-04-30
IS1812B (is) 2002-05-15
JP3225045B2 (ja) 2001-11-05
HU9700034D0 (en) 1997-02-28
HRP950382A2 (en) 1997-08-31
IL114492A0 (en) 1995-11-27
NZ288722A (en) 1998-07-28
SK282046B6 (sk) 2001-10-08
AU2805195A (en) 1996-02-09
DK0769017T3 (da) 2000-09-11
OA10339A (en) 1997-10-07
ZA955644B (en) 1997-01-06
US6077832A (en) 2000-06-20
NO308854B1 (no) 2000-11-06
NO970040L (no) 1997-01-29
HUT77285A (hu) 1998-03-30
NO970040D0 (no) 1997-01-06
SA95160202B1 (ar) 2005-04-16
TJ270B (en) 2000-08-07
PL181136B1 (pl) 2001-06-29
CY2249B1 (en) 2003-07-04
JPH10502356A (ja) 1998-03-03
HU227679B1 (en) 2011-11-28
FI970032A0 (fi) 1997-01-03
US5998605A (en) 1999-12-07
US6307043B1 (en) 2001-10-23
GEP20002298B (en) 2000-11-25
GR3033744T3 (en) 2000-10-31
DE69517172D1 (de) 2000-06-29
HK1003711A1 (en) 1998-11-06
BR9508237A (pt) 1999-06-01
FI117629B (fi) 2006-12-29
IS4394A (is) 1996-12-09
EE03568B1 (et) 2001-12-17
TW418196B (en) 2001-01-11
CN1159194A (zh) 1997-09-10
UA66744C2 (en) 2004-06-15
DE69517172T2 (de) 2000-10-19
EP0769017B1 (en) 2000-05-24
EE9700013A (et) 1997-06-16
SK168896A3 (en) 1997-09-10
YU45095A (sh) 1999-03-04
GB9413724D0 (en) 1994-08-24
FI970032L (fi) 1997-01-03
BG63435B1 (bg) 2002-01-31
EP0769017A1 (en) 1997-04-23
ATE193298T1 (de) 2000-06-15
WO1996001833A1 (en) 1996-01-25
CZ4097A3 (en) 1997-08-13
RU2145963C1 (ru) 2000-02-27

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