MD1838F2 - Derivati de 5,6-diclorbenzimidazol, procedeu de obtinere a lor, compozitie farmaceutica si metoda de tratament sau de prevenire a infectiei virotice herpetice - Google Patents

Derivati de 5,6-diclorbenzimidazol, procedeu de obtinere a lor, compozitie farmaceutica si metoda de tratament sau de prevenire a infectiei virotice herpetice Download PDF

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Publication number
MD1838F2
MD1838F2 MD97-0052A MD970052A MD1838F2 MD 1838 F2 MD1838 F2 MD 1838F2 MD 970052 A MD970052 A MD 970052A MD 1838 F2 MD1838 F2 MD 1838F2
Authority
MD
Moldova
Prior art keywords
dichlorbenzimidazole
prevention
derivatives
obtaining
treatment
Prior art date
Application number
MD97-0052A
Other languages
English (en)
Other versions
MD1838G2 (ro
Inventor
Stanley Dawes Chamberlain
George Walter Koszalka
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of MD1838F2 publication Critical patent/MD1838F2/ro
Publication of MD1838G2 publication Critical patent/MD1838G2/ro

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/052—Imidazole radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
MD97-0052A 1994-07-07 1995-07-06 Derivaţi de 5,6-diclorbenzimidazol, procedeu de obţinere a lor, compoziţie farmaceutică şi metodă de tratament sau de prevenire a infecţiei virotice herpetice MD1838G2 (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9413724A GB9413724D0 (en) 1994-07-07 1994-07-07 Therapeutic nucleosides
PCT/GB1995/001597 WO1996001833A1 (en) 1994-07-07 1995-07-06 Therapeutic compounds

Publications (2)

Publication Number Publication Date
MD1838F2 true MD1838F2 (ro) 2002-01-31
MD1838G2 MD1838G2 (ro) 2002-08-31

Family

ID=10757983

Family Applications (1)

Application Number Title Priority Date Filing Date
MD97-0052A MD1838G2 (ro) 1994-07-07 1995-07-06 Derivaţi de 5,6-diclorbenzimidazol, procedeu de obţinere a lor, compoziţie farmaceutică şi metodă de tratament sau de prevenire a infecţiei virotice herpetice

Country Status (43)

Country Link
US (4) US6077832A (ro)
EP (1) EP0769017B1 (ro)
JP (1) JP3225045B2 (ro)
KR (1) KR100376075B1 (ro)
CN (2) CN1052010C (ro)
AP (1) AP736A (ro)
AT (1) ATE193298T1 (ro)
AU (1) AU702248B2 (ro)
BG (1) BG63435B1 (ro)
BR (1) BR9508237A (ro)
CY (1) CY2249B1 (ro)
CZ (1) CZ290800B6 (ro)
DE (1) DE69517172T2 (ro)
DK (1) DK0769017T3 (ro)
EE (1) EE03568B1 (ro)
ES (1) ES2147294T3 (ro)
FI (1) FI117629B (ro)
GB (1) GB9413724D0 (ro)
GE (1) GEP20002298B (ro)
GR (1) GR3033744T3 (ro)
HR (1) HRP950382B1 (ro)
HU (1) HU227679B1 (ro)
IL (1) IL114492A (ro)
IS (1) IS1812B (ro)
MD (1) MD1838G2 (ro)
MX (1) MX9606732A (ro)
MY (1) MY117892A (ro)
NO (1) NO308854B1 (ro)
NZ (1) NZ288722A (ro)
OA (1) OA10339A (ro)
PL (1) PL181136B1 (ro)
PT (1) PT769017E (ro)
RO (1) RO117699B1 (ro)
RU (1) RU2145963C1 (ro)
SA (1) SA95160202B1 (ro)
SK (1) SK282046B6 (ro)
TJ (1) TJ270B (ro)
TR (1) TR199500832A2 (ro)
TW (1) TW418196B (ro)
UA (1) UA66744C2 (ro)
WO (1) WO1996001833A1 (ro)
YU (1) YU49443B (ro)
ZA (1) ZA955644B (ro)

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GB9413724D0 (en) 1994-07-07 1994-08-24 Wellcome Found Therapeutic nucleosides
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WO1999006424A1 (en) 1997-07-30 1999-02-11 The Regents Of The University Of Michigan Lyxofuranosyl benzimidazoles as antiviral agents
US6258264B1 (en) 1998-04-10 2001-07-10 Transgenomic, Inc. Non-polar media for polynucleotide separations
GB9807355D0 (en) 1998-04-07 1998-06-03 Glaxo Group Ltd Antiviral compound
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GB0008939D0 (en) 2000-04-11 2000-05-31 Glaxo Group Ltd Process for preparing substituted benzimidazole compounds
RU2262344C2 (ru) * 2001-07-25 2005-10-20 Дж.Б.Кемикалс Энд Фармасьютикалс Лтд. Фармацевтическая композиция для лечения кожных инфекций и способ ее получения
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CA2530490A1 (en) 2003-06-25 2005-01-13 Stephen F. Badylak Conditioned matrix compositions for tissue restoration
JP4914611B2 (ja) * 2003-12-26 2012-04-11 キッセイ薬品工業株式会社 ベンズイミダゾール誘導体及びその医薬用途
RU2268741C1 (ru) * 2004-08-04 2006-01-27 Государственное образовательное учреждение высшего профессионального образования "Южно-Уральский государственный университет" Способ лечения герпетического поражения вестибулярного, спирального, тригеминального и коленчатого ганглиев
JPWO2006115137A1 (ja) * 2005-04-22 2008-12-18 キッセイ薬品工業株式会社 ２−アミノベンズイミダゾール誘導体及びその医薬用途
EA008737B1 (ru) * 2005-12-07 2007-08-31 Леонид Андреевич Кожемякин Средство для профилактики и лечения конъюнктивитов и кератитов различной этиологии (варианты), способ его применения
US8546344B2 (en) 2010-10-28 2013-10-01 Viropharma Incorporated Crystalline phases of 5,6-dichloro-2-(isopropylamino)-1-β-L-ribofuranosyl)-1H-benzimidazole
US8940707B2 (en) * 2010-10-28 2015-01-27 Viropharma Incorporated Maribavir isomers, compositions, methods of making and methods of using
US8541391B2 (en) 2010-10-28 2013-09-24 Viropharma Incorporated Crystalline phases of 5,6-dichloro-2-(isopropylamino)-1-β-L-ribofuranosyl-1H-benzimidazole
US9447050B2 (en) 2011-04-05 2016-09-20 The Translational Genomics Research Institute Solid forms of curcumin
WO2014004939A1 (en) 2012-06-29 2014-01-03 The Procter & Gamble Company Textured fibrous webs, apparatus and methods for forming textured fibrous webs
EP2970277B1 (en) 2013-03-15 2021-07-28 Knopp Biosciences LLC Imidazo(4,5-b) pyridin-2-yl amides as kv7 channel activators
SMT202300362T1 (it) 2014-09-12 2023-11-13 Biohaven Therapeutics Ltd Benzoimidazol-1,2-il-ammidi come attivatori di canale kv7
WO2016086060A1 (en) * 2014-11-26 2016-06-02 The J. David Gladstone Institutes Methods for treating a cytomegalovirus infection
RU2629670C2 (ru) * 2016-08-04 2017-08-31 Федеральное государственное бюджетное учреждение науки институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Российской академии наук (ИБХ РАН) 2-Амино-5,6-дифтор-1-(бета-D-рибофуранозил)-бензимидазол, способ получения и противовирусная активность его в отношении вируса герпеса простого 1-го типа
CA3093976A1 (en) 2018-03-19 2019-09-26 Michael E. Bozik Kv7 channel activators compositions and methods of use
JP7376108B2 (ja) * 2020-06-23 2023-11-08 バイオメトリックス テクノロジーズ インコーポレイテッド 新規なベンズイミダゾール誘導体、その製造方法及びその抗癌剤または抗ウイルス剤としての用途
EP4480956A3 (en) 2022-10-12 2025-02-19 Takeda Pharmaceutical Company Limited Viral inhibitors, the synthesis thereof, and intermediates thereto
WO2024103979A1 (zh) * 2022-11-17 2024-05-23 北京凯因科技股份有限公司 一种抑制疱疹病毒的化合物

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Also Published As

Publication number Publication date
EE9700013A (et) 1997-06-16
US5998605A (en) 1999-12-07
CZ290800B6 (cs) 2002-10-16
FI970032L (fi) 1997-01-03
SK168896A3 (en) 1997-09-10
SA95160202B1 (ar) 2005-04-16
FI117629B (fi) 2006-12-29
SK282046B6 (sk) 2001-10-08
CZ4097A3 (en) 1997-08-13
JPH10502356A (ja) 1998-03-03
HRP950382B1 (en) 2000-12-31
DE69517172T2 (de) 2000-10-19
HK1003711A1 (en) 1998-11-06
HU9700034D0 (en) 1997-02-28
ES2147294T3 (es) 2000-09-01
IS4394A (is) 1996-12-09
KR100376075B1 (ko) 2004-02-18
DK0769017T3 (da) 2000-09-11
MD1838G2 (ro) 2002-08-31
ATE193298T1 (de) 2000-06-15
OA10339A (en) 1997-10-07
EP0769017B1 (en) 2000-05-24
CN1052010C (zh) 2000-05-03
NZ288722A (en) 1998-07-28
TW418196B (en) 2001-01-11
IL114492A (en) 2002-05-23
AU2805195A (en) 1996-02-09
HU227679B1 (en) 2011-11-28
GB9413724D0 (en) 1994-08-24
HRP950382A2 (en) 1997-08-31
JP3225045B2 (ja) 2001-11-05
BG101118A (en) 1998-04-30
EE03568B1 (et) 2001-12-17
US20010003744A1 (en) 2001-06-14
NO970040L (no) 1997-01-29
YU45095A (sh) 1999-03-04
UA66744C2 (en) 2004-06-15
TJ270B (en) 2000-08-07
PL318062A1 (en) 1997-05-12
RU2145963C1 (ru) 2000-02-27
GEP20002298B (en) 2000-11-25
RO117699B1 (ro) 2002-06-28
BG63435B1 (bg) 2002-01-31
YU49443B (sh) 2006-03-03
NO970040D0 (no) 1997-01-06
MX9606732A (es) 1997-04-30
EP0769017A1 (en) 1997-04-23
MY117892A (en) 2004-08-30
IL114492A0 (en) 1995-11-27
GR3033744T3 (en) 2000-10-31
AP9600895A0 (en) 1997-01-31
PL181136B1 (pl) 2001-06-29
ZA955644B (en) 1997-01-06
CN1159194A (zh) 1997-09-10
CY2249B1 (en) 2003-07-04
WO1996001833A1 (en) 1996-01-25
TR199500832A2 (tr) 1996-06-21
US6077832A (en) 2000-06-20
BR9508237A (pt) 1999-06-01
FI970032A0 (fi) 1997-01-03
PT769017E (pt) 2000-09-29
AP736A (en) 1999-03-09
AU702248B2 (en) 1999-02-18
CN1236616A (zh) 1999-12-01
IS1812B (is) 2002-05-15
DE69517172D1 (de) 2000-06-29
NO308854B1 (no) 2000-11-06
US6307043B1 (en) 2001-10-23
HUT77285A (hu) 1998-03-30

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