SK282046B6 - Benzimidazolové deriváty, spôsob ich prípravy, farmaceutické prostriedky s ich obsahom a ich použitie - Google Patents

Benzimidazolové deriváty, spôsob ich prípravy, farmaceutické prostriedky s ich obsahom a ich použitie Download PDF

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Publication number
SK282046B6
SK282046B6 SK1688-96A SK168896A SK282046B6 SK 282046 B6 SK282046 B6 SK 282046B6 SK 168896 A SK168896 A SK 168896A SK 282046 B6 SK282046 B6 SK 282046B6
Authority
SK
Slovakia
Prior art keywords
benzimidazole
formula
dichloro
carbon atoms
mmol
Prior art date
Application number
SK1688-96A
Other languages
English (en)
Slovak (sk)
Other versions
SK168896A3 (en
Inventor
Stanley Dawes Chamberlain
George Walter Koszalka
Original Assignee
The Wellcome Foundation Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Wellcome Foundation Limited filed Critical The Wellcome Foundation Limited
Publication of SK168896A3 publication Critical patent/SK168896A3/sk
Publication of SK282046B6 publication Critical patent/SK282046B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/052—Imidazole radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
SK1688-96A 1994-07-07 1995-07-06 Benzimidazolové deriváty, spôsob ich prípravy, farmaceutické prostriedky s ich obsahom a ich použitie SK282046B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9413724A GB9413724D0 (en) 1994-07-07 1994-07-07 Therapeutic nucleosides
PCT/GB1995/001597 WO1996001833A1 (en) 1994-07-07 1995-07-06 Therapeutic compounds

Publications (2)

Publication Number Publication Date
SK168896A3 SK168896A3 (en) 1997-09-10
SK282046B6 true SK282046B6 (sk) 2001-10-08

Family

ID=10757983

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1688-96A SK282046B6 (sk) 1994-07-07 1995-07-06 Benzimidazolové deriváty, spôsob ich prípravy, farmaceutické prostriedky s ich obsahom a ich použitie

Country Status (44)

Country Link
US (4) US6077832A (sh)
EP (1) EP0769017B1 (sh)
JP (1) JP3225045B2 (sh)
KR (1) KR100376075B1 (sh)
CN (2) CN1052010C (sh)
AP (1) AP736A (sh)
AT (1) ATE193298T1 (sh)
AU (1) AU702248B2 (sh)
BG (1) BG63435B1 (sh)
BR (1) BR9508237A (sh)
CY (1) CY2249B1 (sh)
CZ (1) CZ290800B6 (sh)
DE (1) DE69517172T2 (sh)
DK (1) DK0769017T3 (sh)
EE (1) EE03568B1 (sh)
ES (1) ES2147294T3 (sh)
FI (1) FI117629B (sh)
GB (1) GB9413724D0 (sh)
GE (1) GEP20002298B (sh)
GR (1) GR3033744T3 (sh)
HK (1) HK1003711A1 (sh)
HR (1) HRP950382B1 (sh)
HU (1) HU227679B1 (sh)
IL (1) IL114492A (sh)
IS (1) IS1812B (sh)
MD (1) MD1838G2 (sh)
MX (1) MX9606732A (sh)
MY (1) MY117892A (sh)
NO (1) NO308854B1 (sh)
NZ (1) NZ288722A (sh)
OA (1) OA10339A (sh)
PL (1) PL181136B1 (sh)
PT (1) PT769017E (sh)
RO (1) RO117699B1 (sh)
RU (1) RU2145963C1 (sh)
SA (1) SA95160202B1 (sh)
SK (1) SK282046B6 (sh)
TJ (1) TJ270B (sh)
TR (1) TR199500832A2 (sh)
TW (1) TW418196B (sh)
UA (1) UA66744C2 (sh)
WO (1) WO1996001833A1 (sh)
YU (1) YU49443B (sh)
ZA (1) ZA955644B (sh)

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GB9413724D0 (en) * 1994-07-07 1994-08-24 Wellcome Found Therapeutic nucleosides
ATE227734T1 (de) * 1995-08-18 2002-11-15 Univ Michigan 5'-substitutierte-ribofuranosyl benzimidazolen als antivirale.
GB9518465D0 (en) * 1995-09-09 1995-11-08 Smithkline Beecham Seiyaku Kk Pharmaceuticals
GB9600142D0 (en) * 1996-01-05 1996-03-06 Wellcome Found Chemical compounds
GB9600143D0 (en) * 1996-01-05 1996-03-06 Wellcome Found Therapeutic compounds
WO1997027205A1 (en) * 1996-01-23 1997-07-31 The Regents Of The University Of Michigan Imidazo[1,2-a]pyridine c-nucleosides as antiviral agents
US6475388B1 (en) 1996-11-13 2002-11-05 Transgenomic, Inc. Method and system for RNA analysis by matched ion polynucleotide chromatography
US6576133B2 (en) 1996-11-13 2003-06-10 Transgenomic, Inc Method and system for RNA analysis by matched ion polynucleotide chromatography
GB2319961A (en) * 1996-12-07 1998-06-10 Glaxo Group Ltd Pharmaceutical composition for treatment of restenosis
AU6221998A (en) 1997-02-13 1998-09-08 Glaxo Group Limited Benzimidazole derivatives
ATE246700T1 (de) 1997-06-10 2003-08-15 Glaxo Group Ltd Benzimidazolderivate
US6455506B1 (en) 1997-07-30 2002-09-24 Smithkline Beecham Corporation Lyxofuranosyl benzimidazoles as antiviral agents
US6258264B1 (en) 1998-04-10 2001-07-10 Transgenomic, Inc. Non-polar media for polynucleotide separations
GB9807355D0 (en) * 1998-04-07 1998-06-03 Glaxo Group Ltd Antiviral compound
GB9807354D0 (en) 1998-04-07 1998-06-03 Glaxo Group Ltd Antiviral compound
US6277830B1 (en) * 1998-10-16 2001-08-21 Schering Corporation 5′-amino acid esters of ribavirin and the use of same to treat hepatitis C with interferon
US6576265B1 (en) 1999-12-22 2003-06-10 Acell, Inc. Tissue regenerative composition, method of making, and method of use thereof
GB0008939D0 (en) 2000-04-11 2000-05-31 Glaxo Group Ltd Process for preparing substituted benzimidazole compounds
AU2004253508A1 (en) 2003-06-25 2005-01-13 Acell, Inc. Conditioned matrix compositions for tissue restoration
ES2377937T3 (es) * 2003-12-26 2012-04-03 Kissei Pharmaceutical Co., Ltd. Derivados de benzimidazol y usos médicos de los mismos
WO2006115137A1 (ja) * 2005-04-22 2006-11-02 Kissei Pharmaceutical Co., Ltd. ２－アミノベンズイミダゾール誘導体及びその医薬用途
EA008737B1 (ru) * 2005-12-07 2007-08-31 Леонид Андреевич Кожемякин Средство для профилактики и лечения конъюнктивитов и кератитов различной этиологии (варианты), способ его применения
US8546344B2 (en) 2010-10-28 2013-10-01 Viropharma Incorporated Crystalline phases of 5,6-dichloro-2-(isopropylamino)-1-β-L-ribofuranosyl)-1H-benzimidazole
US8541391B2 (en) 2010-10-28 2013-09-24 Viropharma Incorporated Crystalline phases of 5,6-dichloro-2-(isopropylamino)-1-β-L-ribofuranosyl-1H-benzimidazole
US8940707B2 (en) 2010-10-28 2015-01-27 Viropharma Incorporated Maribavir isomers, compositions, methods of making and methods of using
US9447050B2 (en) 2011-04-05 2016-09-20 The Translational Genomics Research Institute Solid forms of curcumin
US20140004307A1 (en) 2012-06-29 2014-01-02 The Procter & Gamble Company Textured Fibrous Webs, Apparatus And Methods For Forming Textured Fibrous Webs
ES2885424T3 (es) 2013-03-15 2021-12-13 Knopp Biosciences Llc Imidazo(4,5-B)piridin-2-il amidas como activadores del canal Kv7
US9481653B2 (en) 2014-09-12 2016-11-01 Knopp Biosciences Llc Benzoimidazol-1,2-yl amides as Kv7 channel activators
WO2016086060A1 (en) * 2014-11-26 2016-06-02 The J. David Gladstone Institutes Methods for treating a cytomegalovirus infection
RU2629670C2 (ru) * 2016-08-04 2017-08-31 Федеральное государственное бюджетное учреждение науки институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Российской академии наук (ИБХ РАН) 2-Амино-5,6-дифтор-1-(бета-D-рибофуранозил)-бензимидазол, способ получения и противовирусная активность его в отношении вируса герпеса простого 1-го типа
BR112020018933A2 (pt) 2018-03-19 2020-12-29 Knopp Biosciences Llc Composto, composição farmacêutica, método de tratamento de um transtorno associado a kv7 e método de tratamento de um transtorno associado a uma mutação kcnq2
US12043644B2 (en) * 2020-06-23 2024-07-23 Biometrix Technology Inc Benzimidazole derivatives, preparation method thereof and use thereof as anti-cancer agent or anti-virus agent comprising the same
WO2024081308A1 (en) 2022-10-12 2024-04-18 Takeda Pharmaceutical Company Limited Method of preparing maribavir
WO2024103979A1 (zh) * 2022-11-17 2024-05-23 北京凯因科技股份有限公司 一种抑制疱疹病毒的化合物

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CH443777A (de) * 1965-08-06 1968-02-15 Agripat Sa Verfahren zum Schützen textiler Keratinfasern vor Insektenfrass und Mittel zur Durchführung dieses Verfahrens
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DE2130030A1 (de) * 1971-06-18 1972-12-21 Bayer Ag Fungizide und bakterizide Mittel
US4002623A (en) * 1974-08-07 1977-01-11 Pfizer Inc. Anti-inflammatory 1-[3-(dialkylamino)propyl]-2-acylaminobenzimidazoles and 2-acylamino-3-[3-(dialkylamino)-propyl]imidazo[4,5-b]pyridines
FR2549938B1 (fr) * 1983-07-25 1987-08-07 Fonderie Soc Gen De Bruleur a premelange gazeux et chaudiere equipee d'un tel bruleur
FR2551442B1 (fr) * 1983-09-05 1987-04-30 Centre Nat Rech Scient Nouveaux derives furaniques, leur preparation et leur application
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US5248672A (en) * 1990-11-01 1993-09-28 The Regents Of The University Of Michigan Polysubstituted benzimidazole nucleosides as antiviral agents
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Also Published As

Publication number Publication date
CN1159194A (zh) 1997-09-10
HU227679B1 (en) 2011-11-28
JP3225045B2 (ja) 2001-11-05
US20010003744A1 (en) 2001-06-14
NO970040L (no) 1997-01-29
BG63435B1 (bg) 2002-01-31
ES2147294T3 (es) 2000-09-01
YU45095A (sh) 1999-03-04
HRP950382A2 (en) 1997-08-31
DE69517172T2 (de) 2000-10-19
ZA955644B (en) 1997-01-06
FI970032A (fi) 1997-01-03
RU2145963C1 (ru) 2000-02-27
IS4394A (is) 1996-12-09
AU2805195A (en) 1996-02-09
US6307043B1 (en) 2001-10-23
US6077832A (en) 2000-06-20
UA66744C2 (en) 2004-06-15
AU702248B2 (en) 1999-02-18
JPH10502356A (ja) 1998-03-03
GEP20002298B (en) 2000-11-25
DE69517172D1 (de) 2000-06-29
KR100376075B1 (ko) 2004-02-18
CN1236616A (zh) 1999-12-01
EP0769017A1 (en) 1997-04-23
MX9606732A (es) 1997-04-30
TJ270B (en) 2000-08-07
DK0769017T3 (da) 2000-09-11
YU49443B (sh) 2006-03-03
CZ4097A3 (en) 1997-08-13
EE03568B1 (et) 2001-12-17
HU9700034D0 (en) 1997-02-28
OA10339A (en) 1997-10-07
SK168896A3 (en) 1997-09-10
MD1838G2 (ro) 2002-08-31
WO1996001833A1 (en) 1996-01-25
ATE193298T1 (de) 2000-06-15
US5998605A (en) 1999-12-07
TW418196B (en) 2001-01-11
GB9413724D0 (en) 1994-08-24
EE9700013A (et) 1997-06-16
HK1003711A1 (en) 1998-11-06
PL181136B1 (pl) 2001-06-29
NO970040D0 (no) 1997-01-06
AP9600895A0 (en) 1997-01-31
TR199500832A2 (tr) 1996-06-21
HUT77285A (hu) 1998-03-30
MD1838F2 (en) 2002-01-31
AP736A (en) 1999-03-09
IS1812B (is) 2002-05-15
GR3033744T3 (en) 2000-10-31
CZ290800B6 (cs) 2002-10-16
IL114492A (en) 2002-05-23
CN1052010C (zh) 2000-05-03
PT769017E (pt) 2000-09-29
SA95160202B1 (ar) 2005-04-16
PL318062A1 (en) 1997-05-12
IL114492A0 (en) 1995-11-27
EP0769017B1 (en) 2000-05-24
FI117629B (fi) 2006-12-29
CY2249B1 (en) 2003-07-04
NZ288722A (en) 1998-07-28
MY117892A (en) 2004-08-30
HRP950382B1 (en) 2000-12-31
NO308854B1 (no) 2000-11-06
BG101118A (en) 1998-04-30
FI970032A0 (fi) 1997-01-03
RO117699B1 (ro) 2002-06-28
BR9508237A (pt) 1999-06-01

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MK4A Patent expired

Expiry date: 20150706