MX2010012189A - Derivados de quinuclidina como antagonistas del receptor m3 muscarinico. - Google Patents

Derivados de quinuclidina como antagonistas del receptor m3 muscarinico.

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Publication number
MX2010012189A
MX2010012189A MX2010012189A MX2010012189A MX2010012189A MX 2010012189 A MX2010012189 A MX 2010012189A MX 2010012189 A MX2010012189 A MX 2010012189A MX 2010012189 A MX2010012189 A MX 2010012189A MX 2010012189 A MX2010012189 A MX 2010012189A
Authority
MX
Mexico
Prior art keywords
muscarinic
receptor antagonists
quinuclidine derivatives
quinuclidine
pharmaceutical compositions
Prior art date
Application number
MX2010012189A
Other languages
English (en)
Inventor
Mete Antonio
James Bull Richard
Lee Ford Rhonan
Nigel Mather Andrew
Anne Skidmore Elizabeth
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of MX2010012189A publication Critical patent/MX2010012189A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
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Abstract

La invención proporciona los compuestos nombrados de fórmula (I) (ver fórmula I) en la que R4 es una quinuclidina N-sustituida (I), composiciones farmacéuticas que los contienen y un proceso para preparar las composiciones farmacéuticas. También se divulga su uso en terapia para el tratamiento de afecciones mediadas por receptores muscarínicos M3, tales como la enfermedad pulmonar obstructiva crónica.
MX2010012189A 2008-05-13 2008-05-13 Derivados de quinuclidina como antagonistas del receptor m3 muscarinico. MX2010012189A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/GB2008/001647 WO2009138707A1 (en) 2008-05-13 2008-05-13 Quinuclidine derivatives as muscarinic m3 receptor antagonists

Publications (1)

Publication Number Publication Date
MX2010012189A true MX2010012189A (es) 2011-03-02

Family

ID=40361403

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010012189A MX2010012189A (es) 2008-05-13 2008-05-13 Derivados de quinuclidina como antagonistas del receptor m3 muscarinico.

Country Status (17)

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US (2) US8329729B2 (es)
EP (1) EP2300464A1 (es)
JP (1) JP4837800B2 (es)
CN (1) CN102089304A (es)
AU (1) AU2008356409B2 (es)
BR (1) BRPI0822693A2 (es)
CA (1) CA2723981A1 (es)
CL (1) CL2009001137A1 (es)
EA (1) EA017627B1 (es)
EC (1) ECSP10010606A (es)
HN (1) HN2010002403A (es)
IL (1) IL209126A0 (es)
MX (1) MX2010012189A (es)
NI (1) NI201000195A (es)
NZ (1) NZ589091A (es)
WO (1) WO2009138707A1 (es)
ZA (1) ZA201007988B (es)

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US5807670A (en) * 1995-08-14 1998-09-15 Abbott Laboratories Detection of hepatitis GB virus genotypes
TW200825084A (en) * 2006-11-14 2008-06-16 Astrazeneca Ab New compounds 521
KR20110010725A (ko) * 2008-05-13 2011-02-07 아스트라제네카 아베 무스카린성 수용체 길항제 및 β２­아드레날린수용체 효능제를 포함하는 제약 생성물
AU2008356409B2 (en) 2008-05-13 2012-01-19 Astrazeneca Ab Quinuclidine derivatives as muscarinic M3 receptor antagonists
TW201036957A (en) 2009-02-20 2010-10-16 Astrazeneca Ab Novel salt 628
GB201016912D0 (en) 2010-10-07 2010-11-24 Astrazeneca Ab Novel combination
CN103265478B (zh) * 2013-05-20 2015-09-30 中国人民解放军第二军医大学 巯基烟酸类化合物及其制备方法
CN114716380B (zh) * 2022-04-01 2024-06-21 新乡医学院 一种相转移催化的4-取代吡唑酮类化合物不对称氟化方法

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