FR2155927A1 - 1-phenylcyclo hexane carboxylic acid esters - with antispasmodic and anticholinergic activity - Google Patents

1-phenylcyclo hexane carboxylic acid esters - with antispasmodic and anticholinergic activity

Info

Publication number
FR2155927A1
FR2155927A1 FR7137146A FR7137146A FR2155927A1 FR 2155927 A1 FR2155927 A1 FR 2155927A1 FR 7137146 A FR7137146 A FR 7137146A FR 7137146 A FR7137146 A FR 7137146A FR 2155927 A1 FR2155927 A1 FR 2155927A1
Authority
FR
France
Prior art keywords
antispasmodic
carboxylic acid
acid esters
anticholinergic activity
hexane carboxylic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7137146A
Other languages
French (fr)
Other versions
FR2155927B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthelabo SA filed Critical Synthelabo SA
Priority to FR7137146A priority Critical patent/FR2155927A1/en
Publication of FR2155927A1 publication Critical patent/FR2155927A1/en
Application granted granted Critical
Publication of FR2155927B1 publication Critical patent/FR2155927B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Cpds. of formula (I) where n is 0 or 1; R is a gp. of formula (a)-(f) where R' is alkyl; R2 is H, alkyl, phenyalkyl; A- is a pharmaceutically acceptable cation. Useful in treating peptic ulcers. Dose is 100-400 mg daily (oral) in dosage units of 10-100mg. A prefd. cpd. I has n=0, R=.
FR7137146A 1971-10-15 1971-10-15 1-phenylcyclo hexane carboxylic acid esters - with antispasmodic and anticholinergic activity Granted FR2155927A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7137146A FR2155927A1 (en) 1971-10-15 1971-10-15 1-phenylcyclo hexane carboxylic acid esters - with antispasmodic and anticholinergic activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7137146A FR2155927A1 (en) 1971-10-15 1971-10-15 1-phenylcyclo hexane carboxylic acid esters - with antispasmodic and anticholinergic activity

Publications (2)

Publication Number Publication Date
FR2155927A1 true FR2155927A1 (en) 1973-05-25
FR2155927B1 FR2155927B1 (en) 1975-03-14

Family

ID=9084452

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7137146A Granted FR2155927A1 (en) 1971-10-15 1971-10-15 1-phenylcyclo hexane carboxylic acid esters - with antispasmodic and anticholinergic activity

Country Status (1)

Country Link
FR (1) FR2155927A1 (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0024960A2 (en) * 1979-07-06 1981-03-11 Societe D'etudes Scientifiques Et Industrielles De L'ile-De-France Substituted heterocyclic phenoxy amines, their preparation method and their use as local anaesthetics
US4847306A (en) * 1986-05-05 1989-07-11 Merck & Co., Inc. Antihypercholesterolemic compounds
EP0499995A2 (en) * 1991-02-20 1992-08-26 Nisshin Flour Milling Co., Ltd. Piperidine derivatives
WO2003087094A2 (en) * 2002-04-16 2003-10-23 Almirall Prodesfarma Ag Pyrrolidinium derivatives as antagonists of m3 muscarinic receptors
KR100990872B1 (en) * 2008-05-06 2010-10-29 한국화학연구원 Novel 1-phenyl-carboxylic acid ester derivative or pharmaceutically acceptable salt thereof, preparation method thereof and muscarinic receptor antagonist or pharmaceutical composition for the prevention and treatment of nervous system diseases by organophosphate intoxication containing the same as an active ingredient
US8207193B2 (en) 2006-11-14 2012-06-26 Astrazeneca Ab Quiniclidine derivatives of (hetero) arylcycloheptanecarboxylic acid as muscarinic receptor antagonists
US8329729B2 (en) 2008-05-13 2012-12-11 Astrazeneca Ab Quinuclidine derivatives as muscarinic M3 receptor antagonists

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1212754A (en) * 1957-06-17 1960-03-25 Robins Co Inc A H Process for preparing esters of amino alcohols, in particular diarylacetates and cycloalkyl-arylacetates of 3-pyrrolidinols
FR2012964A1 (en) * 1968-07-15 1970-03-27 Sogeras

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1212754A (en) * 1957-06-17 1960-03-25 Robins Co Inc A H Process for preparing esters of amino alcohols, in particular diarylacetates and cycloalkyl-arylacetates of 3-pyrrolidinols
FR2012964A1 (en) * 1968-07-15 1970-03-27 Sogeras

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0024960A2 (en) * 1979-07-06 1981-03-11 Societe D'etudes Scientifiques Et Industrielles De L'ile-De-France Substituted heterocyclic phenoxy amines, their preparation method and their use as local anaesthetics
EP0024960A3 (en) * 1979-07-06 1981-06-17 Ile De France Substituted heterocyclic phenoxy amines and their intermediates, their preparation method and their use as local anaesthetics
US4847306A (en) * 1986-05-05 1989-07-11 Merck & Co., Inc. Antihypercholesterolemic compounds
EP0499995A2 (en) * 1991-02-20 1992-08-26 Nisshin Flour Milling Co., Ltd. Piperidine derivatives
EP0499995A3 (en) * 1991-02-20 1992-09-23 Nisshin Flour Milling Co., Ltd. Piperidine derivatives
US5246945A (en) * 1991-02-20 1993-09-21 Nisshin Flour Milling Co., Ltd. Piperidine derivatives
WO2003087094A2 (en) * 2002-04-16 2003-10-23 Almirall Prodesfarma Ag Pyrrolidinium derivatives as antagonists of m3 muscarinic receptors
WO2003087094A3 (en) * 2002-04-16 2004-03-18 Almirall Prodesfarma Sa Pyrrolidinium derivatives as antagonists of m3 muscarinic receptors
US7192978B2 (en) 2002-04-16 2007-03-20 Almirall Prodesfarma Ag Pyrrolidinium derivatives
AU2003233967B2 (en) * 2002-04-16 2009-08-06 Laboratorios Almirall, S.A. Pyrrolidinium derivatives as antagonists of M3 muscarinic receptors
US8207193B2 (en) 2006-11-14 2012-06-26 Astrazeneca Ab Quiniclidine derivatives of (hetero) arylcycloheptanecarboxylic acid as muscarinic receptor antagonists
KR100990872B1 (en) * 2008-05-06 2010-10-29 한국화학연구원 Novel 1-phenyl-carboxylic acid ester derivative or pharmaceutically acceptable salt thereof, preparation method thereof and muscarinic receptor antagonist or pharmaceutical composition for the prevention and treatment of nervous system diseases by organophosphate intoxication containing the same as an active ingredient
US8329729B2 (en) 2008-05-13 2012-12-11 Astrazeneca Ab Quinuclidine derivatives as muscarinic M3 receptor antagonists

Also Published As

Publication number Publication date
FR2155927B1 (en) 1975-03-14

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