EA200970554A1 - 4-(гетероциклил)алкил-n-(арилсульфонил)индолсоединения и их применение в качестве 5-нтлигандов - Google Patents

4-(гетероциклил)алкил-n-(арилсульфонил)индолсоединения и их применение в качестве 5-нтлигандов

Info

Publication number
EA200970554A1
EA200970554A1 EA200970554A EA200970554A EA200970554A1 EA 200970554 A1 EA200970554 A1 EA 200970554A1 EA 200970554 A EA200970554 A EA 200970554A EA 200970554 A EA200970554 A EA 200970554A EA 200970554 A1 EA200970554 A1 EA 200970554A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compounds
disorders
pharmaceutically acceptable
arylsulfonyl
heterocyclyl
Prior art date
Application number
EA200970554A
Other languages
English (en)
Other versions
EA016015B1 (ru
Inventor
Нироджи Венката Сатья Рамакришна
Рама Састри Камбхампати
Амол Динкар Дешпанде
Венкатесварлу Джасти
Original Assignee
Сувен Лайф Сайенсиз Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Сувен Лайф Сайенсиз Лимитед filed Critical Сувен Лайф Сайенсиз Лимитед
Publication of EA200970554A1 publication Critical patent/EA200970554A1/ru
Publication of EA016015B1 publication Critical patent/EA016015B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Epidemiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Настоящее изобретение относится к новым 4-(гетероциклил)алкил-N-(арилсульфонил)индолсоединениям формулы (I), их производным, стереоизомерам, фармацевтически приемлемым солям и содержащим их фармацевтически приемлемым композициям. Настоящее изобретение также относится к способу получения упомянутых выше новых соединений, их производных, стереоизомеров, фармацевтически приемлемых солей и к содержащим их фармацевтически приемлемым композициям. Такие соединения применимы при лечении различных расстройств, которые связаны с 5-НТрецепторными функциями. Конкретно, соединения данного изобретения также применимы при лечении различных расстройств CNS, гематологических расстройств, расстройств пищевого поведения, заболеваний, связанных с болью, респираторных заболеваний, урогенитальных расстройств, сердечно-сосудистых заболеваний и рака.
EA200970554A 2007-01-08 2007-07-26 4-(гетероциклил)алкил-n-(арилсульфонил)индолсоединения и их применение в качестве 5-нтлигандов EA016015B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN44CH2007 2007-01-08
PCT/IN2007/000311 WO2008084491A1 (en) 2007-01-08 2007-07-26 4-(heterocyclyl)alkyl-n-(arylsulfonyl) indole compounds and their use as 5-ht6 ligands

Publications (2)

Publication Number Publication Date
EA200970554A1 true EA200970554A1 (ru) 2009-12-30
EA016015B1 EA016015B1 (ru) 2012-01-30

Family

ID=38819780

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200970554A EA016015B1 (ru) 2007-01-08 2007-07-26 4-(гетероциклил)алкил-n-(арилсульфонил)индолсоединения и их применение в качестве 5-нтлигандов

Country Status (18)

Country Link
US (1) US20100041669A1 (ru)
EP (1) EP2121602B1 (ru)
JP (1) JP2010515673A (ru)
KR (1) KR101176894B1 (ru)
CN (1) CN101563321B (ru)
AU (1) AU2007343062B2 (ru)
BR (1) BRPI0718736A2 (ru)
CA (1) CA2672190C (ru)
DK (1) DK2121602T3 (ru)
EA (1) EA016015B1 (ru)
ES (1) ES2533902T3 (ru)
HK (1) HK1135986A1 (ru)
IL (1) IL199300A (ru)
MX (1) MX2009006757A (ru)
NO (1) NO341958B1 (ru)
NZ (1) NZ578281A (ru)
WO (1) WO2008084491A1 (ru)
ZA (1) ZA200904200B (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8318725B2 (en) 2008-09-17 2012-11-27 Suven Life Sciences Limited Aryl indolyl sulfonamide compounds and their use as 5-HT6 ligands
JP6454346B2 (ja) 2013-12-20 2019-01-16 サンシャイン・レイク・ファーマ・カンパニー・リミテッドＳｕｎｓｈｉｎｅ Ｌａｋｅ Ｐｈａｒｍａ Ｃｏ．，Ｌｔｄ． 芳香族複素環式化合物及び医薬におけるその応用
CN105541693B (zh) * 2014-07-08 2018-10-16 广东东阳光药业有限公司 芳杂环类衍生物及其在药物上的应用
EP3530651A1 (en) * 2018-02-21 2019-08-28 Adamed sp. z o.o. Indole and benzimidazole derivatives as dual 5-ht2a and 5-ht6 receptor antagonists
CN111233736B (zh) * 2020-03-16 2021-07-16 东莞市东阳光新药研发有限公司 芳杂环类衍生物的盐及其用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9820113D0 (en) * 1998-09-15 1998-11-11 Merck Sharp & Dohme Therapeutic agents
EP1343756A2 (en) * 2000-11-02 2003-09-17 Wyeth 1-aryl- or 1-alkylsulfonyl-heterocyclylbenzazoles as 5-hydroxytryptamine-6 ligands
NZ529631A (en) * 2001-06-07 2006-08-31 F Indole derivatives with 5-hydroxytryptamine (5-HT) 5-HT6 receptor affinity in the treatment of disorders of the CNS
US7875605B2 (en) * 2002-11-28 2011-01-25 Suven Life Sciences Limited N-arylsulfonyl-3-substituted indoles having serotonin receptor affinity, process for their preparation and pharmaceutical composition containing them
SE0302760D0 (sv) * 2003-10-20 2003-10-20 Biovitrum Ab New compounds
AU2007271188B2 (en) * 2006-07-03 2012-11-01 Proximagen Limited Indoles as 5-HT6 modulators

Also Published As

Publication number Publication date
NO341958B1 (no) 2018-03-05
EA016015B1 (ru) 2012-01-30
WO2008084491A1 (en) 2008-07-17
EP2121602B1 (en) 2015-03-18
BRPI0718736A2 (pt) 2014-03-25
DK2121602T3 (en) 2015-04-07
MX2009006757A (es) 2009-06-30
ES2533902T3 (es) 2015-04-15
KR101176894B1 (ko) 2012-08-30
EP2121602A1 (en) 2009-11-25
NZ578281A (en) 2011-01-28
CN101563321A (zh) 2009-10-21
US20100041669A1 (en) 2010-02-18
JP2010515673A (ja) 2010-05-13
IL199300A (en) 2014-03-31
KR20090096513A (ko) 2009-09-10
HK1135986A1 (ru) 2010-06-18
ZA200904200B (en) 2010-10-27
CA2672190A1 (en) 2008-07-17
AU2007343062A1 (en) 2008-07-17
CA2672190C (en) 2013-02-05
AU2007343062B2 (en) 2011-02-10
NO20092400L (no) 2009-10-02
CN101563321B (zh) 2012-05-30

Similar Documents

Publication Publication Date Title
EA200900658A1 (ru) Производные индазолилэфиров или -амидов для лечения расстройств, опосредованных глюкокортиодными рецепторами
MX2009000531A (es) Derivados heterociclicos fusionados y metodos de uso.
MX2010007683A (es) Derivados heterociclicos fusionados y metodos de uso como inhibidores de c-met.
TW200720260A (en) Prokineticin 1 receptor antagonists
TW200716566A (en) Prokineticin 2 receptor antagonists
EA200970065A1 (ru) Производные пиперазинила, предназначенные для лечения заболеваний, опосредованных рецептором gpr38
WO2013042135A8 (en) Heteroaryl compounds as 5-ht4 receptor ligands
EA201791829A1 (ru) Амидные соединения в качестве агонистов рецептора 5-ht
CY1111105T1 (el) Ενωσεις 5-(ετεροκυκλυλ)αλκυλ-ν-(αρυλσουλφονυλ)ινδολης και η χρηση τους ως προσδεματα του 5-ητ6
MX2007000576A (es) Agonistas del receptor nicotinico para el tratamiento de enfermedades inflamatorias.
EA201270421A1 (ru) 1,2-дигидро-2-оксохинолиновые соединения в качестве лигандов рецептора 5-нт
EA200970554A1 (ru) 4-(гетероциклил)алкил-n-(арилсульфонил)индолсоединения и их применение в качестве 5-нтлигандов
MX2010012189A (es) Derivados de quinuclidina como antagonistas del receptor m3 muscarinico.
UA88910C2 (ru) Гетероциклические соединения для предотвращения или ослабления симптомов заболеваний, которые лечатся коноплей, и способы их получения
EA200971017A1 (ru) Аминоалкоксиарилсульфонамидные соединения и их применение в качестве 5-нтлигандов
NZ720879A (en) Indazole compounds as 5-ht4 receptor agonists
EA200701758A1 (ru) Замещённые арильные производные 1,4-пиразина
CY1112181T1 (el) Αμινο αρυλοσουλφοναμιδικες ενωσεις και η χρηση τους ως 5-ητ6 συνδετες
EA201390327A1 (ru) Гетероциклильные соединения в качестве лигандов гистаминовых hрецепторов
CY1110087T1 (el) Μεθοδοι παρασκευης ενωσεων που περιεχουν πυρραζολιο
WO2014147636A8 (en) 5-amino-quinoline-8-carboxamide derivatives as 5-ht4 receptor agonists
EA201070381A1 (ru) 5-арил-4,5-дигидро-(1н)-пиразолы в качестве агонистов каннабиоидного сврецептора
EA201170615A1 (ru) Лиганды рецептора тиреоидного гормона

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU