EA201270421A1 - 1,2-дигидро-2-оксохинолиновые соединения в качестве лигандов рецептора 5-нт - Google Patents
1,2-дигидро-2-оксохинолиновые соединения в качестве лигандов рецептора 5-нтInfo
- Publication number
- EA201270421A1 EA201270421A1 EA201270421A EA201270421A EA201270421A1 EA 201270421 A1 EA201270421 A1 EA 201270421A1 EA 201270421 A EA201270421 A EA 201270421A EA 201270421 A EA201270421 A EA 201270421A EA 201270421 A1 EA201270421 A1 EA 201270421A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- compounds
- dihydro
- receptor
- oxohinoline
- ligands
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4704—2-Quinolinones, e.g. carbostyril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
Abstract
Настоящее изобретение относится к новым 1,2-дигидро-2-оксохинолиновым соединениям формулы (I) и их производным, пролекарствам, таутомерам, стереоизомерам, полиморфам, сольватам, гидратам, метаболитам, N-оксидам, фармацевтически приемлемым солям и содержащим их композициям. Настоящее изобретение также относится к способу получения вышеуказанных новых соединений и их производных, пролекарств, таутомеров, стереоизомеров, полиморфов, сольватов, гидратов, метаболитов, N-оксидов, фармацевтически приемлемых солей и содержащих их композиций. Соединения по настоящему изобретению используют в лечении/профилактике различных расстройств, которые опосредованы активностью рецептора 5-НТ.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN2224CH2009 | 2009-09-14 | ||
PCT/IN2009/000745 WO2011030349A1 (en) | 2009-09-14 | 2009-12-29 | L -dihydro-2-oxoquinoline compounds a 5-ht4 receptor ligands |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201270421A1 true EA201270421A1 (ru) | 2012-09-28 |
EA020227B1 EA020227B1 (ru) | 2014-09-30 |
Family
ID=42126528
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201270421A EA020227B1 (ru) | 2009-09-14 | 2009-12-29 | 1,2-дигидро-2-оксохинолиновые соединения в качестве лигандов рецептора 5-нт |
Country Status (17)
Country | Link |
---|---|
US (1) | US8598204B2 (ru) |
EP (1) | EP2507225B1 (ru) |
JP (1) | JP5540099B2 (ru) |
KR (1) | KR101386354B1 (ru) |
CN (1) | CN102639526B (ru) |
AU (1) | AU2009352490B2 (ru) |
CA (1) | CA2771885C (ru) |
DK (1) | DK2507225T3 (ru) |
EA (1) | EA020227B1 (ru) |
ES (1) | ES2578628T3 (ru) |
HK (1) | HK1173140A1 (ru) |
IL (1) | IL218525A (ru) |
MX (1) | MX2012002608A (ru) |
NZ (1) | NZ598505A (ru) |
SG (1) | SG178557A1 (ru) |
WO (1) | WO2011030349A1 (ru) |
ZA (1) | ZA201201429B (ru) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010123115A1 (ja) * | 2009-04-24 | 2010-10-28 | 日産化学工業株式会社 | ビシクロカーバメート化合物からの2-アザアダマンタン化合物の製造方法 |
JP2012530084A (ja) * | 2009-06-19 | 2012-11-29 | アボット・ラボラトリーズ | ジアザホモアダマンタン誘導体およびこの使用方法 |
RU2672468C1 (ru) * | 2011-12-22 | 2018-11-15 | Конекшис Лайф Сайенсиз Пвт. Лтд. | Производные аза-адамантанов и их применение |
RU2557249C1 (ru) * | 2014-03-03 | 2015-07-20 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Самарский государственный технический университет" | Способ получения 1-гидрокси-4-адамантанона |
CN104447490B (zh) * | 2014-11-19 | 2017-06-06 | 连云港恒运医药有限公司 | 一种质子泵抑制剂的晶型、制备中间体及其合成方法和医药用途 |
WO2019109046A1 (en) | 2017-11-30 | 2019-06-06 | Arrakis Therapeutics, Inc. | Nucleic acid-binding photoprobes and uses thereof |
WO2019111218A1 (en) | 2017-12-08 | 2019-06-13 | Cadila Healthcare Limited | Novel heterocyclic compounds as irak4 inhibitors |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994008965A1 (en) | 1992-10-16 | 1994-04-28 | Smithkline Beecham Plc | N-alkylpiperidinyl-4-methyl carboxylic esters/amides of condensed ring systems as 5-ht4 receptor antagonists |
JPH07324087A (ja) * | 1994-04-04 | 1995-12-12 | Taisho Pharmaceut Co Ltd | 複素環化合物 |
US7405235B2 (en) * | 2001-05-04 | 2008-07-29 | Paratek Pharmaceuticals, Inc. | Transcription factor modulating compounds and methods of use thereof |
TWI351282B (en) * | 2004-04-07 | 2011-11-01 | Theravance Inc | Quinolinone-carboxamide compounds as 5-ht4 recepto |
US7407966B2 (en) * | 2004-10-07 | 2008-08-05 | Epix Delaware, Inc. | Thienopyridinone compounds and methods of treatment |
EP1807422B1 (en) * | 2004-11-05 | 2009-09-02 | Theravance, Inc. | 5-ht4 receptor agonist compounds |
MX2007007818A (es) | 2004-12-22 | 2007-09-11 | Theravance Inc | Compuestos de indazol-carboxamida. |
AP2007004067A0 (en) | 2005-02-22 | 2007-08-31 | Pfizer | Oxyindole derivatives as 5HT4 receptor agonists |
CA2598516C (en) | 2005-02-25 | 2010-05-11 | Pfizer Inc. | Benzisoxazole derivatives |
KR20070107807A (ko) * | 2005-03-02 | 2007-11-07 | 세라밴스 인코포레이티드 | 5-ht4 수용체 아고니스트인 퀴놀리논 화합물 |
ES2333545T3 (es) | 2005-07-22 | 2010-02-23 | Pfizer, Inc. | Derivados de indazolcarboxamida como agonistas de receptores 5ht4. |
US8557994B2 (en) * | 2009-07-27 | 2013-10-15 | Daljit Singh Dhanoa | Deuterium-enriched pyridinonecarboxamides and derivatives |
-
2009
- 2009-12-29 US US13/393,539 patent/US8598204B2/en not_active Expired - Fee Related
- 2009-12-29 EP EP09818647.1A patent/EP2507225B1/en not_active Not-in-force
- 2009-12-29 KR KR1020127007464A patent/KR101386354B1/ko active IP Right Grant
- 2009-12-29 SG SG2012013025A patent/SG178557A1/en unknown
- 2009-12-29 AU AU2009352490A patent/AU2009352490B2/en not_active Ceased
- 2009-12-29 CA CA2771885A patent/CA2771885C/en not_active Expired - Fee Related
- 2009-12-29 ES ES09818647.1T patent/ES2578628T3/es active Active
- 2009-12-29 MX MX2012002608A patent/MX2012002608A/es active IP Right Grant
- 2009-12-29 WO PCT/IN2009/000745 patent/WO2011030349A1/en active Application Filing
- 2009-12-29 CN CN200980161395.0A patent/CN102639526B/zh not_active Expired - Fee Related
- 2009-12-29 DK DK09818647.1T patent/DK2507225T3/en active
- 2009-12-29 EA EA201270421A patent/EA020227B1/ru not_active IP Right Cessation
- 2009-12-29 JP JP2012528502A patent/JP5540099B2/ja not_active Expired - Fee Related
- 2009-12-29 NZ NZ598505A patent/NZ598505A/xx not_active IP Right Cessation
-
2012
- 2012-02-27 ZA ZA2012/01429A patent/ZA201201429B/en unknown
- 2012-03-07 IL IL218525A patent/IL218525A/en active IP Right Grant
-
2013
- 2013-01-07 HK HK13100187.8A patent/HK1173140A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
MX2012002608A (es) | 2012-04-02 |
HK1173140A1 (en) | 2013-05-10 |
CA2771885A1 (en) | 2011-03-17 |
IL218525A (en) | 2014-12-31 |
JP2013504561A (ja) | 2013-02-07 |
KR20120081986A (ko) | 2012-07-20 |
US20120277216A1 (en) | 2012-11-01 |
SG178557A1 (en) | 2012-03-29 |
ZA201201429B (en) | 2012-10-31 |
CA2771885C (en) | 2014-04-08 |
EA020227B1 (ru) | 2014-09-30 |
IL218525A0 (en) | 2012-07-31 |
US8598204B2 (en) | 2013-12-03 |
JP5540099B2 (ja) | 2014-07-02 |
CN102639526B (zh) | 2014-06-04 |
CN102639526A (zh) | 2012-08-15 |
WO2011030349A1 (en) | 2011-03-17 |
AU2009352490A1 (en) | 2012-04-19 |
ES2578628T3 (es) | 2016-07-28 |
EP2507225B1 (en) | 2016-06-01 |
KR101386354B1 (ko) | 2014-04-16 |
AU2009352490B2 (en) | 2013-06-20 |
DK2507225T3 (en) | 2016-07-04 |
NZ598505A (en) | 2013-01-25 |
EP2507225A1 (en) | 2012-10-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |