EA201270421A1 - 1,2-дигидро-2-оксохинолиновые соединения в качестве лигандов рецептора 5-нт - Google Patents

1,2-дигидро-2-оксохинолиновые соединения в качестве лигандов рецептора 5-нт

Info

Publication number
EA201270421A1
EA201270421A1 EA201270421A EA201270421A EA201270421A1 EA 201270421 A1 EA201270421 A1 EA 201270421A1 EA 201270421 A EA201270421 A EA 201270421A EA 201270421 A EA201270421 A EA 201270421A EA 201270421 A1 EA201270421 A1 EA 201270421A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compounds
dihydro
receptor
oxohinoline
ligands
Prior art date
Application number
EA201270421A
Other languages
English (en)
Other versions
EA020227B1 (ru
Inventor
Рамакришна Нироджи
Абдул Рашид Мохаммед
Иштияк Ахмад
Прадип Джаяраджан
Нагарадж Вишвоттам Кандикере
Анил Карбхари Схинде
Рама Састри Камбхампати
Геопинадх Бхирапунени
Йотхсна Равула
Срирамахандра Мурти Патнала
Венкатесварлу Джасти
Original Assignee
Сувен Лайф Сайенсиз Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Сувен Лайф Сайенсиз Лимитед filed Critical Сувен Лайф Сайенсиз Лимитед
Publication of EA201270421A1 publication Critical patent/EA201270421A1/ru
Publication of EA020227B1 publication Critical patent/EA020227B1/ru

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/47042-Quinolinones, e.g. carbostyril
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10Laxatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/06Antiarrhythmics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10Spiro-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings

Abstract

Настоящее изобретение относится к новым 1,2-дигидро-2-оксохинолиновым соединениям формулы (I) и их производным, пролекарствам, таутомерам, стереоизомерам, полиморфам, сольватам, гидратам, метаболитам, N-оксидам, фармацевтически приемлемым солям и содержащим их композициям. Настоящее изобретение также относится к способу получения вышеуказанных новых соединений и их производных, пролекарств, таутомеров, стереоизомеров, полиморфов, сольватов, гидратов, метаболитов, N-оксидов, фармацевтически приемлемых солей и содержащих их композиций. Соединения по настоящему изобретению используют в лечении/профилактике различных расстройств, которые опосредованы активностью рецептора 5-НТ.
EA201270421A 2009-09-14 2009-12-29 1,2-дигидро-2-оксохинолиновые соединения в качестве лигандов рецептора 5-нт EA020227B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2224CH2009 2009-09-14
PCT/IN2009/000745 WO2011030349A1 (en) 2009-09-14 2009-12-29 L -dihydro-2-oxoquinoline compounds a 5-ht4 receptor ligands

Publications (2)

Publication Number Publication Date
EA201270421A1 true EA201270421A1 (ru) 2012-09-28
EA020227B1 EA020227B1 (ru) 2014-09-30

Family

ID=42126528

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201270421A EA020227B1 (ru) 2009-09-14 2009-12-29 1,2-дигидро-2-оксохинолиновые соединения в качестве лигандов рецептора 5-нт

Country Status (17)

Country Link
US (1) US8598204B2 (ru)
EP (1) EP2507225B1 (ru)
JP (1) JP5540099B2 (ru)
KR (1) KR101386354B1 (ru)
CN (1) CN102639526B (ru)
AU (1) AU2009352490B2 (ru)
CA (1) CA2771885C (ru)
DK (1) DK2507225T3 (ru)
EA (1) EA020227B1 (ru)
ES (1) ES2578628T3 (ru)
HK (1) HK1173140A1 (ru)
IL (1) IL218525A (ru)
MX (1) MX2012002608A (ru)
NZ (1) NZ598505A (ru)
SG (1) SG178557A1 (ru)
WO (1) WO2011030349A1 (ru)
ZA (1) ZA201201429B (ru)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010123115A1 (ja) * 2009-04-24 2010-10-28 日産化学工業株式会社 ビシクロカーバメート化合物からの2-アザアダマンタン化合物の製造方法
JP2012530084A (ja) * 2009-06-19 2012-11-29 アボット・ラボラトリーズ ジアザホモアダマンタン誘導体およびこの使用方法
RU2672468C1 (ru) * 2011-12-22 2018-11-15 Конекшис Лайф Сайенсиз Пвт. Лтд. Производные аза-адамантанов и их применение
RU2557249C1 (ru) * 2014-03-03 2015-07-20 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Самарский государственный технический университет" Способ получения 1-гидрокси-4-адамантанона
CN104447490B (zh) * 2014-11-19 2017-06-06 连云港恒运医药有限公司 一种质子泵抑制剂的晶型、制备中间体及其合成方法和医药用途
WO2019109046A1 (en) 2017-11-30 2019-06-06 Arrakis Therapeutics, Inc. Nucleic acid-binding photoprobes and uses thereof
WO2019111218A1 (en) 2017-12-08 2019-06-13 Cadila Healthcare Limited Novel heterocyclic compounds as irak4 inhibitors

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994008965A1 (en) 1992-10-16 1994-04-28 Smithkline Beecham Plc N-alkylpiperidinyl-4-methyl carboxylic esters/amides of condensed ring systems as 5-ht4 receptor antagonists
JPH07324087A (ja) * 1994-04-04 1995-12-12 Taisho Pharmaceut Co Ltd 複素環化合物
US7405235B2 (en) * 2001-05-04 2008-07-29 Paratek Pharmaceuticals, Inc. Transcription factor modulating compounds and methods of use thereof
TWI351282B (en) * 2004-04-07 2011-11-01 Theravance Inc Quinolinone-carboxamide compounds as 5-ht4 recepto
US7407966B2 (en) * 2004-10-07 2008-08-05 Epix Delaware, Inc. Thienopyridinone compounds and methods of treatment
EP1807422B1 (en) * 2004-11-05 2009-09-02 Theravance, Inc. 5-ht4 receptor agonist compounds
MX2007007818A (es) 2004-12-22 2007-09-11 Theravance Inc Compuestos de indazol-carboxamida.
AP2007004067A0 (en) 2005-02-22 2007-08-31 Pfizer Oxyindole derivatives as 5HT4 receptor agonists
CA2598516C (en) 2005-02-25 2010-05-11 Pfizer Inc. Benzisoxazole derivatives
KR20070107807A (ko) * 2005-03-02 2007-11-07 세라밴스 인코포레이티드 5-ht4 수용체 아고니스트인 퀴놀리논 화합물
ES2333545T3 (es) 2005-07-22 2010-02-23 Pfizer, Inc. Derivados de indazolcarboxamida como agonistas de receptores 5ht4.
US8557994B2 (en) * 2009-07-27 2013-10-15 Daljit Singh Dhanoa Deuterium-enriched pyridinonecarboxamides and derivatives

Also Published As

Publication number Publication date
MX2012002608A (es) 2012-04-02
HK1173140A1 (en) 2013-05-10
CA2771885A1 (en) 2011-03-17
IL218525A (en) 2014-12-31
JP2013504561A (ja) 2013-02-07
KR20120081986A (ko) 2012-07-20
US20120277216A1 (en) 2012-11-01
SG178557A1 (en) 2012-03-29
ZA201201429B (en) 2012-10-31
CA2771885C (en) 2014-04-08
EA020227B1 (ru) 2014-09-30
IL218525A0 (en) 2012-07-31
US8598204B2 (en) 2013-12-03
JP5540099B2 (ja) 2014-07-02
CN102639526B (zh) 2014-06-04
CN102639526A (zh) 2012-08-15
WO2011030349A1 (en) 2011-03-17
AU2009352490A1 (en) 2012-04-19
ES2578628T3 (es) 2016-07-28
EP2507225B1 (en) 2016-06-01
KR101386354B1 (ko) 2014-04-16
AU2009352490B2 (en) 2013-06-20
DK2507225T3 (en) 2016-07-04
NZ598505A (en) 2013-01-25
EP2507225A1 (en) 2012-10-10

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU