ES2578628T3 - Compuestos de L-dihidro-2-oxoquinolina como ligandos del receptor de 5-HT4 - Google Patents

Compuestos de L-dihidro-2-oxoquinolina como ligandos del receptor de 5-HT4 Download PDF

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Publication number
ES2578628T3
ES2578628T3 ES09818647.1T ES09818647T ES2578628T3 ES 2578628 T3 ES2578628 T3 ES 2578628T3 ES 09818647 T ES09818647 T ES 09818647T ES 2578628 T3 ES2578628 T3 ES 2578628T3
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Prior art keywords
heterocyclyl
alkyl
heteroaryl
represents hydrogen
dihydro
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ES09818647.1T
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English (en)
Inventor
Ramakrishna Nirogi
Abdul Rasheed Mohammed
Ishtiyaque Ahmad
Pradeep Jayarajan
Nagaraj Vishwottam Kandikere
Anil Karbhari Shinde
Rama Sastri Kambhampati
Gopinadh Bhyrapuneni
Jyothsna Ravula
Sriramachandra Murthy Patnala
Venkateswarlu Jasti
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Suven Life Sciences Ltd
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Suven Life Sciences Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Nutrition Science (AREA)
  • Otolaryngology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Quinoline Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Un compuesto de la fórmula general (I) **Fórmula** en donde R1 representa hidrógeno, hidroxi, halógeno haloalquilo, haloalcoxi, nitro, amida, amina, ciano, carboxílico, cilcoalquilo, alquilo, alquenilo, alquinilo, alcoxi, arilo, aralquilo, heteroarilo, heteroaralquilo o heterociclilo; R2 representa hidrógeno, alquilo, cilcoalquilo, arilo, aralquilo, heteroarilo, heteroaralquilo o heterociclilo; R3 representa**Fórmula** R4 representa hidrógeno, hidroxi, amina, alquilo, alcoxi, arilo, ariloxi, cilcoalquilo, cicloalcoxi, heteroarilo, heteroaralquilo o heterociclilo; R5 representa hidrógeno, alquilo, cicloalquilo o heterociclilo; R6 representa heteroarilo; R7 y R8 representan hidrógeno, alquilo, cicloalquilo o heterociclilo; opcionalmente R7 y R8 junto con el átomo de `N' pueden formar anillos de 4 a 9 miembros, que incluyen uno o más heteroátomos seleccionados de C, O, N, S.

Description

imagen1
imagen2

Claims (1)

  1. imagen1
    imagen2
ES09818647.1T 2009-09-14 2009-12-29 Compuestos de L-dihidro-2-oxoquinolina como ligandos del receptor de 5-HT4 Active ES2578628T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN2224CH2009 2009-09-14
INCH22242009 2009-09-14
PCT/IN2009/000745 WO2011030349A1 (en) 2009-09-14 2009-12-29 L -dihydro-2-oxoquinoline compounds a 5-ht4 receptor ligands

Publications (1)

Publication Number Publication Date
ES2578628T3 true ES2578628T3 (es) 2016-07-28

Family

ID=42126528

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09818647.1T Active ES2578628T3 (es) 2009-09-14 2009-12-29 Compuestos de L-dihidro-2-oxoquinolina como ligandos del receptor de 5-HT4

Country Status (17)

Country Link
US (1) US8598204B2 (es)
EP (1) EP2507225B1 (es)
JP (1) JP5540099B2 (es)
KR (1) KR101386354B1 (es)
CN (1) CN102639526B (es)
AU (1) AU2009352490B2 (es)
CA (1) CA2771885C (es)
DK (1) DK2507225T3 (es)
EA (1) EA020227B1 (es)
ES (1) ES2578628T3 (es)
HK (1) HK1173140A1 (es)
IL (1) IL218525A (es)
MX (1) MX2012002608A (es)
NZ (1) NZ598505A (es)
SG (1) SG178557A1 (es)
WO (1) WO2011030349A1 (es)
ZA (1) ZA201201429B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102405221B (zh) * 2009-04-24 2015-01-21 日产化学工业株式会社 由二环氨基甲酸酯化合物制备2-氮杂金刚烷化合物的方法
CN102459268A (zh) * 2009-06-19 2012-05-16 雅培制药有限公司 二氮杂高金刚烷衍生物和其使用方法
SG11201403266RA (en) * 2011-12-22 2014-07-30 Connexios Life Sciences Pvt Ltd Derivatives of aza adamantane and uses thereof
RU2557249C1 (ru) * 2014-03-03 2015-07-20 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Самарский государственный технический университет" Способ получения 1-гидрокси-4-адамантанона
CN104447490B (zh) * 2014-11-19 2017-06-06 连云港恒运医药有限公司 一种质子泵抑制剂的晶型、制备中间体及其合成方法和医药用途
AU2018374389A1 (en) 2017-11-30 2020-05-07 Arrakis Therapeutics, Inc. Nucleic acid-binding photoprobes and uses thereof
WO2019111218A1 (en) 2017-12-08 2019-06-13 Cadila Healthcare Limited Novel heterocyclic compounds as irak4 inhibitors
CN115677567A (zh) * 2022-11-15 2023-02-03 大唐环境产业集团股份有限公司 一种4-氨基-1-哌啶丙醇的合成方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08502283A (ja) 1992-10-16 1996-03-12 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー ５−ｈｔ▲下４▼レセプターアンタゴニスト用の縮合環系ｎ−アルキルピペリジニル−４−メチルカルボン酸エステル／アミド
JPH07324087A (ja) * 1994-04-04 1995-12-12 Taisho Pharmaceut Co Ltd 複素環化合物
US7405235B2 (en) * 2001-05-04 2008-07-29 Paratek Pharmaceuticals, Inc. Transcription factor modulating compounds and methods of use thereof
TWI351282B (en) * 2004-04-07 2011-11-01 Theravance Inc Quinolinone-carboxamide compounds as 5-ht4 recepto
US7407966B2 (en) * 2004-10-07 2008-08-05 Epix Delaware, Inc. Thienopyridinone compounds and methods of treatment
WO2006052640A1 (en) 2004-11-05 2006-05-18 Theravance, Inc. 5-ht4 receptor agonist compounds
NZ555180A (en) 2004-12-22 2010-09-30 Theravance Inc Indazole-carboxamide compounds useful as 5-HT4 receptor agonists
AP2007004067A0 (en) 2005-02-22 2007-08-31 Pfizer Oxyindole derivatives as 5HT4 receptor agonists
DK1856114T3 (en) 2005-02-25 2014-11-17 Raqualia Pharma Inc Benzisoxazol-DERIVATIVES
NZ560828A (en) * 2005-03-02 2011-01-28 Theravance Inc Quinolinone compounds as 5-HT4 receptor agonists
US7906532B2 (en) 2005-07-22 2011-03-15 Pfizer Inc. Indazole derivatives
US8557994B2 (en) * 2009-07-27 2013-10-15 Daljit Singh Dhanoa Deuterium-enriched pyridinonecarboxamides and derivatives

Also Published As

Publication number Publication date
KR20120081986A (ko) 2012-07-20
DK2507225T3 (en) 2016-07-04
HK1173140A1 (en) 2013-05-10
MX2012002608A (es) 2012-04-02
NZ598505A (en) 2013-01-25
KR101386354B1 (ko) 2014-04-16
IL218525A0 (en) 2012-07-31
JP2013504561A (ja) 2013-02-07
SG178557A1 (en) 2012-03-29
AU2009352490B2 (en) 2013-06-20
EA201270421A1 (ru) 2012-09-28
ZA201201429B (en) 2012-10-31
CN102639526B (zh) 2014-06-04
CA2771885C (en) 2014-04-08
US20120277216A1 (en) 2012-11-01
CA2771885A1 (en) 2011-03-17
EP2507225B1 (en) 2016-06-01
AU2009352490A1 (en) 2012-04-19
CN102639526A (zh) 2012-08-15
JP5540099B2 (ja) 2014-07-02
IL218525A (en) 2014-12-31
EA020227B1 (ru) 2014-09-30
EP2507225A1 (en) 2012-10-10
US8598204B2 (en) 2013-12-03
WO2011030349A1 (en) 2011-03-17

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