CO6140056A2 - Compuestos amino -5-4(difluorometoxi)fenil sustituido-5-fenilimidazolona como inhibidores de beta -secretasa - Google Patents

Compuestos amino -5-4(difluorometoxi)fenil sustituido-5-fenilimidazolona como inhibidores de beta -secretasa

Info

Publication number
CO6140056A2
CO6140056A2 CO09100417A CO09100417A CO6140056A2 CO 6140056 A2 CO6140056 A2 CO 6140056A2 CO 09100417 A CO09100417 A CO 09100417A CO 09100417 A CO09100417 A CO 09100417A CO 6140056 A2 CO6140056 A2 CO 6140056A2
Authority
CO
Colombia
Prior art keywords
optionally substituted
alkyl
cycloalkyl
independently
group
Prior art date
Application number
CO09100417A
Other languages
English (en)
Inventor
Michael Sotirios Malamas
Albert Robichaud
Alexander Michael Porte
William Ronald Solvibile
Koi Michele Morris
Schuyler Adam Antane
Ji-In Kim
Robert Emmett Mcdevitt
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of CO6140056A2 publication Critical patent/CO6140056A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/88—Nitrogen atoms, e.g. allantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4168—1,3-Diazoles having a nitrogen attached in position 2, e.g. clonidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

1.- Un compuesto de la Fórmula Ien dondeR1 y R2 son cada uno independientemente H o un grupo alquilo, cicloalquilo, cicloheteroalquilo, arilo o heteroarilo cada uno se sustituye opcionalmente, o R1 y R2 se pueden tomar junto con el átomo al cual ellos se adhieren para formar un anillo de 5 a 7 miembros opcionalmente sustituido que contiene opcionalmente un heteroátomo adicional seleccionado de O, N o S; R3 es H o un grupo alquilo, cicloalquilo, cicloheteroalquilo, arilo o heteroarilo cada uno se sustituye opcionalmente;R4, R5 y R6 son cada uno independientemente H, halógeno, NO2, CN, COR9, NR10CO2R11, NR12R13, OR14, NR15COR16, SOnR17 o un grupo alquilo, haloalquilo, alquenilo, haloalquenilo, alquinilo, cicloalquilo, alcoxi, alqueniloxi, alquiniloxi o cicloheteroalquilo cada unose sustituye opcionalmente, o cuando se adhieren a los átomos de carbono adyacentes R4 y R5 se pueden tomar junto con los átomos a los cuales ellos se adhieren para formar un anillo de 5 a 7 miembros opcionalmente sustituido que contiene opcionalmente uno o dos heteroátomos seleccionados de O, N o S; n es 0, 1 o 2; R7 y R8 son cada uno independientemente H, halógeno, NR20R21 o un grupo alquilo, alquenilo, cicloalquilo o alcoxi cada grupo se sustituye opcionalmente, con la condición que uno de R7 o R8 puede ser diferente a H; R9 y R17 son cada uno independientemente H, NR18R19 o un grupo alquilo, haloalquilo, alcoxialquilo, alquenilo, alquinilo, cicloalquilo o arilo cada uno se sustituye opcionalmente; R10 y R15 son cada uno independientemente H o un grupo alquilo opcionalmente sustituido; R11, R14 y R16 son cada uno independientemente H o un grupo alquilo, haloalquilo, alcoxialquilo, alquenilo, alquinilo, cicloalquilo o arilo cada uno se sustituye opcionalmente;R12 y R13 son cada uno independientemente H o un grupo alquilo o cicloalquilo cada uno se sustituye opcionalmente, ...
CO09100417A 2007-03-20 2009-09-16 Compuestos amino -5-4(difluorometoxi)fenil sustituido-5-fenilimidazolona como inhibidores de beta -secretasa CO6140056A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US91908707P 2007-03-20 2007-03-20

Publications (1)

Publication Number Publication Date
CO6140056A2 true CO6140056A2 (es) 2010-03-19

Family

ID=39564223

Family Applications (1)

Application Number Title Priority Date Filing Date
CO09100417A CO6140056A2 (es) 2007-03-20 2009-09-16 Compuestos amino -5-4(difluorometoxi)fenil sustituido-5-fenilimidazolona como inhibidores de beta -secretasa

Country Status (24)

Country Link
US (1) US20090042964A1 (es)
EP (1) EP2137161A1 (es)
JP (1) JP2010522235A (es)
KR (1) KR20100015376A (es)
CN (1) CN101641335A (es)
AR (1) AR065811A1 (es)
AU (1) AU2008229327A1 (es)
BR (1) BRPI0808944A2 (es)
CA (1) CA2681243A1 (es)
CL (1) CL2008000784A1 (es)
CO (1) CO6140056A2 (es)
CR (1) CR11020A (es)
EC (1) ECSP099639A (es)
GT (1) GT200900241A (es)
IL (1) IL200961A0 (es)
MX (1) MX2009009699A (es)
NI (1) NI200900164A (es)
PA (1) PA8772701A1 (es)
PE (1) PE20090160A1 (es)
RU (1) RU2009133807A (es)
SV (1) SV2009003373A (es)
TW (1) TW200845965A (es)
WO (1) WO2008115552A1 (es)
ZA (1) ZA200906542B (es)

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US7700603B2 (en) 2003-12-15 2010-04-20 Schering Corporation Heterocyclic aspartyl protease inhibitors
CA2609582A1 (en) 2005-06-14 2006-12-28 Schering Corporation Aspartyl protease inhibitors
EP2324032B1 (en) 2008-08-19 2014-10-01 Vitae Pharmaceuticals, Inc. Inhibitors of beta-secretase
EP2184276A1 (en) * 2008-11-07 2010-05-12 Universite Paul Cezanne Aix-Marseille Iii Process to prepare new substituted 1H-Benzo(d) imidazol-2(3h)-Ones, New intermediates and their use as bace 1 inhibitors
CN102348698B (zh) 2009-03-13 2015-06-03 生命医药公司 β-分泌酶的抑制剂
UA108363C2 (uk) 2009-10-08 2015-04-27 Похідні імінотіадіазиндіоксиду як інгібітори bace, композиція на їх основі і їх застосування
WO2011106414A1 (en) 2010-02-24 2011-09-01 Dillard Lawrence W Inhibitors of beta-secretase
WO2012138590A1 (en) 2011-04-07 2012-10-11 Merck Sharp & Dohme Corp. Pyrrolidine-fused thiadiazine dioxide compounds as bace inhibitors, compositions, and their use
EP2694489B1 (en) 2011-04-07 2017-09-06 Merck Sharp & Dohme Corp. C5-c6 oxacyclic-fused thiadiazine dioxide compounds as bace inhibitors, compositions, and their use
AU2012298983A1 (en) 2011-08-22 2014-02-27 Merck Sharp & Dohme Corp. 2-spiro-substituted iminothiazines and their mono-and dioxides as BACE inhibitors, compositions and their use
TWI557112B (zh) 2012-03-05 2016-11-11 百靈佳殷格翰國際股份有限公司 β－分泌酶抑制劑
TW201422592A (zh) 2012-08-27 2014-06-16 Boehringer Ingelheim Int β－分泌酶抑制劑
US9290477B2 (en) 2012-09-28 2016-03-22 Vitae Pharmaceuticals, Inc. Inhibitors of β-secretase
WO2014127042A1 (en) 2013-02-12 2014-08-21 Buck Institute For Research On Aging Hydantoins that modulate bace-mediated app processing
US20160298151A1 (en) 2015-04-09 2016-10-13 Sher Ali Butt Novel Method for the cheap, efficient, and effective production of pharmaceutical and therapeutic api's intermediates, and final products
CN112423756A (zh) 2018-04-23 2021-02-26 默沙东公司 用于合成苯氧基二氨基嘧啶化合物的新方法
CN109289696B (zh) * 2018-10-29 2022-03-22 天津先光化工有限公司 一种咪唑啉两性表面活性剂的制备方法

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IE45198B1 (en) * 1976-06-05 1982-07-14 Wyeth John & Brother Ltd Guanidine derivatives
GB1588096A (en) * 1978-05-20 1981-04-15 Wyeth & Bros Ltd John Pyrrole derivatives
GB9511694D0 (en) * 1995-06-09 1995-08-02 Fujisawa Pharmaceutical Co Benzamide derivatives
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US6492408B1 (en) * 1999-07-21 2002-12-10 Boehringer Ingelheim Pharmaceuticals, Inc. Small molecules useful in the treatment of inflammatory disease
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EP2064201A2 (en) * 2006-09-21 2009-06-03 Wyeth Indolylalkylpyridin-2-amines for the inhibition of beta-secretase

Also Published As

Publication number Publication date
RU2009133807A (ru) 2011-04-27
CA2681243A1 (en) 2008-09-25
CR11020A (es) 2009-10-06
CN101641335A (zh) 2010-02-03
KR20100015376A (ko) 2010-02-12
TW200845965A (en) 2008-12-01
AR065811A1 (es) 2009-07-01
ZA200906542B (en) 2010-06-30
AU2008229327A8 (en) 2009-10-15
US20090042964A1 (en) 2009-02-12
JP2010522235A (ja) 2010-07-01
PE20090160A1 (es) 2009-02-11
MX2009009699A (es) 2009-09-24
PA8772701A1 (es) 2008-11-19
GT200900241A (es) 2010-05-07
NI200900164A (es) 2010-07-29
SV2009003373A (es) 2010-08-10
ECSP099639A (es) 2009-10-30
EP2137161A1 (en) 2009-12-30
BRPI0808944A2 (pt) 2014-09-02
IL200961A0 (en) 2010-05-17
AU2008229327A1 (en) 2008-09-25
WO2008115552A1 (en) 2008-09-25
CL2008000784A1 (es) 2008-05-30

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