EA201290344A1 - БИЦИКЛИЧЕСКИЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ ЛИГАНДОВ αβНИКОТИНОВОГО АЦЕТИЛХОЛИНОВОГО РЕЦЕПТОРА - Google Patents

БИЦИКЛИЧЕСКИЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ ЛИГАНДОВ αβНИКОТИНОВОГО АЦЕТИЛХОЛИНОВОГО РЕЦЕПТОРА

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Publication number
EA201290344A1
EA201290344A1 EA201290344A EA201290344A EA201290344A1 EA 201290344 A1 EA201290344 A1 EA 201290344A1 EA 201290344 A EA201290344 A EA 201290344A EA 201290344 A EA201290344 A EA 201290344A EA 201290344 A1 EA201290344 A1 EA 201290344A1
Authority
EA
Eurasian Patent Office
Prior art keywords
unicotin
ligands
bicyclic compounds
compounds
acetyl choline
Prior art date
Application number
EA201290344A
Other languages
English (en)
Other versions
EA020506B1 (ru
Inventor
Рамакришна Нироджи
Абдул Рашид Мохаммед
Сринивас Вирамалла
Сриниваса Рао Равелла
Иштияк Ахмад
Прадип Джаяраджан
Анил Карбхари Схинде
Рама Састри Камбхампти
Гопинадх Бхирапунени
Венкатесварлу Джасти
Original Assignee
Сувен Лайф Сайенсиз Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Сувен Лайф Сайенсиз Лимитед filed Critical Сувен Лайф Сайенсиз Лимитед
Publication of EA201290344A1 publication Critical patent/EA201290344A1/ru
Publication of EA020506B1 publication Critical patent/EA020506B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Настоящее изобретение относится к новым бициклическим соединениям формулы (I) и их производным, пролекарствам, таутомерам, стереоизомерам, полиморфам, сольватам, гидратам, метаболитам, N-оксидам, фармацевтически приемлемым солям и содержащим их композициям. Настоящее изобретение относится также к способу получения указанных выше новых соединений и их производных, пролекарст, таутомеров, стереоизомеров, полиморфов, сольватов, гидратов, метаболитов, N-оксидов, фармацевтически приемлемых солей и содержащих их композиций. Данные соединения применимы для лечения и предотвращения различных заболеваний, связанных с αβникотиновыми рецепторами.
EA201290344A 2009-11-18 2009-12-31 БИЦИКЛИЧЕСКИЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ ЛИГАНДОВ αβНИКОТИНОВОГО АЦЕТИЛХОЛИНОВОГО РЕЦЕПТОРА EA020506B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2838CH2009 2009-11-18
PCT/IN2009/000758 WO2011061751A1 (en) 2009-11-18 2009-12-31 BICYCLIC COMPOUNDS AS α4β2 NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS

Publications (2)

Publication Number Publication Date
EA201290344A1 true EA201290344A1 (ru) 2012-10-30
EA020506B1 EA020506B1 (ru) 2014-11-28

Family

ID=42228992

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201290344A EA020506B1 (ru) 2009-11-18 2009-12-31 БИЦИКЛИЧЕСКИЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ ЛИГАНДОВ αβНИКОТИНОВОГО АЦЕТИЛХОЛИНОВОГО РЕЦЕПТОРА

Country Status (24)

Country Link
US (1) US8735423B2 (ru)
EP (1) EP2513085B1 (ru)
JP (1) JP5536227B2 (ru)
KR (1) KR101376145B1 (ru)
CN (1) CN102741239B (ru)
CA (1) CA2773409C (ru)
CY (1) CY1118361T1 (ru)
DK (1) DK2513085T3 (ru)
EA (1) EA020506B1 (ru)
ES (1) ES2601905T3 (ru)
HK (1) HK1175782A1 (ru)
HR (1) HRP20161461T1 (ru)
HU (1) HUE033352T2 (ru)
IL (1) IL219637A (ru)
LT (1) LT2513085T (ru)
MX (1) MX2012005637A (ru)
NZ (1) NZ600536A (ru)
PL (1) PL2513085T3 (ru)
PT (1) PT2513085T (ru)
RS (1) RS55469B1 (ru)
SI (1) SI2513085T1 (ru)
SM (1) SMT201600444B (ru)
WO (1) WO2011061751A1 (ru)
ZA (1) ZA201203522B (ru)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2587204T3 (es) * 2011-06-17 2016-10-21 Eli Lilly And Company Derivados de ácido biciclo (3.1.0) hexano-2,6-dicarboxílico como agonistas del receptor mGlu2
JP6103240B2 (ja) 2013-11-18 2017-03-29 トヨタ紡織株式会社 ピッチ材料の調整方法及び調整装置
EP3634408B1 (en) 2017-06-09 2022-12-28 Merck Sharp & Dohme LLC Azabicyclo[4.1.0]heptane allosteric modulators of the m4 muscarinic acetylcholine receptor
AU2023207848A1 (en) 2022-01-11 2024-07-04 Suven Life Sciences Limited Heteroalicyclic derivatives and their use in the treatment of cns disorders

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4337341A (en) * 1976-11-02 1982-06-29 Eli Lilly And Company 4a-Aryl-octahydro-1H-2-pyrindines
FI95572C (fi) 1987-06-22 1996-02-26 Eisai Co Ltd Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi
WO1998027983A1 (en) * 1996-12-20 1998-07-02 Novo Nordisk A/S A method of treating hypercholesterolemia and related disorders
TWI283240B (en) 1999-06-30 2007-07-01 Daiichi Seiyaku Co VLA-4 inhibitor compounds
WO2002089800A2 (en) 2001-05-05 2002-11-14 Smithkline Beecham P.L.C. N-aroyl cyclic amine derivatives as orexin receptor antagonists
FR2889187B1 (fr) 2005-07-28 2007-09-07 Servier Lab Nouveaux composes 1,1-pyridinyloxycyclopropanamines polysusbstitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
TWI404532B (zh) 2006-11-02 2013-08-11 Targacept Inc 菸鹼乙醯膽鹼受體亞型選擇性之二氮雜雙環烷類醯胺

Also Published As

Publication number Publication date
JP5536227B2 (ja) 2014-07-02
EA020506B1 (ru) 2014-11-28
DK2513085T3 (en) 2016-12-05
PL2513085T3 (pl) 2017-09-29
KR101376145B1 (ko) 2014-03-19
HRP20161461T1 (hr) 2017-01-27
CA2773409A1 (en) 2011-05-26
JP2013510901A (ja) 2013-03-28
ZA201203522B (en) 2013-01-31
AU2009355487A1 (en) 2012-05-31
AU2009355487B2 (en) 2013-10-10
SI2513085T1 (sl) 2017-02-28
US8735423B2 (en) 2014-05-27
WO2011061751A1 (en) 2011-05-26
AU2009355487A8 (en) 2012-07-12
CA2773409C (en) 2015-06-16
PT2513085T (pt) 2016-11-14
CN102741239A (zh) 2012-10-17
US20130072518A1 (en) 2013-03-21
CN102741239B (zh) 2015-06-24
EP2513085B1 (en) 2016-09-28
IL219637A (en) 2015-10-29
IL219637A0 (en) 2012-07-31
RS55469B1 (sr) 2017-04-28
SMT201600444B (it) 2017-01-10
NZ600536A (en) 2013-05-31
CY1118361T1 (el) 2017-06-28
ES2601905T3 (es) 2017-02-16
KR20120049943A (ko) 2012-05-17
LT2513085T (lt) 2016-12-27
EP2513085A1 (en) 2012-10-24
HUE033352T2 (en) 2017-11-28
MX2012005637A (es) 2012-06-13
HK1175782A1 (en) 2013-07-12

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