EA201290582A1 - ЛИГАНДЫ НЕЙРОНАЛЬНОГО НИКОТИНОВОГО АЦЕТИЛХОЛИНОВОГО РЕЦЕПТОРА αβ - Google Patents

ЛИГАНДЫ НЕЙРОНАЛЬНОГО НИКОТИНОВОГО АЦЕТИЛХОЛИНОВОГО РЕЦЕПТОРА αβ

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Publication number
EA201290582A1
EA201290582A1 EA201290582A EA201290582A EA201290582A1 EA 201290582 A1 EA201290582 A1 EA 201290582A1 EA 201290582 A EA201290582 A EA 201290582A EA 201290582 A EA201290582 A EA 201290582A EA 201290582 A1 EA201290582 A1 EA 201290582A1
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EA
Eurasian Patent Office
Prior art keywords
ligands
nicotin
neural
acetyl choline
choline receptor
Prior art date
Application number
EA201290582A
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English (en)
Other versions
EA023293B1 (ru
Inventor
Рамакришна Нироджи
Абдул Рашид Мохаммед
Кана Рам Кумават
Иштияк Ахмад
Прадип Джаяраджан
Анил Карбхари Схинде
Нагарадж Вишвоттам Кандикере
Котешвара Мудигонда
Венкатесварлу Джасти
Original Assignee
Сувен Лайф Сайенсиз Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Сувен Лайф Сайенсиз Лимитед filed Critical Сувен Лайф Сайенсиз Лимитед
Publication of EA201290582A1 publication Critical patent/EA201290582A1/ru
Publication of EA023293B1 publication Critical patent/EA023293B1/ru

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
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  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Настоящее изобретение касается новых соединений - лигандов нейронального никотинового ацетилхолинового рецептора αβформулы (I), и соответствующих производных, стереоизомеров, фармацевтически приемлемых солей и композиций, содержащих указанные соединения. Настоящее изобретение касается способов применения новых соединений - лигандов нейронального никотинового ацетилхолинового рецептора αβ, формулы (I), и соответствующих производных, стереоизомеров, фармацевтически приемлемых солей и композиций, содержащих указанные соединения.
EA201290582A 2009-12-29 2010-05-03 ЛИГАНДЫ НЕЙРОНАЛЬНОГО НИКОТИНОВОГО АЦЕТИЛХОЛИНОВОГО РЕЦЕПТОРА αβ EA023293B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN3195CH2009 2009-12-29
PCT/IN2010/000285 WO2011080751A2 (en) 2009-12-29 2010-05-03 α4β2 NEURONAL NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS

Publications (2)

Publication Number Publication Date
EA201290582A1 true EA201290582A1 (ru) 2012-12-28
EA023293B1 EA023293B1 (ru) 2016-05-31

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EA201290582A EA023293B1 (ru) 2009-12-29 2010-05-03 ЛИГАНДЫ НЕЙРОНАЛЬНОГО НИКОТИНОВОГО АЦЕТИЛХОЛИНОВОГО РЕЦЕПТОРА αβ

Country Status (18)

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US (1) US8653071B2 (ru)
EP (1) EP2519514B1 (ru)
JP (1) JP5588018B2 (ru)
KR (1) KR101410903B1 (ru)
CN (1) CN102753540B (ru)
AU (1) AU2010337837B2 (ru)
BR (1) BR112012016201A2 (ru)
CA (1) CA2785957C (ru)
DK (1) DK2519514T3 (ru)
EA (1) EA023293B1 (ru)
ES (1) ES2552932T3 (ru)
HK (1) HK1174913A1 (ru)
IL (1) IL220299A (ru)
MX (1) MX2012006909A (ru)
NZ (1) NZ601088A (ru)
SG (1) SG181502A1 (ru)
WO (1) WO2011080751A2 (ru)
ZA (1) ZA201204562B (ru)

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AU2013302497A1 (en) * 2012-08-16 2015-03-05 The Scripps Research Institute Novel kappa opioid ligands
CN103450072A (zh) * 2013-09-09 2013-12-18 嘉兴学院 具有环丙烷结构r-脯氨酸的吡咯衍生物及其制备方法
CN103467362A (zh) * 2013-09-09 2013-12-25 嘉兴学院 具有环丙烷结构s-二苯基脯氨醇类手性有机小分子化合物及其合成方法
CN103435533A (zh) * 2013-09-09 2013-12-11 嘉兴学院 具有环丙烷结构的s-脯氨醇手性有机小分子化合物及其合成方法
CN103467360A (zh) * 2013-09-09 2013-12-25 嘉兴学院 具有环丙烷结构r-脯氨酸的吗啉衍生物及其制备方法
CN103435536A (zh) * 2013-09-09 2013-12-11 嘉兴学院 具有环丙烷结构s-脯氨酸的吡咯衍生物及其制备方法
CN103467361A (zh) * 2013-09-09 2013-12-25 嘉兴学院 具有环丙烷结构s-脯氨酸的吗啉衍生物及其制备方法
CN103450073A (zh) * 2013-09-09 2013-12-18 嘉兴学院 具有环丙烷结构r-二苯基脯氨醇类手性有机小分子化合物及其合成方法
CN103450074A (zh) * 2013-09-09 2013-12-18 嘉兴学院 具有环丙烷结构的r-脯氨醇手性有机小分子化合物及其合成方法
US10568852B2 (en) 2015-05-22 2020-02-25 Helmholtz Zentrum Munchen - Deutsches Forschungszentrum Fur Gesundheit Und Umwelt (Gmbh) Combination compositions and their use in methods for treating obesity and obesity-related disorders
AU2018326734B2 (en) * 2017-09-01 2023-08-17 Chronos Therapeutics Limited Substituted 2-azabicyclo(3.1.1)heptane and 2-azabicyclo(3.2.1)octane derivatives as orexin receptor antagonists

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DE60110066T2 (de) * 2000-06-16 2006-02-02 Smithkline Beecham P.L.C., Brentford Piperidine zur verwendung als orexinrezeptorantagonisten
EP1386920A4 (en) * 2001-04-20 2005-09-14 Banyu Pharma Co Ltd DERIVATIVES OF BENZIMIDAZOLONE
JP2004534026A (ja) 2001-05-05 2004-11-11 スミスクライン　ビーチャム　パブリック　リミテッド　カンパニー オレキシン受容体アンタゴニストとしてのｎ−アロイルサイクリックアミン誘導体
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Publication number Publication date
KR20120099139A (ko) 2012-09-06
AU2010337837B2 (en) 2013-09-05
EP2519514A2 (en) 2012-11-07
NZ601088A (en) 2013-08-30
AU2010337837A1 (en) 2012-08-02
HK1174913A1 (ru) 2013-06-21
SG181502A1 (en) 2012-07-30
CN102753540A (zh) 2012-10-24
MX2012006909A (es) 2012-07-10
ZA201204562B (en) 2013-02-27
KR101410903B1 (ko) 2014-06-23
WO2011080751A3 (en) 2011-08-18
CA2785957A1 (en) 2011-07-07
EA023293B1 (ru) 2016-05-31
BR112012016201A2 (pt) 2017-12-19
IL220299A0 (en) 2012-07-31
WO2011080751A2 (en) 2011-07-07
ES2552932T3 (es) 2015-12-03
CN102753540B (zh) 2014-01-22
JP5588018B2 (ja) 2014-09-10
CA2785957C (en) 2015-06-16
US20120322808A1 (en) 2012-12-20
IL220299A (en) 2014-08-31
JP2013515762A (ja) 2013-05-09
EP2519514B1 (en) 2015-08-26
US8653071B2 (en) 2014-02-18
DK2519514T3 (en) 2015-11-16

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