EA201390908A1 - Производные бицикло[3.2.1]октиламида и их применение - Google Patents

Производные бицикло[3.2.1]октиламида и их применение

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Publication number
EA201390908A1
EA201390908A1 EA201390908A EA201390908A EA201390908A1 EA 201390908 A1 EA201390908 A1 EA 201390908A1 EA 201390908 A EA201390908 A EA 201390908A EA 201390908 A EA201390908 A EA 201390908A EA 201390908 A1 EA201390908 A1 EA 201390908A1
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EA
Eurasian Patent Office
Prior art keywords
octylamide
derivatives
bicyclo
application
formula
Prior art date
Application number
EA201390908A
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English (en)
Other versions
EA026362B1 (ru
Inventor
Гуйин Ли
Хао Чжоу
Джесс Вайсс
Дарио Доллер
Джеймс Форд
Original Assignee
Х. Лундбекк А/С
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Application filed by Х. Лундбекк А/С filed Critical Х. Лундбекк А/С
Publication of EA201390908A1 publication Critical patent/EA201390908A1/ru
Publication of EA026362B1 publication Critical patent/EA026362B1/ru

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    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Настоящее изобретение предоставляет производные бицикло[3.2.1]октиламида формулы (I)где L, Rи Rявляются такими, как определено в настоящем документе, или его фармацевтически приемлемую соль; фармацевтические композиции и способы их применения.
EA201390908A 2010-12-22 2011-12-22 Производные бицикло[3.2.1]октиламида и их применение EA026362B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201061426379P 2010-12-22 2010-12-22
PCT/US2011/066690 WO2012088365A1 (en) 2010-12-22 2011-12-22 Bicyclo[3.2.1]octyl amide derivatives and uses of same

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EA201390908A1 true EA201390908A1 (ru) 2013-12-30
EA026362B1 EA026362B1 (ru) 2017-03-31

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US (3) US8921370B2 (ru)
EP (2) EP2654422B1 (ru)
JP (2) JP5992436B2 (ru)
KR (1) KR101840076B1 (ru)
CN (2) CN105348185B (ru)
AP (1) AP3758A (ru)
AR (1) AR084457A1 (ru)
AU (2) AU2011348188B2 (ru)
BR (1) BR112013015592A8 (ru)
CA (1) CA2821937A1 (ru)
CO (1) CO6741203A2 (ru)
CR (1) CR20130309A (ru)
DO (1) DOP2013000142A (ru)
EA (1) EA026362B1 (ru)
EC (1) ECSP13012788A (ru)
GE (1) GEP20156219B (ru)
GT (1) GT201300164A (ru)
IL (1) IL226981A (ru)
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PE (1) PE20141529A1 (ru)
SG (1) SG191317A1 (ru)
TN (1) TN2013000253A1 (ru)
TW (1) TWI538905B (ru)
UA (1) UA109802C2 (ru)
WO (1) WO2012088365A1 (ru)
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JP5992436B2 (ja) 2016-09-14
US20150057289A1 (en) 2015-02-26
US8921370B2 (en) 2014-12-30
AP3758A (en) 2016-07-31
CN105348185B (zh) 2018-02-16
AP2013006984A0 (en) 2013-07-31
BR112013015592A2 (pt) 2016-07-12
CN103369961B (zh) 2015-11-25
AU2011348188A1 (en) 2013-07-04
CO6741203A2 (es) 2013-08-30
EP2654422A1 (en) 2013-10-30
WO2012088365A1 (en) 2012-06-28
JP6087006B2 (ja) 2017-03-01
EP2654422A4 (en) 2014-05-14
ZA201406059B (en) 2016-06-29
KR20130140801A (ko) 2013-12-24
JP2016164157A (ja) 2016-09-08
US9656975B2 (en) 2017-05-23
CN105348185A (zh) 2016-02-24
KR101840076B1 (ko) 2018-03-19
US20120190686A1 (en) 2012-07-26
PE20141529A1 (es) 2014-11-19
AR084457A1 (es) 2013-05-15
EP2654422B1 (en) 2017-08-02
CN103369961A (zh) 2013-10-23
MY169432A (en) 2019-04-09
EA026362B1 (ru) 2017-03-31
CR20130309A (es) 2014-01-09
GEP20156219B (en) 2015-01-12
MA34819B1 (fr) 2014-01-02
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JP2014508128A (ja) 2014-04-03
MX349132B (es) 2017-07-13
SG191317A1 (en) 2013-07-31
TW201307291A (zh) 2013-02-16
BR112013015592A8 (pt) 2018-01-16
EP3263566A1 (en) 2018-01-03
AU2016203192B2 (en) 2018-01-18
AU2011348188B2 (en) 2016-06-16
ZA201304624B (en) 2014-12-23
MX2013007104A (es) 2013-08-15
AU2016203192A1 (en) 2016-06-09
DOP2013000142A (es) 2013-10-15
TWI538905B (zh) 2016-06-21
GT201300164A (es) 2015-01-16
IL226981A (en) 2017-11-30
CA2821937A1 (en) 2012-06-28
US20170217950A1 (en) 2017-08-03
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UA109802C2 (xx) 2015-10-12
ECSP13012788A (es) 2013-09-30

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