EA201290416A1 - Новые спиропиперидиновые соединения - Google Patents

Новые спиропиперидиновые соединения

Info

Publication number
EA201290416A1
EA201290416A1 EA201290416A EA201290416A EA201290416A1 EA 201290416 A1 EA201290416 A1 EA 201290416A1 EA 201290416 A EA201290416 A EA 201290416A EA 201290416 A EA201290416 A EA 201290416A EA 201290416 A1 EA201290416 A1 EA 201290416A1
Authority
EA
Eurasian Patent Office
Prior art keywords
spyropyperidine
connections
new
compound
formula
Prior art date
Application number
EA201290416A
Other languages
English (en)
Other versions
EA020507B1 (ru
Inventor
Чафик Амдоучи
Джаяна Панкадж Лайнсвала
Пранаб Маити
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43384775&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201290416(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of EA201290416A1 publication Critical patent/EA201290416A1/ru
Publication of EA020507B1 publication Critical patent/EA020507B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4747—Quinolines; Isoquinolines spiro-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems

Abstract

Соединение формулыили его фармацевтически приемлемая соль, а также фармацевтическая композиция и способ лечения диабета.
EA201290416A 2009-11-30 2010-11-19 Спиропиперидиновые соединения EA020507B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26518109P 2009-11-30 2009-11-30
PCT/US2010/057359 WO2011066183A1 (en) 2009-11-30 2010-11-19 Novel spiropiperidine compounds

Publications (2)

Publication Number Publication Date
EA201290416A1 true EA201290416A1 (ru) 2012-11-30
EA020507B1 EA020507B1 (ru) 2014-11-28

Family

ID=43384775

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201290416A EA020507B1 (ru) 2009-11-30 2010-11-19 Спиропиперидиновые соединения

Country Status (25)

Country Link
US (1) US8822486B2 (ru)
EP (1) EP2507228B1 (ru)
JP (1) JP5709889B2 (ru)
KR (1) KR101410103B1 (ru)
CN (1) CN102648195B (ru)
AR (1) AR078948A1 (ru)
AU (1) AU2010324987B2 (ru)
BR (1) BR112012012903A2 (ru)
CA (1) CA2781292C (ru)
CL (1) CL2012001321A1 (ru)
CR (1) CR20120296A (ru)
DO (1) DOP2012000139A (ru)
EA (1) EA020507B1 (ru)
EC (1) ECSP12011930A (ru)
ES (1) ES2526568T3 (ru)
GT (1) GT201200164A (ru)
IL (1) IL219594A0 (ru)
MA (1) MA33840B1 (ru)
MX (1) MX2012006233A (ru)
NZ (1) NZ600203A (ru)
PE (1) PE20121474A1 (ru)
TN (1) TN2012000248A1 (ru)
TW (1) TW201141866A (ru)
WO (1) WO2011066183A1 (ru)
ZA (1) ZA201203055B (ru)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR078522A1 (es) 2009-10-15 2011-11-16 Lilly Co Eli Compuesto de espiropiperidina, composicion farmaceutica que lo comprende, su uso para preparar un medicamento util para tratar diabetes y compuesto intermediario para su sintesis
WO2011078371A1 (ja) 2009-12-25 2011-06-30 持田製薬株式会社 新規３－ヒドロキシ－５－アリールイソチアゾール誘導体
JP5809157B2 (ja) 2010-10-08 2015-11-10 持田製薬株式会社 環状アミド誘導体
BR112013027883A2 (pt) 2011-04-27 2017-08-08 Mochida Pharm Co Ltd novo derivado de 1-óxido de 3-hidroxiisotiazol
US9072758B2 (en) 2011-04-28 2015-07-07 Mochida Pharmaceutical Co., Ltd. Cyclic amide derivative
TWI537262B (zh) * 2011-08-17 2016-06-11 美國禮來大藥廠 供治療糖尿病使用之新穎１，２，３，４－四氫喹啉衍生物
US10118922B2 (en) 2013-03-14 2018-11-06 Janssen Pharmaceutica Nv GPR120 agonists for the treatment of type II diabetes
EP3068788A1 (en) 2013-11-14 2016-09-21 Cadila Healthcare Limited Novel heterocyclic compounds
EP3076959B1 (en) 2013-12-04 2018-07-04 Merck Sharp & Dohme Corp. Antidiabetic bicyclic compounds
WO2015119899A1 (en) 2014-02-06 2015-08-13 Merck Sharp & Dohme Corp. Antidiabetic compounds
WO2018166855A1 (en) 2017-03-16 2018-09-20 Basf Se Heterobicyclic substituted dihydroisoxazoles
UA126458C2 (uk) 2018-02-13 2022-10-05 Гіліад Сайєнсіз, Інк. Інгібітори pd-1/pd-l1
JP7242702B2 (ja) 2018-04-19 2023-03-20 ギリアード サイエンシーズ， インコーポレイテッド Ｐｄ－１／ｐｄ－ｌ１阻害剤
TWI732245B (zh) 2018-07-13 2021-07-01 美商基利科學股份有限公司 Pd‐1/pd‐l1抑制劑
WO2020086556A1 (en) 2018-10-24 2020-04-30 Gilead Sciences, Inc. Pd-1/pd-l1 inhibitors
CN110590767B (zh) * 2019-08-29 2021-10-08 南方科技大学 一种合成amg837的方法
BR112022006546A2 (pt) 2019-10-07 2022-08-30 Kallyope Inc Agonistas de gpr119
MX2022014505A (es) 2020-05-19 2022-12-13 Kallyope Inc Activadores de la ampk.
CA3183575A1 (en) 2020-06-26 2021-12-30 Iyassu Sebhat Ampk activators

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0202133D0 (sv) * 2002-07-08 2002-07-08 Astrazeneca Ab Novel compounds
EP1613601A4 (en) * 2003-04-04 2007-05-02 Merck & Co Inc ACYLATED SPIROPIPERIDINE DERIVATIVES AS AGONISTS FOR MELANOCORTIN-4 RECEPTOR
EP1682136A4 (en) 2003-11-04 2009-06-03 Elixir Pharmaceuticals Inc THERAPEUTIC COMPOUNDS AND CORRESPONDING USES THEREOF
ES2433466T3 (es) 2004-02-27 2013-12-11 Amgen, Inc Compuestos, composiciones farmacéuticas y métodos para su uso en el tratamiento de trastornos metabólicos
EP2253315A1 (en) 2004-03-30 2010-11-24 Takeda Pharmaceutical Company Limited Alkoxyphenylpropanoic acid derivatives
CN101056861B (zh) * 2004-09-07 2011-04-06 万有制药株式会社 氨基甲酰基取代螺衍生物
CA2657639A1 (en) * 2006-07-19 2008-01-24 Astrazeneca Ab Novel tricyclic spiropiperidine compounds, their synthesis and their uses as modulators of chemokine receptor activity
WO2008047544A1 (fr) * 2006-09-28 2008-04-24 Banyu Pharmaceutical Co., Ltd. Dérivé diarylcétimine
ATE486877T1 (de) * 2006-12-29 2010-11-15 Hoffmann La Roche Azaspiroderivate
CA2683751C (en) * 2007-04-16 2013-01-08 Amgen Inc. Substituted biphenyl phenoxy-, thiophenyl- and aminophenylpropanoic acid gpr40 modulators
CL2008003153A1 (es) 2007-10-26 2009-07-24 Japan Tobacco Inc Compuestos espiro condensados, agonistas de gpr40: composicion farmaceutica que comprende a uno de los compuestos; y el uso de los compuestos en la preparacion de medicamentos para el tratamiento de la diabetes, hiperglicemia, alteracion de tolerancia a la glucosa en ayuna, entre otras.
AR078522A1 (es) 2009-10-15 2011-11-16 Lilly Co Eli Compuesto de espiropiperidina, composicion farmaceutica que lo comprende, su uso para preparar un medicamento util para tratar diabetes y compuesto intermediario para su sintesis
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament

Also Published As

Publication number Publication date
EA020507B1 (ru) 2014-11-28
ZA201203055B (en) 2013-09-25
CN102648195B (zh) 2015-01-07
NZ600203A (en) 2013-09-27
US20120220616A1 (en) 2012-08-30
TN2012000248A1 (en) 2013-12-12
KR20120088770A (ko) 2012-08-08
CL2012001321A1 (es) 2013-11-15
AR078948A1 (es) 2011-12-14
AU2010324987B2 (en) 2014-01-30
CR20120296A (es) 2012-07-16
CN102648195A (zh) 2012-08-22
IL219594A0 (en) 2012-06-28
TW201141866A (en) 2011-12-01
MX2012006233A (es) 2012-07-03
DOP2012000139A (es) 2012-08-15
KR101410103B1 (ko) 2014-06-25
CA2781292C (en) 2014-04-22
CA2781292A1 (en) 2011-06-03
AU2010324987A1 (en) 2012-07-26
JP5709889B2 (ja) 2015-04-30
EP2507228A1 (en) 2012-10-10
ES2526568T3 (es) 2015-01-13
MA33840B1 (fr) 2012-12-03
BR112012012903A2 (pt) 2017-03-01
EP2507228B1 (en) 2014-11-05
JP2013512277A (ja) 2013-04-11
GT201200164A (es) 2014-02-27
PE20121474A1 (es) 2012-11-05
US8822486B2 (en) 2014-09-02
ECSP12011930A (es) 2012-07-31
WO2011066183A1 (en) 2011-06-03

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU