AR078948A1 - Compuestos de espiropiperidina, composicion farmaceutica que lo comprenden y su uso para preparar un medicamento util para tratar la diabetes - Google Patents

Compuestos de espiropiperidina, composicion farmaceutica que lo comprenden y su uso para preparar un medicamento util para tratar la diabetes

Info

Publication number
AR078948A1
AR078948A1 ARP100104151A ARP100104151A AR078948A1 AR 078948 A1 AR078948 A1 AR 078948A1 AR P100104151 A ARP100104151 A AR P100104151A AR P100104151 A ARP100104151 A AR P100104151A AR 078948 A1 AR078948 A1 AR 078948A1
Authority
AR
Argentina
Prior art keywords
group
prepare
pharmaceutical composition
spyropiperidine
compounds
Prior art date
Application number
ARP100104151A
Other languages
English (en)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43384775&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR078948(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of AR078948A1 publication Critical patent/AR078948A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4747—Quinolines; Isoquinolines spiro-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems

Abstract

Compuesto de espiropiperidina de la formula: (1) o una sal del mismo farmacéuticamente aceptable: donde: R1 se selecciona del grupo que consiste de H, F y CI; R5 es H o -C:::CCH3; X se selecciona del grupo que consiste de -CH2CH2-, -CH=CH-, y -N(R7)CH2-; R7 se selecciona del grupo que consiste de H y alquilo de C1-3; Z1 se selecciona del grupo que consiste de -C(R3)- y -N-; R3 se selecciona del grupo que consiste de H, OCH3, y CH3; Z2 se selecciona del grupo que consiste de -S- y -O-; Z3 se selecciona del grupo que consiste de -C(R4)- y -N-; R4 se selecciona del grupo que consiste de H, OCH3, y CH3; y en donde al menos uno seleccionado del grupo que consiste de Z1 y Z3 es -C(R3)- o -C(R4)-. Composicion farmacéutica que lo comprende y su uso para preparar un medicamento util para tratar la diabetes. Son activadores de receptores GPR40.
ARP100104151A 2009-11-30 2010-11-08 Compuestos de espiropiperidina, composicion farmaceutica que lo comprenden y su uso para preparar un medicamento util para tratar la diabetes AR078948A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US26518109P 2009-11-30 2009-11-30

Publications (1)

Publication Number Publication Date
AR078948A1 true AR078948A1 (es) 2011-12-14

Family

ID=43384775

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP100104151A AR078948A1 (es) 2009-11-30 2010-11-08 Compuestos de espiropiperidina, composicion farmaceutica que lo comprenden y su uso para preparar un medicamento util para tratar la diabetes

Country Status (25)

Country Link
US (1) US8822486B2 (es)
EP (1) EP2507228B1 (es)
JP (1) JP5709889B2 (es)
KR (1) KR101410103B1 (es)
CN (1) CN102648195B (es)
AR (1) AR078948A1 (es)
AU (1) AU2010324987B2 (es)
BR (1) BR112012012903A2 (es)
CA (1) CA2781292C (es)
CL (1) CL2012001321A1 (es)
CR (1) CR20120296A (es)
DO (1) DOP2012000139A (es)
EA (1) EA020507B1 (es)
EC (1) ECSP12011930A (es)
ES (1) ES2526568T3 (es)
GT (1) GT201200164A (es)
IL (1) IL219594A0 (es)
MA (1) MA33840B1 (es)
MX (1) MX2012006233A (es)
NZ (1) NZ600203A (es)
PE (1) PE20121474A1 (es)
TN (1) TN2012000248A1 (es)
TW (1) TW201141866A (es)
WO (1) WO2011066183A1 (es)
ZA (1) ZA201203055B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR078522A1 (es) 2009-10-15 2011-11-16 Lilly Co Eli Compuesto de espiropiperidina, composicion farmaceutica que lo comprende, su uso para preparar un medicamento util para tratar diabetes y compuesto intermediario para su sintesis
WO2011078371A1 (ja) 2009-12-25 2011-06-30 持田製薬株式会社 新規３－ヒドロキシ－５－アリールイソチアゾール誘導体
AU2011313191A1 (en) 2010-10-08 2013-05-02 Mochida Pharmaceutical Co., Ltd. Cyclic amide derivative
KR20140021624A (ko) 2011-04-27 2014-02-20 모찌다 세이야쿠 가부시끼가이샤 신규 3-히드록시이소티아졸 1-옥시드 유도체
CA2834465A1 (en) 2011-04-28 2012-11-01 Mochida Pharmaceutical Co., Ltd. Cyclic amide derivative
TWI537262B (zh) * 2011-08-17 2016-06-11 美國禮來大藥廠 供治療糖尿病使用之新穎１，２，３，４－四氫喹啉衍生物
ES2690145T3 (es) 2013-03-14 2018-11-19 Janssen Pharmaceutica Nv Agonistas de GPR120 para el tratamiento de diabetes de tipo 2
AP2016009176A0 (en) 2013-11-14 2016-04-30 Cadila Healthcare Ltd Novel heterocyclic compounds
US9957219B2 (en) 2013-12-04 2018-05-01 Merck Sharp & Dohme Corp. Antidiabetic bicyclic compounds
WO2015119899A1 (en) 2014-02-06 2015-08-13 Merck Sharp & Dohme Corp. Antidiabetic compounds
WO2018166855A1 (en) 2017-03-16 2018-09-20 Basf Se Heterobicyclic substituted dihydroisoxazoles
EP4227302A1 (en) 2018-02-13 2023-08-16 Gilead Sciences, Inc. Pd-1/pd-l1 inhibitors
JP7242702B2 (ja) 2018-04-19 2023-03-20 ギリアード サイエンシーズ， インコーポレイテッド Ｐｄ－１／ｐｄ－ｌ１阻害剤
PT3820572T (pt) 2018-07-13 2023-11-10 Gilead Sciences Inc Inibidores pd-1/pd-l1
US11236085B2 (en) 2018-10-24 2022-02-01 Gilead Sciences, Inc. PD-1/PD-L1 inhibitors
CN110590767B (zh) * 2019-08-29 2021-10-08 南方科技大学 一种合成amg837的方法
AU2020363377A1 (en) 2019-10-07 2022-04-21 Kallyope, Inc. GPR119 agonists
JP2023526625A (ja) 2020-05-19 2023-06-22 キャリーオペ，インク． Ａｍｐｋアクチベーター
CA3183575A1 (en) 2020-06-26 2021-12-30 Iyassu Sebhat Ampk activators

Family Cites Families (14)

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Publication number Priority date Publication date Assignee Title
SE0202133D0 (sv) * 2002-07-08 2002-07-08 Astrazeneca Ab Novel compounds
JP3856815B2 (ja) * 2003-04-04 2006-12-13 メルク エンド カムパニー インコーポレーテッド メラノコルチン−４受容体アゴニストとしてのアシル化スピロピペリジン誘導体
CA2544602A1 (en) 2003-11-04 2005-05-26 Elixir Pharmaceuticals, Inc. Therapeutic compounds and uses thereof
EA011010B1 (ru) 2004-02-27 2008-12-30 Эмджен, Инк. Соединения, модулирующие рецептор gpr40, фармацевтическая композиция, способ лечения заболеваний, чувствительных к модулированию рецептора gpr40 (варианты), способ модулирования функции gpr40 (варианты) и способ модулирования циркулирующей концентрации инсулина
US7517910B2 (en) 2004-03-30 2009-04-14 Takeda Pharmaceutical Company Limited Alkoxyphenylpropanoic acid derivatives
CN101056861B (zh) * 2004-09-07 2011-04-06 万有制药株式会社 氨基甲酰基取代螺衍生物
CN101553493B (zh) * 2006-07-19 2012-07-04 阿斯利康(瑞典)有限公司 三环螺哌啶化合物、它们的合成和它们作为趋化因子受体活性调节剂的用途
JPWO2008038692A1 (ja) * 2006-09-28 2010-01-28 萬有製薬株式会社 ジアリールケチミン誘導体
JP2010514727A (ja) * 2006-12-29 2010-05-06 エフ．ホフマン−ラ ロシュ アーゲー アザスピロ誘導体
JP2010524932A (ja) * 2007-04-16 2010-07-22 アムジエン・インコーポレーテツド 置換ビフェニルフェノキシ−、チオフェニル−及びアミノフェニルプロパン酸ｇｐｒ４０調節物質
DK2202216T3 (da) * 2007-10-26 2012-09-10 Japan Tobacco Inc Spiro-ringforbindelse samt dens anvendelse til medicinske formål
AR078522A1 (es) * 2009-10-15 2011-11-16 Lilly Co Eli Compuesto de espiropiperidina, composicion farmaceutica que lo comprende, su uso para preparar un medicamento util para tratar diabetes y compuesto intermediario para su sintesis
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament

Also Published As

Publication number Publication date
CN102648195A (zh) 2012-08-22
AU2010324987B2 (en) 2014-01-30
AU2010324987A1 (en) 2012-07-26
KR20120088770A (ko) 2012-08-08
KR101410103B1 (ko) 2014-06-25
JP2013512277A (ja) 2013-04-11
JP5709889B2 (ja) 2015-04-30
DOP2012000139A (es) 2012-08-15
EA201290416A1 (ru) 2012-11-30
BR112012012903A2 (pt) 2017-03-01
ECSP12011930A (es) 2012-07-31
WO2011066183A1 (en) 2011-06-03
TN2012000248A1 (en) 2013-12-12
US8822486B2 (en) 2014-09-02
EA020507B1 (ru) 2014-11-28
MA33840B1 (fr) 2012-12-03
ZA201203055B (en) 2013-09-25
CL2012001321A1 (es) 2013-11-15
NZ600203A (en) 2013-09-27
CN102648195B (zh) 2015-01-07
PE20121474A1 (es) 2012-11-05
US20120220616A1 (en) 2012-08-30
TW201141866A (en) 2011-12-01
CA2781292C (en) 2014-04-22
CR20120296A (es) 2012-07-16
MX2012006233A (es) 2012-07-03
GT201200164A (es) 2014-02-27
ES2526568T3 (es) 2015-01-13
EP2507228A1 (en) 2012-10-10
IL219594A0 (en) 2012-06-28
EP2507228B1 (en) 2014-11-05
CA2781292A1 (en) 2011-06-03

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Legal Events

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FA Abandonment or withdrawal